MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AUX4_LEIMU

TriTrypDb:

LmxM.21.0080

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AUX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.509
CLV_PCSK_SKI1_1	317	321	PF00082	0.247
CLV_PCSK_SKI1_1	412	416	PF00082	0.598
CLV_PCSK_SKI1_1	73	77	PF00082	0.226
DOC_CDC14_PxL_1	165	173	PF14671	0.361
DOC_CYCLIN_RxL_1	170	181	PF00134	0.324
DOC_CYCLIN_RxL_1	46	58	PF00134	0.278
DOC_MAPK_gen_1	317	327	PF00069	0.427
DOC_MAPK_gen_1	9	19	PF00069	0.429
DOC_MAPK_MEF2A_6	12	21	PF00069	0.421
DOC_MAPK_MEF2A_6	320	329	PF00069	0.361
DOC_MAPK_MEF2A_6	77	85	PF00069	0.514
DOC_PP1_RVXF_1	171	178	PF00149	0.324
DOC_PP1_RVXF_1	318	325	PF00149	0.437
DOC_USP7_MATH_1	105	109	PF00917	0.305
DOC_USP7_MATH_1	223	227	PF00917	0.478
DOC_WW_Pin1_4	123	128	PF00397	0.296
DOC_WW_Pin1_4	338	343	PF00397	0.369
LIG_14-3-3_CanoR_1	146	156	PF00244	0.437
LIG_14-3-3_CanoR_1	440	446	PF00244	0.520
LIG_Actin_WH2_2	67	84	PF00022	0.298
LIG_APCC_ABBA_1	273	278	PF00400	0.361
LIG_BRCT_BRCA1_1	265	269	PF00533	0.316
LIG_BRCT_BRCA1_1	284	288	PF00533	0.159
LIG_BRCT_BRCA1_1	410	414	PF00533	0.388
LIG_FHA_1	107	113	PF00498	0.285
LIG_FHA_1	128	134	PF00498	0.304
LIG_FHA_1	170	176	PF00498	0.292
LIG_FHA_1	426	432	PF00498	0.286
LIG_FHA_2	137	143	PF00498	0.416
LIG_FHA_2	179	185	PF00498	0.304
LIG_FHA_2	339	345	PF00498	0.406
LIG_FHA_2	74	80	PF00498	0.469
LIG_FHA_2	87	93	PF00498	0.329
LIG_LIR_Apic_2	137	143	PF02991	0.305
LIG_LIR_Apic_2	248	253	PF02991	0.524
LIG_LIR_Gen_1	162	171	PF02991	0.292
LIG_LIR_Gen_1	176	185	PF02991	0.204
LIG_LIR_Gen_1	193	203	PF02991	0.230
LIG_LIR_Gen_1	270	280	PF02991	0.356
LIG_LIR_Gen_1	355	363	PF02991	0.435
LIG_LIR_Gen_1	4	11	PF02991	0.559
LIG_LIR_Nem_3	108	113	PF02991	0.244
LIG_LIR_Nem_3	162	168	PF02991	0.292
LIG_LIR_Nem_3	176	180	PF02991	0.156
LIG_LIR_Nem_3	181	186	PF02991	0.252
LIG_LIR_Nem_3	270	275	PF02991	0.391
LIG_LIR_Nem_3	278	283	PF02991	0.233
LIG_LIR_Nem_3	285	291	PF02991	0.222
LIG_LIR_Nem_3	293	298	PF02991	0.322
LIG_LIR_Nem_3	355	359	PF02991	0.369
LIG_LIR_Nem_3	4	10	PF02991	0.600
LIG_LIR_Nem_3	444	448	PF02991	0.520
LIG_LIR_Nem_3	57	62	PF02991	0.256
LIG_LIR_Nem_3	76	81	PF02991	0.417
LIG_MLH1_MIPbox_1	410	414	PF16413	0.388
LIG_OCRL_FandH_1	9	21	PF00620	0.385
LIG_PDZ_Class_3	452	457	PF00595	0.550
LIG_Pex14_1	272	276	PF04695	0.284
LIG_Pex14_2	6	10	PF04695	0.581
LIG_Pex14_2	64	68	PF04695	0.331
LIG_PTB_Apo_2	331	338	PF02174	0.304
LIG_REV1ctd_RIR_1	4	13	PF16727	0.473
LIG_SH2_CRK	407	411	PF00017	0.284
