Phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphotransferase

Gene product:

hexokinase, putative

Species:

Leishmania mexicana

UniProt:

E9AUZ1_LEIMU

TriTrypDb:

LmxM.21.0240

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005739	mitochondrion	5	2
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9AUZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUZ1

Function

Biological processes
Term	Name	Level	Count
GO:0001678	intracellular glucose homeostasis	4	17
GO:0005975	carbohydrate metabolic process	3	17
GO:0006082	organic acid metabolic process	3	17
GO:0006090	pyruvate metabolic process	7	17
GO:0006091	generation of precursor metabolites and energy	3	17
GO:0006096	glycolytic process	5	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006163	purine nucleotide metabolic process	5	17
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	17
GO:0006725	cellular aromatic compound metabolic process	3	17
GO:0006753	nucleoside phosphate metabolic process	4	17
GO:0006757	obsolete ATP generation from ADP	4	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009056	catabolic process	2	17
GO:0009117	nucleotide metabolic process	5	17
GO:0009132	nucleoside diphosphate metabolic process	5	17
GO:0009135	purine nucleoside diphosphate metabolic process	6	17
GO:0009141	nucleoside triphosphate metabolic process	5	17
GO:0009144	purine nucleoside triphosphate metabolic process	6	17
GO:0009150	purine ribonucleotide metabolic process	6	17
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	17
GO:0009185	ribonucleoside diphosphate metabolic process	6	17
GO:0009199	ribonucleoside triphosphate metabolic process	6	17
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	17
GO:0009259	ribonucleotide metabolic process	5	17
GO:0009987	cellular process	1	17
GO:0016052	carbohydrate catabolic process	4	17
GO:0016310	phosphorylation	5	17
GO:0019637	organophosphate metabolic process	3	17
GO:0019693	ribose phosphate metabolic process	4	17
GO:0019725	cellular homeostasis	2	17
GO:0019752	carboxylic acid metabolic process	5	17
GO:0032787	monocarboxylic acid metabolic process	6	17
GO:0033500	carbohydrate homeostasis	5	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0042592	homeostatic process	3	17
GO:0042593	glucose homeostasis	6	17
GO:0043436	oxoacid metabolic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044281	small molecule metabolic process	2	17
GO:0046031	ADP metabolic process	7	17
GO:0046034	ATP metabolic process	7	17
GO:0046483	heterocycle metabolic process	3	17
GO:0046939	obsolete nucleotide phosphorylation	6	17
GO:0048878	chemical homeostasis	4	17
GO:0055082	intracellular chemical homeostasis	3	17
GO:0055086	nucleobase-containing small molecule metabolic process	3	17
GO:0065007	biological regulation	1	17
GO:0065008	regulation of biological quality	2	17
GO:0071704	organic substance metabolic process	2	17
GO:0072521	purine-containing compound metabolic process	4	17
GO:1901135	carbohydrate derivative metabolic process	3	17
GO:1901360	organic cyclic compound metabolic process	3	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901575	organic substance catabolic process	3	17
GO:0005996	monosaccharide metabolic process	3	2
GO:0006006	glucose metabolic process	5	2
