Nucleolar protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nucleolar protein 9

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUY4_LEIMU

TriTrypDb:

LmxM.21.0170

Length:

764

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AUY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUY4

Function

Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000966	RNA 5'-end processing	7	1
GO:0000967	rRNA 5'-end processing	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0034470	ncRNA processing	7	1
GO:0034471	ncRNA 5'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0036260	RNA capping	7	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.648
CLV_C14_Caspase3-7	74	78	PF00656	0.481
CLV_NRD_NRD_1	35	37	PF00675	0.536
CLV_NRD_NRD_1	420	422	PF00675	0.507
CLV_NRD_NRD_1	491	493	PF00675	0.480
CLV_NRD_NRD_1	631	633	PF00675	0.402
CLV_NRD_NRD_1	738	740	PF00675	0.531
CLV_NRD_NRD_1	758	760	PF00675	0.331
CLV_PCSK_KEX2_1	34	36	PF00082	0.531
CLV_PCSK_KEX2_1	420	422	PF00082	0.507
CLV_PCSK_KEX2_1	445	447	PF00082	0.451
CLV_PCSK_KEX2_1	623	625	PF00082	0.513
CLV_PCSK_KEX2_1	631	633	PF00082	0.358
CLV_PCSK_KEX2_1	720	722	PF00082	0.519
CLV_PCSK_KEX2_1	758	760	PF00082	0.539
CLV_PCSK_KEX2_1	9	11	PF00082	0.666
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.451
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.621
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.305
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.666
CLV_PCSK_SKI1_1	118	122	PF00082	0.389
CLV_PCSK_SKI1_1	309	313	PF00082	0.400
CLV_PCSK_SKI1_1	420	424	PF00082	0.424
CLV_PCSK_SKI1_1	426	430	PF00082	0.392
CLV_PCSK_SKI1_1	446	450	PF00082	0.383
CLV_PCSK_SKI1_1	523	527	PF00082	0.531
CLV_PCSK_SKI1_1	547	551	PF00082	0.409
CLV_PCSK_SKI1_1	662	666	PF00082	0.441
CLV_PCSK_SKI1_1	758	762	PF00082	0.665
CLV_PCSK_SKI1_1	85	89	PF00082	0.495
DEG_APCC_DBOX_1	568	576	PF00400	0.512
DEG_SCF_FBW7_1	453	459	PF00400	0.403
DEG_SCF_FBW7_1	685	690	PF00400	0.615
DOC_CDC14_PxL_1	430	438	PF14671	0.462
DOC_CKS1_1	453	458	PF01111	0.606
DOC_CYCLIN_RxL_1	755	764	PF00134	0.677
DOC_MAPK_DCC_7	500	508	PF00069	0.515
DOC_MAPK_gen_1	209	218	PF00069	0.374
DOC_MAPK_gen_1	566	575	PF00069	0.522
DOC_MAPK_gen_1	623	629	PF00069	0.506
DOC_MAPK_gen_1	739	746	PF00069	0.500
DOC_MAPK_HePTP_8	206	218	PF00069	0.417
DOC_MAPK_MEF2A_6	118	125	PF00069	0.390
DOC_MAPK_MEF2A_6	209	218	PF00069	0.391
DOC_MAPK_MEF2A_6	375	384	PF00069	0.509
DOC_MAPK_MEF2A_6	420	429	PF00069	0.402
DOC_MAPK_MEF2A_6	500	508	PF00069	0.479
DOC_PP2B_LxvP_1	329	332	PF13499	0.445
DOC_PP2B_LxvP_1	407	410	PF13499	0.395
DOC_PP2B_LxvP_1	594	597	PF13499	0.586
DOC_PP4_FxxP_1	431	434	PF00568	0.518
