Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUY8_LEIMU

TriTrypDb:

LmxM.21.0210

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.613
CLV_C14_Caspase3-7	212	216	PF00656	0.664
CLV_NRD_NRD_1	115	117	PF00675	0.343
CLV_NRD_NRD_1	141	143	PF00675	0.509
CLV_NRD_NRD_1	222	224	PF00675	0.447
CLV_NRD_NRD_1	245	247	PF00675	0.516
CLV_NRD_NRD_1	304	306	PF00675	0.538
CLV_NRD_NRD_1	376	378	PF00675	0.376
CLV_NRD_NRD_1	389	391	PF00675	0.360
CLV_PCSK_KEX2_1	115	117	PF00082	0.276
CLV_PCSK_KEX2_1	141	143	PF00082	0.509
CLV_PCSK_KEX2_1	221	223	PF00082	0.475
CLV_PCSK_KEX2_1	245	247	PF00082	0.516
CLV_PCSK_KEX2_1	304	306	PF00082	0.470
CLV_PCSK_KEX2_1	376	378	PF00082	0.364
CLV_PCSK_KEX2_1	389	391	PF00082	0.372
CLV_PCSK_SKI1_1	179	183	PF00082	0.393
CLV_PCSK_SKI1_1	314	318	PF00082	0.463
CLV_PCSK_SKI1_1	384	388	PF00082	0.436
CLV_PCSK_SKI1_1	456	460	PF00082	0.617
DEG_APCC_DBOX_1	389	397	PF00400	0.511
DEG_Nend_Nbox_1	1	3	PF02207	0.641
DOC_CYCLIN_RxL_1	374	385	PF00134	0.386
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.448
DOC_MAPK_DCC_7	221	229	PF00069	0.474
DOC_MAPK_gen_1	141	147	PF00069	0.373
DOC_MAPK_gen_1	151	160	PF00069	0.362
DOC_MAPK_gen_1	221	229	PF00069	0.474
DOC_MAPK_gen_1	245	253	PF00069	0.442
DOC_MAPK_gen_1	304	312	PF00069	0.474
DOC_MAPK_gen_1	376	383	PF00069	0.400
DOC_MAPK_gen_1	453	461	PF00069	0.564
DOC_MAPK_MEF2A_6	179	186	PF00069	0.419
DOC_MAPK_MEF2A_6	222	231	PF00069	0.459
DOC_MAPK_MEF2A_6	246	255	PF00069	0.408
DOC_MAPK_MEF2A_6	376	383	PF00069	0.417
DOC_MAPK_NFAT4_5	376	384	PF00069	0.406
DOC_USP7_MATH_1	202	206	PF00917	0.655
DOC_USP7_MATH_1	439	443	PF00917	0.713
DOC_USP7_MATH_1	60	64	PF00917	0.434
DOC_WW_Pin1_4	278	283	PF00397	0.642
DOC_WW_Pin1_4	437	442	PF00397	0.775
LIG_14-3-3_CanoR_1	153	158	PF00244	0.381
LIG_14-3-3_CanoR_1	376	380	PF00244	0.399
LIG_14-3-3_CanoR_1	460	468	PF00244	0.621
LIG_Actin_WH2_2	296	313	PF00022	0.309
LIG_BIR_III_2	249	253	PF00653	0.438
LIG_Clathr_ClatBox_1	407	411	PF01394	0.470
LIG_CtBP_PxDLS_1	217	223	PF00389	0.412
LIG_deltaCOP1_diTrp_1	266	271	PF00928	0.463
LIG_deltaCOP1_diTrp_1	482	488	PF00928	0.501
LIG_EVH1_1	431	435	PF00568	0.623
LIG_FHA_1	138	144	PF00498	0.500
LIG_FHA_1	191	197	PF00498	0.432
LIG_FHA_1	199	205	PF00498	0.478
LIG_FHA_1	232	238	PF00498	0.541
LIG_FHA_1	351	357	PF00498	0.403
LIG_FHA_1	376	382	PF00498	0.398
LIG_FHA_1	453	459	PF00498	0.566
LIG_FHA_1	7	13	PF00498	0.672
LIG_FHA_2	134	140	PF00498	0.429
LIG_FHA_2	261	267	PF00498	0.258
LIG_FHA_2	380	386	PF00498	0.505
LIG_FHA_2	89	95	PF00498	0.530
LIG_GBD_Chelix_1	379	387	PF00786	0.466
LIG_GBD_Chelix_1	400	408	PF00786	0.376
LIG_LIR_Apic_2	363	369	PF02991	0.384
LIG_LIR_Gen_1	483	494	PF02991	0.531
LIG_LIR_Nem_3	162	167	PF02991	0.320
LIG_LIR_Nem_3	423	428	PF02991	0.601
LIG_LIR_Nem_3	483	489	PF02991	0.530
LIG_LYPXL_SIV_4	338	346	PF13949	0.405
LIG_NRBOX	382	388	PF00104	0.417
LIG_NRBOX	399	405	PF00104	0.297
LIG_NRBOX	73	79	PF00104	0.453
LIG_PCNA_yPIPBox_3	389	399	PF02747	0.479
LIG_RPA_C_Fungi	372	384	PF08784	0.337
LIG_SH2_STAT5	352	355	PF00017	0.482
LIG_SH2_STAT5	366	369	PF00017	0.399
LIG_SH2_STAT5	505	508	PF00017	0.539
