WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AV12_LEIMU

TriTrypDb:

LmxM.21.0450

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AV12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	88	94	PF00089	0.593
CLV_NRD_NRD_1	102	104	PF00675	0.520
CLV_NRD_NRD_1	214	216	PF00675	0.542
CLV_NRD_NRD_1	227	229	PF00675	0.555
CLV_NRD_NRD_1	59	61	PF00675	0.519
CLV_PCSK_KEX2_1	102	104	PF00082	0.544
CLV_PCSK_KEX2_1	213	215	PF00082	0.542
CLV_PCSK_KEX2_1	227	229	PF00082	0.557
CLV_PCSK_KEX2_1	59	61	PF00082	0.528
CLV_PCSK_SKI1_1	158	162	PF00082	0.453
CLV_PCSK_SKI1_1	2	6	PF00082	0.489
DEG_APCC_DBOX_1	157	165	PF00400	0.458
DEG_APCC_DBOX_1	26	34	PF00400	0.426
DEG_Nend_UBRbox_1	1	4	PF02207	0.505
DOC_CYCLIN_RxL_1	181	192	PF00134	0.591
DOC_MAPK_gen_1	59	68	PF00069	0.529
DOC_PP2B_LxvP_1	186	189	PF13499	0.592
DOC_USP7_MATH_1	168	172	PF00917	0.561
DOC_USP7_MATH_1	84	88	PF00917	0.579
DOC_USP7_MATH_1	95	99	PF00917	0.499
LIG_14-3-3_CanoR_1	213	221	PF00244	0.540
LIG_14-3-3_CanoR_1	27	31	PF00244	0.431
LIG_14-3-3_CanoR_1	97	101	PF00244	0.555
LIG_Actin_WH2_2	47	64	PF00022	0.509
LIG_APCC_ABBA_1	132	137	PF00400	0.431
LIG_APCC_ABBA_1	43	48	PF00400	0.444
LIG_BIR_III_4	208	212	PF00653	0.482
LIG_Clathr_ClatBox_1	21	25	PF01394	0.474
LIG_FHA_1	16	22	PF00498	0.423
LIG_FHA_1	181	187	PF00498	0.597
LIG_FHA_1	216	222	PF00498	0.462
LIG_GBD_Chelix_1	146	154	PF00786	0.512
LIG_LIR_Gen_1	18	26	PF02991	0.454
LIG_LIR_Nem_3	18	22	PF02991	0.463
LIG_SH2_PTP2	115	118	PF00017	0.608
LIG_SH2_STAT5	105	108	PF00017	0.662
LIG_SH2_STAT5	115	118	PF00017	0.681
LIG_SH2_STAT5	196	199	PF00017	0.504
LIG_SH3_3	63	69	PF00018	0.496
MOD_CK1_1	136	142	PF00069	0.549
MOD_CK1_1	176	182	PF00069	0.469
MOD_CK1_1	87	93	PF00069	0.594
MOD_CK1_1	96	102	PF00069	0.489
MOD_GlcNHglycan	107	110	PF01048	0.518
MOD_GlcNHglycan	170	173	PF01048	0.534
MOD_GlcNHglycan	199	202	PF01048	0.598
MOD_GlcNHglycan	223	226	PF01048	0.591
MOD_GSK3_1	176	183	PF00069	0.592
MOD_GSK3_1	192	199	PF00069	0.455
MOD_GSK3_1	216	223	PF00069	0.461
MOD_GSK3_1	80	87	PF00069	0.625
MOD_NEK2_1	197	202	PF00069	0.533
MOD_NEK2_2	39	44	PF00069	0.516
MOD_PKA_1	214	220	PF00069	0.461
MOD_PKA_2	214	220	PF00069	0.461
MOD_PKA_2	26	32	PF00069	0.429
MOD_PKA_2	96	102	PF00069	0.562
MOD_PKB_1	213	221	PF00069	0.460
MOD_Plk_1	136	142	PF00069	0.415
MOD_Plk_1	173	179	PF00069	0.460
MOD_Plk_1	37	43	PF00069	0.457
MOD_Plk_4	15	21	PF00069	0.428
MOD_Plk_4	173	179	PF00069	0.460
MOD_Plk_4	192	198	PF00069	0.493
MOD_Plk_4	216	222	PF00069	0.548
MOD_Plk_4	84	90	PF00069	0.628
TRG_DiLeu_BaEn_1	156	161	PF01217	0.521
TRG_DiLeu_BaEn_2	14	20	PF01217	0.371
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.532
TRG_ER_diArg_1	213	215	PF00400	0.542
TRG_ER_diArg_1	227	229	PF00400	0.557
TRG_ER_diArg_1	59	62	PF00400	0.514
TRG_NES_CRM1_1	25	38	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE19	Leptomonas seymouri	43%	100%
A0A3Q8IBT2	Leishmania donovani	85%	90%
A4HZ44	Leishmania infantum	85%	90%
Q4QCH0	Leishmania major	86%	100%