Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUZ8_LEIMU

TriTrypDb:

LmxM.21.0310

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AUZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.771
CLV_MEL_PAP_1	182	188	PF00089	0.335
CLV_NRD_NRD_1	203	205	PF00675	0.441
CLV_NRD_NRD_1	268	270	PF00675	0.370
CLV_PCSK_FUR_1	76	80	PF00082	0.526
CLV_PCSK_KEX2_1	78	80	PF00082	0.538
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.538
CLV_PCSK_SKI1_1	154	158	PF00082	0.371
CLV_PCSK_SKI1_1	309	313	PF00082	0.355
CLV_PCSK_SKI1_1	335	339	PF00082	0.583
CLV_Separin_Metazoa	115	119	PF03568	0.440
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.562
DOC_MAPK_gen_1	78	88	PF00069	0.441
DOC_MAPK_JIP1_4	118	124	PF00069	0.436
DOC_MAPK_MEF2A_6	290	297	PF00069	0.618
DOC_MAPK_RevD_3	63	79	PF00069	0.351
DOC_PP1_RVXF_1	259	265	PF00149	0.517
DOC_PP2B_LxvP_1	122	125	PF13499	0.513
DOC_SPAK_OSR1_1	149	153	PF12202	0.279
DOC_SPAK_OSR1_1	185	189	PF12202	0.545
DOC_USP7_MATH_1	167	171	PF00917	0.580
DOC_WW_Pin1_4	140	145	PF00397	0.435
DOC_WW_Pin1_4	47	52	PF00397	0.677
DOC_WW_Pin1_4	55	60	PF00397	0.517
LIG_14-3-3_CanoR_1	185	189	PF00244	0.539
LIG_14-3-3_CanoR_1	261	265	PF00244	0.487
LIG_14-3-3_CanoR_1	309	314	PF00244	0.410
LIG_14-3-3_CanoR_1	82	86	PF00244	0.432
LIG_BIR_III_4	103	107	PF00653	0.409
LIG_BRCT_BRCA1_1	146	150	PF00533	0.336
LIG_CSL_BTD_1	197	200	PF09270	0.510
LIG_FHA_1	133	139	PF00498	0.308
LIG_FHA_1	18	24	PF00498	0.508
LIG_FHA_1	206	212	PF00498	0.593
LIG_FHA_1	28	34	PF00498	0.314
LIG_FHA_1	70	76	PF00498	0.304
LIG_FHA_2	110	116	PF00498	0.446
LIG_LIR_Gen_1	84	93	PF02991	0.396
LIG_LIR_Nem_3	195	201	PF02991	0.516
LIG_LIR_Nem_3	263	268	PF02991	0.504
LIG_LIR_Nem_3	84	88	PF02991	0.505
LIG_REV1ctd_RIR_1	263	274	PF16727	0.525
LIG_SH2_STAP1	207	211	PF00017	0.578
LIG_SH2_STAP1	285	289	PF00017	0.448
LIG_SH2_STAT3	207	210	PF00017	0.547
LIG_SH2_STAT5	207	210	PF00017	0.667
LIG_SH2_STAT5	258	261	PF00017	0.481
LIG_SH2_STAT5	74	77	PF00017	0.340
LIG_SH3_2	304	309	PF14604	0.630
LIG_SH3_3	113	119	PF00018	0.442
LIG_SH3_3	20	26	PF00018	0.383
LIG_SH3_3	301	307	PF00018	0.681
LIG_SH3_3	326	332	PF00018	0.410
LIG_SH3_3	53	59	PF00018	0.460
LIG_Sin3_3	316	323	PF02671	0.355
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.395
LIG_SUMO_SIM_anti_2	315	322	PF11976	0.298
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.329
LIG_TRAF2_1	170	173	PF00917	0.611
LIG_WRC_WIRS_1	276	281	PF05994	0.516
MOD_CDK_SPK_2	144	149	PF00069	0.407
MOD_CK1_1	143	149	PF00069	0.241
MOD_CK1_1	17	23	PF00069	0.530
MOD_CK1_1	260	266	PF00069	0.545
MOD_CK1_1	322	328	PF00069	0.343
MOD_CK1_1	333	339	PF00069	0.369
MOD_CK1_1	55	61	PF00069	0.478
MOD_CK1_1	84	90	PF00069	0.381
MOD_CK2_1	109	115	PF00069	0.449
MOD_CK2_1	167	173	PF00069	0.594
MOD_GlcNHglycan	314	317	PF01048	0.371
MOD_GSK3_1	123	130	PF00069	0.498
MOD_GSK3_1	140	147	PF00069	0.408
MOD_GSK3_1	205	212	PF00069	0.566
MOD_N-GLC_1	160	165	PF02516	0.349
MOD_N-GLC_1	17	22	PF02516	0.597
MOD_NEK2_1	1	6	PF00069	0.491
MOD_NEK2_1	127	132	PF00069	0.497
MOD_NEK2_1	159	164	PF00069	0.284
MOD_NEK2_1	184	189	PF00069	0.546
MOD_NEK2_1	211	216	PF00069	0.653
MOD_NEK2_1	244	249	PF00069	0.657
MOD_NEK2_1	27	32	PF00069	0.378
MOD_NEK2_1	338	343	PF00069	0.506
MOD_NEK2_2	160	165	PF00069	0.414
MOD_PIKK_1	338	344	PF00454	0.435
MOD_PK_1	57	63	PF00069	0.435
MOD_PKA_1	205	211	PF00069	0.628
MOD_PKA_2	184	190	PF00069	0.590
MOD_PKA_2	260	266	PF00069	0.484
MOD_PKA_2	81	87	PF00069	0.458
MOD_Plk_1	160	166	PF00069	0.410
MOD_Plk_1	194	200	PF00069	0.603
MOD_Plk_4	154	160	PF00069	0.376
MOD_Plk_4	194	200	PF00069	0.569
MOD_Plk_4	260	266	PF00069	0.557
MOD_Plk_4	319	325	PF00069	0.349
MOD_Plk_4	69	75	PF00069	0.361
MOD_Plk_4	81	87	PF00069	0.506
MOD_ProDKin_1	140	146	PF00069	0.430
MOD_ProDKin_1	47	53	PF00069	0.679
MOD_ProDKin_1	55	61	PF00069	0.516
MOD_SUMO_rev_2	170	177	PF00179	0.504
MOD_SUMO_rev_2	286	291	PF00179	0.531
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.360
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.446
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H6	Leptomonas seymouri	51%	99%
A0A1X0NXE2	Trypanosomatidae	30%	100%
A0A3S5IR94	Trypanosoma rangeli	28%	100%
A0A3S7WWC8	Leishmania donovani	93%	100%
A4HBM9	Leishmania braziliensis	77%	100%
A4HZB8	Leishmania infantum	93%	100%
D0A1M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QCI4	Leishmania major	92%	100%
V5B0L2	Trypanosoma cruzi	27%	100%