DNA topoisomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase

Gene product:

DNA topoisomerase 1A

Species:

Leishmania mexicana

UniProt:

E9AUX9_LEIMU

TriTrypDb:

LmxM.21.0125

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006265	DNA topological change	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006996	organelle organization	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0051276	chromosome organization	5	12
GO:0071103	DNA conformation change	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003916	DNA topoisomerase activity	3	12
GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	4	12
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.528
CLV_C14_Caspase3-7	238	242	PF00656	0.453
CLV_C14_Caspase3-7	405	409	PF00656	0.418
CLV_C14_Caspase3-7	728	732	PF00656	0.527
CLV_NRD_NRD_1	106	108	PF00675	0.242
CLV_NRD_NRD_1	148	150	PF00675	0.309
CLV_NRD_NRD_1	172	174	PF00675	0.389
CLV_NRD_NRD_1	178	180	PF00675	0.412
CLV_NRD_NRD_1	261	263	PF00675	0.366
CLV_NRD_NRD_1	272	274	PF00675	0.290
CLV_NRD_NRD_1	3	5	PF00675	0.512
CLV_NRD_NRD_1	378	380	PF00675	0.395
CLV_NRD_NRD_1	398	400	PF00675	0.348
CLV_NRD_NRD_1	445	447	PF00675	0.322
CLV_NRD_NRD_1	751	753	PF00675	0.453
CLV_NRD_NRD_1	799	801	PF00675	0.640
CLV_PCSK_KEX2_1	106	108	PF00082	0.258
CLV_PCSK_KEX2_1	148	150	PF00082	0.233
CLV_PCSK_KEX2_1	172	174	PF00082	0.498
CLV_PCSK_KEX2_1	178	180	PF00082	0.540
CLV_PCSK_KEX2_1	261	263	PF00082	0.333
CLV_PCSK_KEX2_1	3	5	PF00082	0.512
CLV_PCSK_KEX2_1	378	380	PF00082	0.383
CLV_PCSK_KEX2_1	383	385	PF00082	0.445
CLV_PCSK_KEX2_1	398	400	PF00082	0.177
CLV_PCSK_KEX2_1	445	447	PF00082	0.333
CLV_PCSK_KEX2_1	698	700	PF00082	0.544
CLV_PCSK_KEX2_1	720	722	PF00082	0.471
CLV_PCSK_KEX2_1	751	753	PF00082	0.453
CLV_PCSK_KEX2_1	799	801	PF00082	0.650
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.463
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.558
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.519
CLV_PCSK_PC7_1	379	385	PF00082	0.383
CLV_PCSK_SKI1_1	148	152	PF00082	0.309
CLV_PCSK_SKI1_1	179	183	PF00082	0.359
CLV_PCSK_SKI1_1	20	24	PF00082	0.230
CLV_PCSK_SKI1_1	320	324	PF00082	0.338
CLV_PCSK_SKI1_1	383	387	PF00082	0.298
CLV_PCSK_SKI1_1	592	596	PF00082	0.289
CLV_PCSK_SKI1_1	642	646	PF00082	0.383
CLV_PCSK_SKI1_1	67	71	PF00082	0.276
CLV_PCSK_SKI1_1	690	694	PF00082	0.350
CLV_PCSK_SKI1_1	717	721	PF00082	0.389
CLV_PCSK_SKI1_1	737	741	PF00082	0.405
DEG_MDM2_SWIB_1	96	103	PF02201	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DEG_SCF_FBW7_2	500	505	PF00400	0.154
DEG_SPOP_SBC_1	763	767	PF00917	0.613
DOC_CKS1_1	221	226	PF01111	0.273
DOC_CKS1_1	433	438	PF01111	0.244
DOC_CYCLIN_RxL_1	378	390	PF00134	0.365
DOC_CYCLIN_RxL_1	684	697	PF00134	0.441
DOC_MAPK_gen_1	148	156	PF00069	0.376
DOC_MAPK_gen_1	261	269	PF00069	0.458
DOC_MAPK_gen_1	3	14	PF00069	0.509
DOC_MAPK_gen_1	445	451	PF00069	0.381
DOC_MAPK_gen_1	457	465	PF00069	0.232
DOC_MAPK_gen_1	545	551	PF00069	0.422
