RTR1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rtr1/RPAP2 family, putative

Species:

Leishmania mexicana

UniProt:

E9AV04_LEIMU

TriTrypDb:

LmxM.21.0370

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.582
CLV_C14_Caspase3-7	202	206	PF00656	0.688
CLV_C14_Caspase3-7	218	222	PF00656	0.546
CLV_C14_Caspase3-7	232	236	PF00656	0.565
CLV_MEL_PAP_1	334	340	PF00089	0.475
CLV_NRD_NRD_1	215	217	PF00675	0.795
CLV_NRD_NRD_1	267	269	PF00675	0.564
CLV_NRD_NRD_1	336	338	PF00675	0.515
CLV_NRD_NRD_1	426	428	PF00675	0.557
CLV_NRD_NRD_1	542	544	PF00675	0.397
CLV_NRD_NRD_1	58	60	PF00675	0.719
CLV_NRD_NRD_1	626	628	PF00675	0.455
CLV_PCSK_FUR_1	56	60	PF00082	0.593
CLV_PCSK_KEX2_1	20	22	PF00082	0.646
CLV_PCSK_KEX2_1	214	216	PF00082	0.739
CLV_PCSK_KEX2_1	336	338	PF00082	0.515
CLV_PCSK_KEX2_1	426	428	PF00082	0.648
CLV_PCSK_KEX2_1	542	544	PF00082	0.397
CLV_PCSK_KEX2_1	58	60	PF00082	0.719
CLV_PCSK_KEX2_1	588	590	PF00082	0.489
CLV_PCSK_KEX2_1	626	628	PF00082	0.455
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.525
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.463
CLV_PCSK_PC7_1	16	22	PF00082	0.524
CLV_PCSK_SKI1_1	147	151	PF00082	0.463
CLV_PCSK_SKI1_1	169	173	PF00082	0.540
CLV_PCSK_SKI1_1	260	264	PF00082	0.480
CLV_PCSK_SKI1_1	380	384	PF00082	0.682
CLV_PCSK_SKI1_1	459	463	PF00082	0.528
CLV_PCSK_SKI1_1	520	524	PF00082	0.620
CLV_PCSK_SKI1_1	542	546	PF00082	0.392
CLV_PCSK_SKI1_1	553	557	PF00082	0.389
CLV_PCSK_SKI1_1	558	562	PF00082	0.439
CLV_PCSK_SKI1_1	627	631	PF00082	0.379
CLV_PCSK_SKI1_1	645	649	PF00082	0.426
DEG_APCC_DBOX_1	142	150	PF00400	0.447
DEG_APCC_DBOX_1	259	267	PF00400	0.484
DEG_APCC_DBOX_1	458	466	PF00400	0.526
DEG_APCC_DBOX_1	523	531	PF00400	0.452
DEG_Nend_UBRbox_4	1	3	PF02207	0.493
DEG_SPOP_SBC_1	27	31	PF00917	0.497
DEG_SPOP_SBC_1	371	375	PF00917	0.506
DOC_CKS1_1	701	706	PF01111	0.286
DOC_CYCLIN_RxL_1	166	176	PF00134	0.502
DOC_CYCLIN_RxL_1	624	632	PF00134	0.461
DOC_CYCLIN_RxL_1	642	650	PF00134	0.248
DOC_MAPK_gen_1	143	151	PF00069	0.366
DOC_MAPK_MEF2A_6	411	419	PF00069	0.617
DOC_MAPK_MEF2A_6	524	532	PF00069	0.431
DOC_PP1_RVXF_1	643	649	PF00149	0.385
DOC_PP1_RVXF_1	682	689	PF00149	0.332
DOC_PP2B_LxvP_1	669	672	PF13499	0.507
DOC_PP4_FxxP_1	23	26	PF00568	0.516
DOC_PP4_FxxP_1	321	324	PF00568	0.481
DOC_USP7_MATH_1	173	177	PF00917	0.729
DOC_USP7_MATH_1	281	285	PF00917	0.608
