LeishMANIAdb
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Major vault protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Major vault protein-like protein
Gene product:
major vault protein-like protein
Species:
Leishmania mexicana
UniProt:
E9AUY7_LEIMU
TriTrypDb:
LmxM.21.0200
Length:
959

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 9
GO:0005737 cytoplasm 2 9
GO:0032991 protein-containing complex 1 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043229 intracellular organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9
GO:0110165 cellular anatomical entity 1 9
GO:1990904 ribonucleoprotein complex 2 9

Expansion

Sequence features

E9AUY7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUY7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 282 286 PF00656 0.418
CLV_C14_Caspase3-7 369 373 PF00656 0.478
CLV_C14_Caspase3-7 510 514 PF00656 0.703
CLV_C14_Caspase3-7 652 656 PF00656 0.372
CLV_C14_Caspase3-7 712 716 PF00656 0.510
CLV_C14_Caspase3-7 74 78 PF00656 0.489
CLV_NRD_NRD_1 300 302 PF00675 0.475
CLV_NRD_NRD_1 40 42 PF00675 0.388
CLV_NRD_NRD_1 402 404 PF00675 0.328
CLV_NRD_NRD_1 449 451 PF00675 0.251
CLV_NRD_NRD_1 853 855 PF00675 0.428
CLV_NRD_NRD_1 875 877 PF00675 0.437
CLV_PCSK_FUR_1 297 301 PF00082 0.409
CLV_PCSK_KEX2_1 299 301 PF00082 0.483
CLV_PCSK_KEX2_1 401 403 PF00082 0.297
CLV_PCSK_KEX2_1 449 451 PF00082 0.251
CLV_PCSK_KEX2_1 855 857 PF00082 0.421
CLV_PCSK_PC1ET2_1 855 857 PF00082 0.504
CLV_PCSK_PC7_1 397 403 PF00082 0.421
CLV_PCSK_SKI1_1 347 351 PF00082 0.424
CLV_PCSK_SKI1_1 403 407 PF00082 0.267
CLV_PCSK_SKI1_1 424 428 PF00082 0.283
CLV_PCSK_SKI1_1 449 453 PF00082 0.243
CLV_PCSK_SKI1_1 742 746 PF00082 0.414
CLV_PCSK_SKI1_1 776 780 PF00082 0.410
CLV_Separin_Metazoa 796 800 PF03568 0.426
CLV_Separin_Metazoa 851 855 PF03568 0.498
DEG_APCC_DBOX_1 793 801 PF00400 0.375
DOC_CKS1_1 177 182 PF01111 0.439
DOC_CKS1_1 701 706 PF01111 0.439
DOC_CYCLIN_RxL_1 446 454 PF00134 0.439
DOC_CYCLIN_yCln2_LP_2 28 34 PF00134 0.424
DOC_MAPK_gen_1 297 305 PF00069 0.468
DOC_MAPK_gen_1 401 407 PF00069 0.301
DOC_MAPK_gen_1 774 783 PF00069 0.279
DOC_MAPK_gen_1 854 861 PF00069 0.398
DOC_MAPK_gen_1 909 918 PF00069 0.452
DOC_MAPK_HePTP_8 771 783 PF00069 0.269
DOC_MAPK_MEF2A_6 747 755 PF00069 0.349
DOC_MAPK_MEF2A_6 774 783 PF00069 0.380
DOC_MAPK_NFAT4_5 776 784 PF00069 0.381
DOC_PP4_FxxP_1 172 175 PF00568 0.439
DOC_PP4_FxxP_1 232 235 PF00568 0.292
DOC_PP4_FxxP_1 427 430 PF00568 0.483
DOC_PP4_FxxP_1 583 586 PF00568 0.441
DOC_PP4_FxxP_1 660 663 PF00568 0.400
DOC_USP7_MATH_1 106 110 PF00917 0.400
DOC_USP7_MATH_1 455 459 PF00917 0.457
DOC_USP7_MATH_1 470 474 PF00917 0.400
