Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AV13_LEIMU

TriTrypDb:

LmxM.21.0460

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.650
CLV_C14_Caspase3-7	516	520	PF00656	0.778
CLV_C14_Caspase3-7	599	603	PF00656	0.538
CLV_C14_Caspase3-7	617	621	PF00656	0.532
CLV_C14_Caspase3-7	664	668	PF00656	0.613
CLV_NRD_NRD_1	183	185	PF00675	0.556
CLV_NRD_NRD_1	291	293	PF00675	0.721
CLV_NRD_NRD_1	388	390	PF00675	0.848
CLV_NRD_NRD_1	398	400	PF00675	0.684
CLV_NRD_NRD_1	417	419	PF00675	0.588
CLV_NRD_NRD_1	436	438	PF00675	0.807
CLV_NRD_NRD_1	61	63	PF00675	0.623
CLV_NRD_NRD_1	633	635	PF00675	0.775
CLV_NRD_NRD_1	650	652	PF00675	0.555
CLV_NRD_NRD_1	687	689	PF00675	0.580
CLV_NRD_NRD_1	731	733	PF00675	0.693
CLV_PCSK_KEX2_1	183	185	PF00082	0.556
CLV_PCSK_KEX2_1	291	293	PF00082	0.721
CLV_PCSK_KEX2_1	388	390	PF00082	0.839
CLV_PCSK_KEX2_1	398	400	PF00082	0.674
CLV_PCSK_KEX2_1	417	419	PF00082	0.656
CLV_PCSK_KEX2_1	61	63	PF00082	0.627
CLV_PCSK_KEX2_1	633	635	PF00082	0.775
CLV_PCSK_KEX2_1	652	654	PF00082	0.502
CLV_PCSK_KEX2_1	731	733	PF00082	0.693
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.528
CLV_PCSK_SKI1_1	232	236	PF00082	0.633
CLV_PCSK_SKI1_1	245	249	PF00082	0.687
CLV_PCSK_SKI1_1	360	364	PF00082	0.682
CLV_PCSK_SKI1_1	418	422	PF00082	0.628
CLV_PCSK_SKI1_1	433	437	PF00082	0.822
CLV_Separin_Metazoa	282	286	PF03568	0.660
DEG_APCC_DBOX_1	276	284	PF00400	0.657
DEG_SCF_FBW7_2	574	579	PF00400	0.769
DEG_SPOP_SBC_1	852	856	PF00917	0.545
DOC_ANK_TNKS_1	612	619	PF00023	0.571
DOC_CKS1_1	10	15	PF01111	0.562
DOC_CKS1_1	187	192	PF01111	0.561
DOC_CKS1_1	336	341	PF01111	0.736
DOC_CYCLIN_RxL_1	242	249	PF00134	0.456
DOC_MAPK_gen_1	291	298	PF00069	0.679
DOC_MAPK_gen_1	651	657	PF00069	0.528
DOC_MAPK_gen_1	844	853	PF00069	0.774
DOC_MAPK_MEF2A_6	188	197	PF00069	0.668
DOC_PP2B_LxvP_1	791	794	PF13499	0.719
DOC_PP2B_LxvP_1	93	96	PF13499	0.639
DOC_PP2B_PxIxI_1	190	196	PF00149	0.663
DOC_PP4_FxxP_1	864	867	PF00568	0.564
DOC_PP4_MxPP_1	228	231	PF00568	0.724
DOC_USP7_MATH_1	162	166	PF00917	0.469
DOC_USP7_MATH_1	2	6	PF00917	0.748
DOC_USP7_MATH_1	224	228	PF00917	0.741
DOC_USP7_MATH_1	325	329	PF00917	0.654
DOC_USP7_MATH_1	348	352	PF00917	0.681
DOC_USP7_MATH_1	36	40	PF00917	0.605
DOC_USP7_MATH_1	374	378	PF00917	0.698
DOC_USP7_MATH_1	49	53	PF00917	0.667
DOC_USP7_MATH_1	545	549	PF00917	0.781
DOC_USP7_MATH_1	665	669	PF00917	0.830
DOC_USP7_MATH_1	683	687	PF00917	0.566
DOC_USP7_MATH_1	815	819	PF00917	0.829
DOC_USP7_MATH_1	827	831	PF00917	0.635
DOC_USP7_MATH_1	852	856	PF00917	0.642
DOC_USP7_UBL2_3	126	130	PF12436	0.477
DOC_WW_Pin1_4	186	191	PF00397	0.598
DOC_WW_Pin1_4	305	310	PF00397	0.588
DOC_WW_Pin1_4	335	340	PF00397	0.738
DOC_WW_Pin1_4	45	50	PF00397	0.686
