Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUY1_LEIMU

TriTrypDb:

LmxM.21.0140

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.530
CLV_C14_Caspase3-7	621	625	PF00656	0.469
CLV_NRD_NRD_1	158	160	PF00675	0.389
CLV_NRD_NRD_1	2	4	PF00675	0.473
CLV_NRD_NRD_1	416	418	PF00675	0.488
CLV_NRD_NRD_1	568	570	PF00675	0.396
CLV_NRD_NRD_1	573	575	PF00675	0.374
CLV_NRD_NRD_1	634	636	PF00675	0.655
CLV_PCSK_FUR_1	156	160	PF00082	0.462
CLV_PCSK_KEX2_1	158	160	PF00082	0.387
CLV_PCSK_KEX2_1	2	4	PF00082	0.473
CLV_PCSK_KEX2_1	250	252	PF00082	0.486
CLV_PCSK_KEX2_1	568	570	PF00082	0.360
CLV_PCSK_KEX2_1	573	575	PF00082	0.361
CLV_PCSK_KEX2_1	634	636	PF00082	0.655
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.504
CLV_PCSK_PC7_1	569	575	PF00082	0.385
CLV_PCSK_SKI1_1	107	111	PF00082	0.264
CLV_PCSK_SKI1_1	182	186	PF00082	0.396
CLV_PCSK_SKI1_1	212	216	PF00082	0.370
CLV_PCSK_SKI1_1	222	226	PF00082	0.320
CLV_PCSK_SKI1_1	372	376	PF00082	0.366
CLV_PCSK_SKI1_1	462	466	PF00082	0.309
CLV_PCSK_SKI1_1	98	102	PF00082	0.410
DEG_APCC_DBOX_1	106	114	PF00400	0.333
DEG_Nend_UBRbox_1	1	4	PF02207	0.428
DEG_SCF_FBW7_1	364	371	PF00400	0.389
DEG_SPOP_SBC_1	330	334	PF00917	0.376
DEG_SPOP_SBC_1	41	45	PF00917	0.450
DEG_SPOP_SBC_1	86	90	PF00917	0.483
DOC_CKS1_1	365	370	PF01111	0.384
DOC_CKS1_1	404	409	PF01111	0.448
DOC_CYCLIN_RxL_1	155	165	PF00134	0.351
DOC_CYCLIN_RxL_1	369	380	PF00134	0.454
DOC_MAPK_gen_1	101	110	PF00069	0.536
DOC_MAPK_gen_1	250	256	PF00069	0.459
DOC_PP1_RVXF_1	156	163	PF00149	0.385
DOC_PP1_RVXF_1	210	216	PF00149	0.366
DOC_PP1_RVXF_1	220	226	PF00149	0.348
DOC_PP1_RVXF_1	262	269	PF00149	0.447
DOC_PP1_RVXF_1	370	377	PF00149	0.316
DOC_PP1_RVXF_1	450	457	PF00149	0.380
DOC_PP4_FxxP_1	344	347	PF00568	0.451
DOC_USP7_MATH_1	142	146	PF00917	0.410
DOC_USP7_MATH_1	25	29	PF00917	0.692
DOC_USP7_MATH_1	31	35	PF00917	0.506
DOC_USP7_MATH_1	368	372	PF00917	0.342
DOC_USP7_MATH_1	86	90	PF00917	0.471
DOC_WW_Pin1_4	187	192	PF00397	0.433
DOC_WW_Pin1_4	29	34	PF00397	0.708
DOC_WW_Pin1_4	343	348	PF00397	0.533
DOC_WW_Pin1_4	364	369	PF00397	0.377
DOC_WW_Pin1_4	403	408	PF00397	0.437
DOC_WW_Pin1_4	468	473	PF00397	0.327
DOC_WW_Pin1_4	522	527	PF00397	0.389
LIG_14-3-3_CanoR_1	112	121	PF00244	0.441
LIG_14-3-3_CanoR_1	159	165	PF00244	0.380
LIG_14-3-3_CanoR_1	241	245	PF00244	0.545
LIG_14-3-3_CanoR_1	293	299	PF00244	0.427
LIG_14-3-3_CanoR_1	396	401	PF00244	0.462
LIG_14-3-3_CanoR_1	615	620	PF00244	0.500
LIG_Actin_WH2_2	68	84	PF00022	0.571
LIG_BRCT_BRCA1_1	180	184	PF00533	0.354
LIG_CaM_IQ_9	90	106	PF13499	0.383
LIG_deltaCOP1_diTrp_1	149	157	PF00928	0.298
LIG_deltaCOP1_diTrp_1	437	443	PF00928	0.349