DOC_USP7_MATH_1 505 509 PF00917 0.664
DOC_USP7_MATH_1 672 676 PF00917 0.459
DOC_USP7_MATH_1 759 763 PF00917 0.540
DOC_USP7_MATH_1 810 814 PF00917 0.531
DOC_USP7_MATH_1 840 844 PF00917 0.528
DOC_USP7_MATH_1 941 945 PF00917 0.470
DOC_USP7_MATH_2 704 710 PF00917 0.430
DOC_WW_Pin1_4 115 120 PF00397 0.467
DOC_WW_Pin1_4 129 134 PF00397 0.495
DOC_WW_Pin1_4 176 181 PF00397 0.525
DOC_WW_Pin1_4 193 198 PF00397 0.309
DOC_WW_Pin1_4 43 48 PF00397 0.488
DOC_WW_Pin1_4 588 593 PF00397 0.416
DOC_WW_Pin1_4 700 705 PF00397 0.439
DOC_WW_Pin1_4 832 837 PF00397 0.459
DOC_WW_Pin1_4 85 90 PF00397 0.507
DOC_WW_Pin1_4 925 930 PF00397 0.487
DOC_WW_Pin1_4 944 949 PF00397 0.553
LIG_14-3-3_CanoR_1 456 460 PF00244 0.431
LIG_14-3-3_CanoR_1 864 868 PF00244 0.437
LIG_14-3-3_CterR_2 957 959 PF00244 0.515
LIG_Actin_WH2_2 444 462 PF00022 0.439
LIG_BIR_II_1 1 5 PF00653 0.521
LIG_BIR_III_2 77 81 PF00653 0.398
LIG_BIR_III_2 833 837 PF00653 0.491
LIG_BRCT_BRCA1_1 715 719 PF00533 0.416
LIG_CtBP_PxDLS_1 592 596 PF00389 0.416
LIG_EVH1_2 54 58 PF00568 0.347
LIG_FHA_1 1 7 PF00498 0.621
LIG_FHA_1 177 183 PF00498 0.439
LIG_FHA_1 20 26 PF00498 0.244
LIG_FHA_1 31 37 PF00498 0.327
LIG_FHA_1 320 326 PF00498 0.552
LIG_FHA_1 344 350 PF00498 0.457
LIG_FHA_1 418 424 PF00498 0.420
LIG_FHA_1 490 496 PF00498 0.598
LIG_FHA_1 552 558 PF00498 0.445
LIG_FHA_1 579 585 PF00498 0.431
LIG_FHA_1 68 74 PF00498 0.314
LIG_FHA_1 726 732 PF00498 0.480
LIG_FHA_1 793 799 PF00498 0.511
LIG_FHA_2 125 131 PF00498 0.492
LIG_FHA_2 136 142 PF00498 0.302
LIG_FHA_2 246 252 PF00498 0.451
LIG_FHA_2 33 39 PF00498 0.354
LIG_FHA_2 365 371 PF00498 0.434
LIG_FHA_2 372 378 PF00498 0.400
LIG_FHA_2 659 665 PF00498 0.508
LIG_FHA_2 701 707 PF00498 0.430
LIG_FHA_2 725 731 PF00498 0.400
LIG_FHA_2 803 809 PF00498 0.394
LIG_FHA_2 846 852 PF00498 0.489
LIG_FHA_2 882 888 PF00498 0.431
LIG_LIR_Apic_2 101 106 PF02991 0.390
LIG_LIR_Apic_2 191 197 PF02991 0.536
LIG_LIR_Apic_2 425 430 PF02991 0.435
LIG_LIR_Apic_2 437 443 PF02991 0.365
LIG_LIR_Apic_2 581 586 PF02991 0.483
LIG_LIR_Apic_2 610 615 PF02991 0.479
LIG_LIR_Apic_2 657 663 PF02991 0.439
LIG_LIR_Gen_1 13 19 PF02991 0.306
LIG_LIR_Gen_1 204 215 PF02991 0.412
LIG_LIR_Gen_1 24 34 PF02991 0.316
LIG_LIR_Gen_1 248 258 PF02991 0.459
LIG_LIR_Gen_1 308 317 PF02991 0.400
LIG_LIR_Gen_1 475 483 PF02991 0.359
LIG_LIR_Gen_1 548 557 PF02991 0.275
LIG_LIR_Gen_1 56 65 PF02991 0.299
LIG_LIR_Gen_1 884 893 PF02991 0.446
LIG_LIR_Nem_3 117 123 PF02991 0.447
LIG_LIR_Nem_3 13 17 PF02991 0.303
LIG_LIR_Nem_3 168 172 PF02991 0.335
LIG_LIR_Nem_3 204 210 PF02991 0.398
LIG_LIR_Nem_3 24 29 PF02991 0.311
LIG_LIR_Nem_3 248 253 PF02991 0.430
