EXPERA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUZ7_LEIMU

TriTrypDb:

LmxM.21.0300

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AUZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.535
CLV_PCSK_KEX2_1	223	225	PF00082	0.535
CLV_PCSK_SKI1_1	63	67	PF00082	0.451
DOC_MAPK_gen_1	50	57	PF00069	0.562
DOC_MAPK_MEF2A_6	50	57	PF00069	0.745
DOC_USP7_MATH_1	188	192	PF00917	0.720
DOC_USP7_MATH_1	28	32	PF00917	0.715
DOC_USP7_MATH_1	33	37	PF00917	0.686
DOC_USP7_MATH_1	51	55	PF00917	0.664
DOC_WW_Pin1_4	211	216	PF00397	0.688
DOC_WW_Pin1_4	234	239	PF00397	0.783
DOC_WW_Pin1_4	3	8	PF00397	0.755
DOC_WW_Pin1_4	42	47	PF00397	0.691
DOC_WW_Pin1_4	65	70	PF00397	0.560
LIG_14-3-3_CanoR_1	223	228	PF00244	0.816
LIG_BRCT_BRCA1_1	43	47	PF00533	0.790
LIG_DLG_GKlike_1	223	231	PF00625	0.759
LIG_FHA_1	130	136	PF00498	0.501
LIG_FHA_1	168	174	PF00498	0.394
LIG_FHA_1	80	86	PF00498	0.332
LIG_G3BP_FGDF_1	93	98	PF02136	0.280
LIG_LIR_Gen_1	122	131	PF02991	0.338
LIG_LIR_Gen_1	88	99	PF02991	0.418
LIG_LIR_Nem_3	122	126	PF02991	0.329
LIG_LIR_Nem_3	170	175	PF02991	0.387
LIG_LIR_Nem_3	61	67	PF02991	0.654
LIG_LIR_Nem_3	88	94	PF02991	0.371
LIG_LYPXL_yS_3	118	121	PF13949	0.461
LIG_Pex14_2	91	95	PF04695	0.436
LIG_PTB_Apo_2	72	79	PF02174	0.623
LIG_SH2_CRK	116	120	PF00017	0.403
LIG_SH2_CRK	179	183	PF00017	0.650
LIG_SH2_CRK	67	71	PF00017	0.639
LIG_SH2_NCK_1	227	231	PF00017	0.815
LIG_SH2_STAP1	100	104	PF00017	0.469
LIG_SH2_STAT5	131	134	PF00017	0.428
LIG_SH2_STAT5	67	70	PF00017	0.638
LIG_SH3_1	235	241	PF00018	0.739
LIG_SH3_3	235	241	PF00018	0.781
LIG_SH3_3	54	60	PF00018	0.736
LIG_SUMO_SIM_par_1	164	171	PF11976	0.436
LIG_WRC_WIRS_1	169	174	PF05994	0.436
LIG_WRC_WIRS_1	95	100	PF05994	0.274
MOD_CDK_SPxK_1	65	71	PF00069	0.570
MOD_CDK_SPxxK_3	3	10	PF00069	0.753
MOD_CK1_1	214	220	PF00069	0.682
MOD_CK1_1	22	28	PF00069	0.799
MOD_CK1_1	36	42	PF00069	0.645
MOD_CMANNOS	8	11	PF00535	0.550
MOD_GlcNHglycan	157	160	PF01048	0.513
MOD_GlcNHglycan	190	193	PF01048	0.582
MOD_GlcNHglycan	196	199	PF01048	0.556
MOD_GlcNHglycan	26	29	PF01048	0.565
MOD_GlcNHglycan	3	6	PF01048	0.483
MOD_GlcNHglycan	38	41	PF01048	0.445
MOD_GlcNHglycan	60	63	PF01048	0.437
MOD_GSK3_1	145	152	PF00069	0.475
MOD_GSK3_1	18	25	PF00069	0.799
MOD_GSK3_1	186	193	PF00069	0.621
MOD_GSK3_1	209	216	PF00069	0.810
MOD_GSK3_1	28	35	PF00069	0.712
MOD_GSK3_1	38	45	PF00069	0.679
MOD_NEK2_1	1	6	PF00069	0.752
MOD_NEK2_1	167	172	PF00069	0.400
MOD_NEK2_2	33	38	PF00069	0.609
MOD_PKA_1	223	229	PF00069	0.817
MOD_PKA_2	223	229	PF00069	0.817
MOD_Plk_4	168	174	PF00069	0.436
MOD_Plk_4	94	100	PF00069	0.528
MOD_ProDKin_1	211	217	PF00069	0.689
MOD_ProDKin_1	234	240	PF00069	0.785
MOD_ProDKin_1	3	9	PF00069	0.752
MOD_ProDKin_1	42	48	PF00069	0.691
MOD_ProDKin_1	65	71	PF00069	0.561
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.697
TRG_ENDOCYTIC_2	118	121	PF00928	0.426
TRG_ENDOCYTIC_2	179	182	PF00928	0.638
TRG_ENDOCYTIC_2	67	70	PF00928	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBS2	Leishmania donovani	93%	100%
A0A3R7KF63	Trypanosoma rangeli	36%	100%
A4HBM8	Leishmania braziliensis	74%	100%
A4HZB7	Leishmania infantum	93%	100%
Q4QCI5	Leishmania major	91%	100%