DOC_MAPK_HePTP_8	146	158	PF00069	0.477
DOC_MAPK_MEF2A_6	148	156	PF00069	0.411
DOC_MAPK_MEF2A_6	220	228	PF00069	0.289
DOC_MAPK_MEF2A_6	445	453	PF00069	0.445
DOC_MAPK_MEF2A_6	457	466	PF00069	0.348
DOC_MAPK_MEF2A_6	560	567	PF00069	0.383
DOC_PP1_RVXF_1	65	72	PF00149	0.442
DOC_PP2B_LxvP_1	154	157	PF13499	0.430
DOC_USP7_MATH_1	296	300	PF00917	0.352
DOC_USP7_MATH_1	656	660	PF00917	0.566
DOC_USP7_MATH_1	688	692	PF00917	0.271
DOC_USP7_MATH_1	73	77	PF00917	0.501
DOC_USP7_MATH_1	763	767	PF00917	0.632
DOC_USP7_UBL2_3	792	796	PF12436	0.726
DOC_USP7_UBL2_3	806	810	PF12436	0.755
DOC_WW_Pin1_4	14	19	PF00397	0.430
DOC_WW_Pin1_4	220	225	PF00397	0.273
DOC_WW_Pin1_4	267	272	PF00397	0.410
DOC_WW_Pin1_4	303	308	PF00397	0.348
DOC_WW_Pin1_4	313	318	PF00397	0.314
DOC_WW_Pin1_4	432	437	PF00397	0.185
DOC_WW_Pin1_4	498	503	PF00397	0.322
DOC_WW_Pin1_4	559	564	PF00397	0.327
DOC_WW_Pin1_4	607	612	PF00397	0.289
DOC_WW_Pin1_4	69	74	PF00397	0.470
DOC_WW_Pin1_4	704	709	PF00397	0.536
DOC_WW_Pin1_4	794	799	PF00397	0.640
LIG_14-3-3_CanoR_1	261	269	PF00244	0.405
LIG_14-3-3_CanoR_1	445	450	PF00244	0.311
LIG_14-3-3_CanoR_1	583	588	PF00244	0.273
LIG_14-3-3_CanoR_1	597	603	PF00244	0.272
LIG_14-3-3_CanoR_1	621	625	PF00244	0.334
LIG_14-3-3_CanoR_1	690	695	PF00244	0.536
LIG_14-3-3_CanoR_1	699	708	PF00244	0.600
LIG_14-3-3_CanoR_1	721	730	PF00244	0.450
LIG_14-3-3_CanoR_1	737	746	PF00244	0.418
LIG_BRCT_BRCA1_1	489	493	PF00533	0.410
LIG_Clathr_ClatBox_1	12	16	PF01394	0.430
LIG_CSL_BTD_1	70	73	PF09270	0.509
LIG_deltaCOP1_diTrp_1	36	39	PF00928	0.430
LIG_deltaCOP1_diTrp_1	486	493	PF00928	0.289
LIG_EH1_1	321	329	PF00400	0.365
LIG_EVH1_2	318	322	PF00568	0.289
LIG_EVH1_2	563	567	PF00568	0.383
LIG_FHA_1	122	128	PF00498	0.452
LIG_FHA_1	221	227	PF00498	0.273
LIG_FHA_1	244	250	PF00498	0.290
LIG_FHA_1	446	452	PF00498	0.354
LIG_FHA_1	456	462	PF00498	0.312
LIG_FHA_1	607	613	PF00498	0.281
LIG_FHA_1	687	693	PF00498	0.471
LIG_FHA_2	128	134	PF00498	0.438
LIG_FHA_2	361	367	PF00498	0.289
LIG_FHA_2	419	425	PF00498	0.461
LIG_FHA_2	47	53	PF00498	0.528
LIG_FHA_2	502	508	PF00498	0.319
LIG_FHA_2	81	87	PF00498	0.491
LIG_LIR_Apic_2	651	655	PF02991	0.384
LIG_LIR_Gen_1	372	380	PF02991	0.310
LIG_LIR_Gen_1	60	69	PF02991	0.434
LIG_LIR_Gen_1	738	746	PF02991	0.371
LIG_LIR_Gen_1	97	108	PF02991	0.455
LIG_LIR_Nem_3	197	203	PF02991	0.290
LIG_LIR_Nem_3	372	377	PF02991	0.310
LIG_LIR_Nem_3	525	531	PF02991	0.276
LIG_LIR_Nem_3	585	590	PF02991	0.273
LIG_LIR_Nem_3	60	66	PF02991	0.464
LIG_LIR_Nem_3	623	627	PF02991	0.290
LIG_LIR_Nem_3	670	675	PF02991	0.334
LIG_LIR_Nem_3	735	739	PF02991	0.389
LIG_LIR_Nem_3	97	103	PF02991	0.442
LIG_LYPXL_yS_3	587	590	PF13949	0.273
LIG_PCNA_PIPBox_1	196	205	PF02747	0.289
LIG_PCNA_PIPBox_1	743	752	PF02747	0.375
LIG_PCNA_yPIPBox_3	106	116	PF02747	0.455
LIG_PCNA_yPIPBox_3	737	750	PF02747	0.384
LIG_Pex14_1	489	493	PF04695	0.289
LIG_Pex14_2	632	636	PF04695	0.273
LIG_Pex14_2	668	672	PF04695	0.323
LIG_Pex14_2	96	100	PF04695	0.528