DOC_WW_Pin1_4	455	460	PF00397	0.711
DOC_WW_Pin1_4	520	525	PF00397	0.637
DOC_WW_Pin1_4	572	577	PF00397	0.847
DOC_WW_Pin1_4	60	65	PF00397	0.625
DOC_WW_Pin1_4	679	684	PF00397	0.796
DOC_WW_Pin1_4	718	723	PF00397	0.681
DOC_WW_Pin1_4	754	759	PF00397	0.428
DOC_WW_Pin1_4	9	14	PF00397	0.564
DOC_WW_Pin1_4	907	912	PF00397	0.550
LIG_14-3-3_CanoR_1	245	254	PF00244	0.491
LIG_14-3-3_CanoR_1	324	334	PF00244	0.790
LIG_14-3-3_CanoR_1	403	409	PF00244	0.588
LIG_14-3-3_CanoR_1	417	421	PF00244	0.661
LIG_14-3-3_CanoR_1	437	447	PF00244	0.537
LIG_14-3-3_CanoR_1	653	658	PF00244	0.533
LIG_14-3-3_CanoR_1	67	75	PF00244	0.639
LIG_14-3-3_CanoR_1	673	680	PF00244	0.765
LIG_14-3-3_CanoR_1	681	691	PF00244	0.818
LIG_BIR_II_1	1	5	PF00653	0.751
LIG_BIR_III_2	519	523	PF00653	0.775
LIG_BIR_III_2	560	564	PF00653	0.664
LIG_BIR_III_4	117	121	PF00653	0.489
LIG_CtBP_PxDLS_1	563	567	PF00389	0.655
LIG_FHA_1	105	111	PF00498	0.682
LIG_FHA_1	13	19	PF00498	0.713
LIG_FHA_1	285	291	PF00498	0.674
LIG_FHA_1	417	423	PF00498	0.695
LIG_FHA_1	426	432	PF00498	0.592
LIG_FHA_1	499	505	PF00498	0.807
LIG_FHA_1	509	515	PF00498	0.703
LIG_FHA_1	682	688	PF00498	0.649
LIG_FHA_1	746	752	PF00498	0.726
LIG_FHA_1	854	860	PF00498	0.704
LIG_FHA_1	908	914	PF00498	0.478
LIG_FHA_2	274	280	PF00498	0.666
LIG_FHA_2	597	603	PF00498	0.535
LIG_FHA_2	662	668	PF00498	0.534
LIG_FHA_2	740	746	PF00498	0.720
LIG_FHA_2	75	81	PF00498	0.743
LIG_FHA_2	872	878	PF00498	0.682
LIG_Integrin_isoDGR_2	386	388	PF01839	0.657
LIG_LIR_Apic_2	862	867	PF02991	0.653
LIG_LIR_Gen_1	12	22	PF02991	0.650
LIG_LIR_Gen_1	129	139	PF02991	0.658
LIG_LIR_Gen_1	140	149	PF02991	0.520
LIG_LIR_Gen_1	213	223	PF02991	0.587
LIG_LIR_Gen_1	249	258	PF02991	0.638
LIG_LIR_Gen_1	872	881	PF02991	0.599
LIG_LIR_Nem_3	12	17	PF02991	0.661
LIG_LIR_Nem_3	129	135	PF02991	0.666
LIG_LIR_Nem_3	140	144	PF02991	0.504
LIG_LIR_Nem_3	145	149	PF02991	0.468
LIG_LIR_Nem_3	19	24	PF02991	0.643
LIG_LIR_Nem_3	213	218	PF02991	0.445
LIG_LIR_Nem_3	246	251	PF02991	0.661
LIG_LIR_Nem_3	604	609	PF02991	0.707
LIG_LIR_Nem_3	872	876	PF02991	0.616
LIG_PCNA_PIPBox_1	768	777	PF02747	0.378
LIG_Pex14_2	596	600	PF04695	0.701
LIG_RPA_C_Fungi	23	35	PF08784	0.479
LIG_SH2_CRK	14	18	PF00017	0.717
LIG_SH2_CRK	146	150	PF00017	0.615
LIG_SH2_NCK_1	406	410	PF00017	0.555
LIG_SH2_STAP1	14	18	PF00017	0.717
LIG_SH2_STAP1	21	25	PF00017	0.580
LIG_SH2_STAT5	14	17	PF00017	0.717
LIG_SH2_STAT5	406	409	PF00017	0.748
LIG_SH2_STAT5	606	609	PF00017	0.734
LIG_SH2_STAT5	871	874	PF00017	0.499
LIG_SH3_1	398	404	PF00018	0.557
LIG_SH3_1	688	694	PF00018	0.564
LIG_SH3_3	184	190	PF00018	0.648
LIG_SH3_3	263	269	PF00018	0.613
LIG_SH3_3	333	339	PF00018	0.822
LIG_SH3_3	398	404	PF00018	0.739
LIG_SH3_3	453	459	PF00018	0.611
