Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AUZ0_LEIMU

TriTrypDb:

LmxM.21.0230

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0000118	histone deacetylase complex	3	1
GO:0000812	Swr1 complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0097346	INO80-type complex	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AUZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006338	chromatin remodeling	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1
GO:0031491	nucleosome binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	373	377	PF00656	0.524
CLV_C14_Caspase3-7	473	477	PF00656	0.671
CLV_NRD_NRD_1	184	186	PF00675	0.309
CLV_NRD_NRD_1	285	287	PF00675	0.295
CLV_NRD_NRD_1	314	316	PF00675	0.333
CLV_NRD_NRD_1	94	96	PF00675	0.214
CLV_PCSK_KEX2_1	186	188	PF00082	0.309
CLV_PCSK_KEX2_1	285	287	PF00082	0.322
CLV_PCSK_KEX2_1	314	316	PF00082	0.272
CLV_PCSK_KEX2_1	478	480	PF00082	0.581
CLV_PCSK_KEX2_1	94	96	PF00082	0.214
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.309
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.581
CLV_PCSK_SKI1_1	246	250	PF00082	0.270
CLV_PCSK_SKI1_1	420	424	PF00082	0.246
CLV_PCSK_SKI1_1	431	435	PF00082	0.243
CLV_PCSK_SKI1_1	560	564	PF00082	0.396
CLV_Separin_Metazoa	561	565	PF03568	0.378
DEG_APCC_DBOX_1	345	353	PF00400	0.427
DEG_APCC_DBOX_1	419	427	PF00400	0.446
DEG_SPOP_SBC_1	160	164	PF00917	0.445
DEG_SPOP_SBC_1	24	28	PF00917	0.486
DEG_SPOP_SBC_1	37	41	PF00917	0.499
DOC_CDC14_PxL_1	349	357	PF14671	0.427
DOC_CKS1_1	396	401	PF01111	0.509
DOC_CYCLIN_RxL_1	417	427	PF00134	0.460
DOC_CYCLIN_yClb3_PxF_3	507	515	PF00134	0.366
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	396	402	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	429	435	PF00134	0.460
DOC_MAPK_DCC_7	389	397	PF00069	0.509
DOC_MAPK_gen_1	151	160	PF00069	0.432
DOC_MAPK_gen_1	251	258	PF00069	0.455
DOC_MAPK_MEF2A_6	329	337	PF00069	0.343
DOC_MAPK_MEF2A_6	389	397	PF00069	0.509
DOC_PP2B_LxvP_1	131	134	PF13499	0.445
DOC_PP2B_LxvP_1	18	21	PF13499	0.356
DOC_PP2B_LxvP_1	358	361	PF13499	0.418
DOC_PP2B_LxvP_1	61	64	PF13499	0.460
DOC_PP4_FxxP_1	135	138	PF00568	0.417
DOC_PP4_FxxP_1	390	393	PF00568	0.414
DOC_SPAK_OSR1_1	389	393	PF12202	0.509
DOC_USP7_MATH_1	233	237	PF00917	0.453
DOC_USP7_MATH_1	24	28	PF00917	0.578
DOC_USP7_MATH_1	284	288	PF00917	0.456
DOC_USP7_MATH_1	37	41	PF00917	0.623
DOC_USP7_MATH_1	370	374	PF00917	0.535
DOC_USP7_MATH_1	537	541	PF00917	0.567
DOC_WW_Pin1_4	321	326	PF00397	0.491
DOC_WW_Pin1_4	337	342	PF00397	0.510
DOC_WW_Pin1_4	395	400	PF00397	0.470
DOC_WW_Pin1_4	503	508	PF00397	0.384
LIG_14-3-3_CanoR_1	175	180	PF00244	0.568
LIG_14-3-3_CanoR_1	187	193	PF00244	0.429
LIG_14-3-3_CanoR_1	285	289	PF00244	0.470
LIG_14-3-3_CanoR_1	29	38	PF00244	0.560
LIG_14-3-3_CanoR_1	499	507	PF00244	0.462
LIG_14-3-3_CanoR_1	584	588	PF00244	0.432
LIG_APCC_ABBA_1	4	9	PF00400	0.345
LIG_APCC_ABBAyCdc20_2	3	9	PF00400	0.423
LIG_BRCT_BRCA1_1	151	155	PF00533	0.440
LIG_BRCT_BRCA1_1	161	165	PF00533	0.387