DOC_USP7_MATH_1	135	139	PF00917	0.377
DOC_USP7_MATH_1	210	214	PF00917	0.393
DOC_USP7_MATH_1	274	278	PF00917	0.415
DOC_USP7_MATH_1	348	352	PF00917	0.565
DOC_USP7_MATH_1	396	400	PF00917	0.514
DOC_USP7_MATH_1	448	452	PF00917	0.501
DOC_USP7_MATH_1	456	460	PF00917	0.630
DOC_USP7_MATH_1	463	467	PF00917	0.626
DOC_USP7_MATH_1	468	472	PF00917	0.563
DOC_USP7_MATH_1	554	558	PF00917	0.420
DOC_USP7_MATH_1	619	623	PF00917	0.519
DOC_USP7_MATH_1	685	689	PF00917	0.767
DOC_USP7_MATH_1	71	75	PF00917	0.514
DOC_USP7_MATH_1	89	93	PF00917	0.307
DOC_WW_Pin1_4	131	136	PF00397	0.370
DOC_WW_Pin1_4	24	29	PF00397	0.596
DOC_WW_Pin1_4	259	264	PF00397	0.455
DOC_WW_Pin1_4	434	439	PF00397	0.433
DOC_WW_Pin1_4	452	457	PF00397	0.621
DOC_WW_Pin1_4	499	504	PF00397	0.515
DOC_WW_Pin1_4	681	686	PF00397	0.771
DOC_WW_Pin1_4	713	718	PF00397	0.592
LIG_14-3-3_CanoR_1	209	215	PF00244	0.479
LIG_14-3-3_CanoR_1	22	28	PF00244	0.564
LIG_14-3-3_CanoR_1	631	641	PF00244	0.448
LIG_14-3-3_CanoR_1	677	685	PF00244	0.685
LIG_14-3-3_CterR_2	759	764	PF00244	0.680
LIG_Actin_RPEL_3	96	115	PF02755	0.416
LIG_Actin_WH2_2	199	214	PF00022	0.507
LIG_APCC_ABBA_1	670	675	PF00400	0.495
LIG_eIF4E_1	139	145	PF01652	0.476
LIG_eIF4E_1	306	312	PF01652	0.526
LIG_eIF4E_1	400	406	PF01652	0.398
LIG_FAT_LD_1	141	149	PF03623	0.440
LIG_FHA_1	274	280	PF00498	0.498
LIG_FHA_1	333	339	PF00498	0.549
LIG_FHA_1	377	383	PF00498	0.553
LIG_FHA_1	396	402	PF00498	0.274
LIG_FHA_1	435	441	PF00498	0.409
LIG_FHA_1	471	477	PF00498	0.706
LIG_FHA_2	156	162	PF00498	0.555
LIG_FHA_2	239	245	PF00498	0.458
LIG_FHA_2	602	608	PF00498	0.707
LIG_FHA_2	616	622	PF00498	0.615
LIG_IRF3_LxIS_1	128	134	PF10401	0.480
LIG_LIR_Gen_1	119	128	PF02991	0.380
LIG_LIR_Gen_1	17	28	PF02991	0.639
LIG_LIR_Gen_1	327	336	PF02991	0.519
LIG_LIR_Gen_1	507	516	PF02991	0.481
LIG_LIR_Gen_1	643	653	PF02991	0.491
LIG_LIR_Gen_1	741	747	PF02991	0.401
LIG_LIR_Gen_1	77	87	PF02991	0.411
LIG_LIR_LC3C_4	276	280	PF02991	0.475
LIG_LIR_Nem_3	119	125	PF02991	0.374
LIG_LIR_Nem_3	17	23	PF02991	0.652
LIG_LIR_Nem_3	327	331	PF02991	0.458
LIG_LIR_Nem_3	507	511	PF02991	0.493
LIG_LIR_Nem_3	639	645	PF02991	0.453
LIG_LIR_Nem_3	741	746	PF02991	0.437
LIG_LIR_Nem_3	77	83	PF02991	0.408
LIG_LIR_Nem_3	90	96	PF02991	0.400
LIG_MYND_1	434	438	PF01753	0.526
LIG_NRBOX	140	146	PF00104	0.436
LIG_NRBOX	311	317	PF00104	0.378
LIG_NRBOX	82	88	PF00104	0.422
LIG_PCNA_yPIPBox_3	628	641	PF02747	0.494
LIG_PCNA_yPIPBox_3	749	761	PF02747	0.521
LIG_Rb_pABgroove_1	425	433	PF01858	0.500
LIG_SH2_CRK	501	505	PF00017	0.509
LIG_SH2_NCK_1	501	505	PF00017	0.488
LIG_SH2_NCK_1	654	658	PF00017	0.510
LIG_SH2_PTP2	122	125	PF00017	0.404
LIG_SH2_PTP2	588	591	PF00017	0.494
