Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUZ5_LEIMU

TriTrypDb:

LmxM.21.0280

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.588
CLV_NRD_NRD_1	109	111	PF00675	0.631
CLV_NRD_NRD_1	113	115	PF00675	0.617
CLV_NRD_NRD_1	314	316	PF00675	0.590
CLV_NRD_NRD_1	432	434	PF00675	0.730
CLV_NRD_NRD_1	461	463	PF00675	0.491
CLV_NRD_NRD_1	488	490	PF00675	0.602
CLV_PCSK_FUR_1	312	316	PF00082	0.616
CLV_PCSK_KEX2_1	109	111	PF00082	0.583
CLV_PCSK_KEX2_1	113	115	PF00082	0.566
CLV_PCSK_KEX2_1	314	316	PF00082	0.590
CLV_PCSK_KEX2_1	432	434	PF00082	0.730
CLV_PCSK_KEX2_1	461	463	PF00082	0.491
CLV_PCSK_KEX2_1	488	490	PF00082	0.602
CLV_PCSK_PC7_1	109	115	PF00082	0.581
CLV_PCSK_SKI1_1	11	15	PF00082	0.692
CLV_PCSK_SKI1_1	133	137	PF00082	0.672
CLV_PCSK_SKI1_1	295	299	PF00082	0.485
CLV_PCSK_SKI1_1	462	466	PF00082	0.479
CLV_PCSK_SKI1_1	497	501	PF00082	0.468
CLV_PCSK_SKI1_1	81	85	PF00082	0.559
DEG_Nend_Nbox_1	1	3	PF02207	0.573
DEG_SPOP_SBC_1	216	220	PF00917	0.607
DEG_SPOP_SBC_1	242	246	PF00917	0.662
DOC_CKS1_1	254	259	PF01111	0.639
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	410	416	PF00134	0.512
DOC_MAPK_gen_1	14	22	PF00069	0.711
DOC_MAPK_gen_1	289	298	PF00069	0.496
DOC_MAPK_gen_1	443	453	PF00069	0.498
DOC_MAPK_gen_1	461	468	PF00069	0.446
DOC_MAPK_gen_1	488	494	PF00069	0.680
DOC_MAPK_MEF2A_6	461	470	PF00069	0.363
DOC_PP1_RVXF_1	293	299	PF00149	0.487
DOC_PP2B_LxvP_1	151	154	PF13499	0.562
DOC_PP2B_LxvP_1	410	413	PF13499	0.476
DOC_PP2B_LxvP_1	7	10	PF13499	0.421
DOC_PP4_FxxP_1	280	283	PF00568	0.605
DOC_USP7_MATH_1	122	126	PF00917	0.657
DOC_USP7_MATH_1	131	135	PF00917	0.718
DOC_USP7_MATH_1	209	213	PF00917	0.784
DOC_USP7_MATH_1	216	220	PF00917	0.745
DOC_USP7_MATH_1	221	225	PF00917	0.669
DOC_USP7_MATH_1	227	231	PF00917	0.566
DOC_USP7_MATH_1	242	246	PF00917	0.566
DOC_USP7_MATH_1	340	344	PF00917	0.540
DOC_USP7_MATH_1	38	42	PF00917	0.622
DOC_USP7_MATH_1	397	401	PF00917	0.556
DOC_USP7_MATH_1	472	476	PF00917	0.453
DOC_USP7_MATH_1	526	530	PF00917	0.549
DOC_WW_Pin1_4	212	217	PF00397	0.784
DOC_WW_Pin1_4	253	258	PF00397	0.635
DOC_WW_Pin1_4	28	33	PF00397	0.686
DOC_WW_Pin1_4	81	86	PF00397	0.644
LIG_14-3-3_CanoR_1	113	119	PF00244	0.598
LIG_14-3-3_CanoR_1	133	143	PF00244	0.663
LIG_14-3-3_CanoR_1	186	194	PF00244	0.683
LIG_14-3-3_CanoR_1	289	299	PF00244	0.528
LIG_14-3-3_CanoR_1	70	76	PF00244	0.520
LIG_Actin_WH2_2	132	147	PF00022	0.664