LIG_deltaCOP1_diTrp_1	128	135	PF00928	0.509
LIG_FHA_1	221	227	PF00498	0.429
LIG_FHA_1	247	253	PF00498	0.470
LIG_FHA_1	265	271	PF00498	0.470
LIG_FHA_1	370	376	PF00498	0.491
LIG_FHA_1	412	418	PF00498	0.509
LIG_FHA_1	425	431	PF00498	0.490
LIG_FHA_1	504	510	PF00498	0.366
LIG_FHA_2	297	303	PF00498	0.390
LIG_FHA_2	337	343	PF00498	0.564
LIG_FHA_2	396	402	PF00498	0.509
LIG_FHA_2	41	47	PF00498	0.598
LIG_FHA_2	468	474	PF00498	0.482
LIG_FHA_2	536	542	PF00498	0.525
LIG_LIR_Apic_2	132	138	PF02991	0.398
LIG_LIR_Apic_2	388	393	PF02991	0.414
LIG_LIR_Gen_1	128	138	PF02991	0.486
LIG_LIR_Gen_1	162	173	PF02991	0.414
LIG_LIR_Gen_1	254	263	PF02991	0.461
LIG_LIR_Nem_3	128	133	PF02991	0.486
LIG_LIR_Nem_3	152	158	PF02991	0.444
LIG_LIR_Nem_3	162	168	PF02991	0.396
LIG_LIR_Nem_3	254	258	PF02991	0.460
LIG_MYND_1	353	357	PF01753	0.427
LIG_NRBOX	143	149	PF00104	0.509
LIG_NRBOX	379	385	PF00104	0.470
LIG_NRBOX	425	431	PF00104	0.460
LIG_PCNA_PIPBox_1	419	428	PF02747	0.460
LIG_PCNA_yPIPBox_3	584	598	PF02747	0.497
LIG_PTB_Apo_2	7	14	PF02174	0.282
LIG_PTB_Phospho_1	7	13	PF10480	0.282
LIG_SH2_CRK	88	92	PF00017	0.470
LIG_SH2_GRB2like	228	231	PF00017	0.509
LIG_SH2_PTP2	231	234	PF00017	0.429
LIG_SH2_SRC	19	22	PF00017	0.468
LIG_SH2_SRC	231	234	PF00017	0.429
LIG_SH2_STAP1	13	17	PF00017	0.304
LIG_SH2_STAP1	291	295	PF00017	0.514
LIG_SH2_STAT5	19	22	PF00017	0.376
LIG_SH2_STAT5	228	231	PF00017	0.414
LIG_SH2_STAT5	255	258	PF00017	0.517
LIG_SH2_STAT5	348	351	PF00017	0.427
LIG_SH3_1	347	353	PF00018	0.414
LIG_SH3_2	341	346	PF14604	0.460
LIG_SH3_3	327	333	PF00018	0.538
LIG_SH3_3	338	344	PF00018	0.355
LIG_SH3_3	347	353	PF00018	0.388
LIG_SH3_3	460	466	PF00018	0.517
LIG_SH3_3	504	510	PF00018	0.509
LIG_SH3_3	90	96	PF00018	0.470
LIG_SUMO_SIM_anti_2	157	164	PF11976	0.444
LIG_TRAF2_1	123	126	PF00917	0.460
LIG_TYR_ITIM	229	234	PF00017	0.460
LIG_UBA3_1	422	428	PF00899	0.429
LIG_WRC_WIRS_1	255	260	PF05994	0.445
LIG_WRC_WIRS_1	587	592	PF05994	0.445
MOD_CDK_SPK_2	321	326	PF00069	0.390
MOD_CK1_1	120	126	PF00069	0.429
MOD_CK1_1	164	170	PF00069	0.499
MOD_CK1_1	178	184	PF00069	0.513
MOD_CK1_1	203	209	PF00069	0.536
MOD_CK1_1	221	227	PF00069	0.348
MOD_CK1_1	23	29	PF00069	0.559
MOD_CK1_1	30	36	PF00069	0.539
MOD_CK1_1	40	46	PF00069	0.438
MOD_CK1_1	477	483	PF00069	0.698
MOD_CK1_1	484	490	PF00069	0.768
MOD_CK2_1	120	126	PF00069	0.451
MOD_CK2_1	40	46	PF00069	0.596
MOD_CK2_1	555	561	PF00069	0.559
MOD_CK2_1	570	576	PF00069	0.472
MOD_GlcNHglycan	177	180	PF01048	0.343
MOD_GlcNHglycan	181	184	PF01048	0.240
MOD_GlcNHglycan	202	205	PF01048	0.279
MOD_GlcNHglycan	22	25	PF01048	0.470
MOD_GlcNHglycan	220	223	PF01048	0.148
MOD_GlcNHglycan	29	32	PF01048	0.525
MOD_GlcNHglycan	35	38	PF01048	0.508
MOD_GlcNHglycan	372	375	PF01048	0.309
MOD_GlcNHglycan	503	506	PF01048	0.397
MOD_GlcNHglycan	550	553	PF01048	0.600
MOD_GlcNHglycan	572	575	PF01048	0.443
MOD_GSK3_1	156	163	PF00069	0.445
MOD_GSK3_1	175	182	PF00069	0.445
MOD_GSK3_1	187	194	PF00069	0.481
