Ferredoxin NADP+ reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADPH:adrenodoxin oxidoreductase, mitochondrial, putative

Species:

Leishmania mexicana

UniProt:

E9AV09_LEIMU

TriTrypDb:

LmxM.21.0420

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AV09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV09

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004324	ferredoxin-NADP+ reductase activity	6	5
GO:0008937	ferredoxin-NAD(P) reductase activity	5	5
GO:0016491	oxidoreductase activity	2	10
GO:0016730	oxidoreductase activity, acting on iron-sulfur proteins as donors	3	7
GO:0016731	oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	4	7
GO:0015039	NADPH-adrenodoxin reductase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.420
CLV_C14_Caspase3-7	509	513	PF00656	0.408
CLV_NRD_NRD_1	10	12	PF00675	0.587
CLV_NRD_NRD_1	283	285	PF00675	0.401
CLV_NRD_NRD_1	420	422	PF00675	0.466
CLV_NRD_NRD_1	438	440	PF00675	0.515
CLV_NRD_NRD_1	86	88	PF00675	0.495
CLV_PCSK_FUR_1	230	234	PF00082	0.488
CLV_PCSK_KEX2_1	10	12	PF00082	0.634
CLV_PCSK_KEX2_1	232	234	PF00082	0.450
CLV_PCSK_KEX2_1	283	285	PF00082	0.401
CLV_PCSK_KEX2_1	333	335	PF00082	0.415
CLV_PCSK_KEX2_1	85	87	PF00082	0.545
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.450
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.415
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.608
CLV_PCSK_SKI1_1	20	24	PF00082	0.709
CLV_PCSK_SKI1_1	297	301	PF00082	0.394
CLV_PCSK_SKI1_1	632	636	PF00082	0.415
CLV_PCSK_SKI1_1	652	656	PF00082	0.617
CLV_PCSK_SKI1_1	666	670	PF00082	0.525
DEG_APCC_DBOX_1	406	414	PF00400	0.382
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DEG_SCF_FBW7_1	654	659	PF00400	0.663
DEG_SPOP_SBC_1	381	385	PF00917	0.465
DEG_SPOP_SBC_1	547	551	PF00917	0.748
DEG_SPOP_SBC_1	579	583	PF00917	0.673
DEG_SPOP_SBC_1	74	78	PF00917	0.707
DOC_ANK_TNKS_1	232	239	PF00023	0.464
DOC_CYCLIN_RxL_1	105	116	PF00134	0.370
DOC_CYCLIN_RxL_1	663	673	PF00134	0.597
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.311
DOC_MAPK_DCC_7	405	415	PF00069	0.386
DOC_MAPK_DCC_7	463	472	PF00069	0.374
DOC_MAPK_FxFP_2	214	217	PF00069	0.207
DOC_MAPK_gen_1	108	115	PF00069	0.295
DOC_MAPK_gen_1	230	237	PF00069	0.472
DOC_MAPK_gen_1	330	338	PF00069	0.436
DOC_MAPK_gen_1	396	406	PF00069	0.384
DOC_MAPK_gen_1	597	604	PF00069	0.384
DOC_MAPK_gen_1	85	92	PF00069	0.444
DOC_MAPK_HePTP_8	460	472	PF00069	0.369
DOC_MAPK_MEF2A_6	108	117	PF00069	0.295
DOC_MAPK_MEF2A_6	463	472	PF00069	0.374
DOC_MAPK_MEF2A_6	632	639	PF00069	0.416
DOC_MAPK_MEF2A_6	85	92	PF00069	0.530
DOC_MAPK_NFAT4_5	108	116	PF00069	0.370
DOC_PP1_RVXF_1	152	158	PF00149	0.359
DOC_PP2B_LxvP_1	121	124	PF13499	0.311
DOC_PP2B_LxvP_1	191	194	PF13499	0.406
DOC_PP4_FxxP_1	214	217	PF00568	0.305
DOC_USP7_MATH_1	185	189	PF00917	0.429
DOC_USP7_MATH_1	203	207	PF00917	0.242
DOC_USP7_MATH_1	343	347	PF00917	0.475
DOC_USP7_MATH_1	364	368	PF00917	0.518
DOC_USP7_MATH_1	546	550	PF00917	0.712
DOC_USP7_MATH_1	656	660	PF00917	0.642
DOC_USP7_MATH_1	69	73	PF00917	0.730
DOC_USP7_MATH_1	74	78	PF00917	0.727
DOC_USP7_MATH_2	559	565	PF00917	0.468
