Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV15_LEIMU

TriTrypDb:

LmxM.21.0480

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.488
CLV_C14_Caspase3-7	414	418	PF00656	0.550
CLV_C14_Caspase3-7	444	448	PF00656	0.456
CLV_NRD_NRD_1	118	120	PF00675	0.536
CLV_PCSK_KEX2_1	117	119	PF00082	0.534
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.534
CLV_PCSK_SKI1_1	240	244	PF00082	0.348
CLV_PCSK_SKI1_1	253	257	PF00082	0.613
CLV_PCSK_SKI1_1	268	272	PF00082	0.372
CLV_PCSK_SKI1_1	372	376	PF00082	0.328
CLV_TASPASE1	394	400	PF01112	0.555
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DOC_ANK_TNKS_1	391	398	PF00023	0.550
DOC_CKS1_1	486	491	PF01111	0.669
DOC_MAPK_gen_1	184	193	PF00069	0.465
DOC_MAPK_MEF2A_6	345	353	PF00069	0.423
DOC_PP1_RVXF_1	260	267	PF00149	0.525
DOC_USP7_MATH_1	295	299	PF00917	0.536
DOC_USP7_MATH_1	337	341	PF00917	0.367
DOC_USP7_MATH_1	36	40	PF00917	0.674
DOC_USP7_MATH_1	411	415	PF00917	0.465
DOC_USP7_MATH_1	43	47	PF00917	0.605
DOC_USP7_MATH_1	445	449	PF00917	0.478
DOC_USP7_MATH_1	451	455	PF00917	0.489
DOC_USP7_MATH_1	456	460	PF00917	0.604
DOC_WW_Pin1_4	311	316	PF00397	0.603
DOC_WW_Pin1_4	485	490	PF00397	0.619
LIG_14-3-3_CanoR_1	161	169	PF00244	0.467
LIG_Actin_WH2_2	176	194	PF00022	0.430
LIG_Actin_WH2_2	238	255	PF00022	0.487
LIG_BRCT_BRCA1_1	334	338	PF00533	0.457
LIG_FHA_1	108	114	PF00498	0.545
LIG_FHA_1	3	9	PF00498	0.526
LIG_FHA_1	414	420	PF00498	0.436
LIG_FHA_1	501	507	PF00498	0.702
LIG_FHA_1	52	58	PF00498	0.574
LIG_FHA_1	66	72	PF00498	0.486
LIG_FHA_2	282	288	PF00498	0.620
LIG_FHA_2	364	370	PF00498	0.573
LIG_LIR_Gen_1	267	277	PF02991	0.570
LIG_LIR_Gen_1	335	346	PF02991	0.344
LIG_LIR_Nem_3	267	273	PF02991	0.544
LIG_LIR_Nem_3	335	341	PF02991	0.493
LIG_NRP_CendR_1	508	509	PF00754	0.555
LIG_Pex14_1	266	270	PF04695	0.448
LIG_Pex14_2	334	338	PF04695	0.524
LIG_PTAP_UEV_1	329	334	PF05743	0.431
LIG_RPA_C_Fungi	441	453	PF08784	0.404
LIG_SH2_STAT5	227	230	PF00017	0.422
LIG_SH3_3	32	38	PF00018	0.755
LIG_SH3_3	327	333	PF00018	0.659
LIG_SH3_3	483	489	PF00018	0.722
LIG_SUMO_SIM_anti_2	468	473	PF11976	0.489
LIG_SUMO_SIM_par_1	4	9	PF11976	0.412
LIG_TRAF2_1	122	125	PF00917	0.445
LIG_TRAF2_1	231	234	PF00917	0.444
LIG_TRAF2_1	289	292	PF00917	0.695
LIG_TRAF2_1	91	94	PF00917	0.546
LIG_UBA3_1	380	385	PF00899	0.426
MOD_CK1_1	298	304	PF00069	0.746
MOD_CK1_1	314	320	PF00069	0.574
MOD_CK1_1	324	330	PF00069	0.701
MOD_CK1_1	39	45	PF00069	0.657
MOD_CK1_1	458	464	PF00069	0.650
MOD_CK1_1	46	52	PF00069	0.573
MOD_CK1_1	465	471	PF00069	0.677
MOD_CK1_1	480	486	PF00069	0.614
MOD_CK1_1	491	497	PF00069	0.719
MOD_CK2_1	133	139	PF00069	0.530
