Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP41

Species:

Leishmania mexicana

UniProt:

E9AV19_LEIMU

TriTrypDb:

LmxM.21.0520

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AV19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.628
CLV_NRD_NRD_1	111	113	PF00675	0.364
CLV_NRD_NRD_1	3	5	PF00675	0.521
CLV_NRD_NRD_1	317	319	PF00675	0.585
CLV_NRD_NRD_1	34	36	PF00675	0.398
CLV_PCSK_KEX2_1	111	113	PF00082	0.364
CLV_PCSK_KEX2_1	3	5	PF00082	0.535
CLV_PCSK_KEX2_1	317	319	PF00082	0.585
CLV_PCSK_SKI1_1	298	302	PF00082	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.519
DEG_SPOP_SBC_1	135	139	PF00917	0.496
DOC_CKS1_1	190	195	PF01111	0.376
DOC_CKS1_1	340	345	PF01111	0.425
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.275
DOC_MAPK_gen_1	33	43	PF00069	0.398
DOC_PP2B_LxvP_1	239	242	PF13499	0.550
DOC_PP2B_LxvP_1	347	350	PF13499	0.329
DOC_USP7_MATH_1	104	108	PF00917	0.313
DOC_USP7_MATH_1	158	162	PF00917	0.561
DOC_USP7_MATH_1	200	204	PF00917	0.450
DOC_USP7_MATH_1	263	267	PF00917	0.540
DOC_USP7_MATH_1	269	273	PF00917	0.543
DOC_USP7_MATH_1	334	338	PF00917	0.580
DOC_USP7_MATH_1	406	410	PF00917	0.550
DOC_USP7_MATH_1	433	437	PF00917	0.337
DOC_USP7_MATH_1	70	74	PF00917	0.435
DOC_WW_Pin1_4	189	194	PF00397	0.525
DOC_WW_Pin1_4	339	344	PF00397	0.467
DOC_WW_Pin1_4	36	41	PF00397	0.478
LIG_14-3-3_CanoR_1	157	167	PF00244	0.480
LIG_14-3-3_CanoR_1	218	222	PF00244	0.263
LIG_14-3-3_CanoR_1	271	275	PF00244	0.488
LIG_14-3-3_CanoR_1	285	292	PF00244	0.459
LIG_14-3-3_CanoR_1	318	328	PF00244	0.495
LIG_14-3-3_CanoR_1	35	40	PF00244	0.425
LIG_14-3-3_CanoR_1	4	10	PF00244	0.434
LIG_Actin_WH2_2	252	267	PF00022	0.467
LIG_BIR_III_4	359	363	PF00653	0.474
LIG_BRCT_BRCA1_1	38	42	PF00533	0.552
LIG_EH1_1	232	240	PF00400	0.485
LIG_FHA_1	104	110	PF00498	0.421
LIG_FHA_1	222	228	PF00498	0.384
LIG_FHA_1	242	248	PF00498	0.448
LIG_FHA_1	351	357	PF00498	0.432
LIG_FHA_2	415	421	PF00498	0.541
LIG_FHA_2	42	48	PF00498	0.514
LIG_FHA_2	94	100	PF00498	0.571
LIG_LIR_Apic_2	222	228	PF02991	0.405
LIG_LIR_Gen_1	166	175	PF02991	0.443
LIG_LIR_Gen_1	429	435	PF02991	0.505
LIG_LIR_Gen_1	85	93	PF02991	0.474
LIG_LIR_Nem_3	166	170	PF02991	0.525
LIG_LIR_Nem_3	345	351	PF02991	0.451
LIG_LIR_Nem_3	39	45	PF02991	0.518
LIG_LIR_Nem_3	429	434	PF02991	0.510
LIG_LIR_Nem_3	85	90	PF02991	0.468
LIG_SH2_CRK	152	156	PF00017	0.403
LIG_SH2_CRK	34	38	PF00017	0.374
LIG_SH2_CRK	7	11	PF00017	0.449
LIG_SH2_PTP2	87	90	PF00017	0.452
LIG_SH2_STAT3	110	113	PF00017	0.554
LIG_SH2_STAT5	108	111	PF00017	0.389
LIG_SH2_STAT5	444	447	PF00017	0.469
LIG_SH2_STAT5	7	10	PF00017	0.386
LIG_SH2_STAT5	87	90	PF00017	0.452
LIG_SH3_3	187	193	PF00018	0.443
LIG_SH3_3	410	416	PF00018	0.523
LIG_SH3_3	60	66	PF00018	0.390
LIG_SH3_3	8	14	PF00018	0.379
LIG_Sin3_3	74	81	PF02671	0.341
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.467
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.336