DOC_USP7_MATH_1	302	306	PF00917	0.618
DOC_USP7_MATH_1	371	375	PF00917	0.487
DOC_USP7_MATH_1	399	403	PF00917	0.630
DOC_USP7_MATH_1	493	497	PF00917	0.527
DOC_USP7_MATH_1	569	573	PF00917	0.513
DOC_USP7_MATH_1	600	604	PF00917	0.488
DOC_USP7_MATH_1	699	703	PF00917	0.357
DOC_USP7_MATH_1	752	756	PF00917	0.341
DOC_USP7_MATH_1	88	92	PF00917	0.648
DOC_WW_Pin1_4	1	6	PF00397	0.476
DOC_WW_Pin1_4	30	35	PF00397	0.495
DOC_WW_Pin1_4	320	325	PF00397	0.606
DOC_WW_Pin1_4	336	341	PF00397	0.394
DOC_WW_Pin1_4	494	499	PF00397	0.626
DOC_WW_Pin1_4	562	567	PF00397	0.464
DOC_WW_Pin1_4	59	64	PF00397	0.600
DOC_WW_Pin1_4	67	72	PF00397	0.535
DOC_WW_Pin1_4	700	705	PF00397	0.405
DOC_WW_Pin1_4	84	89	PF00397	0.551
LIG_14-3-3_CanoR_1	479	485	PF00244	0.550
LIG_14-3-3_CanoR_1	558	566	PF00244	0.470
LIG_14-3-3_CanoR_1	570	575	PF00244	0.405
LIG_14-3-3_CanoR_1	58	63	PF00244	0.639
LIG_Actin_WH2_2	133	149	PF00022	0.489
LIG_Actin_WH2_2	346	363	PF00022	0.512
LIG_BIR_III_4	193	197	PF00653	0.571
LIG_BRCT_BRCA1_1	338	342	PF00533	0.549
LIG_BRCT_BRCA1_1	43	47	PF00533	0.458
LIG_BRCT_BRCA1_1	571	575	PF00533	0.444
LIG_BRCT_BRCA1_1	631	635	PF00533	0.439
LIG_BRCT_BRCA1_1	684	688	PF00533	0.354
LIG_Clathr_ClatBox_1	527	531	PF01394	0.468
LIG_Clathr_ClatBox_1	646	650	PF01394	0.362
LIG_DLG_GKlike_1	570	578	PF00625	0.428
LIG_EVH1_1	23	27	PF00568	0.511
LIG_FHA_1	115	121	PF00498	0.565
LIG_FHA_1	30	36	PF00498	0.493
LIG_FHA_1	539	545	PF00498	0.387
LIG_FHA_1	638	644	PF00498	0.391
LIG_FHA_1	701	707	PF00498	0.460
LIG_FHA_1	77	83	PF00498	0.502
LIG_FHA_2	121	127	PF00498	0.613
LIG_FHA_2	197	203	PF00498	0.603
LIG_FHA_2	605	611	PF00498	0.605
LIG_FHA_2	743	749	PF00498	0.376
LIG_LIR_Gen_1	152	162	PF02991	0.426
LIG_LIR_Gen_1	44	55	PF02991	0.485
LIG_LIR_Gen_1	650	658	PF02991	0.355
LIG_LIR_Gen_1	732	742	PF02991	0.383
LIG_LIR_Nem_3	152	158	PF02991	0.438
LIG_LIR_Nem_3	339	344	PF02991	0.494
LIG_LIR_Nem_3	345	349	PF02991	0.517
LIG_LIR_Nem_3	354	360	PF02991	0.526
LIG_LIR_Nem_3	44	50	PF02991	0.479
LIG_LIR_Nem_3	572	578	PF02991	0.495
LIG_LIR_Nem_3	650	654	PF02991	0.353
LIG_LIR_Nem_3	656	662	PF02991	0.357
LIG_LIR_Nem_3	732	738	PF02991	0.380
LIG_LYPXL_yS_3	346	349	PF13949	0.585
LIG_MLH1_MIPbox_1	338	342	PF16413	0.549
LIG_NRBOX	642	648	PF00104	0.358
LIG_PDZ_Class_3	757	762	PF00595	0.509
LIG_Pex14_2	317	321	PF04695	0.418
LIG_SH2_CRK	344	348	PF00017	0.594
LIG_SH2_CRK	651	655	PF00017	0.422