LIG_deltaCOP1_diTrp_1	455	461	PF00928	0.341
LIG_deltaCOP1_diTrp_1	509	517	PF00928	0.491
LIG_EVH1_2	294	298	PF00568	0.479
LIG_FHA_1	114	120	PF00498	0.452
LIG_FHA_1	196	202	PF00498	0.372
LIG_FHA_1	219	225	PF00498	0.308
LIG_FHA_1	226	232	PF00498	0.293
LIG_FHA_1	30	36	PF00498	0.680
LIG_FHA_1	307	313	PF00498	0.404
LIG_FHA_1	332	338	PF00498	0.393
LIG_FHA_1	365	371	PF00498	0.465
LIG_FHA_1	88	94	PF00498	0.542
LIG_FHA_2	455	461	PF00498	0.457
LIG_FHA_2	486	492	PF00498	0.483
LIG_FHA_2	542	548	PF00498	0.544
LIG_FHA_2	596	602	PF00498	0.490
LIG_LIR_Apic_2	560	565	PF02991	0.377
LIG_LIR_Gen_1	145	155	PF02991	0.345
LIG_LIR_Gen_1	171	180	PF02991	0.329
LIG_LIR_Gen_1	399	408	PF02991	0.574
LIG_LIR_Gen_1	455	464	PF02991	0.427
LIG_LIR_Nem_3	145	151	PF02991	0.344
LIG_LIR_Nem_3	171	176	PF02991	0.371
LIG_LIR_Nem_3	399	404	PF02991	0.585
LIG_LIR_Nem_3	455	459	PF02991	0.337
LIG_LIR_Nem_3	460	464	PF02991	0.298
LIG_LIR_Nem_3	509	514	PF02991	0.427
LIG_NRP_CendR_1	640	642	PF00754	0.574
LIG_PCNA_PIPBox_1	299	308	PF02747	0.330
LIG_PCNA_yPIPBox_3	396	404	PF02747	0.564
LIG_Pex14_2	244	248	PF04695	0.483
LIG_REV1ctd_RIR_1	373	383	PF16727	0.386
LIG_SH2_CRK	220	224	PF00017	0.341
LIG_SH2_NCK_1	582	586	PF00017	0.541
LIG_SH2_PTP2	562	565	PF00017	0.368
LIG_SH2_STAP1	115	119	PF00017	0.459
LIG_SH2_STAP1	220	224	PF00017	0.317
LIG_SH2_STAP1	582	586	PF00017	0.446
LIG_SH2_STAT5	115	118	PF00017	0.482
LIG_SH2_STAT5	220	223	PF00017	0.371
LIG_SH2_STAT5	233	236	PF00017	0.426
LIG_SH2_STAT5	306	309	PF00017	0.315
LIG_SH2_STAT5	4	7	PF00017	0.630
LIG_SH2_STAT5	401	404	PF00017	0.497
LIG_SH2_STAT5	562	565	PF00017	0.430
LIG_SH3_3	288	294	PF00018	0.438
LIG_SH3_3	344	350	PF00018	0.359
LIG_SH3_3	355	361	PF00018	0.409
LIG_SH3_3	635	641	PF00018	0.582
LIG_SUMO_SIM_par_1	313	321	PF11976	0.365
LIG_SUMO_SIM_par_1	525	531	PF11976	0.337
LIG_TRAF2_1	528	531	PF00917	0.535
LIG_TRAF2_1	89	92	PF00917	0.444
LIG_TRAF2_2	58	63	PF00917	0.513
LIG_TYR_ITIM	218	223	PF00017	0.354
LIG_UBA3_1	619	623	PF00899	0.476
MOD_CDK_SPK_2	468	473	PF00069	0.327
MOD_CK1_1	192	198	PF00069	0.468
MOD_CK1_1	40	46	PF00069	0.621
MOD_CK2_1	240	246	PF00069	0.617
MOD_CK2_1	325	331	PF00069	0.568
MOD_CK2_1	454	460	PF00069	0.463
MOD_CK2_1	541	547	PF00069	0.543
MOD_CK2_1	595	601	PF00069	0.581
MOD_CK2_1	85	91	PF00069	0.485
MOD_GlcNHglycan	27	30	PF01048	0.577
MOD_GlcNHglycan	379	382	PF01048	0.358
MOD_GlcNHglycan	437	441	PF01048	0.475
MOD_GlcNHglycan	51	54	PF01048	0.743
MOD_GlcNHglycan	624	627	PF01048	0.596
MOD_GlcNHglycan	98	101	PF01048	0.448
MOD_GSK3_1	160	167	PF00069	0.294
MOD_GSK3_1	225	232	PF00069	0.366
MOD_GSK3_1	25	32	PF00069	0.615