MOD_CK2_1	191	197	PF00069	0.446
MOD_CK2_1	227	233	PF00069	0.419
MOD_CK2_1	337	343	PF00069	0.414
MOD_CK2_1	88	94	PF00069	0.539
MOD_Cter_Amidation	506	509	PF01082	0.631
MOD_GlcNHglycan	193	196	PF01048	0.515
MOD_GlcNHglycan	229	232	PF01048	0.464
MOD_GlcNHglycan	296	300	PF01048	0.691
MOD_GlcNHglycan	301	304	PF01048	0.671
MOD_GlcNHglycan	316	319	PF01048	0.648
MOD_GlcNHglycan	334	337	PF01048	0.424
MOD_GlcNHglycan	38	41	PF01048	0.756
MOD_GlcNHglycan	443	446	PF01048	0.526
MOD_GlcNHglycan	45	48	PF01048	0.656
MOD_GlcNHglycan	458	461	PF01048	0.598
MOD_GlcNHglycan	464	467	PF01048	0.637
MOD_GlcNHglycan	472	475	PF01048	0.661
MOD_GlcNHglycan	490	493	PF01048	0.671
MOD_GlcNHglycan	7	11	PF01048	0.538
MOD_GlcNHglycan	77	80	PF01048	0.556
MOD_GSK3_1	156	163	PF00069	0.529
MOD_GSK3_1	2	9	PF00069	0.422
MOD_GSK3_1	295	302	PF00069	0.613
MOD_GSK3_1	324	331	PF00069	0.563
MOD_GSK3_1	39	46	PF00069	0.631
MOD_GSK3_1	441	448	PF00069	0.569
MOD_GSK3_1	451	458	PF00069	0.527
MOD_N-GLC_1	25	30	PF02516	0.620
MOD_NEK2_1	167	172	PF00069	0.405
MOD_NEK2_1	179	184	PF00069	0.504
MOD_NEK2_1	191	196	PF00069	0.365
MOD_NEK2_1	281	286	PF00069	0.494
MOD_NEK2_1	375	380	PF00069	0.514
MOD_NEK2_1	41	46	PF00069	0.572
MOD_NEK2_1	493	498	PF00069	0.666
MOD_PIKK_1	108	114	PF00454	0.605
MOD_PIKK_1	148	154	PF00454	0.523
MOD_PIKK_1	432	438	PF00454	0.550
MOD_PIKK_1	491	497	PF00454	0.719
MOD_PKA_2	160	166	PF00069	0.462
MOD_PKA_2	191	197	PF00069	0.430
MOD_PKA_2	445	451	PF00069	0.465
MOD_PKA_2	477	483	PF00069	0.671
MOD_PKB_1	498	506	PF00069	0.705
MOD_Plk_1	25	31	PF00069	0.616
MOD_Plk_1	368	374	PF00069	0.537
MOD_Plk_1	376	382	PF00069	0.420
MOD_Plk_1	480	486	PF00069	0.708
MOD_Plk_1	6	12	PF00069	0.540
MOD_Plk_2-3	2	8	PF00069	0.483
MOD_Plk_2-3	287	293	PF00069	0.636
MOD_Plk_4	337	343	PF00069	0.344
MOD_Plk_4	376	382	PF00069	0.511
MOD_Plk_4	383	389	PF00069	0.553
MOD_ProDKin_1	311	317	PF00069	0.604
MOD_ProDKin_1	485	491	PF00069	0.622
MOD_SUMO_rev_2	170	177	PF00179	0.523
MOD_SUMO_rev_2	340	347	PF00179	0.367
MOD_SUMO_rev_2	97	107	PF00179	0.493
TRG_DiLeu_BaEn_1	164	169	PF01217	0.524
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.459
TRG_ENDOCYTIC_2	134	137	PF00928	0.437
TRG_ER_diArg_1	183	186	PF00400	0.587
TRG_ER_diArg_1	204	207	PF00400	0.474
TRG_ER_diArg_1	498	501	PF00400	0.620
TRG_ER_diArg_1	502	505	PF00400	0.604
TRG_NES_CRM1_1	7	19	PF08389	0.586
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF17	Leptomonas seymouri	43%	90%
A0A3S7WWD2	Leishmania donovani	88%	100%
A4HBP6	Leishmania braziliensis	79%	100%
A4HZ47	Leishmania infantum	87%	100%
Q4QCG7	Leishmania major	87%	97%