LIG_LIR_Nem_3 254 258 PF02991 0.336
LIG_LIR_Nem_3 308 313 PF02991 0.397
LIG_LIR_Nem_3 33 37 PF02991 0.219
LIG_LIR_Nem_3 548 553 PF02991 0.395
LIG_LIR_Nem_3 56 61 PF02991 0.304
LIG_LIR_Nem_3 588 593 PF02991 0.419
LIG_LIR_Nem_3 641 645 PF02991 0.483
LIG_LIR_Nem_3 685 689 PF02991 0.398
LIG_LIR_Nem_3 884 889 PF02991 0.440
LIG_Pex14_1 103 107 PF04695 0.410
LIG_Pex14_2 427 431 PF04695 0.483
LIG_Rb_pABgroove_1 560 568 PF01858 0.400
LIG_SH2_CRK 310 314 PF00017 0.299
LIG_SH2_CRK 395 399 PF00017 0.427
LIG_SH2_CRK 550 554 PF00017 0.370
LIG_SH2_CRK 82 86 PF00017 0.383
LIG_SH2_NCK_1 368 372 PF00017 0.551
LIG_SH2_PTP2 194 197 PF00017 0.460
LIG_SH2_PTP2 390 393 PF00017 0.416
LIG_SH2_SRC 14 17 PF00017 0.298
LIG_SH2_SRC 276 279 PF00017 0.318
LIG_SH2_SRC 37 40 PF00017 0.476
LIG_SH2_SRC 390 393 PF00017 0.400
LIG_SH2_STAP1 262 266 PF00017 0.314
LIG_SH2_STAP1 395 399 PF00017 0.427
LIG_SH2_STAP1 886 890 PF00017 0.519
LIG_SH2_STAT5 14 17 PF00017 0.292
LIG_SH2_STAT5 169 172 PF00017 0.397
LIG_SH2_STAT5 178 181 PF00017 0.402
LIG_SH2_STAT5 194 197 PF00017 0.293
LIG_SH2_STAT5 202 205 PF00017 0.301
LIG_SH2_STAT5 245 248 PF00017 0.453
LIG_SH2_STAT5 276 279 PF00017 0.433
LIG_SH2_STAT5 288 291 PF00017 0.455
LIG_SH2_STAT5 310 313 PF00017 0.274
LIG_SH2_STAT5 34 37 PF00017 0.215
LIG_SH2_STAT5 368 371 PF00017 0.482
LIG_SH2_STAT5 390 393 PF00017 0.429
LIG_SH2_STAT5 414 417 PF00017 0.405
LIG_SH2_STAT5 447 450 PF00017 0.479
LIG_SH2_STAT5 612 615 PF00017 0.483
LIG_SH2_STAT5 725 728 PF00017 0.443
LIG_SH2_STAT5 82 85 PF00017 0.443
LIG_SH3_3 118 124 PF00018 0.333
LIG_SH3_3 125 131 PF00018 0.389
LIG_SH3_3 150 156 PF00018 0.439
LIG_SH3_3 192 198 PF00018 0.541
LIG_SH3_3 310 316 PF00018 0.402
LIG_SH3_3 381 387 PF00018 0.431
LIG_SH3_3 48 54 PF00018 0.385
LIG_SH3_3 573 579 PF00018 0.483
LIG_SH3_3 58 64 PF00018 0.305
LIG_SH3_3 597 603 PF00018 0.441
LIG_SH3_3 947 953 PF00018 0.694
LIG_SUMO_SIM_anti_2 847 854 PF11976 0.503
LIG_SUMO_SIM_par_1 591 596 PF11976 0.443
LIG_SUMO_SIM_par_1 620 626 PF11976 0.440
LIG_SUMO_SIM_par_1 727 733 PF11976 0.455
LIG_SUMO_SIM_par_1 896 902 PF11976 0.409
LIG_SUMO_SIM_par_1 931 937 PF11976 0.395
LIG_TRFH_1 120 124 PF08558 0.318
LIG_TRFH_1 337 341 PF08558 0.357
LIG_TYR_ITSM 306 313 PF00017 0.421
LIG_TYR_ITSM 882 889 PF00017 0.511
LIG_UBA3_1 889 895 PF00899 0.354
LIG_UBA3_1 932 938 PF00899 0.531
LIG_WRC_WIRS_1 247 252 PF05994 0.389
LIG_WW_1 392 395 PF00397 0.367
LIG_WW_1 79 82 PF00397 0.360
LIG_WW_3 539 543 PF00397 0.438
MOD_CDK_SPK_2 176 181 PF00069 0.287
MOD_CDK_SPxK_1 832 838 PF00069 0.433
MOD_CK1_1 2 8 PF00069 0.454
MOD_CK1_1 504 510 PF00069 0.648
MOD_CK1_1 511 517 PF00069 0.627
MOD_CK1_1 644 650 PF00069 0.275