LIG_SH2_CRK	210	214	PF00017	0.410
LIG_SH2_CRK	374	378	PF00017	0.289
LIG_SH2_CRK	441	445	PF00017	0.308
LIG_SH2_GRB2like	210	213	PF00017	0.410
LIG_SH2_NCK_1	184	188	PF00017	0.308
LIG_SH2_NCK_1	210	214	PF00017	0.410
LIG_SH2_PTP2	599	602	PF00017	0.273
LIG_SH2_SRC	210	213	PF00017	0.419
LIG_SH2_SRC	239	242	PF00017	0.383
LIG_SH2_STAP1	337	341	PF00017	0.410
LIG_SH2_STAT5	115	118	PF00017	0.455
LIG_SH2_STAT5	239	242	PF00017	0.373
LIG_SH2_STAT5	254	257	PF00017	0.251
LIG_SH2_STAT5	354	357	PF00017	0.367
LIG_SH2_STAT5	599	602	PF00017	0.273
LIG_SH2_STAT5	663	666	PF00017	0.327
LIG_SH2_STAT5	675	678	PF00017	0.328
LIG_SH2_STAT5	749	752	PF00017	0.408
LIG_SH3_1	560	566	PF00018	0.290
LIG_SH3_3	12	18	PF00018	0.430
LIG_SH3_3	218	224	PF00018	0.273
LIG_SH3_3	312	318	PF00018	0.310
LIG_SH3_3	389	395	PF00018	0.252
LIG_SH3_3	430	436	PF00018	0.410
LIG_SH3_3	481	487	PF00018	0.284
LIG_SH3_3	515	521	PF00018	0.337
LIG_SH3_3	558	564	PF00018	0.273
LIG_SH3_3	578	584	PF00018	0.124
LIG_SH3_3	702	708	PF00018	0.508
LIG_SH3_3	72	78	PF00018	0.408
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.293
LIG_SUMO_SIM_anti_2	458	465	PF11976	0.322
LIG_SUMO_SIM_par_1	10	17	PF11976	0.278
LIG_SUMO_SIM_par_1	225	231	PF11976	0.273
LIG_TRAF2_1	174	177	PF00917	0.403
LIG_TRAF2_1	426	429	PF00917	0.383
LIG_UBA3_1	453	457	PF00899	0.344
LIG_UBA3_1	572	577	PF00899	0.289
LIG_WRC_WIRS_1	665	670	PF05994	0.328
LIG_WRC_WIRS_1	736	741	PF05994	0.506
LIG_WRC_WIRS_1	93	98	PF05994	0.528
LIG_WW_2	563	566	PF00397	0.333
MOD_CDC14_SPxK_1	17	20	PF00782	0.430
MOD_CDK_SPK_2	794	799	PF00069	0.680
MOD_CDK_SPxK_1	14	20	PF00069	0.430
MOD_CDK_SPxK_1	267	273	PF00069	0.230
MOD_CDK_SPxK_1	432	438	PF00069	0.244
MOD_CDK_SPxK_1	794	800	PF00069	0.607
MOD_CDK_SPxxK_3	267	274	PF00069	0.410
MOD_CDK_SPxxK_3	303	310	PF00069	0.352
MOD_CDK_SPxxK_3	313	320	PF00069	0.284
MOD_CDK_SPxxK_3	607	614	PF00069	0.289
MOD_CK1_1	242	248	PF00069	0.455
MOD_CK1_1	298	304	PF00069	0.336
MOD_CK1_1	397	403	PF00069	0.300
MOD_CK1_1	422	428	PF00069	0.219
MOD_CK1_1	496	502	PF00069	0.332
MOD_CK1_1	620	626	PF00069	0.410
MOD_CK1_1	667	673	PF00069	0.417
MOD_CK1_1	735	741	PF00069	0.425
MOD_CK1_1	766	772	PF00069	0.659
MOD_CK1_1	77	83	PF00069	0.477
MOD_CK1_1	776	782	PF00069	0.718
MOD_CK2_1	242	248	PF00069	0.373
MOD_CK2_1	422	428	PF00069	0.334
MOD_CK2_1	46	52	PF00069	0.528
MOD_CK2_1	521	527	PF00069	0.338
MOD_CK2_1	62	68	PF00069	0.455
MOD_CK2_1	631	637	PF00069	0.383
MOD_CK2_1	645	651	PF00069	0.631
MOD_Cter_Amidation	104	107	PF01082	0.258
MOD_Cter_Amidation	271	274	PF01082	0.154
MOD_Cter_Amidation	381	384	PF01082	0.388
MOD_DYRK1A_RPxSP_1	220	224	PF00069	0.273
MOD_GlcNHglycan	298	301	PF01048	0.377
MOD_GlcNHglycan	489	492	PF01048	0.379
MOD_GlcNHglycan	552	555	PF01048	0.362
MOD_GlcNHglycan	633	636	PF01048	0.459
MOD_GlcNHglycan	647	650	PF01048	0.502
MOD_GlcNHglycan	701	704	PF01048	0.449
MOD_GlcNHglycan	756	759	PF01048	0.610
MOD_GlcNHglycan	766	769	PF01048	0.587
MOD_GlcNHglycan	79	82	PF01048	0.245