LIG_SH2_STAP1	254	258	PF00017	0.310
LIG_SH2_STAP1	642	646	PF00017	0.447
LIG_SH2_STAT3	400	403	PF00017	0.407
LIG_SH2_STAT5	122	125	PF00017	0.404
LIG_SH2_STAT5	139	142	PF00017	0.444
LIG_SH2_STAT5	328	331	PF00017	0.368
LIG_SH2_STAT5	400	403	PF00017	0.429
LIG_SH2_STAT5	51	54	PF00017	0.435
LIG_SH2_STAT5	531	534	PF00017	0.454
LIG_SH2_STAT5	588	591	PF00017	0.408
LIG_SH2_STAT5	603	606	PF00017	0.644
LIG_SH2_STAT5	736	739	PF00017	0.497
LIG_SH2_STAT5	94	97	PF00017	0.476
LIG_SH3_3	226	232	PF00018	0.576
LIG_SH3_3	268	274	PF00018	0.509
LIG_SH3_3	328	334	PF00018	0.405
LIG_SH3_3	419	425	PF00018	0.464
LIG_SH3_CIN85_PxpxPR_1	232	237	PF14604	0.453
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.416
LIG_SUMO_SIM_anti_2	570	577	PF11976	0.534
LIG_SUMO_SIM_par_1	378	383	PF11976	0.503
LIG_TRAF2_1	249	252	PF00917	0.513
LIG_TRAF2_1	58	61	PF00917	0.469
LIG_TRFH_1	452	456	PF08558	0.584
LIG_TYR_ITIM	120	125	PF00017	0.393
LIG_TYR_ITIM	499	504	PF00017	0.429
LIG_UBA3_1	572	580	PF00899	0.477
LIG_UBA3_1	83	88	PF00899	0.447
LIG_WRC_WIRS_1	449	454	PF05994	0.586
MOD_CDK_SPxxK_3	24	31	PF00069	0.593
MOD_CDK_SPxxK_3	713	720	PF00069	0.559
MOD_CK1_1	182	188	PF00069	0.417
MOD_CK1_1	24	30	PF00069	0.591
MOD_CK1_1	355	361	PF00069	0.660
MOD_CK1_1	457	463	PF00069	0.435
MOD_CK1_1	515	521	PF00069	0.443
MOD_CK1_1	599	605	PF00069	0.665
MOD_CK1_1	613	619	PF00069	0.670
MOD_CK1_1	635	641	PF00069	0.502
MOD_CK1_1	680	686	PF00069	0.758
MOD_CK1_1	696	702	PF00069	0.462
MOD_CK2_1	155	161	PF00069	0.544
MOD_CK2_1	186	192	PF00069	0.513
MOD_CK2_1	238	244	PF00069	0.487
MOD_CK2_1	259	265	PF00069	0.530
MOD_CK2_1	348	354	PF00069	0.594
MOD_CK2_1	615	621	PF00069	0.550
MOD_Cter_Amidation	7	10	PF01082	0.736
MOD_GlcNHglycan	152	155	PF01048	0.450
MOD_GlcNHglycan	177	180	PF01048	0.515
MOD_GlcNHglycan	182	185	PF01048	0.416
MOD_GlcNHglycan	3	6	PF01048	0.733
MOD_GlcNHglycan	348	351	PF01048	0.579
MOD_GlcNHglycan	456	459	PF01048	0.558
MOD_GlcNHglycan	470	473	PF01048	0.545
MOD_GlcNHglycan	591	594	PF01048	0.483
MOD_GlcNHglycan	63	66	PF01048	0.587
MOD_GlcNHglycan	680	683	PF01048	0.736
MOD_GlcNHglycan	687	690	PF01048	0.757
MOD_GlcNHglycan	698	701	PF01048	0.673
MOD_GSK3_1	131	138	PF00069	0.375
MOD_GSK3_1	140	147	PF00069	0.426
MOD_GSK3_1	175	182	PF00069	0.504
MOD_GSK3_1	284	291	PF00069	0.475
MOD_GSK3_1	348	355	PF00069	0.618
MOD_GSK3_1	356	363	PF00069	0.682
MOD_GSK3_1	367	374	PF00069	0.474
MOD_GSK3_1	448	455	PF00069	0.428
MOD_GSK3_1	470	477	PF00069	0.645
MOD_GSK3_1	507	514	PF00069	0.326
MOD_GSK3_1	597	604	PF00069	0.593
MOD_GSK3_1	615	622	PF00069	0.594
MOD_GSK3_1	632	639	PF00069	0.493
MOD_GSK3_1	677	684	PF00069	0.695
MOD_N-GLC_1	97	102	PF02516	0.419