LIG_SH2_SRC	344	347	PF00017	0.600
LIG_SH2_STAP1	243	247	PF00017	0.556
LIG_SH2_STAP1	330	334	PF00017	0.523
LIG_SH2_STAT5	119	122	PF00017	0.511
LIG_SH2_STAT5	248	251	PF00017	0.498
LIG_SH2_STAT5	341	344	PF00017	0.497
LIG_SH3_1	21	27	PF00018	0.516
LIG_SH3_1	291	297	PF00018	0.633
LIG_SH3_3	126	132	PF00018	0.599
LIG_SH3_3	21	27	PF00018	0.494
LIG_SH3_3	291	297	PF00018	0.681
LIG_SH3_3	3	9	PF00018	0.475
LIG_SH3_3	515	521	PF00018	0.769
LIG_SH3_3	563	569	PF00018	0.411
LIG_SH3_3	60	66	PF00018	0.593
LIG_SH3_3	698	704	PF00018	0.314
LIG_SUMO_SIM_anti_2	526	531	PF11976	0.419
LIG_SUMO_SIM_par_1	526	531	PF11976	0.419
LIG_TRAF2_1	200	203	PF00917	0.563
LIG_TRAF2_1	599	602	PF00917	0.531
LIG_TYR_ITIM	649	654	PF00017	0.349
LIG_UBA3_1	262	270	PF00899	0.486
LIG_WW_3	517	521	PF00397	0.654
MOD_CDK_SPK_2	562	567	PF00069	0.464
MOD_CDK_SPxxK_3	30	37	PF00069	0.493
MOD_CK1_1	114	120	PF00069	0.558
MOD_CK1_1	185	191	PF00069	0.593
MOD_CK1_1	208	214	PF00069	0.643
MOD_CK1_1	418	424	PF00069	0.699
MOD_CK1_1	496	502	PF00069	0.621
MOD_CK1_1	665	671	PF00069	0.383
MOD_CK1_1	678	684	PF00069	0.347
MOD_CK1_1	97	103	PF00069	0.507
MOD_CK2_1	120	126	PF00069	0.537
MOD_CK2_1	189	195	PF00069	0.669
MOD_CK2_1	196	202	PF00069	0.601
MOD_CK2_1	562	568	PF00069	0.489
MOD_CK2_1	699	705	PF00069	0.412
MOD_GlcNHglycan	175	178	PF01048	0.614
MOD_GlcNHglycan	189	192	PF01048	0.553
MOD_GlcNHglycan	374	377	PF01048	0.568
MOD_GlcNHglycan	397	400	PF01048	0.712
MOD_GlcNHglycan	401	404	PF01048	0.762
MOD_GlcNHglycan	453	456	PF01048	0.655
MOD_GlcNHglycan	499	502	PF01048	0.674
MOD_GlcNHglycan	509	512	PF01048	0.606
MOD_GlcNHglycan	578	581	PF01048	0.390
MOD_GlcNHglycan	659	662	PF01048	0.353
MOD_GlcNHglycan	90	93	PF01048	0.680
MOD_GlcNHglycan	96	99	PF01048	0.628
MOD_GSK3_1	158	165	PF00069	0.332
MOD_GSK3_1	173	180	PF00069	0.628
MOD_GSK3_1	183	190	PF00069	0.562
MOD_GSK3_1	197	204	PF00069	0.650
MOD_GSK3_1	26	33	PF00069	0.499
MOD_GSK3_1	326	333	PF00069	0.469
MOD_GSK3_1	395	402	PF00069	0.618
MOD_GSK3_1	415	422	PF00069	0.499
MOD_GSK3_1	493	500	PF00069	0.642
MOD_GSK3_1	534	541	PF00069	0.371
MOD_GSK3_1	558	565	PF00069	0.513
MOD_GSK3_1	600	607	PF00069	0.496
MOD_GSK3_1	629	636	PF00069	0.380
MOD_GSK3_1	637	644	PF00069	0.326
MOD_GSK3_1	653	660	PF00069	0.260
MOD_GSK3_1	674	681	PF00069	0.438
MOD_GSK3_1	84	91	PF00069	0.582
MOD_N-GLC_1	395	400	PF02516	0.613
MOD_N-GLC_1	534	539	PF02516	0.370