GO:0019318	hexose metabolic process	4	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0046835	carbohydrate phosphorylation	4	2
GO:0051156	glucose 6-phosphate metabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004396	hexokinase activity	5	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0005536	glucose binding	4	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0019200	carbohydrate kinase activity	5	17
GO:0030246	carbohydrate binding	2	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0048029	monosaccharide binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17
GO:0004340	glucokinase activity	6	2
GO:0008865	fructokinase activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.392
CLV_C14_Caspase3-7	377	381	PF00656	0.345
CLV_NRD_NRD_1	289	291	PF00675	0.377
CLV_NRD_NRD_1	405	407	PF00675	0.285
CLV_NRD_NRD_1	5	7	PF00675	0.505
CLV_PCSK_KEX2_1	241	243	PF00082	0.373
CLV_PCSK_KEX2_1	289	291	PF00082	0.321
CLV_PCSK_KEX2_1	405	407	PF00082	0.285
CLV_PCSK_KEX2_1	455	457	PF00082	0.424
CLV_PCSK_KEX2_1	5	7	PF00082	0.505
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.369
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.369
CLV_PCSK_PC7_1	451	457	PF00082	0.420
CLV_PCSK_SKI1_1	112	116	PF00082	0.372
CLV_PCSK_SKI1_1	117	121	PF00082	0.364
CLV_PCSK_SKI1_1	135	139	PF00082	0.224
CLV_PCSK_SKI1_1	209	213	PF00082	0.321
CLV_PCSK_SKI1_1	260	264	PF00082	0.309
CLV_PCSK_SKI1_1	367	371	PF00082	0.304
CLV_PCSK_SKI1_1	537	541	PF00082	0.377
DEG_APCC_DBOX_1	116	124	PF00400	0.426
DEG_SCF_FBW7_2	382	387	PF00400	0.409
DOC_ANK_TNKS_1	418	425	PF00023	0.369
DOC_CDC14_PxL_1	489	497	PF14671	0.420
DOC_CKS1_1	36	41	PF01111	0.452
DOC_CKS1_1	56	61	PF01111	0.458
DOC_CKS1_1	86	91	PF01111	0.438
DOC_CYCLIN_RxL_1	256	267	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.420
DOC_MAPK_DCC_7	348	357	PF00069	0.377
DOC_MAPK_FxFP_2	249	252	PF00069	0.272
DOC_MAPK_gen_1	112	120	PF00069	0.439
DOC_MAPK_gen_1	241	247	PF00069	0.369
DOC_MAPK_gen_1	289	297	PF00069	0.324
DOC_MAPK_gen_1	365	374	PF00069	0.328
DOC_MAPK_gen_1	390	400	PF00069	0.377
DOC_MAPK_gen_1	405	411	PF00069	0.301
DOC_MAPK_gen_1	455	462	PF00069	0.360
DOC_MAPK_MEF2A_6	289	297	PF00069	0.276
DOC_MAPK_MEF2A_6	365	374	PF00069	0.409
DOC_PP2B_LxvP_1	37	40	PF13499	0.452
DOC_PP4_FxxP_1	205	208	PF00568	0.272
DOC_PP4_FxxP_1	249	252	PF00568	0.272
DOC_USP7_MATH_1	119	123	PF00917	0.324
DOC_USP7_MATH_1	24	28	PF00917	0.465
DOC_USP7_MATH_1	343	347	PF00917	0.347
DOC_USP7_MATH_1	430	434	PF00917	0.406
DOC_USP7_MATH_1	46	50	PF00917	0.473
DOC_USP7_MATH_1	84	88	PF00917	0.530
DOC_USP7_UBL2_3	256	260	PF12436	0.420
DOC_WW_Pin1_4	10	15	PF00397	0.482
DOC_WW_Pin1_4	127	132	PF00397	0.164
DOC_WW_Pin1_4	26	31	PF00397	0.446
DOC_WW_Pin1_4	32	37	PF00397	0.451
DOC_WW_Pin1_4	350	355	PF00397	0.318
DOC_WW_Pin1_4	380	385	PF00397	0.365
DOC_WW_Pin1_4	512	517	PF00397	0.328
DOC_WW_Pin1_4	55	60	PF00397	0.552
DOC_WW_Pin1_4	66	71	PF00397	0.524
DOC_WW_Pin1_4	75	80	PF00397	0.468
DOC_WW_Pin1_4	85	90	PF00397	0.450
LIG_14-3-3_CanoR_1	152	157	PF00244	0.420
LIG_14-3-3_CanoR_1	189	193	PF00244	0.321
LIG_14-3-3_CanoR_1	335	343	PF00244	0.420
LIG_14-3-3_CanoR_1	47	56	PF00244	0.516
LIG_Actin_WH2_2	276	291	PF00022	0.328
LIG_APCC_ABBA_1	372	377	PF00400	0.409
LIG_EH1_1	139	147	PF00400	0.328