MOD_GSK3_1	235	242	PF00069	0.381
MOD_GSK3_1	280	287	PF00069	0.385
MOD_GSK3_1	336	343	PF00069	0.286
MOD_GSK3_1	35	42	PF00069	0.509
MOD_GSK3_1	353	360	PF00069	0.220
MOD_GSK3_1	365	372	PF00069	0.273
MOD_GSK3_1	390	397	PF00069	0.365
MOD_GSK3_1	418	425	PF00069	0.361
MOD_GSK3_1	616	623	PF00069	0.290
MOD_GSK3_1	663	670	PF00069	0.326
MOD_GSK3_1	686	693	PF00069	0.426
MOD_GSK3_1	69	76	PF00069	0.503
MOD_GSK3_1	762	769	PF00069	0.613
MOD_GSK3_1	773	780	PF00069	0.709
MOD_GSK3_1	783	790	PF00069	0.603
MOD_LATS_1	259	265	PF00433	0.185
MOD_N-GLC_1	121	126	PF02516	0.232
MOD_N-GLC_1	280	285	PF02516	0.154
MOD_N-GLC_1	656	661	PF02516	0.441
MOD_NEK2_1	202	207	PF00069	0.273
MOD_NEK2_1	341	346	PF00069	0.383
MOD_NEK2_1	39	44	PF00069	0.526
MOD_NEK2_1	493	498	PF00069	0.464
MOD_NEK2_1	57	62	PF00069	0.351
MOD_NEK2_1	616	621	PF00069	0.282
MOD_NEK2_1	742	747	PF00069	0.479
MOD_NEK2_1	92	97	PF00069	0.535
MOD_PIKK_1	261	267	PF00454	0.292
MOD_PIKK_1	721	727	PF00454	0.447
MOD_PK_1	419	425	PF00069	0.244
MOD_PKA_1	261	267	PF00069	0.185
MOD_PKA_1	398	404	PF00069	0.267
MOD_PKA_1	445	451	PF00069	0.320
MOD_PKA_1	545	551	PF00069	0.396
MOD_PKA_1	783	789	PF00069	0.679
MOD_PKA_2	261	267	PF00069	0.415
MOD_PKA_2	397	403	PF00069	0.339
MOD_PKA_2	418	424	PF00069	0.273
MOD_PKA_2	445	451	PF00069	0.353
MOD_PKA_2	493	499	PF00069	0.312
MOD_PKA_2	582	588	PF00069	0.273
MOD_PKA_2	620	626	PF00069	0.410
MOD_PKA_2	774	780	PF00069	0.590
MOD_Plk_1	35	41	PF00069	0.435
MOD_Plk_1	360	366	PF00069	0.289
MOD_Plk_1	423	429	PF00069	0.383
MOD_Plk_1	67	73	PF00069	0.490
MOD_Plk_2-3	284	290	PF00069	0.346
MOD_Plk_4	203	209	PF00069	0.273
MOD_Plk_4	235	241	PF00069	0.351
MOD_Plk_4	323	329	PF00069	0.365
MOD_Plk_4	365	371	PF00069	0.402
MOD_Plk_4	590	596	PF00069	0.276
MOD_Plk_4	623	629	PF00069	0.289
MOD_Plk_4	664	670	PF00069	0.317
MOD_ProDKin_1	14	20	PF00069	0.430
MOD_ProDKin_1	220	226	PF00069	0.273
MOD_ProDKin_1	267	273	PF00069	0.410
MOD_ProDKin_1	303	309	PF00069	0.348
MOD_ProDKin_1	313	319	PF00069	0.314
MOD_ProDKin_1	432	438	PF00069	0.185
MOD_ProDKin_1	498	504	PF00069	0.322
MOD_ProDKin_1	559	565	PF00069	0.327
MOD_ProDKin_1	607	613	PF00069	0.289
MOD_ProDKin_1	69	75	PF00069	0.470
MOD_ProDKin_1	704	710	PF00069	0.534
MOD_ProDKin_1	794	800	PF00069	0.643
MOD_SUMO_for_1	22	25	PF00179	0.442
MOD_SUMO_for_1	456	459	PF00179	0.344
MOD_SUMO_rev_2	113	120	PF00179	0.507
MOD_SUMO_rev_2	231	236	PF00179	0.288
MOD_SUMO_rev_2	25	34	PF00179	0.509
MOD_SUMO_rev_2	522	531	PF00179	0.376
MOD_SUMO_rev_2	634	640	PF00179	0.337
MOD_SUMO_rev_2	716	722	PF00179	0.421
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.383
TRG_ENDOCYTIC_2	374	377	PF00928	0.289
TRG_ENDOCYTIC_2	441	444	PF00928	0.273
TRG_ENDOCYTIC_2	587	590	PF00928	0.273
TRG_ENDOCYTIC_2	599	602	PF00928	0.273
TRG_ENDOCYTIC_2	736	739	PF00928	0.404
TRG_ER_diArg_1	106	108	PF00400	0.442
TRG_ER_diArg_1	147	149	PF00400	0.509
TRG_ER_diArg_1	171	173	PF00400	0.509
TRG_ER_diArg_1	2	4	PF00400	0.524