LIG_SH3_3	654	660	PF00018	0.588
LIG_SH3_3	677	683	PF00018	0.781
LIG_SH3_3	688	694	PF00018	0.596
LIG_SH3_3	7	13	PF00018	0.724
LIG_SH3_3	709	715	PF00018	0.832
LIG_SH3_3	760	766	PF00018	0.617
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.653
LIG_SUMO_SIM_par_1	371	377	PF11976	0.650
LIG_SUMO_SIM_par_1	418	423	PF11976	0.651
LIG_TRAF2_1	276	279	PF00917	0.679
LIG_TRAF2_1	465	468	PF00917	0.720
LIG_TYR_ITSM	10	17	PF00017	0.560
LIG_WRC_WIRS_1	141	146	PF05994	0.435
LIG_WW_3	229	233	PF00397	0.804
MOD_CDC14_SPxK_1	48	51	PF00782	0.667
MOD_CDK_SPxK_1	45	51	PF00069	0.670
MOD_CDK_SPxxK_3	335	342	PF00069	0.734
MOD_CDK_SPxxK_3	60	67	PF00069	0.699
MOD_CK1_1	246	252	PF00069	0.636
MOD_CK1_1	446	452	PF00069	0.719
MOD_CK1_1	471	477	PF00069	0.576
MOD_CK1_1	525	531	PF00069	0.585
MOD_CK1_1	567	573	PF00069	0.835
MOD_CK1_1	60	66	PF00069	0.713
MOD_CK1_1	682	688	PF00069	0.817
MOD_CK1_1	721	727	PF00069	0.826
MOD_CK1_1	737	743	PF00069	0.548
MOD_CK1_1	74	80	PF00069	0.576
MOD_CK1_1	830	836	PF00069	0.740
MOD_CK2_1	273	279	PF00069	0.686
MOD_CK2_1	562	568	PF00069	0.838
MOD_CK2_1	66	72	PF00069	0.747
MOD_CK2_1	871	877	PF00069	0.680
MOD_CMANNOS	154	157	PF00535	0.665
MOD_Cter_Amidation	386	389	PF01082	0.652
MOD_DYRK1A_RPxSP_1	455	459	PF00069	0.540
MOD_GlcNHglycan	164	167	PF01048	0.443
MOD_GlcNHglycan	176	179	PF01048	0.479
MOD_GlcNHglycan	315	318	PF01048	0.798
MOD_GlcNHglycan	320	323	PF01048	0.748
MOD_GlcNHglycan	328	331	PF01048	0.625
MOD_GlcNHglycan	376	379	PF01048	0.682
MOD_GlcNHglycan	38	41	PF01048	0.570
MOD_GlcNHglycan	51	54	PF01048	0.628
MOD_GlcNHglycan	547	550	PF01048	0.859
MOD_GlcNHglycan	610	613	PF01048	0.851
MOD_GlcNHglycan	68	71	PF01048	0.603
MOD_GlcNHglycan	696	700	PF01048	0.843
MOD_GlcNHglycan	734	737	PF01048	0.746
MOD_GlcNHglycan	739	742	PF01048	0.753
MOD_GlcNHglycan	763	766	PF01048	0.675
MOD_GlcNHglycan	808	811	PF01048	0.781
MOD_GlcNHglycan	823	826	PF01048	0.637
MOD_GSK3_1	120	127	PF00069	0.716
MOD_GSK3_1	174	181	PF00069	0.559
MOD_GSK3_1	246	253	PF00069	0.476
MOD_GSK3_1	41	48	PF00069	0.734
MOD_GSK3_1	416	423	PF00069	0.672
MOD_GSK3_1	433	440	PF00069	0.728
MOD_GSK3_1	467	474	PF00069	0.636
MOD_GSK3_1	536	543	PF00069	0.621
MOD_GSK3_1	604	611	PF00069	0.773
MOD_GSK3_1	62	69	PF00069	0.653
MOD_GSK3_1	661	668	PF00069	0.535
MOD_GSK3_1	679	686	PF00069	0.797
MOD_GSK3_1	721	728	PF00069	0.761
MOD_GSK3_1	730	737	PF00069	0.685
MOD_GSK3_1	806	813	PF00069	0.748
MOD_GSK3_1	815	822	PF00069	0.780
MOD_LATS_1	679	685	PF00433	0.768
MOD_N-GLC_1	820	825	PF02516	0.754
MOD_NEK2_1	243	248	PF00069	0.460
MOD_NEK2_1	283	288	PF00069	0.363
MOD_NEK2_1	596	601	PF00069	0.766
MOD_NEK2_1	637	642	PF00069	0.591
MOD_NEK2_1	819	824	PF00069	0.756