LIG_SH3_3	123	129	PF00018	0.457
LIG_SH3_3	155	161	PF00018	0.462
LIG_SH3_3	262	268	PF00018	0.383
LIG_SH3_3	429	435	PF00018	0.669
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.381
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.399
LIG_SUMO_SIM_par_1	182	187	PF11976	0.478
LIG_SUMO_SIM_par_1	227	235	PF11976	0.458
LIG_SUMO_SIM_par_1	377	382	PF11976	0.386
LIG_SUMO_SIM_par_1	405	412	PF11976	0.457
LIG_TRAF2_1	85	88	PF00917	0.335
LIG_TYR_ITIM	81	86	PF00017	0.332
MOD_CK1_1	114	120	PF00069	0.237
MOD_CK1_1	190	196	PF00069	0.436
MOD_CK1_1	476	482	PF00069	0.517
MOD_CK2_1	133	139	PF00069	0.431
MOD_CK2_1	29	35	PF00069	0.512
MOD_CK2_1	379	385	PF00069	0.467
MOD_CK2_1	439	445	PF00069	0.496
MOD_CK2_1	476	482	PF00069	0.403
MOD_GlcNHglycan	241	244	PF01048	0.449
MOD_GlcNHglycan	411	414	PF01048	0.543
MOD_GlcNHglycan	420	423	PF01048	0.677
MOD_GlcNHglycan	475	478	PF01048	0.565
MOD_GlcNHglycan	499	502	PF01048	0.473
MOD_GlcNHglycan	52	55	PF01048	0.614
MOD_GlcNHglycan	56	59	PF01048	0.599
MOD_GSK3_1	133	140	PF00069	0.522
MOD_GSK3_1	198	205	PF00069	0.495
MOD_GSK3_1	256	263	PF00069	0.209
MOD_GSK3_1	375	382	PF00069	0.377
MOD_GSK3_1	437	444	PF00069	0.738
MOD_GSK3_1	50	57	PF00069	0.670
MOD_NEK2_1	231	236	PF00069	0.467
MOD_NEK2_1	260	265	PF00069	0.217
MOD_NEK2_1	379	384	PF00069	0.383
MOD_NEK2_1	402	407	PF00069	0.460
MOD_NEK2_1	459	464	PF00069	0.495
MOD_NEK2_2	216	221	PF00069	0.483
MOD_PIKK_1	114	120	PF00454	0.510
MOD_PIKK_1	21	27	PF00454	0.698
MOD_PIKK_1	321	327	PF00454	0.521
MOD_PIKK_1	459	465	PF00454	0.425
MOD_PKA_2	114	120	PF00069	0.237
MOD_PKA_2	133	139	PF00069	0.508
MOD_PKA_2	375	381	PF00069	0.436
MOD_PKA_2	452	458	PF00069	0.721
MOD_PKA_2	459	465	PF00069	0.630
MOD_PKB_1	151	159	PF00069	0.365
MOD_Plk_1	232	238	PF00069	0.584
MOD_Plk_1	482	488	PF00069	0.552
MOD_Plk_1	87	93	PF00069	0.419
MOD_Plk_2-3	515	521	PF00069	0.464
MOD_Plk_2-3	88	94	PF00069	0.502
MOD_Plk_4	153	159	PF00069	0.462
MOD_Plk_4	232	238	PF00069	0.500
MOD_Plk_4	260	266	PF00069	0.291
MOD_Plk_4	29	35	PF00069	0.544
MOD_Plk_4	402	408	PF00069	0.399
MOD_ProDKin_1	278	284	PF00069	0.626
MOD_ProDKin_1	437	443	PF00069	0.777
MOD_SUMO_for_1	92	95	PF00179	0.442
TRG_DiLeu_BaEn_1	394	399	PF01217	0.393
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.446
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.418
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.346
TRG_ENDOCYTIC_2	83	86	PF00928	0.354
TRG_ER_diArg_1	131	134	PF00400	0.480
TRG_ER_diArg_1	141	143	PF00400	0.446
TRG_ER_diArg_1	220	223	PF00400	0.516
TRG_ER_diArg_1	244	246	PF00400	0.506
TRG_ER_diArg_1	303	305	PF00400	0.535
TRG_ER_diArg_1	388	390	PF00400	0.406
TRG_ER_diArg_1	40	43	PF00400	0.490
TRG_NES_CRM1_1	397	411	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I200	Leptomonas seymouri	45%	90%
A0A0S4IXJ4	Bodo saltans	25%	100%
A0A1X0NXC9	Trypanosomatidae	26%	100%
A0A3R7KNI1	Trypanosoma rangeli	31%	89%
A0A3S5H793	Leishmania donovani	92%	100%
A4HBM0	Leishmania braziliensis	79%	100%
A4HZA8	Leishmania infantum	92%	100%
Q4QCJ4	Leishmania major	91%	100%
V5DGY6	Trypanosoma cruzi	29%	100%