MOD_NEK2_1	144	149	PF00069	0.421
MOD_NEK2_1	155	160	PF00069	0.456
MOD_NEK2_1	186	191	PF00069	0.488
MOD_NEK2_1	316	321	PF00069	0.500
MOD_NEK2_1	633	638	PF00069	0.474
MOD_NEK2_1	665	670	PF00069	0.477
MOD_NEK2_2	219	224	PF00069	0.435
MOD_NEK2_2	89	94	PF00069	0.477
MOD_PIKK_1	146	152	PF00454	0.495
MOD_PIKK_1	675	681	PF00454	0.657
MOD_PIKK_1	715	721	PF00454	0.532
MOD_PKA_2	21	27	PF00069	0.561
MOD_PKA_2	284	290	PF00069	0.452
MOD_PKA_2	346	352	PF00069	0.569
MOD_Plk_1	45	51	PF00069	0.455
MOD_Plk_1	89	95	PF00069	0.456
MOD_Plk_4	116	122	PF00069	0.384
MOD_Plk_4	140	146	PF00069	0.382
MOD_Plk_4	182	188	PF00069	0.413
MOD_Plk_4	274	280	PF00069	0.378
MOD_Plk_4	288	294	PF00069	0.418
MOD_Plk_4	324	330	PF00069	0.454
MOD_Plk_4	396	402	PF00069	0.537
MOD_Plk_4	448	454	PF00069	0.429
MOD_Plk_4	478	484	PF00069	0.537
MOD_Plk_4	507	513	PF00069	0.298
MOD_Plk_4	554	560	PF00069	0.444
MOD_Plk_4	579	585	PF00069	0.398
MOD_Plk_4	636	642	PF00069	0.440
MOD_Plk_4	665	671	PF00069	0.485
MOD_Plk_4	71	77	PF00069	0.451
MOD_Plk_4	89	95	PF00069	0.355
MOD_ProDKin_1	131	137	PF00069	0.366
MOD_ProDKin_1	24	30	PF00069	0.596
MOD_ProDKin_1	259	265	PF00069	0.453
MOD_ProDKin_1	434	440	PF00069	0.428
MOD_ProDKin_1	452	458	PF00069	0.627
MOD_ProDKin_1	499	505	PF00069	0.513
MOD_ProDKin_1	681	687	PF00069	0.773
MOD_ProDKin_1	713	719	PF00069	0.585
MOD_SUMO_rev_2	617	625	PF00179	0.491
MOD_SUMO_rev_2	703	713	PF00179	0.482
TRG_DiLeu_BaEn_1	383	388	PF01217	0.524
TRG_DiLeu_BaEn_1	82	87	PF01217	0.413
TRG_DiLeu_BaEn_2	543	549	PF01217	0.508
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.463
TRG_DiLeu_BaLyEn_6	752	757	PF01217	0.503
TRG_ENDOCYTIC_2	122	125	PF00928	0.385
TRG_ENDOCYTIC_2	328	331	PF00928	0.368
TRG_ENDOCYTIC_2	501	504	PF00928	0.423
TRG_ENDOCYTIC_2	531	534	PF00928	0.431
TRG_ENDOCYTIC_2	588	591	PF00928	0.494
TRG_ENDOCYTIC_2	645	648	PF00928	0.489
TRG_ENDOCYTIC_2	673	676	PF00928	0.454
TRG_ENDOCYTIC_2	725	728	PF00928	0.502
TRG_ER_diArg_1	297	300	PF00400	0.404
TRG_ER_diArg_1	34	36	PF00400	0.545
TRG_ER_diArg_1	419	421	PF00400	0.460
TRG_ER_diArg_1	630	632	PF00400	0.406
TRG_ER_diArg_1	757	759	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	489	494	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	759	764	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K4	Leptomonas seymouri	68%	97%
A0A0S4J166	Bodo saltans	34%	100%
A0A1X0NXL8	Trypanosomatidae	42%	96%
A0A3S5IR95	Trypanosoma rangeli	39%	100%
A0A3S7WW94	Leishmania donovani	92%	100%
A4HBL6	Leishmania braziliensis	84%	100%
A4HZA4	Leishmania infantum	92%	100%
D0A1L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QCJ8	Leishmania major	91%	100%
V5B0J8	Trypanosoma cruzi	43%	100%