LIG_BIR_III_2	441	445	PF00653	0.476
LIG_BIR_III_4	126	130	PF00653	0.524
LIG_eIF4E_1	2	8	PF01652	0.440
LIG_FHA_1	100	106	PF00498	0.526
LIG_FHA_1	134	140	PF00498	0.696
LIG_FHA_1	248	254	PF00498	0.632
LIG_FHA_1	291	297	PF00498	0.510
LIG_FHA_1	342	348	PF00498	0.482
LIG_FHA_1	396	402	PF00498	0.599
LIG_FHA_1	405	411	PF00498	0.429
LIG_FHA_1	518	524	PF00498	0.477
LIG_FHA_1	66	72	PF00498	0.628
LIG_FHA_1	88	94	PF00498	0.548
LIG_FHA_2	119	125	PF00498	0.650
LIG_FHA_2	223	229	PF00498	0.713
LIG_FHA_2	315	321	PF00498	0.599
LIG_LIR_Apic_2	74	80	PF02991	0.556
LIG_LIR_Gen_1	376	385	PF02991	0.519
LIG_LIR_Gen_1	479	485	PF02991	0.504
LIG_LIR_Gen_1	533	541	PF02991	0.431
LIG_LIR_LC3C_4	534	539	PF02991	0.369
LIG_LIR_Nem_3	376	380	PF02991	0.519
LIG_LIR_Nem_3	513	519	PF02991	0.475
LIG_LIR_Nem_3	533	538	PF02991	0.303
LIG_MYND_1	6	10	PF01753	0.491
LIG_SH2_CRK	77	81	PF00017	0.573
LIG_SH2_NCK_1	46	50	PF00017	0.673
LIG_SH2_PTP2	377	380	PF00017	0.522
LIG_SH2_STAP1	406	410	PF00017	0.461
LIG_SH2_STAP1	46	50	PF00017	0.673
LIG_SH2_STAT5	28	31	PF00017	0.507
LIG_SH2_STAT5	377	380	PF00017	0.557
LIG_SH2_STAT5	395	398	PF00017	0.598
LIG_SH2_STAT5	406	409	PF00017	0.409
LIG_SH2_STAT5	46	49	PF00017	0.587
LIG_SH3_2	254	259	PF14604	0.639
LIG_SH3_3	140	146	PF00018	0.685
LIG_SH3_3	164	170	PF00018	0.636
LIG_SH3_3	251	257	PF00018	0.669
LIG_SH3_3	259	265	PF00018	0.629
LIG_SH3_3	410	416	PF00018	0.512
LIG_Sin3_3	5	12	PF02671	0.425
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.559
LIG_SUMO_SIM_anti_2	536	542	PF11976	0.429
LIG_SUMO_SIM_par_1	536	542	PF11976	0.429
LIG_TRAF2_1	188	191	PF00917	0.576
LIG_TRAF2_1	317	320	PF00917	0.650
LIG_TRAF2_1	417	420	PF00917	0.575
LIG_WRC_WIRS_1	467	472	PF05994	0.405
MOD_CDK_SPK_2	212	217	PF00069	0.717
MOD_CDK_SPxK_1	253	259	PF00069	0.638
MOD_CK1_1	125	131	PF00069	0.750
MOD_CK1_1	134	140	PF00069	0.692
MOD_CK1_1	174	180	PF00069	0.560
MOD_CK1_1	212	218	PF00069	0.790
MOD_CK1_1	31	37	PF00069	0.608
MOD_CK1_1	428	434	PF00069	0.719
MOD_CK1_1	476	482	PF00069	0.490
MOD_CK1_1	533	539	PF00069	0.433
MOD_CK1_1	87	93	PF00069	0.548
MOD_CK1_1	96	102	PF00069	0.511
MOD_CK2_1	185	191	PF00069	0.576
MOD_CK2_1	21	27	PF00069	0.450
MOD_CK2_1	222	228	PF00069	0.601
MOD_CK2_1	297	303	PF00069	0.486
MOD_CK2_1	314	320	PF00069	0.429
MOD_CK2_1	340	346	PF00069	0.499
MOD_GlcNHglycan	126	130	PF01048	0.658
MOD_GlcNHglycan	173	176	PF01048	0.558
MOD_GlcNHglycan	219	222	PF01048	0.665