MOD_GSK3_1	20	27	PF00069	0.513
MOD_GSK3_1	33	40	PF00069	0.622
MOD_GSK3_1	474	481	PF00069	0.747
MOD_GSK3_1	494	501	PF00069	0.408
MOD_GSK3_1	517	524	PF00069	0.508
MOD_GSK3_1	533	540	PF00069	0.522
MOD_N-GLC_1	24	29	PF02516	0.460
MOD_N-GLC_2	437	439	PF02516	0.260
MOD_NEK2_1	147	152	PF00069	0.491
MOD_NEK2_1	200	205	PF00069	0.455
MOD_NEK2_1	220	225	PF00069	0.420
MOD_NEK2_1	264	269	PF00069	0.471
MOD_NEK2_1	38	43	PF00069	0.591
MOD_NEK2_1	535	540	PF00069	0.405
MOD_NEK2_2	11	16	PF00069	0.332
MOD_NEK2_2	149	154	PF00069	0.509
MOD_PIKK_1	256	262	PF00454	0.427
MOD_PIKK_1	309	315	PF00454	0.404
MOD_PIKK_1	443	449	PF00454	0.460
MOD_PIKK_1	555	561	PF00454	0.426
MOD_PK_1	154	160	PF00069	0.453
MOD_PKA_1	478	484	PF00069	0.584
MOD_PKA_2	188	194	PF00069	0.429
MOD_PKA_2	284	290	PF00069	0.470
MOD_PKA_2	478	484	PF00069	0.680
MOD_PKA_2	498	504	PF00069	0.312
MOD_PKA_2	583	589	PF00069	0.488
MOD_PKB_1	185	193	PF00069	0.429
MOD_Plk_1	264	270	PF00069	0.470
MOD_Plk_1	521	527	PF00069	0.451
MOD_Plk_4	156	162	PF00069	0.414
MOD_Plk_4	164	170	PF00069	0.414
MOD_Plk_4	221	227	PF00069	0.427
MOD_Plk_4	234	240	PF00069	0.427
MOD_Plk_4	264	270	PF00069	0.500
MOD_ProDKin_1	321	327	PF00069	0.491
MOD_ProDKin_1	337	343	PF00069	0.510
MOD_ProDKin_1	395	401	PF00069	0.470
MOD_ProDKin_1	503	509	PF00069	0.380
MOD_SUMO_rev_2	469	477	PF00179	0.553
TRG_DiLeu_BaEn_1	265	270	PF01217	0.427
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.560
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.420
TRG_ENDOCYTIC_2	231	234	PF00928	0.422
TRG_ENDOCYTIC_2	255	258	PF00928	0.504
TRG_ENDOCYTIC_2	291	294	PF00928	0.522
TRG_ENDOCYTIC_2	88	91	PF00928	0.470
TRG_ER_diArg_1	185	188	PF00400	0.460
TRG_ER_diArg_1	284	286	PF00400	0.560
TRG_ER_diArg_1	563	566	PF00400	0.379
TRG_ER_diArg_1	93	95	PF00400	0.414
TRG_NLS_MonoCore_2	185	190	PF00514	0.460
TRG_NLS_MonoExtC_3	184	189	PF00514	0.509
TRG_NLS_MonoExtN_4	185	190	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	566	571	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I4	Leptomonas seymouri	51%	95%
A0A0S4IXC8	Bodo saltans	34%	100%
A0A3R7KCE3	Trypanosoma rangeli	41%	100%
A0A3S7WWF5	Leishmania donovani	92%	100%
A2WNB0	Oryza sativa subsp. indica	28%	100%
A4HBM2	Leishmania braziliensis	79%	99%
A4HZB0	Leishmania infantum	91%	100%
D0A1L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
O94241	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P0CM04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	100%
P0CM05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	100%
Q09443	Caenorhabditis elegans	27%	100%
Q4QCJ2	Leishmania major	91%	98%
Q4W9M3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q5AXH1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q5NBI2	Oryza sativa subsp. japonica	28%	100%
Q6CJF4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	100%
Q74ZV8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q7S6X6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
V5B0N4	Trypanosoma cruzi	41%	100%