MOD_CK1_1 709 715 PF00069 0.299
MOD_CK1_1 762 768 PF00069 0.509
MOD_CK1_1 88 94 PF00069 0.603
MOD_CK1_1 944 950 PF00069 0.550
MOD_CK2_1 124 130 PF00069 0.458
MOD_CK2_1 135 141 PF00069 0.228
MOD_CK2_1 245 251 PF00069 0.355
MOD_CK2_1 352 358 PF00069 0.381
MOD_CK2_1 364 370 PF00069 0.258
MOD_CK2_1 371 377 PF00069 0.251
MOD_CK2_1 462 468 PF00069 0.445
MOD_CK2_1 504 510 PF00069 0.729
MOD_CK2_1 700 706 PF00069 0.450
MOD_CK2_1 802 808 PF00069 0.401
MOD_CK2_1 845 851 PF00069 0.485
MOD_CK2_1 876 882 PF00069 0.431
MOD_Cter_Amidation 297 300 PF01082 0.414
MOD_GlcNHglycan 203 206 PF01048 0.365
MOD_GlcNHglycan 305 308 PF01048 0.359
MOD_GlcNHglycan 463 467 PF01048 0.607
MOD_GlcNHglycan 503 506 PF01048 0.679
MOD_GlcNHglycan 507 510 PF01048 0.611
MOD_GlcNHglycan 513 516 PF01048 0.497
MOD_GlcNHglycan 595 598 PF01048 0.232
MOD_GlcNHglycan 678 681 PF01048 0.348
MOD_GlcNHglycan 820 823 PF01048 0.499
MOD_GlcNHglycan 878 881 PF01048 0.412
MOD_GlcNHglycan 943 946 PF01048 0.494
MOD_GSK3_1 137 144 PF00069 0.385
MOD_GSK3_1 276 283 PF00069 0.384
MOD_GSK3_1 343 350 PF00069 0.390
MOD_GSK3_1 455 462 PF00069 0.311
MOD_GSK3_1 501 508 PF00069 0.651
MOD_GSK3_1 53 60 PF00069 0.514
MOD_GSK3_1 541 548 PF00069 0.491
MOD_GSK3_1 566 573 PF00069 0.272
MOD_GSK3_1 672 679 PF00069 0.349
MOD_GSK3_1 709 716 PF00069 0.308
MOD_GSK3_1 80 87 PF00069 0.410
MOD_GSK3_1 921 928 PF00069 0.512
MOD_N-GLC_1 691 696 PF02516 0.249
MOD_N-GLC_2 21 23 PF02516 0.394
MOD_NEK2_1 1 6 PF00069 0.425
MOD_NEK2_1 305 310 PF00069 0.469
MOD_NEK2_1 565 570 PF00069 0.280
MOD_NEK2_1 593 598 PF00069 0.341
MOD_NEK2_1 658 663 PF00069 0.343
MOD_NEK2_1 717 722 PF00069 0.257
MOD_NEK2_1 724 729 PF00069 0.208
MOD_NEK2_1 745 750 PF00069 0.383
MOD_NEK2_1 818 823 PF00069 0.498
MOD_NEK2_1 84 89 PF00069 0.469
MOD_NEK2_2 292 297 PF00069 0.392
MOD_NEK2_2 371 376 PF00069 0.374
MOD_NEK2_2 455 460 PF00069 0.349
MOD_PIKK_1 305 311 PF00454 0.426
MOD_PIKK_1 53 59 PF00454 0.320
MOD_PKA_1 876 882 PF00069 0.422
MOD_PKA_2 455 461 PF00069 0.290
MOD_PKA_2 541 547 PF00069 0.474
MOD_PKA_2 863 869 PF00069 0.499
MOD_Plk_1 124 130 PF00069 0.291
MOD_Plk_1 470 476 PF00069 0.539
MOD_Plk_1 691 697 PF00069 0.249
MOD_Plk_1 802 808 PF00069 0.435
MOD_Plk_2-3 141 147 PF00069 0.287
MOD_Plk_2-3 623 629 PF00069 0.172
MOD_Plk_2-3 730 736 PF00069 0.232
MOD_Plk_4 2 8 PF00069 0.454
MOD_Plk_4 251 257 PF00069 0.343
MOD_Plk_4 32 38 PF00069 0.475
MOD_Plk_4 333 339 PF00069 0.375
MOD_Plk_4 443 449 PF00069 0.272
MOD_Plk_4 558 564 PF00069 0.392
MOD_Plk_4 578 584 PF00069 0.121
MOD_Plk_4 607 613 PF00069 0.292
MOD_Plk_4 68 74 PF00069 0.314
MOD_Plk_4 692 698 PF00069 0.245
MOD_Plk_4 706 712 PF00069 0.232
MOD_Plk_4 80 86 PF00069 0.410