MOD_GlcNHglycan	228	232	PF01048	0.560
MOD_GlcNHglycan	245	248	PF01048	0.652
MOD_GlcNHglycan	250	253	PF01048	0.659
MOD_GlcNHglycan	328	332	PF01048	0.572
MOD_GlcNHglycan	40	43	PF01048	0.707
MOD_GlcNHglycan	426	430	PF01048	0.683
MOD_GlcNHglycan	528	531	PF01048	0.554
MOD_GlcNHglycan	86	89	PF01048	0.548
MOD_GSK3_1	114	121	PF00069	0.653
MOD_GSK3_1	133	140	PF00069	0.652
MOD_GSK3_1	212	219	PF00069	0.720
MOD_GSK3_1	237	244	PF00069	0.664
MOD_GSK3_1	27	34	PF00069	0.583
MOD_GSK3_1	298	305	PF00069	0.589
MOD_GSK3_1	40	47	PF00069	0.680
MOD_GSK3_1	428	435	PF00069	0.596
MOD_GSK3_1	466	473	PF00069	0.410
MOD_GSK3_1	526	533	PF00069	0.519
MOD_N-GLC_1	242	247	PF02516	0.691
MOD_NEK2_1	118	123	PF00069	0.577
MOD_NEK2_1	156	161	PF00069	0.558
MOD_NEK2_1	327	332	PF00069	0.496
MOD_NEK2_1	466	471	PF00069	0.508
MOD_NEK2_1	71	76	PF00069	0.519
MOD_NEK2_2	456	461	PF00069	0.450
MOD_NEK2_2	65	70	PF00069	0.557
MOD_OFUCOSY	279	286	PF10250	0.523
MOD_PIKK_1	202	208	PF00454	0.520
MOD_PIKK_1	451	457	PF00454	0.446
MOD_PIKK_1	483	489	PF00454	0.487
MOD_PKA_1	109	115	PF00069	0.581
MOD_PKA_1	314	320	PF00069	0.572
MOD_PKA_1	432	438	PF00069	0.540
MOD_PKA_2	109	115	PF00069	0.627
MOD_PKA_2	144	150	PF00069	0.590
MOD_PKA_2	185	191	PF00069	0.656
MOD_PKA_2	216	222	PF00069	0.766
MOD_PKA_2	314	320	PF00069	0.572
MOD_PKA_2	432	438	PF00069	0.629
MOD_PKB_1	312	320	PF00069	0.631
MOD_Plk_1	327	333	PF00069	0.506
MOD_Plk_1	96	102	PF00069	0.407
MOD_Plk_2-3	21	27	PF00069	0.585
MOD_Plk_4	114	120	PF00069	0.649
MOD_Plk_4	268	274	PF00069	0.608
MOD_Plk_4	31	37	PF00069	0.594
MOD_Plk_4	373	379	PF00069	0.533
MOD_Plk_4	466	472	PF00069	0.407
MOD_Plk_4	476	482	PF00069	0.462
MOD_ProDKin_1	212	218	PF00069	0.782
MOD_ProDKin_1	253	259	PF00069	0.638
MOD_ProDKin_1	28	34	PF00069	0.688
MOD_ProDKin_1	81	87	PF00069	0.643
MOD_SUMO_rev_2	491	499	PF00179	0.547
TRG_DiLeu_BaEn_1	103	108	PF01217	0.564
TRG_DiLeu_BaEn_4	319	325	PF01217	0.620
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.436
TRG_ENDOCYTIC_2	2	5	PF00928	0.586
TRG_ENDOCYTIC_2	377	380	PF00928	0.543
TRG_ENDOCYTIC_2	481	484	PF00928	0.480
TRG_ER_diArg_1	108	110	PF00400	0.567
TRG_ER_diArg_1	311	314	PF00400	0.612
TRG_ER_diArg_1	460	462	PF00400	0.478
TRG_NES_CRM1_1	97	111	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K7	Leptomonas seymouri	52%	93%
A0A3S7WWB2	Leishmania donovani	91%	100%
A4HBM6	Leishmania braziliensis	78%	99%
Q4QCI7	Leishmania major	90%	100%