MOD_NEK2_2	178	183	PF00069	0.557
MOD_NEK2_2	224	229	PF00069	0.721
MOD_NEK2_2	683	688	PF00069	0.574
MOD_PIKK_1	2	8	PF00454	0.669
MOD_PIKK_1	439	445	PF00454	0.824
MOD_PIKK_1	618	624	PF00454	0.858
MOD_PIKK_1	725	731	PF00454	0.835
MOD_PK_1	653	659	PF00069	0.535
MOD_PKA_1	437	443	PF00069	0.831
MOD_PKA_1	653	659	PF00069	0.535
MOD_PKA_1	731	737	PF00069	0.765
MOD_PKA_2	104	110	PF00069	0.668
MOD_PKA_2	284	290	PF00069	0.661
MOD_PKA_2	416	422	PF00069	0.682
MOD_PKA_2	570	576	PF00069	0.647
MOD_PKA_2	604	610	PF00069	0.556
MOD_PKA_2	66	72	PF00069	0.586
MOD_PKA_2	672	678	PF00069	0.632
MOD_PKA_2	730	736	PF00069	0.763
MOD_PKA_2	843	849	PF00069	0.834
MOD_PKB_1	651	659	PF00069	0.565
MOD_Plk_1	2	8	PF00069	0.680
MOD_Plk_1	637	643	PF00069	0.747
MOD_Plk_1	71	77	PF00069	0.722
MOD_Plk_4	120	126	PF00069	0.686
MOD_Plk_4	150	156	PF00069	0.504
MOD_Plk_4	446	452	PF00069	0.766
MOD_Plk_4	745	751	PF00069	0.735
MOD_Plk_4	756	762	PF00069	0.501
MOD_Plk_4	767	773	PF00069	0.507
MOD_Plk_4	815	821	PF00069	0.765
MOD_Plk_4	924	930	PF00069	0.535
MOD_Plk_4	95	101	PF00069	0.561
MOD_ProDKin_1	186	192	PF00069	0.593
MOD_ProDKin_1	305	311	PF00069	0.592
MOD_ProDKin_1	335	341	PF00069	0.738
MOD_ProDKin_1	45	51	PF00069	0.686
MOD_ProDKin_1	455	461	PF00069	0.707
MOD_ProDKin_1	520	526	PF00069	0.633
MOD_ProDKin_1	572	578	PF00069	0.848
MOD_ProDKin_1	60	66	PF00069	0.625
MOD_ProDKin_1	679	685	PF00069	0.796
MOD_ProDKin_1	718	724	PF00069	0.682
MOD_ProDKin_1	754	760	PF00069	0.419
MOD_ProDKin_1	9	15	PF00069	0.564
MOD_ProDKin_1	907	913	PF00069	0.546
MOD_SUMO_rev_2	153	163	PF00179	0.601
MOD_SUMO_rev_2	213	223	PF00179	0.736
TRG_DiLeu_BaEn_1	279	284	PF01217	0.647
TRG_DiLeu_BaEn_3	19	25	PF01217	0.584
TRG_DiLeu_BaEn_4	158	164	PF01217	0.657
TRG_DiLeu_BaEn_4	213	219	PF01217	0.439
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.703
TRG_DiLeu_BaLyEn_6	928	933	PF01217	0.524
TRG_ENDOCYTIC_2	14	17	PF00928	0.717
TRG_ENDOCYTIC_2	141	144	PF00928	0.636
TRG_ENDOCYTIC_2	146	149	PF00928	0.625
TRG_ENDOCYTIC_2	21	24	PF00928	0.583
TRG_ENDOCYTIC_2	251	254	PF00928	0.626
TRG_ENDOCYTIC_2	892	895	PF00928	0.716
TRG_ER_diArg_1	182	184	PF00400	0.547
TRG_ER_diArg_1	290	292	PF00400	0.688
TRG_ER_diArg_1	388	390	PF00400	0.839
TRG_ER_diArg_1	397	399	PF00400	0.696
TRG_ER_diArg_1	632	634	PF00400	0.857
TRG_NLS_Bipartite_1	633	655	PF00514	0.533
TRG_NLS_MonoCore_2	650	655	PF00514	0.521
TRG_NLS_MonoExtN_4	651	656	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	653	658	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	883	887	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA94	Leishmania donovani	77%	100%
A4HBP4	Leishmania braziliensis	60%	98%
A4HZ45	Leishmania infantum	75%	100%
Q4QCG9	Leishmania major	77%	97%