Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV18_LEIMU

TriTrypDb:

LmxM.21.0510

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.637
CLV_C14_Caspase3-7	50	54	PF00656	0.516
CLV_NRD_NRD_1	256	258	PF00675	0.474
CLV_NRD_NRD_1	464	466	PF00675	0.639
CLV_PCSK_KEX2_1	142	144	PF00082	0.415
CLV_PCSK_KEX2_1	4	6	PF00082	0.592
CLV_PCSK_KEX2_1	463	465	PF00082	0.639
CLV_PCSK_KEX2_1	84	86	PF00082	0.737
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.514
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.592
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.750
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.737
CLV_PCSK_SKI1_1	143	147	PF00082	0.412
CLV_PCSK_SKI1_1	29	33	PF00082	0.680
CLV_PCSK_SKI1_1	37	41	PF00082	0.546
DEG_APCC_DBOX_1	142	150	PF00400	0.418
DEG_SCF_FBW7_1	148	154	PF00400	0.527
DEG_SCF_FBW7_2	520	527	PF00400	0.515
DEG_SPOP_SBC_1	320	324	PF00917	0.740
DOC_CDC14_PxL_1	131	139	PF14671	0.538
DOC_CDC14_PxL_1	192	200	PF14671	0.538
DOC_CKS1_1	148	153	PF01111	0.521
DOC_CKS1_1	484	489	PF01111	0.703
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.605
DOC_MAPK_gen_1	142	148	PF00069	0.410
DOC_MAPK_gen_1	413	420	PF00069	0.669
DOC_MAPK_MEF2A_6	413	422	PF00069	0.774
DOC_MAPK_MEF2A_6	521	528	PF00069	0.513
DOC_PP2B_LxvP_1	193	196	PF13499	0.473
DOC_USP7_MATH_1	10	14	PF00917	0.718
DOC_USP7_MATH_1	103	107	PF00917	0.628
DOC_USP7_MATH_1	112	116	PF00917	0.554
DOC_USP7_MATH_1	214	218	PF00917	0.697
DOC_USP7_MATH_1	319	323	PF00917	0.743
DOC_USP7_MATH_1	33	37	PF00917	0.544
DOC_USP7_MATH_1	333	337	PF00917	0.643
DOC_USP7_MATH_1	405	409	PF00917	0.773
DOC_USP7_MATH_1	478	482	PF00917	0.585
DOC_USP7_MATH_1	510	514	PF00917	0.703
DOC_USP7_MATH_1	515	519	PF00917	0.729
DOC_USP7_MATH_1	70	74	PF00917	0.480
DOC_WW_Pin1_4	147	152	PF00397	0.430
DOC_WW_Pin1_4	483	488	PF00397	0.708
DOC_WW_Pin1_4	520	525	PF00397	0.819
DOC_WW_Pin1_4	77	82	PF00397	0.709
LIG_14-3-3_CanoR_1	343	347	PF00244	0.534
LIG_14-3-3_CanoR_1	37	45	PF00244	0.610
LIG_14-3-3_CanoR_1	464	468	PF00244	0.645
LIG_14-3-3_CanoR_1	483	487	PF00244	0.627
LIG_14-3-3_CanoR_1	516	520	PF00244	0.665
LIG_14-3-3_CanoR_1	8	13	PF00244	0.751
LIG_Actin_WH2_2	127	144	PF00022	0.569
LIG_APCC_ABBA_1	248	253	PF00400	0.471
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_BRCT_BRCA1_1	304	308	PF00533	0.658
LIG_BRCT_BRCA1_1	322	326	PF00533	0.449
LIG_BRCT_BRCA1_1	79	83	PF00533	0.633
LIG_FHA_1	148	154	PF00498	0.495
LIG_FHA_1	176	182	PF00498	0.439
LIG_FHA_1	219	225	PF00498	0.649
LIG_FHA_1	273	279	PF00498	0.547
LIG_FHA_1	376	382	PF00498	0.560
LIG_FHA_1	413	419	PF00498	0.750
LIG_FHA_1	424	430	PF00498	0.563
LIG_FHA_1	464	470	PF00498	0.592
LIG_FHA_1	521	527	PF00498	0.539
LIG_FHA_1	92	98	PF00498	0.480
LIG_FHA_2	227	233	PF00498	0.582
LIG_FHA_2	330	336	PF00498	0.713
LIG_FHA_2	38	44	PF00498	0.523
LIG_FHA_2	395	401	PF00498	0.707
LIG_FHA_2	548	554	PF00498	0.655
LIG_LIR_Gen_1	109	119	PF02991	0.455
LIG_LIR_Gen_1	157	165	PF02991	0.492
LIG_LIR_Gen_1	305	315	PF02991	0.425
LIG_LIR_Nem_3	157	162	PF02991	0.489
LIG_LIR_Nem_3	305	311	PF02991	0.518
LIG_LIR_Nem_3	80	86	PF02991	0.483
LIG_MYND_1	196	200	PF01753	0.543
LIG_MYND_1	450	454	PF01753	0.638
LIG_MYND_3	134	138	PF01753	0.533
LIG_NRBOX	176	182	PF00104	0.491
LIG_NRBOX	223	229	PF00104	0.650
LIG_SH2_CRK	119	123	PF00017	0.514
LIG_SH2_NCK_1	304	308	PF00017	0.576
LIG_SH2_SRC	203	206	PF00017	0.607
LIG_SH2_STAP1	203	207	PF00017	0.593
LIG_SH2_STAP1	304	308	PF00017	0.674
