Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUX5_LEIMU

TriTrypDb:

LmxM.21.0090

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AUX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.384
CLV_PCSK_KEX2_1	87	89	PF00082	0.384
CLV_PCSK_SKI1_1	88	92	PF00082	0.326
DEG_APCC_DBOX_1	13	21	PF00400	0.478
DEG_Nend_UBRbox_2	1	3	PF02207	0.688
DEG_SPOP_SBC_1	174	178	PF00917	0.578
DOC_MAPK_gen_1	87	95	PF00069	0.453
DOC_MAPK_gen_1	9	19	PF00069	0.650
DOC_MAPK_HePTP_8	85	97	PF00069	0.504
DOC_MAPK_MEF2A_6	12	21	PF00069	0.472
DOC_MAPK_MEF2A_6	87	95	PF00069	0.461
DOC_MAPK_NFAT4_5	88	96	PF00069	0.478
DOC_USP7_MATH_1	161	165	PF00917	0.694
DOC_USP7_MATH_1	174	178	PF00917	0.689
DOC_WW_Pin1_4	80	85	PF00397	0.644
LIG_14-3-3_CanoR_1	175	183	PF00244	0.612
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.392
LIG_EH1_1	22	30	PF00400	0.341
LIG_FHA_1	118	124	PF00498	0.409
LIG_FHA_1	24	30	PF00498	0.218
LIG_LIR_Gen_1	116	126	PF02991	0.415
LIG_LIR_Gen_1	127	137	PF02991	0.321
LIG_LIR_Gen_1	50	59	PF02991	0.332
LIG_LIR_Nem_3	116	122	PF02991	0.404
LIG_LIR_Nem_3	127	132	PF02991	0.288
LIG_LIR_Nem_3	142	146	PF02991	0.294
LIG_LIR_Nem_3	43	48	PF02991	0.453
LIG_LIR_Nem_3	50	56	PF02991	0.319
LIG_LIR_Nem_3	61	67	PF02991	0.364
LIG_PDZ_Class_2	178	183	PF00595	0.676
LIG_Pex14_2	104	108	PF04695	0.302
LIG_Pex14_2	135	139	PF04695	0.304
LIG_SH2_SRC	76	79	PF00017	0.679
LIG_SH2_STAP1	146	150	PF00017	0.580
LIG_SH2_STAT5	34	37	PF00017	0.568
LIG_SH2_STAT5	53	56	PF00017	0.383
LIG_SH3_3	64	70	PF00018	0.328
LIG_SUMO_SIM_anti_2	26	33	PF11976	0.170
LIG_WRC_WIRS_1	114	119	PF05994	0.523
LIG_WRC_WIRS_1	96	101	PF05994	0.391
MOD_CDK_SPxxK_3	80	87	PF00069	0.683
MOD_CK1_1	83	89	PF00069	0.679
MOD_GlcNHglycan	165	168	PF01048	0.404
MOD_GlcNHglycan	67	70	PF01048	0.375
MOD_GSK3_1	113	120	PF00069	0.416
MOD_GSK3_1	124	131	PF00069	0.306
MOD_GSK3_1	144	151	PF00069	0.330
MOD_GSK3_1	23	30	PF00069	0.171
MOD_GSK3_1	54	61	PF00069	0.170
MOD_NEK2_1	113	118	PF00069	0.456
MOD_NEK2_1	128	133	PF00069	0.258
MOD_NEK2_1	139	144	PF00069	0.288
MOD_NEK2_1	173	178	PF00069	0.745
MOD_NEK2_1	59	64	PF00069	0.317
MOD_PIKK_1	161	167	PF00454	0.669
MOD_PKA_2	174	180	PF00069	0.705
MOD_Plk_4	128	134	PF00069	0.303
MOD_Plk_4	139	145	PF00069	0.284
MOD_Plk_4	27	33	PF00069	0.181
MOD_Plk_4	59	65	PF00069	0.222
MOD_ProDKin_1	80	86	PF00069	0.644
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.293
TRG_ENDOCYTIC_2	44	47	PF00928	0.489
TRG_ENDOCYTIC_2	53	56	PF00928	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC80	Leptomonas seymouri	70%	100%
A0A0S4J4Y6	Bodo saltans	37%	100%
A0A0S4JQJ3	Bodo saltans	31%	100%
A0A1X0NXC4	Trypanosomatidae	43%	100%
A0A3Q8IF10	Leishmania donovani	93%	100%
A0A422N768	Trypanosoma rangeli	40%	100%
A4HBK6	Leishmania braziliensis	79%	100%
A4HZL0	Leishmania infantum	93%	100%
E9AZH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QCK7	Leishmania major	93%	100%