TRG_ER_diArg_1	261	263	PF00400	0.185
TRG_ER_diArg_1	377	379	PF00400	0.383
TRG_ER_diArg_1	444	446	PF00400	0.333
TRG_ER_diArg_1	750	752	PF00400	0.443
TRG_ER_diArg_1	798	800	PF00400	0.706
TRG_ER_diLys_1	806	810	PF00400	0.640
TRG_NLS_Bipartite_1	795	810	PF00514	0.645
TRG_NLS_MonoCore_2	805	810	PF00514	0.727
TRG_NLS_MonoExtC_3	805	810	PF00514	0.696
TRG_NLS_MonoExtN_4	804	810	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P1	Leptomonas seymouri	24%	94%
A0A0N1PDE4	Leptomonas seymouri	68%	94%
A0A0S4J933	Bodo saltans	22%	92%
A0A0S4JDQ6	Bodo saltans	37%	99%
A0A1X0NXB2	Trypanosomatidae	51%	95%
A0A3S7WW83	Leishmania donovani	94%	100%
A0A3S7X1K1	Leishmania donovani	23%	93%
A0A422N774	Trypanosoma rangeli	51%	97%
A0R5D9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	27%	87%
A0R979	Bacillus thuringiensis (strain Al Hakam)	25%	100%
A4HBL0	Leishmania braziliensis	86%	99%
A4HGN1	Leishmania braziliensis	23%	100%
A4HPI6	Leishmania braziliensis	22%	85%
A4HZ99	Leishmania infantum	94%	100%
A4I3Q5	Leishmania infantum	23%	93%
D0A1K4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AZZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	94%
O27661	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O28469	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O34204	Fervidobacterium islandicum	25%	100%
O58356	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	23%	100%
O67226	Aquifex aeolicus (strain VF5)	26%	70%
O69548	Mycobacterium leprae (strain TN)	27%	86%
P06612	Escherichia coli (strain K12)	26%	94%
P0A2I1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	94%
P0A2I2	Salmonella typhi	26%	94%
P0A621	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	87%
P0C2W6	Staphylococcus aureus (strain bovine RF122 / ET3-1)	21%	100%
P14294	Escherichia coli (strain K12)	21%	100%
P34184	Alkalihalophilus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4)	23%	100%
P39814	Bacillus subtilis (strain 168)	27%	100%
P43012	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	25%	93%
P43704	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	21%	100%
P46799	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	26%	100%
P47368	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	24%	100%
P55991	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
P57371	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	24%	94%
P73810	Synechocystis sp. (strain PCC 6803 / Kazusa)	28%	90%
P78032	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	25%	100%
P95479	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	24%	67%
P9WG48	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	87%
P9WG49	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	87%
Q06AK7	Staphylococcus aureus	25%	100%
Q1RIM1	Rickettsia bellii (strain RML369-C)	25%	100%
Q2FEN5	Staphylococcus aureus (strain USA300)	21%	100%
Q2FHI8	Staphylococcus aureus (strain USA300)	25%	100%
Q2FW03	Staphylococcus aureus (strain NCTC 8325 / PS 47)	21%	100%