LIG_SH2_STAT3	129	132	PF00017	0.441
LIG_SH2_STAT3	62	65	PF00017	0.575
LIG_SH2_STAT5	272	275	PF00017	0.526
LIG_SH2_STAT5	298	301	PF00017	0.588
LIG_SH2_STAT5	62	65	PF00017	0.555
LIG_SH3_3	145	151	PF00018	0.422
LIG_SH3_3	364	370	PF00018	0.541
LIG_SH3_3	415	421	PF00018	0.729
LIG_SH3_3	444	450	PF00018	0.635
LIG_SH3_3	474	480	PF00018	0.675
LIG_SH3_3	481	487	PF00018	0.687
LIG_SH3_3	493	499	PF00018	0.482
LIG_SH3_3	504	510	PF00018	0.704
LIG_SH3_3	519	525	PF00018	0.769
LIG_SH3_3	531	537	PF00018	0.684
LIG_SH3_3	538	544	PF00018	0.625
LIG_Sin3_3	455	462	PF02671	0.732
LIG_SUMO_SIM_par_1	189	194	PF11976	0.559
LIG_SUMO_SIM_par_1	226	233	PF11976	0.601
LIG_TRAF2_1	136	139	PF00917	0.473
LIG_TRAF2_1	300	303	PF00917	0.624
LIG_TRAF2_1	40	43	PF00917	0.599
LIG_TYR_ITIM	117	122	PF00017	0.520
LIG_UBA3_1	133	142	PF00899	0.520
MOD_CDK_SPxxK_3	77	84	PF00069	0.713
MOD_CK1_1	13	19	PF00069	0.697
MOD_CK1_1	240	246	PF00069	0.670
MOD_CK1_1	322	328	PF00069	0.676
MOD_CK1_1	35	41	PF00069	0.660
MOD_CK2_1	133	139	PF00069	0.581
MOD_CK2_1	151	157	PF00069	0.443
MOD_CK2_1	226	232	PF00069	0.601
MOD_CK2_1	297	303	PF00069	0.557
MOD_CK2_1	37	43	PF00069	0.523
MOD_Cter_Amidation	411	414	PF01082	0.577
MOD_DYRK1A_RPxSP_1	483	487	PF00069	0.524
MOD_GlcNHglycan	114	117	PF01048	0.534
MOD_GlcNHglycan	12	15	PF01048	0.743
MOD_GlcNHglycan	212	215	PF01048	0.647
MOD_GlcNHglycan	238	242	PF01048	0.735
MOD_GlcNHglycan	480	483	PF01048	0.735
MOD_GlcNHglycan	517	520	PF01048	0.616
MOD_GlcNHglycan	72	75	PF01048	0.490
MOD_GSK3_1	10	17	PF00069	0.736
MOD_GSK3_1	147	154	PF00069	0.483
MOD_GSK3_1	210	217	PF00069	0.618
MOD_GSK3_1	310	317	PF00069	0.653
MOD_GSK3_1	329	336	PF00069	0.663
MOD_GSK3_1	33	40	PF00069	0.578
MOD_GSK3_1	401	408	PF00069	0.760
MOD_GSK3_1	463	470	PF00069	0.575
MOD_GSK3_1	478	485	PF00069	0.681
MOD_GSK3_1	510	517	PF00069	0.680
MOD_GSK3_1	91	98	PF00069	0.658
MOD_N-GLC_1	401	406	PF02516	0.719
MOD_N-GLC_1	8	13	PF02516	0.699
MOD_NEK2_1	164	169	PF00069	0.414
MOD_NEK2_1	180	185	PF00069	0.483
MOD_NEK2_1	32	37	PF00069	0.653
MOD_NEK2_1	342	347	PF00069	0.462
MOD_NEK2_1	361	366	PF00069	0.280
MOD_NEK2_1	373	378	PF00069	0.532
MOD_NEK2_1	394	399	PF00069	0.723
MOD_NEK2_1	97	102	PF00069	0.726
MOD_PIKK_1	405	411	PF00454	0.704
MOD_PIKK_1	60	66	PF00454	0.556
MOD_PK_1	414	420	PF00069	0.583
MOD_PK_1	8	14	PF00069	0.751
MOD_PKA_1	463	469	PF00069	0.679
MOD_PKA_2	342	348	PF00069	0.572
MOD_PKA_2	463	469	PF00069	0.683
MOD_PKA_2	482	488	PF00069	0.621
MOD_PKA_2	515	521	PF00069	0.616
MOD_PKA_2	95	101	PF00069	0.515
MOD_Plk_1	8	14	PF00069	0.607
MOD_Plk_4	180	186	PF00069	0.489
MOD_Plk_4	322	328	PF00069	0.577
MOD_ProDKin_1	147	153	PF00069	0.428
MOD_ProDKin_1	483	489	PF00069	0.706
MOD_ProDKin_1	520	526	PF00069	0.818
MOD_ProDKin_1	77	83	PF00069	0.714
TRG_DiLeu_BaEn_1	187	192	PF01217	0.511
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.600
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.736
TRG_ENDOCYTIC_2	119	122	PF00928	0.516
TRG_ER_diArg_1	27	30	PF00400	0.530
TRG_NLS_MonoExtN_4	254	261	PF00514	0.519
TRG_NLS_MonoExtN_4	461	467	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT9	Leptomonas seymouri	57%	95%
A0A3Q8IAT2	Leishmania donovani	90%	100%
A0A422NBI2	Trypanosoma rangeli	28%	100%
A4HBP8	Leishmania braziliensis	75%	97%
A4HZ50	Leishmania infantum	83%	94%
D0A1Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QCG4	Leishmania major	84%	97%
V5BKP0	Trypanosoma cruzi	29%	100%