DOC_USP7_UBL2_3	140	144	PF12436	0.481
DOC_USP7_UBL2_3	268	272	PF12436	0.502
DOC_USP7_UBL2_3	483	487	PF12436	0.508
DOC_USP7_UBL2_3	499	503	PF12436	0.265
DOC_USP7_UBL2_3	623	627	PF12436	0.395
DOC_WW_Pin1_4	130	135	PF00397	0.428
DOC_WW_Pin1_4	217	222	PF00397	0.371
DOC_WW_Pin1_4	255	260	PF00397	0.440
DOC_WW_Pin1_4	373	378	PF00397	0.673
DOC_WW_Pin1_4	408	413	PF00397	0.439
DOC_WW_Pin1_4	568	573	PF00397	0.685
DOC_WW_Pin1_4	652	657	PF00397	0.671
LIG_14-3-3_CanoR_1	10	17	PF00244	0.535
LIG_14-3-3_CanoR_1	154	158	PF00244	0.340
LIG_AP2alpha_1	146	150	PF02296	0.396
LIG_APCC_ABBA_1	111	116	PF00400	0.370
LIG_BIR_III_4	359	363	PF00653	0.567
LIG_BRCT_BRCA1_1	219	223	PF00533	0.387
LIG_BRCT_BRCA1_1	97	101	PF00533	0.418
LIG_CtBP_PxDLS_1	618	623	PF00389	0.438
LIG_eIF4E_1	424	430	PF01652	0.502
LIG_eIF4E_1	585	591	PF01652	0.475
LIG_FHA_1	229	235	PF00498	0.397
LIG_FHA_1	30	36	PF00498	0.701
LIG_FHA_1	594	600	PF00498	0.503
LIG_FHA_2	181	187	PF00498	0.397
LIG_FHA_2	343	349	PF00498	0.469
LIG_FHA_2	383	389	PF00498	0.762
LIG_FHA_2	431	437	PF00498	0.541
LIG_FHA_2	628	634	PF00498	0.502
LIG_LIR_Apic_2	213	217	PF02991	0.200
LIG_LIR_Apic_2	253	259	PF02991	0.408
LIG_LIR_Gen_1	116	125	PF02991	0.295
LIG_LIR_Gen_1	143	150	PF02991	0.372
LIG_LIR_Gen_1	206	215	PF02991	0.397
LIG_LIR_Gen_1	445	456	PF02991	0.497
LIG_LIR_Nem_3	116	121	PF02991	0.311
LIG_LIR_Nem_3	143	149	PF02991	0.494
LIG_LIR_Nem_3	206	210	PF02991	0.314
LIG_LIR_Nem_3	220	226	PF02991	0.358
LIG_LIR_Nem_3	253	257	PF02991	0.382
LIG_LIR_Nem_3	293	299	PF02991	0.391
LIG_LIR_Nem_3	445	451	PF02991	0.499
LIG_LIR_Nem_3	582	588	PF02991	0.487
LIG_NRBOX	664	670	PF00104	0.465
LIG_Pex14_2	146	150	PF04695	0.336
LIG_Pex14_2	210	214	PF04695	0.169
LIG_SH2_CRK	176	180	PF00017	0.317
LIG_SH2_CRK	218	222	PF00017	0.424
LIG_SH2_CRK	448	452	PF00017	0.522
LIG_SH2_STAP1	176	180	PF00017	0.317
LIG_SH2_STAT5	256	259	PF00017	0.385
LIG_SH2_STAT5	424	427	PF00017	0.479
LIG_SH2_STAT5	448	451	PF00017	0.466
LIG_SH2_STAT5	493	496	PF00017	0.336
LIG_SH2_STAT5	593	596	PF00017	0.423
LIG_SH2_STAT5	664	667	PF00017	0.468
LIG_SH3_3	131	137	PF00018	0.295
LIG_SH3_3	360	366	PF00018	0.501
LIG_SH3_3	374	380	PF00018	0.619
LIG_SH3_3	465	471	PF00018	0.375
LIG_SH3_3	527	533	PF00018	0.615
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.479
LIG_SUMO_SIM_anti_2	411	418	PF11976	0.483
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.758
LIG_SUMO_SIM_par_1	30	38	PF11976	0.558
LIG_SUMO_SIM_par_1	558	564	PF11976	0.641
LIG_TRAF2_1	345	348	PF00917	0.551
LIG_TRFH_1	408	412	PF08558	0.383
LIG_UBA3_1	662	666	PF00899	0.611
LIG_WRC_WIRS_1	562	567	PF05994	0.768
MOD_CDK_SPxK_1	568	574	PF00069	0.687
MOD_CDK_SPxK_1	652	658	PF00069	0.672
MOD_CK1_1	28	34	PF00069	0.644
MOD_CK1_1	45	51	PF00069	0.691
MOD_CK1_1	549	555	PF00069	0.678
MOD_CK1_1	68	74	PF00069	0.660
MOD_CK1_1	95	101	PF00069	0.295
MOD_CK2_1	203	209	PF00069	0.452
MOD_CK2_1	263	269	PF00069	0.226
MOD_CK2_1	342	348	PF00069	0.497
MOD_CK2_1	373	379	PF00069	0.636
MOD_CK2_1	382	388	PF00069	0.650
MOD_CK2_1	430	436	PF00069	0.536
MOD_Cter_Amidation	621	624	PF01082	0.444
MOD_Cter_Amidation	643	646	PF01082	0.539
MOD_GlcNHglycan	12	15	PF01048	0.569
MOD_GlcNHglycan	151	154	PF01048	0.390
MOD_GlcNHglycan	287	291	PF01048	0.380
MOD_GlcNHglycan	366	369	PF01048	0.528
MOD_GlcNHglycan	37	40	PF01048	0.703
MOD_GlcNHglycan	371	374	PF01048	0.585
MOD_GlcNHglycan	58	62	PF01048	0.733
MOD_GlcNHglycan	67	70	PF01048	0.670
MOD_GlcNHglycan	71	74	PF01048	0.632
MOD_GlcNHglycan	94	97	PF01048	0.313
MOD_GSK3_1	149	156	PF00069	0.348
MOD_GSK3_1	25	32	PF00069	0.692
MOD_GSK3_1	286	293	PF00069	0.464
MOD_GSK3_1	369	376	PF00069	0.578
MOD_GSK3_1	380	387	PF00069	0.599
MOD_GSK3_1	42	49	PF00069	0.681
MOD_GSK3_1	64	71	PF00069	0.671
MOD_GSK3_1	652	659	PF00069	0.645
MOD_GSK3_1	74	81	PF00069	0.631
MOD_N-GLC_1	159	164	PF02516	0.403
MOD_N-GLC_1	408	413	PF02516	0.474
MOD_N-GLC_1	568	573	PF02516	0.720
MOD_N-GLC_1	64	69	PF02516	0.708
MOD_N-GLC_1	74	79	PF02516	0.708
MOD_NEK2_1	101	106	PF00069	0.382
MOD_NEK2_1	149	154	PF00069	0.343
MOD_NEK2_1	2	7	PF00069	0.606
MOD_NEK2_1	210	215	PF00069	0.277
MOD_NEK2_1	228	233	PF00069	0.519
MOD_NEK2_1	250	255	PF00069	0.353
MOD_NEK2_1	35	40	PF00069	0.657
MOD_NEK2_1	430	435	PF00069	0.491
MOD_NEK2_1	455	460	PF00069	0.420
MOD_NEK2_2	4	9	PF00069	0.648
MOD_NEK2_2	580	585	PF00069	0.562
MOD_PIKK_1	2	8	PF00454	0.437
MOD_PK_1	463	469	PF00069	0.461
MOD_PKA_1	10	16	PF00069	0.445
MOD_PKA_2	10	16	PF00069	0.534
MOD_PKA_2	153	159	PF00069	0.349
MOD_Plk_1	159	165	PF00069	0.400
MOD_Plk_1	286	292	PF00069	0.420
MOD_Plk_2-3	561	567	PF00069	0.661
MOD_Plk_4	153	159	PF00069	0.355
MOD_Plk_4	506	512	PF00069	0.435
MOD_Plk_4	516	522	PF00069	0.356
MOD_Plk_4	580	586	PF00069	0.573
MOD_ProDKin_1	130	136	PF00069	0.428
MOD_ProDKin_1	217	223	PF00069	0.377
MOD_ProDKin_1	255	261	PF00069	0.435
MOD_ProDKin_1	373	379	PF00069	0.682
MOD_ProDKin_1	408	414	PF00069	0.438
MOD_ProDKin_1	568	574	PF00069	0.687
MOD_ProDKin_1	652	658	PF00069	0.668
MOD_SUMO_for_1	307	310	PF00179	0.490
MOD_SUMO_rev_2	133	142	PF00179	0.362
TRG_ENDOCYTIC_2	176	179	PF00928	0.319
TRG_ENDOCYTIC_2	211	214	PF00928	0.443
TRG_ENDOCYTIC_2	254	257	PF00928	0.387
TRG_ENDOCYTIC_2	448	451	PF00928	0.509
TRG_ENDOCYTIC_2	588	591	PF00928	0.367
TRG_ER_diArg_1	86	88	PF00400	0.547
TRG_NLS_Bipartite_1	421	435	PF00514	0.468
TRG_NLS_MonoExtC_3	430	436	PF00514	0.520
TRG_NLS_MonoExtN_4	84	89	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	609	614	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ8	Leptomonas seymouri	67%	99%
A0A0S4J2F1	Bodo saltans	43%	100%
A0A1X0NYU3	Trypanosomatidae	52%	100%
A0A3S5H794	Leishmania donovani	91%	100%
A0A422MZJ3	Trypanosoma rangeli	50%	100%
A4HBP0	Leishmania braziliensis	85%	100%
A4HZ41	Leishmania infantum	91%	100%
D0A1P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
O33064	Mycobacterium leprae (strain TN)	31%	100%
P65529	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P82861	Salvelinus fontinalis	31%	100%
P9WJI0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WJI1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
Q4QCH3	Leishmania major	91%	99%
Q54KG7	Dictyostelium discoideum	28%	100%
V5BQ55	Trypanosoma cruzi	53%	100%