LIG_FHA_1	270	276	PF00498	0.290
LIG_FHA_1	448	454	PF00498	0.321
LIG_FHA_1	463	469	PF00498	0.321
LIG_FHA_1	497	503	PF00498	0.310
LIG_FHA_1	525	531	PF00498	0.363
LIG_FHA_1	67	73	PF00498	0.481
LIG_FHA_2	371	377	PF00498	0.301
LIG_FHA_2	468	474	PF00498	0.456
LIG_GBD_Chelix_1	280	288	PF00786	0.301
LIG_LIR_Apic_2	202	208	PF02991	0.282
LIG_LIR_Apic_2	248	252	PF02991	0.272
LIG_LIR_Gen_1	217	227	PF02991	0.269
LIG_LIR_Gen_1	515	526	PF02991	0.341
LIG_LIR_Nem_3	172	178	PF02991	0.276
LIG_LIR_Nem_3	183	188	PF02991	0.293
LIG_LIR_Nem_3	217	223	PF02991	0.257
LIG_LIR_Nem_3	515	521	PF02991	0.282
LIG_OCRL_FandH_1	430	442	PF00620	0.420
LIG_PCNA_yPIPBox_3	302	311	PF02747	0.304
LIG_Pex14_1	266	270	PF04695	0.272
LIG_Pex14_2	247	251	PF04695	0.283
LIG_SH2_CRK	368	372	PF00017	0.311
LIG_SH2_STAP1	176	180	PF00017	0.273
LIG_SH2_STAP1	375	379	PF00017	0.321
LIG_SH2_STAT3	113	116	PF00017	0.521
LIG_SH2_STAT5	113	116	PF00017	0.521
LIG_SH2_STAT5	164	167	PF00017	0.280
LIG_SH2_STAT5	312	315	PF00017	0.328
LIG_SH2_STAT5	332	335	PF00017	0.308
LIG_SH2_STAT5	399	402	PF00017	0.295
LIG_SH3_3	33	39	PF00018	0.461
LIG_SH3_3	56	62	PF00018	0.515
LIG_SH3_3	76	82	PF00018	0.495
LIG_SH3_3	83	89	PF00018	0.466
LIG_SUMO_SIM_anti_2	278	285	PF11976	0.286
LIG_SUMO_SIM_par_1	370	378	PF11976	0.409
LIG_SUMO_SIM_par_1	503	508	PF11976	0.272
LIG_UBA3_1	219	228	PF00899	0.301
LIG_UBA3_1	551	560	PF00899	0.496
LIG_WRC_WIRS_1	159	164	PF05994	0.326
MOD_CDC14_SPxK_1	130	133	PF00782	0.164
MOD_CDK_SPxK_1	127	133	PF00069	0.164
MOD_CDK_SPxK_1	380	386	PF00069	0.377
MOD_CDK_SPxxK_3	10	17	PF00069	0.483
MOD_CK1_1	12	18	PF00069	0.481
MOD_CK1_1	122	128	PF00069	0.347
MOD_CK1_1	337	343	PF00069	0.321
MOD_CK1_1	35	41	PF00069	0.520
MOD_CK1_1	487	493	PF00069	0.338
MOD_CK1_1	73	79	PF00069	0.546
MOD_CK1_1	87	93	PF00069	0.418
MOD_CK2_1	103	109	PF00069	0.585
MOD_CK2_1	467	473	PF00069	0.420
MOD_CK2_1	507	513	PF00069	0.290
MOD_GlcNHglycan	20	23	PF01048	0.528
MOD_GlcNHglycan	209	212	PF01048	0.450
MOD_GlcNHglycan	336	339	PF01048	0.305
MOD_GlcNHglycan	345	348	PF01048	0.353
MOD_GlcNHglycan	395	398	PF01048	0.285
MOD_GlcNHglycan	543	547	PF01048	0.297
MOD_GSK3_1	158	165	PF00069	0.430
MOD_GSK3_1	24	31	PF00069	0.446
MOD_GSK3_1	264	271	PF00069	0.332
MOD_GSK3_1	463	470	PF00069	0.416
MOD_GSK3_1	525	532	PF00069	0.399
MOD_GSK3_1	6	13	PF00069	0.496
MOD_GSK3_1	66	73	PF00069	0.489
MOD_GSK3_1	80	87	PF00069	0.770
MOD_LATS_1	45	51	PF00433	0.473
MOD_N-GLC_1	301	306	PF02516	0.280
MOD_N-GLC_2	329	331	PF02516	0.272
MOD_NEK2_1	180	185	PF00069	0.277
MOD_NEK2_1	188	193	PF00069	0.287
MOD_NEK2_1	245	250	PF00069	0.320
MOD_NEK2_1	284	289	PF00069	0.376
MOD_NEK2_1	494	499	PF00069	0.315
MOD_NEK2_1	530	535	PF00069	0.335
MOD_PIKK_1	122	128	PF00454	0.345
MOD_PIKK_1	496	502	PF00454	0.373
MOD_PIKK_1	87	93	PF00454	0.490
MOD_PKA_2	103	109	PF00069	0.570
MOD_PKA_2	151	157	PF00069	0.275
MOD_PKA_2	188	194	PF00069	0.321
MOD_PKA_2	334	340	PF00069	0.378
MOD_PKA_2	46	52	PF00069	0.486
MOD_Plk_1	301	307	PF00069	0.276
MOD_Plk_1	6	12	PF00069	0.527
MOD_Plk_2-3	105	111	PF00069	0.560
MOD_Plk_2-3	467	473	PF00069	0.342
MOD_Plk_4	135	141	PF00069	0.366
MOD_Plk_4	158	164	PF00069	0.284
MOD_Plk_4	304	310	PF00069	0.297
MOD_Plk_4	484	490	PF00069	0.164
MOD_Plk_4	507	513	PF00069	0.284
MOD_Plk_4	525	531	PF00069	0.409
MOD_ProDKin_1	10	16	PF00069	0.482