MOD_GSK3_1	321	328	PF00069	0.546
MOD_GSK3_1	36	43	PF00069	0.598
MOD_GSK3_1	364	371	PF00069	0.389
MOD_GSK3_1	47	54	PF00069	0.602
MOD_N-GLC_1	396	401	PF02516	0.462
MOD_N-GLC_1	522	527	PF02516	0.454
MOD_NEK2_1	160	165	PF00069	0.357
MOD_NEK2_1	225	230	PF00069	0.335
MOD_NEK2_1	35	40	PF00069	0.630
MOD_NEK2_1	375	380	PF00069	0.388
MOD_NEK2_1	42	47	PF00069	0.607
MOD_NEK2_1	446	451	PF00069	0.445
MOD_NEK2_1	534	539	PF00069	0.367
MOD_NEK2_1	578	583	PF00069	0.441
MOD_NEK2_1	622	627	PF00069	0.509
MOD_NEK2_1	96	101	PF00069	0.548
MOD_NEK2_2	172	177	PF00069	0.452
MOD_NEK2_2	77	82	PF00069	0.435
MOD_PIKK_1	426	432	PF00454	0.341
MOD_PIKK_1	589	595	PF00454	0.552
MOD_PK_1	189	195	PF00069	0.333
MOD_PK_1	396	402	PF00069	0.463
MOD_PKA_2	240	246	PF00069	0.550
MOD_PKB_1	187	195	PF00069	0.438
MOD_Plk_1	368	374	PF00069	0.318
MOD_Plk_1	396	402	PF00069	0.463
MOD_Plk_1	454	460	PF00069	0.452
MOD_Plk_4	189	195	PF00069	0.503
MOD_Plk_4	225	231	PF00069	0.320
MOD_Plk_4	31	37	PF00069	0.599
MOD_Plk_4	396	402	PF00069	0.463
MOD_Plk_4	534	540	PF00069	0.428
MOD_Plk_4	558	564	PF00069	0.383
MOD_Plk_4	615	621	PF00069	0.540
MOD_ProDKin_1	187	193	PF00069	0.424
MOD_ProDKin_1	29	35	PF00069	0.709
MOD_ProDKin_1	343	349	PF00069	0.525
MOD_ProDKin_1	364	370	PF00069	0.370
MOD_ProDKin_1	403	409	PF00069	0.432
MOD_ProDKin_1	468	474	PF00069	0.323
MOD_ProDKin_1	522	528	PF00069	0.385
MOD_SUMO_rev_2	471	480	PF00179	0.366
MOD_SUMO_rev_2	618	625	PF00179	0.514
TRG_DiLeu_BaEn_1	476	481	PF01217	0.344
TRG_DiLeu_BaEn_1	601	606	PF01217	0.455
TRG_DiLeu_BaEn_2	459	465	PF01217	0.312
TRG_DiLeu_BaEn_2	488	494	PF01217	0.364
TRG_DiLeu_BaEn_3	91	97	PF01217	0.430
TRG_DiLeu_BaEn_4	427	433	PF01217	0.452
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.390
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.315
TRG_ENDOCYTIC_2	148	151	PF00928	0.202
TRG_ENDOCYTIC_2	220	223	PF00928	0.395
TRG_ENDOCYTIC_2	401	404	PF00928	0.588
TRG_ER_diArg_1	1	3	PF00400	0.464
TRG_ER_diArg_1	157	159	PF00400	0.389
TRG_ER_diArg_1	568	570	PF00400	0.392
TRG_ER_diArg_1	573	575	PF00400	0.366
TRG_ER_diArg_1	639	642	PF00400	0.733
TRG_NES_CRM1_1	547	560	PF08389	0.502
TRG_NLS_MonoExtN_4	414	421	PF00514	0.483
TRG_NLS_MonoExtN_4	512	519	PF00514	0.387
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X2	Leptomonas seymouri	69%	96%
A0A0S4IQX1	Bodo saltans	45%	100%
A0A1X0NXS1	Trypanosomatidae	63%	94%
A0A3S7WWA1	Leishmania donovani	96%	100%
A4HBL3	Leishmania braziliensis	92%	100%
A4HZJ6	Leishmania infantum	96%	95%
D0A1K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
Q4QCK1	Leishmania major	94%	100%
V5DGX7	Trypanosoma cruzi	61%	95%