Q2FZ32	Staphylococcus aureus (strain NCTC 8325 / PS 47)	25%	100%
Q4L8B8	Staphylococcus haemolyticus (strain JCSC1435)	21%	100%
Q4Q888	Leishmania major	23%	94%
Q4QCK3	Leishmania major	94%	100%
Q4UM42	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	26%	100%
Q59046	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	23%	100%
Q5HDV4	Staphylococcus aureus (strain COL)	21%	100%
Q5HGI2	Staphylococcus aureus (strain COL)	25%	100%
Q5HLZ4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	21%	100%
Q5UQB5	Acanthamoeba polyphaga mimivirus	23%	95%
Q5WAX6	Alkalihalobacillus clausii (strain KSM-K16)	23%	100%
Q63GK5	Bacillus cereus (strain ZK / E33L)	25%	100%
Q68X45	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	25%	100%
Q6G767	Staphylococcus aureus (strain MSSA476)	21%	100%
Q6G9W3	Staphylococcus aureus (strain MSSA476)	25%	100%
Q6GEH9	Staphylococcus aureus (strain MRSA252)	21%	100%
Q6GHI5	Staphylococcus aureus (strain MRSA252)	25%	100%
Q6HP19	Bacillus thuringiensis subsp. konkukian (strain 97-27)	25%	100%
Q73E74	Bacillus cereus (strain ATCC 10987 / NRS 248)	26%	100%
Q7A075	Staphylococcus aureus (strain MW2)	21%	100%
Q7A455	Staphylococcus aureus (strain N315)	21%	100%
Q7A5Y5	Staphylococcus aureus (strain N315)	25%	100%
Q81IH1	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	26%	100%
Q81Z97	Bacillus anthracis	25%	100%
Q87AQ6	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	28%	99%
Q8CRF7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	21%	100%
Q8K9P7	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	95%
Q8NWZ9	Staphylococcus aureus (strain MW2)	25%	100%
Q92IH1	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	26%	100%
Q97ZF5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	69%
Q99S17	Staphylococcus aureus (strain Mu50 / ATCC 700699)	21%	100%
Q99UM1	Staphylococcus aureus (strain Mu50 / ATCC 700699)	25%	100%
Q9CG80	Lactococcus lactis subsp. lactis (strain IL1403)	26%	100%
Q9CN30	Pasteurella multocida (strain Pm70)	27%	93%
Q9HM08	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	24%	100%
Q9HZJ5	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	25%	93%
Q9JN65	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	25%	100%
Q9KQF5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	23%	100%
Q9KRB2	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	27%	92%
Q9PEV8	Xylella fastidiosa (strain 9a5c)	28%	99%
Q9PHK2	Xylella fastidiosa (strain 9a5c)	26%	100%
Q9PLZ2	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	26%	100%
Q9UYS8	Pyrococcus abyssi (strain GE5 / Orsay)	23%	100%
Q9X3X7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	28%	67%
Q9YB01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	22%	100%
Q9YC75	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	25%	67%
Q9ZDK2	Rickettsia prowazekii (strain Madrid E)	25%	100%
Q9ZMV7	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5BG04	Trypanosoma cruzi	53%	99%