NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV10_LEIMU

TriTrypDb:

LmxM.21.0430

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AV10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV10

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.462
CLV_NRD_NRD_1	167	169	PF00675	0.496
CLV_NRD_NRD_1	174	176	PF00675	0.500
CLV_NRD_NRD_1	245	247	PF00675	0.744
CLV_NRD_NRD_1	269	271	PF00675	0.692
CLV_NRD_NRD_1	308	310	PF00675	0.732
CLV_NRD_NRD_1	334	336	PF00675	0.725
CLV_NRD_NRD_1	338	340	PF00675	0.565
CLV_NRD_NRD_1	78	80	PF00675	0.435
CLV_PCSK_KEX2_1	110	112	PF00082	0.462
CLV_PCSK_KEX2_1	166	168	PF00082	0.532
CLV_PCSK_KEX2_1	174	176	PF00082	0.503
CLV_PCSK_KEX2_1	338	340	PF00082	0.711
CLV_PCSK_SKI1_1	110	114	PF00082	0.439
CLV_PCSK_SKI1_1	175	179	PF00082	0.559
CLV_PCSK_SKI1_1	354	358	PF00082	0.485
CLV_PCSK_SKI1_1	374	378	PF00082	0.599
CLV_PCSK_SKI1_1	403	407	PF00082	0.566
DOC_ANK_TNKS_1	294	301	PF00023	0.729
DOC_CYCLIN_RxL_1	172	179	PF00134	0.550
DOC_MAPK_gen_1	107	116	PF00069	0.450
DOC_MAPK_gen_1	174	180	PF00069	0.554
DOC_MAPK_gen_1	79	86	PF00069	0.434
DOC_MAPK_MEF2A_6	107	116	PF00069	0.483
DOC_PP1_RVXF_1	372	379	PF00149	0.550
DOC_PP2B_LxvP_1	350	353	PF13499	0.497
DOC_PP4_FxxP_1	294	297	PF00568	0.553
DOC_USP7_MATH_1	214	218	PF00917	0.754
DOC_USP7_MATH_1	34	38	PF00917	0.474
DOC_WW_Pin1_4	289	294	PF00397	0.733
DOC_WW_Pin1_4	325	330	PF00397	0.763
DOC_WW_Pin1_4	339	344	PF00397	0.618
LIG_14-3-3_CanoR_1	125	130	PF00244	0.461
LIG_14-3-3_CanoR_1	213	222	PF00244	0.647
LIG_14-3-3_CanoR_1	43	49	PF00244	0.460
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_BRCT_BRCA1_1	366	370	PF00533	0.554
LIG_CaM_IQ_9	177	192	PF13499	0.559
LIG_FHA_1	126	132	PF00498	0.437
LIG_FHA_1	342	348	PF00498	0.637
LIG_FHA_1	86	92	PF00498	0.480
LIG_FHA_2	45	51	PF00498	0.473
LIG_LIR_Apic_2	292	297	PF02991	0.551
LIG_LIR_Gen_1	133	139	PF02991	0.484
LIG_LIR_Gen_1	25	34	PF02991	0.512
LIG_LIR_Gen_1	367	377	PF02991	0.509
LIG_LIR_Gen_1	42	51	PF02991	0.477
LIG_LIR_Nem_3	108	112	PF02991	0.535
LIG_LIR_Nem_3	133	138	PF02991	0.422
LIG_LIR_Nem_3	17	22	PF02991	0.463
LIG_LIR_Nem_3	25	30	PF02991	0.444
LIG_LIR_Nem_3	367	373	PF02991	0.515
LIG_LIR_Nem_3	42	48	PF02991	0.586
LIG_Pex14_2	113	117	PF04695	0.374
LIG_Rb_pABgroove_1	34	42	PF01858	0.471
LIG_SH2_CRK	109	113	PF00017	0.477
LIG_SH2_CRK	45	49	PF00017	0.491
LIG_SH2_STAP1	24	28	PF00017	0.454
LIG_SH2_STAT5	105	108	PF00017	0.456
LIG_SH2_STAT5	135	138	PF00017	0.427