MOD_ProDKin_1	127	133	PF00069	0.164
MOD_ProDKin_1	26	32	PF00069	0.447
MOD_ProDKin_1	35	41	PF00069	0.442
MOD_ProDKin_1	350	356	PF00069	0.318
MOD_ProDKin_1	380	386	PF00069	0.365
MOD_ProDKin_1	512	518	PF00069	0.328
MOD_ProDKin_1	55	61	PF00069	0.531
MOD_ProDKin_1	66	72	PF00069	0.524
MOD_ProDKin_1	75	81	PF00069	0.468
MOD_ProDKin_1	85	91	PF00069	0.446
MOD_SUMO_rev_2	198	206	PF00179	0.359
MOD_SUMO_rev_2	250	258	PF00179	0.321
TRG_DiLeu_BaEn_1	473	478	PF01217	0.390
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.326
TRG_ENDOCYTIC_2	175	178	PF00928	0.377
TRG_ER_diArg_1	288	290	PF00400	0.377
TRG_ER_diArg_1	405	407	PF00400	0.285
TRG_ER_diArg_1	478	481	PF00400	0.293
TRG_NES_CRM1_1	452	464	PF08389	0.369
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0K0JFP3	Brugia malayi	34%	98%
A0A0N0P4X5	Leptomonas seymouri	83%	100%
A0A0S4IU04	Bodo saltans	54%	100%
A0A1X0NYR8	Trypanosomatidae	68%	100%
A0A3Q8IBX3	Leishmania donovani	98%	100%
A0A3S7WWB0	Leishmania donovani	98%	100%
A0A422NIL0	Trypanosoma rangeli	69%	100%
A4HBM3	Leishmania braziliensis	90%	100%
A4HZB1	Leishmania infantum	98%	100%
A4HZB2	Leishmania infantum	97%	100%
D0A1L5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A1L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AUZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O64390	Solanum tuberosum	35%	100%
P04806	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P04807	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P17709	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P17712	Rattus norvegicus	32%	100%
P33284	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	35%	100%
P35557	Homo sapiens	33%	100%
P50506	Schwanniomyces occidentalis	35%	100%
P50521	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P52792	Mus musculus	32%	100%
P80581	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	100%
P83776	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	100%
P93834	Arabidopsis thaliana	36%	100%
Q02155	Plasmodium falciparum	32%	100%
Q04409	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q09756	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q1WM15	Oryza sativa subsp. japonica	37%	100%
Q1WM16	Oryza sativa subsp. japonica	37%	100%
Q26609	Schistosoma mansoni	36%	100%
Q2KNB4	Oryza sativa subsp. japonica	35%	100%
Q2KNB5	Oryza sativa subsp. japonica	33%	100%
Q2KNB7	Oryza sativa subsp. japonica	36%	100%
Q2KNB9	Oryza sativa subsp. japonica	36%	100%
Q42525	Arabidopsis thaliana	35%	100%
Q4QCJ0	Leishmania major	97%	100%
Q4VT70	Leishmania major	97%	100%
Q56XE8	Arabidopsis thaliana	33%	100%
Q5W676	Oryza sativa subsp. japonica	37%	100%
Q6CUZ3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	100%
Q6Q8A5	Nicotiana tabacum	38%	100%
Q6Z398	Oryza sativa subsp. japonica	38%	100%
Q8LH82	Oryza sativa subsp. japonica	36%	100%
Q8LQ68	Oryza sativa subsp. japonica	37%	100%
Q92407	Aspergillus niger	34%	100%
Q969A8	Toxoplasma gondii	32%	100%
Q9FZG4	Arabidopsis thaliana	35%	100%
Q9LPS1	Arabidopsis thaliana	34%	100%
Q9NFT7	Drosophila melanogaster	33%	100%
Q9NFT9	Drosophila melanogaster	25%	100%
Q9SEK2	Nicotiana tabacum	37%	100%
Q9SEK3	Spinacia oleracea	38%	100%
Q9SQ76	Solanum tuberosum	35%	100%
Q9T071	Arabidopsis thaliana	26%	100%
V5BQ43	Trypanosoma cruzi	67%	100%