LIG_TRAF2_1	234	237	PF00917	0.345
LIG_TRAF2_1	417	420	PF00917	0.564
LIG_TRFH_1	7	11	PF08558	0.449
LIG_TYR_ITIM	150	155	PF00017	0.390
LIG_TYR_ITIM	32	37	PF00017	0.261
LIG_TYR_ITIM	5	10	PF00017	0.453
MOD_CK1_1	139	145	PF00069	0.560
MOD_CK1_1	163	169	PF00069	0.518
MOD_CK1_1	272	278	PF00069	0.442
MOD_CK2_1	252	258	PF00069	0.460
MOD_CK2_1	284	290	PF00069	0.314
MOD_CK2_1	41	47	PF00069	0.514
MOD_CK2_1	414	420	PF00069	0.522
MOD_CK2_1	93	99	PF00069	0.506
MOD_GlcNHglycan	138	141	PF01048	0.595
MOD_GlcNHglycan	144	147	PF01048	0.517
MOD_GlcNHglycan	160	163	PF01048	0.606
MOD_GlcNHglycan	200	203	PF01048	0.579
MOD_GlcNHglycan	23	26	PF01048	0.494
MOD_GlcNHglycan	261	264	PF01048	0.534
MOD_GlcNHglycan	265	268	PF01048	0.386
MOD_GlcNHglycan	286	289	PF01048	0.362
MOD_GlcNHglycan	336	339	PF01048	0.518
MOD_GlcNHglycan	359	363	PF01048	0.477
MOD_GlcNHglycan	396	399	PF01048	0.607
MOD_GlcNHglycan	72	75	PF01048	0.447
MOD_GlcNHglycan	79	82	PF01048	0.431
MOD_GSK3_1	135	142	PF00069	0.683
MOD_GSK3_1	178	185	PF00069	0.714
MOD_GSK3_1	196	203	PF00069	0.491
MOD_GSK3_1	217	224	PF00069	0.399
MOD_GSK3_1	237	244	PF00069	0.504
MOD_GSK3_1	259	266	PF00069	0.408
MOD_GSK3_1	350	357	PF00069	0.373
MOD_N-GLC_1	183	188	PF02516	0.572
MOD_N-GLC_1	259	264	PF02516	0.399
MOD_NEK2_1	20	25	PF00069	0.512
MOD_NEK2_1	214	219	PF00069	0.372
MOD_NEK2_1	221	226	PF00069	0.387
MOD_NEK2_1	394	399	PF00069	0.657
MOD_NEK2_1	41	46	PF00069	0.459
MOD_PIKK_1	241	247	PF00454	0.513
MOD_PIKK_1	400	406	PF00454	0.507
MOD_PKA_1	317	323	PF00069	0.582
MOD_PKA_1	35	41	PF00069	0.426
MOD_PKA_2	217	223	PF00069	0.288
MOD_PKA_2	270	276	PF00069	0.417
MOD_PKA_2	284	290	PF00069	0.465
MOD_PKA_2	317	323	PF00069	0.531
MOD_PKB_1	33	41	PF00069	0.408
MOD_PKB_1	368	376	PF00069	0.420
MOD_Plk_1	183	189	PF00069	0.501
MOD_Plk_1	221	227	PF00069	0.432
MOD_Plk_1	259	265	PF00069	0.491
MOD_Plk_4	104	110	PF00069	0.371
MOD_Plk_4	252	258	PF00069	0.408
MOD_Plk_4	5	11	PF00069	0.435
MOD_ProDKin_1	189	195	PF00069	0.509
MOD_ProDKin_1	339	345	PF00069	0.462
MOD_ProDKin_1	36	42	PF00069	0.469
TRG_DiLeu_BaEn_4	236	242	PF01217	0.301
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.537
TRG_ENDOCYTIC_2	152	155	PF00928	0.392
TRG_ENDOCYTIC_2	34	37	PF00928	0.370
TRG_ENDOCYTIC_2	7	10	PF00928	0.409
TRG_ENDOCYTIC_2	87	90	PF00928	0.462
TRG_ER_diArg_1	110	112	PF00400	0.348
TRG_ER_diArg_1	149	152	PF00400	0.500
TRG_ER_diArg_1	2	4	PF00400	0.526
TRG_ER_diArg_1	316	318	PF00400	0.543
TRG_ER_diArg_1	407	410	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P853	Leptomonas seymouri	53%	88%
A0A1X0NY38	Trypanosomatidae	30%	100%
A0A3Q8IDW0	Leishmania donovani	94%	100%
A0A422NBK7	Trypanosoma rangeli	30%	100%
A4HBP9	Leishmania braziliensis	86%	99%
A4HZ51	Leishmania infantum	94%	100%
D0A1Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QCG3	Leishmania major	95%	100%
V5BQ65	Trypanosoma cruzi	28%	100%