MOD_NEK2_1	120	125	PF00069	0.530
MOD_NEK2_1	158	163	PF00069	0.413
MOD_NEK2_1	187	192	PF00069	0.709
MOD_NEK2_1	313	318	PF00069	0.417
MOD_NEK2_1	480	485	PF00069	0.575
MOD_NEK2_1	523	528	PF00069	0.444
MOD_NEK2_1	534	539	PF00069	0.370
MOD_NEK2_1	629	634	PF00069	0.443
MOD_NEK2_1	657	662	PF00069	0.427
MOD_NEK2_1	682	687	PF00069	0.352
MOD_NEK2_1	74	79	PF00069	0.503
MOD_PIKK_1	131	137	PF00454	0.633
MOD_PIKK_1	41	47	PF00454	0.459
MOD_PKA_1	58	64	PF00069	0.600
MOD_PKA_2	227	233	PF00069	0.660
MOD_PKA_2	478	484	PF00069	0.541
MOD_PKA_2	523	529	PF00069	0.431
MOD_PKA_2	569	575	PF00069	0.442
MOD_PKA_2	58	64	PF00069	0.648
MOD_PKA_2	82	88	PF00069	0.616
MOD_PKB_1	56	64	PF00069	0.596
MOD_Plk_1	183	189	PF00069	0.602
MOD_Plk_1	326	332	PF00069	0.505
MOD_Plk_1	600	606	PF00069	0.492
MOD_Plk_2-3	197	203	PF00069	0.609
MOD_Plk_4	111	117	PF00069	0.654
MOD_Plk_4	330	336	PF00069	0.531
MOD_Plk_4	345	351	PF00069	0.426
MOD_Plk_4	523	529	PF00069	0.431
MOD_Plk_4	570	576	PF00069	0.491
MOD_Plk_4	678	684	PF00069	0.449
MOD_Plk_4	752	758	PF00069	0.370
MOD_ProDKin_1	1	7	PF00069	0.479
MOD_ProDKin_1	30	36	PF00069	0.493
MOD_ProDKin_1	320	326	PF00069	0.606
MOD_ProDKin_1	336	342	PF00069	0.389
MOD_ProDKin_1	494	500	PF00069	0.627
MOD_ProDKin_1	562	568	PF00069	0.465
MOD_ProDKin_1	59	65	PF00069	0.601
MOD_ProDKin_1	67	73	PF00069	0.530
MOD_ProDKin_1	700	706	PF00069	0.394
MOD_ProDKin_1	84	90	PF00069	0.553
TRG_DiLeu_BaEn_1	420	425	PF01217	0.625
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.632
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.486
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.352
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.485
TRG_ENDOCYTIC_2	155	158	PF00928	0.446
TRG_ENDOCYTIC_2	346	349	PF00928	0.518
TRG_ENDOCYTIC_2	651	654	PF00928	0.347
TRG_ER_diArg_1	143	146	PF00400	0.437
TRG_ER_diArg_1	214	216	PF00400	0.768
TRG_ER_diArg_1	335	337	PF00400	0.513
TRG_ER_diArg_1	425	427	PF00400	0.563
TRG_ER_diArg_1	542	544	PF00400	0.397
TRG_ER_diArg_1	55	58	PF00400	0.586
TRG_ER_diArg_1	551	554	PF00400	0.408
TRG_NES_CRM1_1	747	761	PF08389	0.447
TRG_NLS_MonoExtN_4	265	272	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT3	Leptomonas seymouri	49%	100%
A0A3Q8IF20	Leishmania donovani	88%	100%
A4HBN5	Leishmania braziliensis	74%	100%
A4HZ36	Leishmania infantum	87%	100%
Q4QCH8	Leishmania major	86%	100%