Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AV03_LEIMU

TriTrypDb:

LmxM.21.0360

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AV03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AV03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.702
CLV_C14_Caspase3-7	205	209	PF00656	0.734
CLV_NRD_NRD_1	10	12	PF00675	0.538
CLV_NRD_NRD_1	116	118	PF00675	0.637
CLV_NRD_NRD_1	142	144	PF00675	0.656
CLV_NRD_NRD_1	216	218	PF00675	0.843
CLV_NRD_NRD_1	36	38	PF00675	0.553
CLV_PCSK_FUR_1	116	120	PF00082	0.643
CLV_PCSK_KEX2_1	10	12	PF00082	0.538
CLV_PCSK_KEX2_1	116	118	PF00082	0.641
CLV_PCSK_KEX2_1	142	144	PF00082	0.656
CLV_PCSK_KEX2_1	195	197	PF00082	0.653
CLV_PCSK_KEX2_1	216	218	PF00082	0.843
CLV_PCSK_KEX2_1	36	38	PF00082	0.558
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.642
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.653
DOC_MAPK_gen_1	87	95	PF00069	0.701
DOC_PP2B_LxvP_1	110	113	PF13499	0.581
DOC_PP4_FxxP_1	265	268	PF00568	0.692
DOC_USP7_MATH_1	171	175	PF00917	0.626
DOC_USP7_MATH_1	2	6	PF00917	0.588
DOC_USP7_MATH_1	215	219	PF00917	0.786
DOC_USP7_MATH_1	65	69	PF00917	0.351
DOC_WW_Pin1_4	124	129	PF00397	0.632
DOC_WW_Pin1_4	175	180	PF00397	0.715
DOC_WW_Pin1_4	203	208	PF00397	0.828
DOC_WW_Pin1_4	211	216	PF00397	0.702
LIG_14-3-3_CanoR_1	49	53	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_FHA_1	180	186	PF00498	0.607
LIG_FHA_1	78	84	PF00498	0.613
LIG_FHA_2	14	20	PF00498	0.502
LIG_FHA_2	142	148	PF00498	0.746
LIG_LIR_Apic_2	263	268	PF02991	0.798
LIG_LIR_Gen_1	17	27	PF02991	0.522
LIG_LIR_Nem_3	17	23	PF02991	0.522
LIG_MYND_1	268	272	PF01753	0.666
LIG_SH2_NCK_1	189	193	PF00017	0.816
LIG_SH2_SRC	189	192	PF00017	0.815
LIG_SH2_STAP1	20	24	PF00017	0.530
LIG_SH2_STAT5	63	66	PF00017	0.504
LIG_SH3_2	212	217	PF14604	0.756
LIG_SH3_2	268	273	PF14604	0.610
LIG_SH3_3	162	168	PF00018	0.678
LIG_SH3_3	209	215	PF00018	0.675
LIG_SH3_3	265	271	PF00018	0.616
LIG_WRC_WIRS_1	98	103	PF05994	0.485
LIG_WW_1	186	189	PF00397	0.644
LIG_WW_3	185	189	PF00397	0.639
MOD_CDC14_SPxK_1	214	217	PF00782	0.645
MOD_CDK_SPK_2	211	216	PF00069	0.640
MOD_CDK_SPxK_1	211	217	PF00069	0.641
MOD_CK1_1	163	169	PF00069	0.734
MOD_CK1_1	173	179	PF00069	0.684
MOD_CK1_1	218	224	PF00069	0.681
MOD_CK2_1	13	19	PF00069	0.460
MOD_CK2_1	141	147	PF00069	0.744
MOD_CK2_1	249	255	PF00069	0.740
MOD_Cter_Amidation	193	196	PF01082	0.647
MOD_GlcNHglycan	155	158	PF01048	0.730
MOD_GlcNHglycan	161	165	PF01048	0.692
MOD_GlcNHglycan	173	176	PF01048	0.522
MOD_GlcNHglycan	218	221	PF01048	0.766
MOD_GlcNHglycan	229	232	PF01048	0.686
MOD_GlcNHglycan	241	244	PF01048	0.775
MOD_GlcNHglycan	251	254	PF01048	0.567
MOD_GlcNHglycan	262	265	PF01048	0.729
MOD_GSK3_1	166	173	PF00069	0.804
MOD_GSK3_1	175	182	PF00069	0.714
MOD_GSK3_1	211	218	PF00069	0.719
MOD_GSK3_1	219	226	PF00069	0.734
MOD_N-GLC_1	65	70	PF02516	0.357
MOD_NEK2_1	260	265	PF00069	0.785
MOD_PIKK_1	121	127	PF00454	0.761
MOD_PIKK_1	65	71	PF00454	0.411
MOD_PKA_1	216	222	PF00069	0.552
MOD_PKA_2	141	147	PF00069	0.688
MOD_PKA_2	215	221	PF00069	0.842
MOD_PKA_2	48	54	PF00069	0.528
MOD_PKB_1	119	127	PF00069	0.762
MOD_Plk_4	97	103	PF00069	0.437
MOD_ProDKin_1	124	130	PF00069	0.626
MOD_ProDKin_1	175	181	PF00069	0.715
MOD_ProDKin_1	203	209	PF00069	0.829
MOD_ProDKin_1	211	217	PF00069	0.703
TRG_ENDOCYTIC_2	20	23	PF00928	0.528
TRG_ER_diArg_1	116	119	PF00400	0.628
TRG_ER_diArg_1	133	136	PF00400	0.591
TRG_ER_diArg_1	215	217	PF00400	0.841
TRG_ER_diArg_1	9	11	PF00400	0.550
TRG_NLS_MonoExtC_3	116	121	PF00514	0.769
TRG_NLS_MonoExtN_4	116	122	PF00514	0.767
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD3	Leptomonas seymouri	55%	100%
A0A3S7WWE9	Leishmania donovani	92%	99%
A4HBN4	Leishmania braziliensis	74%	99%
A4HZ35	Leishmania infantum	92%	99%
Q4QCH9	Leishmania major	83%	98%