MOD_Plk_4 894 900 PF00069 0.539
MOD_ProDKin_1 115 121 PF00069 0.462
MOD_ProDKin_1 129 135 PF00069 0.491
MOD_ProDKin_1 176 182 PF00069 0.408
MOD_ProDKin_1 193 199 PF00069 0.306
MOD_ProDKin_1 43 49 PF00069 0.489
MOD_ProDKin_1 588 594 PF00069 0.255
MOD_ProDKin_1 700 706 PF00069 0.287
MOD_ProDKin_1 832 838 PF00069 0.460
MOD_ProDKin_1 85 91 PF00069 0.504
MOD_ProDKin_1 925 931 PF00069 0.488
MOD_ProDKin_1 944 950 PF00069 0.550
MOD_SUMO_for_1 788 791 PF00179 0.476
MOD_SUMO_rev_2 902 910 PF00179 0.414
TRG_DiLeu_BaEn_1 24 29 PF01217 0.359
TRG_DiLeu_BaEn_1 356 361 PF01217 0.349
TRG_DiLeu_BaEn_1 558 563 PF01217 0.349
TRG_DiLeu_BaEn_2 250 256 PF01217 0.328
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.441
TRG_DiLeu_BaLyEn_6 132 137 PF01217 0.475
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.255
TRG_ENDOCYTIC_2 14 17 PF00928 0.298
TRG_ENDOCYTIC_2 169 172 PF00928 0.142
TRG_ENDOCYTIC_2 207 210 PF00928 0.484
TRG_ENDOCYTIC_2 258 261 PF00928 0.377
TRG_ENDOCYTIC_2 310 313 PF00928 0.274
TRG_ENDOCYTIC_2 395 398 PF00928 0.461
TRG_ENDOCYTIC_2 550 553 PF00928 0.453
TRG_ENDOCYTIC_2 82 85 PF00928 0.443
TRG_ENDOCYTIC_2 886 889 PF00928 0.516
TRG_ER_diArg_1 296 299 PF00400 0.487
TRG_ER_diArg_1 401 403 PF00400 0.348
TRG_ER_diArg_1 448 450 PF00400 0.349
TRG_ER_diArg_1 631 634 PF00400 0.349
TRG_ER_diArg_1 853 856 PF00400 0.504
TRG_NES_CRM1_1 184 199 PF08389 0.384
TRG_NES_CRM1_1 907 919 PF08389 0.547
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 449 454 PF00026 0.258
TRG_Pf-PMV_PEXEL_1 911 915 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCB5 Leptomonas seymouri 63% 96%
A0A0S4JL46 Bodo saltans 30% 100%
A0A1X0NXD4 Trypanosomatidae 42% 100%
A0A1X0P8P2 Trypanosomatidae 28% 100%
A0A3Q8IKW2 Leishmania donovani 94% 100%
A0A3S7XAQ4 Leishmania donovani 32% 100%
A0A422NLE5 Trypanosoma rangeli 29% 100%
A0A422NYK3 Trypanosoma rangeli 30% 100%
A4HP51 Leishmania braziliensis 32% 90%
A4HZA7 Leishmania infantum 94% 100%
A4IDF8 Leishmania infantum 32% 100%
C9ZPY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A1L3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
D0A336 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ASV9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 90%
Q14764 Homo sapiens 31% 100%
Q4CUM2 Trypanosoma cruzi (strain CL Brener) 34% 100%
Q4Q1N7 Leishmania major 32% 90%
Q4QCJ5 Leishmania major 94% 100%
Q57Z03 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 33% 100%
Q5ZMI4 Gallus gallus 35% 100%
Q62667 Rattus norvegicus 36% 100%
Q9EQK5 Mus musculus 32% 100%
V5AUX6 Trypanosoma cruzi 30% 100%
V5B0K2 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS