Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9AV07_LEIMU

TriTrypDb:

LmxM.21.0400

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV07

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0016579	protein deubiquitination	6	10
GO:0019538	protein metabolic process	3	10
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0070646	protein modification by small protein removal	5	10
GO:0070647	protein modification by small protein conjugation or removal	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004843	cysteine-type deubiquitinase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008234	cysteine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0019783	ubiquitin-like protein peptidase activity	4	10
GO:0101005	deubiquitinase activity	5	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.407
CLV_C14_Caspase3-7	522	526	PF00656	0.358
CLV_NRD_NRD_1	561	563	PF00675	0.374
CLV_NRD_NRD_1	604	606	PF00675	0.387
CLV_NRD_NRD_1	78	80	PF00675	0.692
CLV_PCSK_KEX2_1	471	473	PF00082	0.294
CLV_PCSK_KEX2_1	561	563	PF00082	0.363
CLV_PCSK_KEX2_1	604	606	PF00082	0.387
CLV_PCSK_KEX2_1	77	79	PF00082	0.686
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.272
CLV_PCSK_SKI1_1	266	270	PF00082	0.308
CLV_PCSK_SKI1_1	377	381	PF00082	0.252
CLV_PCSK_SKI1_1	451	455	PF00082	0.387
CLV_PCSK_SKI1_1	617	621	PF00082	0.453
DEG_APCC_DBOX_1	211	219	PF00400	0.297
DEG_APCC_DBOX_1	560	568	PF00400	0.387
DEG_APCC_KENBOX_2	343	347	PF00400	0.309
DEG_Nend_UBRbox_2	1	3	PF02207	0.459
DEG_SCF_FBW7_1	22	29	PF00400	0.588
DEG_SPOP_SBC_1	166	170	PF00917	0.447
DEG_SPOP_SBC_1	526	530	PF00917	0.398
DEG_SPOP_SBC_1	544	548	PF00917	0.234
DEG_SPOP_SBC_1	632	636	PF00917	0.309
DOC_MAPK_gen_1	323	330	PF00069	0.309
DOC_MAPK_gen_1	484	491	PF00069	0.279
DOC_MAPK_HePTP_8	402	414	PF00069	0.387
DOC_MAPK_MEF2A_6	377	386	PF00069	0.161
DOC_MAPK_MEF2A_6	405	414	PF00069	0.277
DOC_MAPK_MEF2A_6	41	49	PF00069	0.621
DOC_MAPK_MEF2A_6	484	493	PF00069	0.387
DOC_MAPK_RevD_3	456	472	PF00069	0.272
DOC_PP2B_LxvP_1	88	91	PF13499	0.594
DOC_PP4_FxxP_1	119	122	PF00568	0.461
DOC_PP4_FxxP_1	429	432	PF00568	0.297
DOC_PP4_FxxP_1	623	626	PF00568	0.387
DOC_USP7_MATH_1	135	139	PF00917	0.604
DOC_USP7_MATH_1	147	151	PF00917	0.640
DOC_USP7_MATH_1	158	162	PF00917	0.554
DOC_USP7_MATH_1	166	170	PF00917	0.443
DOC_USP7_MATH_1	26	30	PF00917	0.612
DOC_USP7_MATH_1	356	360	PF00917	0.305
DOC_USP7_MATH_1	361	365	PF00917	0.297
DOC_USP7_MATH_1	526	530	PF00917	0.328
DOC_USP7_UBL2_3	262	266	PF12436	0.374
DOC_WW_Pin1_4	105	110	PF00397	0.583
DOC_WW_Pin1_4	128	133	PF00397	0.570
DOC_WW_Pin1_4	154	159	PF00397	0.548
DOC_WW_Pin1_4	22	27	PF00397	0.584
DOC_WW_Pin1_4	29	34	PF00397	0.561
DOC_WW_Pin1_4	377	382	PF00397	0.297
DOC_WW_Pin1_4	68	73	PF00397	0.641
LIG_14-3-3_CanoR_1	115	120	PF00244	0.569
LIG_14-3-3_CanoR_1	28	33	PF00244	0.617
LIG_APCC_ABBAyCdc20_2	405	411	PF00400	0.387
LIG_BIR_III_4	628	632	PF00653	0.387
LIG_BRCT_BRCA1_1	326	330	PF00533	0.371
LIG_BRCT_BRCA1_1	60	64	PF00533	0.721
LIG_CaM_IQ_9	470	486	PF13499	0.361
LIG_FHA_1	175	181	PF00498	0.516
LIG_FHA_1	289	295	PF00498	0.332
LIG_FHA_1	392	398	PF00498	0.328
LIG_FHA_1	418	424	PF00498	0.445
LIG_FHA_1	436	442	PF00498	0.365
LIG_FHA_1	453	459	PF00498	0.380
LIG_FHA_1	545	551	PF00498	0.161
LIG_FHA_1	575	581	PF00498	0.387
LIG_FHA_1	634	640	PF00498	0.280
LIG_FHA_1	85	91	PF00498	0.729
LIG_FHA_1	95	101	PF00498	0.555
LIG_FHA_2	355	361	PF00498	0.371
LIG_FHA_2	401	407	PF00498	0.334
LIG_FHA_2	500	506	PF00498	0.387
LIG_FHA_2	611	617	PF00498	0.308
LIG_FHA_2	97	103	PF00498	0.643
LIG_LIR_Apic_2	118	122	PF02991	0.470
LIG_LIR_Apic_2	16	22	PF02991	0.636
LIG_LIR_Apic_2	427	432	PF02991	0.332
LIG_LIR_Gen_1	177	187	PF02991	0.426
LIG_LIR_Gen_1	289	298	PF02991	0.299
LIG_LIR_Gen_1	406	417	PF02991	0.276
LIG_LIR_Gen_1	635	646	PF02991	0.274
LIG_LIR_Nem_3	177	182	PF02991	0.473
LIG_LIR_Nem_3	289	293	PF02991	0.299
LIG_LIR_Nem_3	406	412	PF02991	0.276
LIG_LIR_Nem_3	635	641	PF02991	0.274
LIG_PCNA_PIPBox_1	494	503	PF02747	0.387
LIG_PTB_Apo_2	191	198	PF02174	0.251
LIG_PTB_Phospho_1	191	197	PF10480	0.251
LIG_Rb_LxCxE_1	438	455	PF01857	0.161
LIG_SH2_CRK	19	23	PF00017	0.649
LIG_SH2_CRK	464	468	PF00017	0.272
LIG_SH2_NCK_1	642	646	PF00017	0.343
LIG_SH2_PTP2	638	641	PF00017	0.297
LIG_SH2_SRC	11	14	PF00017	0.597
LIG_SH2_STAP1	464	468	PF00017	0.272
LIG_SH2_STAP1	642	646	PF00017	0.343
LIG_SH2_STAT3	598	601	PF00017	0.380
LIG_SH2_STAT5	11	14	PF00017	0.597
LIG_SH2_STAT5	19	22	PF00017	0.647
LIG_SH2_STAT5	197	200	PF00017	0.294
LIG_SH2_STAT5	222	225	PF00017	0.363
LIG_SH2_STAT5	434	437	PF00017	0.351
LIG_SH2_STAT5	500	503	PF00017	0.387
LIG_SH2_STAT5	592	595	PF00017	0.272
LIG_SH2_STAT5	622	625	PF00017	0.359
LIG_SH2_STAT5	638	641	PF00017	0.173
LIG_SH3_2	72	77	PF14604	0.647
LIG_SH3_3	129	135	PF00018	0.668
LIG_SH3_3	486	492	PF00018	0.332
LIG_SH3_3	66	72	PF00018	0.597
LIG_SUMO_SIM_par_1	85	92	PF11976	0.617
LIG_TRAF2_1	556	559	PF00917	0.378
LIG_TYR_ITIM	640	645	PF00017	0.309
LIG_UBA3_1	243	249	PF00899	0.272
LIG_UBA3_1	466	471	PF00899	0.272
LIG_WRC_WIRS_1	550	555	PF05994	0.161
MOD_CDC14_SPxK_1	74	77	PF00782	0.648
MOD_CDK_SPK_2	128	133	PF00069	0.438
MOD_CDK_SPxK_1	22	28	PF00069	0.587
MOD_CDK_SPxK_1	71	77	PF00069	0.648
MOD_CDK_SPxxK_3	105	112	PF00069	0.568
MOD_CDK_SPxxK_3	71	78	PF00069	0.651
MOD_CK1_1	105	111	PF00069	0.570
MOD_CK1_1	131	137	PF00069	0.581
MOD_CK1_1	157	163	PF00069	0.666
MOD_CK1_1	169	175	PF00069	0.547
MOD_CK1_1	29	35	PF00069	0.666
MOD_CK1_1	413	419	PF00069	0.387
MOD_CK1_1	549	555	PF00069	0.345
MOD_CK1_1	59	65	PF00069	0.654
MOD_CK1_1	71	77	PF00069	0.579
MOD_CK2_1	226	232	PF00069	0.302
MOD_CK2_1	339	345	PF00069	0.373
MOD_CK2_1	499	505	PF00069	0.365
MOD_CK2_1	610	616	PF00069	0.310
MOD_CK2_1	83	89	PF00069	0.672
MOD_CK2_1	96	102	PF00069	0.634
MOD_GlcNHglycan	145	148	PF01048	0.611
MOD_GlcNHglycan	163	166	PF01048	0.692
MOD_GlcNHglycan	228	231	PF01048	0.296
MOD_GlcNHglycan	34	37	PF01048	0.738
MOD_GlcNHglycan	352	355	PF01048	0.278
MOD_GlcNHglycan	363	366	PF01048	0.319
MOD_GlcNHglycan	521	524	PF01048	0.322
MOD_GlcNHglycan	534	538	PF01048	0.241
MOD_GlcNHglycan	588	591	PF01048	0.324
MOD_GSK3_1	13	20	PF00069	0.526
MOD_GSK3_1	131	138	PF00069	0.515
MOD_GSK3_1	143	150	PF00069	0.550
MOD_GSK3_1	154	161	PF00069	0.672
MOD_GSK3_1	165	172	PF00069	0.587
MOD_GSK3_1	22	29	PF00069	0.587
MOD_GSK3_1	247	254	PF00069	0.419
MOD_GSK3_1	324	331	PF00069	0.307
MOD_GSK3_1	350	357	PF00069	0.290
MOD_GSK3_1	373	380	PF00069	0.371
MOD_GSK3_1	413	420	PF00069	0.433
MOD_GSK3_1	515	522	PF00069	0.301
MOD_GSK3_1	545	552	PF00069	0.384
MOD_GSK3_1	67	74	PF00069	0.592
MOD_GSK3_1	89	96	PF00069	0.560
MOD_N-GLC_1	251	256	PF02516	0.387
MOD_N-GLC_1	400	405	PF02516	0.332
MOD_N-GLC_1	544	549	PF02516	0.305
MOD_N-GLC_1	82	87	PF02516	0.652
MOD_N-GLC_1	93	98	PF02516	0.528
MOD_N-GLC_2	194	196	PF02516	0.251
MOD_NEK2_1	104	109	PF00069	0.611
MOD_NEK2_1	17	22	PF00069	0.691
MOD_NEK2_1	180	185	PF00069	0.474
MOD_NEK2_1	247	252	PF00069	0.387
MOD_NEK2_1	348	353	PF00069	0.346
MOD_NEK2_1	435	440	PF00069	0.398
MOD_NEK2_1	49	54	PF00069	0.640
MOD_NEK2_1	57	62	PF00069	0.730
MOD_NEK2_1	574	579	PF00069	0.272
MOD_NEK2_2	135	140	PF00069	0.577
MOD_NEK2_2	192	197	PF00069	0.272
MOD_NEK2_2	452	457	PF00069	0.371
MOD_PIKK_1	117	123	PF00454	0.487
MOD_PIKK_1	39	45	PF00454	0.703
MOD_PIKK_1	49	55	PF00454	0.671
MOD_PIKK_1	515	521	PF00454	0.326
MOD_PKA_1	324	330	PF00069	0.371
MOD_PKA_1	478	484	PF00069	0.186
MOD_Plk_1	26	32	PF00069	0.609
MOD_Plk_1	288	294	PF00069	0.363
MOD_Plk_1	318	324	PF00069	0.414
MOD_Plk_1	410	416	PF00069	0.289
MOD_Plk_1	607	613	PF00069	0.297
MOD_Plk_2-3	499	505	PF00069	0.387
MOD_Plk_4	13	19	PF00069	0.626
MOD_Plk_4	197	203	PF00069	0.387
MOD_Plk_4	232	238	PF00069	0.272
MOD_Plk_4	239	245	PF00069	0.272
MOD_Plk_4	418	424	PF00069	0.297
MOD_Plk_4	96	102	PF00069	0.580
MOD_ProDKin_1	105	111	PF00069	0.584
MOD_ProDKin_1	128	134	PF00069	0.568
MOD_ProDKin_1	154	160	PF00069	0.561
MOD_ProDKin_1	22	28	PF00069	0.587
MOD_ProDKin_1	29	35	PF00069	0.563
MOD_ProDKin_1	377	383	PF00069	0.297
MOD_ProDKin_1	68	74	PF00069	0.641
MOD_SUMO_for_1	274	277	PF00179	0.309
MOD_SUMO_for_1	316	319	PF00179	0.309
MOD_SUMO_rev_2	341	348	PF00179	0.316
MOD_SUMO_rev_2	444	449	PF00179	0.433
MOD_SUMO_rev_2	7	17	PF00179	0.589
TRG_DiLeu_BaEn_2	288	294	PF01217	0.272
TRG_DiLeu_BaEn_2	574	580	PF01217	0.387
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.297
TRG_ENDOCYTIC_2	464	467	PF00928	0.272
TRG_ENDOCYTIC_2	622	625	PF00928	0.359
TRG_ENDOCYTIC_2	638	641	PF00928	0.173
TRG_ENDOCYTIC_2	642	645	PF00928	0.321
TRG_ER_diArg_1	211	214	PF00400	0.272
TRG_ER_diArg_1	560	562	PF00400	0.363
TRG_ER_diArg_1	603	605	PF00400	0.387
TRG_ER_diArg_1	77	79	PF00400	0.460
TRG_NLS_MonoExtN_4	561	566	PF00514	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	23%	80%
A0A0N0P852	Leptomonas seymouri	69%	85%
A0A0S4IVV7	Bodo saltans	23%	100%
A0A3Q8IB18	Leishmania donovani	92%	90%
A0A422MZT5	Trypanosoma rangeli	41%	100%
A4HBN8	Leishmania braziliensis	78%	100%
A4HZ39	Leishmania infantum	92%	90%
D0A1P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
P39944	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	80%
Q4QCH5	Leishmania major	90%	100%
Q8IQ27	Drosophila melanogaster	24%	69%
Q91W36	Mus musculus	23%	100%
V5DGZ8	Trypanosoma cruzi	40%	99%