LIG_SH2_STAT5	161	164	PF00017	0.551
LIG_SH3_2	231	236	PF14604	0.692
LIG_SH3_3	201	207	PF00018	0.646
LIG_SH3_3	219	225	PF00018	0.709
LIG_SH3_3	228	234	PF00018	0.702
LIG_SH3_3	269	275	PF00018	0.624
LIG_SH3_3	290	296	PF00018	0.626
LIG_SH3_3	86	92	PF00018	0.480
LIG_SUMO_SIM_par_1	82	88	PF11976	0.495
LIG_TRFH_1	117	121	PF08558	0.394
LIG_UBA3_1	347	355	PF00899	0.488
LIG_WW_3	233	237	PF00397	0.745
MOD_CDC14_SPxK_1	292	295	PF00782	0.726
MOD_CDK_SPxK_1	289	295	PF00069	0.732
MOD_CK1_1	209	215	PF00069	0.749
MOD_CK1_1	341	347	PF00069	0.656
MOD_CK1_1	44	50	PF00069	0.394
MOD_CK2_1	138	144	PF00069	0.577
MOD_CK2_1	388	394	PF00069	0.539
MOD_Cter_Amidation	299	302	PF01082	0.736
MOD_GlcNHglycan	216	219	PF01048	0.771
MOD_GlcNHglycan	302	305	PF01048	0.593
MOD_GlcNHglycan	382	385	PF01048	0.490
MOD_GlcNHglycan	390	393	PF01048	0.468
MOD_GSK3_1	11	18	PF00069	0.489
MOD_GSK3_1	119	126	PF00069	0.475
MOD_GSK3_1	216	223	PF00069	0.697
MOD_GSK3_1	321	328	PF00069	0.791
MOD_GSK3_1	364	371	PF00069	0.551
MOD_NEK2_1	162	167	PF00069	0.556
MOD_NEK2_1	72	77	PF00069	0.514
MOD_PIKK_1	364	370	PF00454	0.545
MOD_PKA_1	338	344	PF00069	0.689
MOD_PKA_2	209	215	PF00069	0.666
MOD_PKA_2	338	344	PF00069	0.670
MOD_PKA_2	34	40	PF00069	0.465
MOD_PKA_2	380	386	PF00069	0.555
MOD_Plk_1	41	47	PF00069	0.412
MOD_Plk_1	72	78	PF00069	0.482
MOD_Plk_2-3	82	88	PF00069	0.495
MOD_Plk_4	15	21	PF00069	0.476
MOD_Plk_4	44	50	PF00069	0.400
MOD_ProDKin_1	289	295	PF00069	0.732
MOD_ProDKin_1	325	331	PF00069	0.761
MOD_ProDKin_1	339	345	PF00069	0.603
MOD_SUMO_for_1	361	364	PF00179	0.538
MOD_SUMO_rev_2	265	272	PF00179	0.673
MOD_SUMO_rev_2	274	281	PF00179	0.774
MOD_SUMO_rev_2	283	289	PF00179	0.675
MOD_SUMO_rev_2	359	363	PF00179	0.538
MOD_SUMO_rev_2	367	376	PF00179	0.547
MOD_SUMO_rev_2	398	405	PF00179	0.550
TRG_ENDOCYTIC_2	109	112	PF00928	0.490
TRG_ENDOCYTIC_2	135	138	PF00928	0.427
TRG_ENDOCYTIC_2	24	27	PF00928	0.432
TRG_ENDOCYTIC_2	45	48	PF00928	0.452
TRG_ER_diArg_1	109	111	PF00400	0.495
TRG_ER_diArg_1	166	168	PF00400	0.491
TRG_ER_diArg_1	183	186	PF00400	0.542
TRG_ER_diArg_1	337	339	PF00400	0.837
TRG_NLS_Bipartite_1	338	358	PF00514	0.597
TRG_NLS_MonoExtN_4	351	358	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P850	Leptomonas seymouri	59%	89%
A0A3Q8IBY3	Leishmania donovani	89%	100%
A0A422MZN2	Trypanosoma rangeli	33%	85%
A4HBP1	Leishmania braziliensis	82%	99%
A4HZ42	Leishmania infantum	89%	100%
Q4QCH2	Leishmania major	86%	94%