Matrin-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein C, putative

Species:

Leishmania mexicana

UniProt:

E9AUZ9_LEIMU

TriTrypDb:

LmxM.21.0320

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	5
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	3
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	3

Expansion

Sequence features

E9AUZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.578
CLV_NRD_NRD_1	56	58	PF00675	0.585
CLV_NRD_NRD_1	64	66	PF00675	0.572
CLV_PCSK_FUR_1	43	47	PF00082	0.557
CLV_PCSK_KEX2_1	40	42	PF00082	0.537
CLV_PCSK_KEX2_1	45	47	PF00082	0.546
CLV_PCSK_KEX2_1	56	58	PF00082	0.508
CLV_PCSK_KEX2_1	64	66	PF00082	0.514
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.590
CLV_PCSK_PC7_1	41	47	PF00082	0.546
CLV_PCSK_SKI1_1	196	200	PF00082	0.679
DEG_Nend_UBRbox_2	1	3	PF02207	0.796
DOC_PP2B_LxvP_1	169	172	PF13499	0.782
DOC_PP2B_LxvP_1	229	232	PF13499	0.794
DOC_PP2B_PxIxI_1	155	161	PF00149	0.626
DOC_PP2B_PxIxI_1	188	194	PF00149	0.689
DOC_PP4_FxxP_1	175	178	PF00568	0.810
DOC_USP7_MATH_1	102	106	PF00917	0.607
DOC_USP7_MATH_1	201	205	PF00917	0.756
DOC_USP7_MATH_1	206	210	PF00917	0.815
DOC_USP7_MATH_1	217	221	PF00917	0.818
DOC_USP7_MATH_1	7	11	PF00917	0.518
DOC_WW_Pin1_4	144	149	PF00397	0.661
DOC_WW_Pin1_4	185	190	PF00397	0.723
DOC_WW_Pin1_4	204	209	PF00397	0.504
DOC_WW_Pin1_4	49	54	PF00397	0.596
LIG_14-3-3_CanoR_1	219	229	PF00244	0.802
LIG_14-3-3_CanoR_1	86	91	PF00244	0.549
LIG_14-3-3_CanoR_1	98	106	PF00244	0.532
LIG_CaM_NSCaTE_8	90	97	PF13499	0.546
LIG_EVH1_1	169	173	PF00568	0.781
LIG_EVH1_2	171	175	PF00568	0.791
LIG_FHA_1	180	186	PF00498	0.661
LIG_FHA_1	188	194	PF00498	0.687
LIG_FHA_2	213	219	PF00498	0.623
LIG_FHA_2	9	15	PF00498	0.520
LIG_LIR_Apic_2	174	178	PF02991	0.520
LIG_LIR_Gen_1	105	113	PF02991	0.534
LIG_LIR_Gen_1	77	83	PF02991	0.455
LIG_LIR_Nem_3	100	106	PF02991	0.486
LIG_LIR_Nem_3	77	81	PF02991	0.457
LIG_SH2_CRK	107	111	PF00017	0.599
LIG_SH2_NCK_1	107	111	PF00017	0.473
LIG_SH2_STAP1	107	111	PF00017	0.527
LIG_SH2_STAT5	75	78	PF00017	0.444
LIG_SH3_3	167	173	PF00018	0.682
LIG_SH3_3	202	208	PF00018	0.721
LIG_SH3_3	224	230	PF00018	0.506
MOD_CDK_SPxxK_3	185	192	PF00069	0.759
MOD_CDK_SPxxK_3	49	56	PF00069	0.594
MOD_CK1_1	204	210	PF00069	0.737
MOD_CK1_1	220	226	PF00069	0.814
MOD_CK2_1	212	218	PF00069	0.763
MOD_CK2_1	32	38	PF00069	0.611
MOD_CK2_1	8	14	PF00069	0.521
MOD_GlcNHglycan	138	141	PF01048	0.601
MOD_GlcNHglycan	2	6	PF01048	0.727
MOD_GlcNHglycan	208	211	PF01048	0.656
MOD_GlcNHglycan	23	26	PF01048	0.726
MOD_GlcNHglycan	29	32	PF01048	0.694
MOD_GlcNHglycan	95	98	PF01048	0.540
MOD_GSK3_1	8	15	PF00069	0.579
MOD_GSK3_1	82	89	PF00069	0.474
MOD_GSK3_1	93	100	PF00069	0.486
MOD_N-GLC_1	21	26	PF02516	0.678
MOD_NEK2_1	136	141	PF00069	0.389
MOD_NEK2_1	81	86	PF00069	0.431
MOD_PIKK_1	173	179	PF00454	0.512
MOD_PKA_2	220	226	PF00069	0.814
MOD_PKA_2	97	103	PF00069	0.591
MOD_Plk_4	112	118	PF00069	0.429
MOD_Plk_4	194	200	PF00069	0.751
MOD_Plk_4	86	92	PF00069	0.539
MOD_ProDKin_1	144	150	PF00069	0.661
MOD_ProDKin_1	185	191	PF00069	0.720
MOD_ProDKin_1	204	210	PF00069	0.505
MOD_ProDKin_1	49	55	PF00069	0.595
MOD_SUMO_rev_2	35	42	PF00179	0.654
TRG_ENDOCYTIC_2	106	109	PF00928	0.485
TRG_ENDOCYTIC_2	78	81	PF00928	0.449
TRG_ER_diArg_1	42	45	PF00400	0.541
TRG_ER_diArg_1	46	48	PF00400	0.567
TRG_NES_CRM1_1	108	120	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S9	Leptomonas seymouri	64%	100%
A0A3Q8IA85	Leishmania donovani	86%	98%
A4HBN0	Leishmania braziliensis	73%	100%
A4HZ31	Leishmania infantum	86%	98%
D0A1N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QCI3	Leishmania major	84%	99%