LIG_SH2_CRK	78	82	PF00017	0.517
LIG_SH2_NCK_1	376	380	PF00017	0.437
LIG_SH2_PTP2	165	168	PF00017	0.329
LIG_SH2_STAP1	183	187	PF00017	0.284
LIG_SH2_STAP1	280	284	PF00017	0.273
LIG_SH2_STAP1	376	380	PF00017	0.437
LIG_SH2_STAT3	448	451	PF00017	0.611
LIG_SH2_STAT5	165	168	PF00017	0.284
LIG_SH2_STAT5	300	303	PF00017	0.287
LIG_SH2_STAT5	309	312	PF00017	0.253
LIG_SH2_STAT5	314	317	PF00017	0.398
LIG_SH2_STAT5	321	324	PF00017	0.248
LIG_SH2_STAT5	448	451	PF00017	0.539
LIG_SH3_3	121	127	PF00018	0.284
LIG_SH3_3	194	200	PF00018	0.361
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.526
LIG_TRAF2_1	385	388	PF00917	0.524
LIG_TYR_ITIM	163	168	PF00017	0.284
LIG_TYR_ITIM	260	265	PF00017	0.449
LIG_TYR_ITIM	374	379	PF00017	0.284
LIG_TYR_ITIM	405	410	PF00017	0.329
LIG_UBA3_1	67	73	PF00899	0.282
LIG_WRC_WIRS_1	291	296	PF05994	0.304
MOD_CDK_SPxxK_3	338	345	PF00069	0.369
MOD_CK1_1	134	140	PF00069	0.284
MOD_CK1_1	178	184	PF00069	0.419
MOD_CK1_1	241	247	PF00069	0.336
MOD_CK1_1	248	254	PF00069	0.241
MOD_CK2_1	136	142	PF00069	0.382
MOD_CK2_1	178	184	PF00069	0.284
MOD_CK2_1	393	399	PF00069	0.284
MOD_CK2_1	86	92	PF00069	0.368
MOD_GlcNHglycan	121	124	PF01048	0.340
MOD_GlcNHglycan	133	136	PF01048	0.284
MOD_GlcNHglycan	177	180	PF01048	0.398
MOD_GlcNHglycan	204	207	PF01048	0.378
MOD_GlcNHglycan	265	268	PF01048	0.323
MOD_GlcNHglycan	269	272	PF01048	0.336
MOD_GlcNHglycan	390	393	PF01048	0.284
MOD_GSK3_1	119	126	PF00069	0.350
MOD_GSK3_1	127	134	PF00069	0.284
MOD_GSK3_1	155	162	PF00069	0.326
MOD_GSK3_1	169	176	PF00069	0.304
MOD_GSK3_1	209	216	PF00069	0.326
MOD_GSK3_1	221	228	PF00069	0.299
MOD_GSK3_1	241	248	PF00069	0.356
MOD_GSK3_1	263	270	PF00069	0.291
MOD_GSK3_1	278	285	PF00069	0.278
MOD_GSK3_1	408	415	PF00069	0.398
MOD_GSK3_1	417	424	PF00069	0.286
MOD_N-GLC_1	441	446	PF02516	0.376
MOD_NEK2_1	136	141	PF00069	0.354
MOD_NEK2_1	155	160	PF00069	0.308
MOD_NEK2_1	175	180	PF00069	0.350
MOD_NEK2_1	276	281	PF00069	0.354
MOD_NEK2_1	313	318	PF00069	0.306
MOD_NEK2_1	352	357	PF00069	0.393
MOD_NEK2_1	425	430	PF00069	0.302
MOD_NEK2_1	55	60	PF00069	0.342
MOD_NEK2_2	271	276	PF00069	0.298
MOD_NEK2_2	290	295	PF00069	0.120
MOD_PIKK_1	241	247	PF00454	0.406
MOD_PKA_1	173	179	PF00069	0.341
MOD_PKA_2	147	153	PF00069	0.284
MOD_Plk_1	213	219	PF00069	0.414
MOD_Plk_1	343	349	PF00069	0.367
MOD_Plk_1	380	386	PF00069	0.271
MOD_Plk_1	441	447	PF00069	0.380
MOD_Plk_2-3	225	231	PF00069	0.452
MOD_Plk_4	136	142	PF00069	0.413
MOD_Plk_4	178	184	PF00069	0.314
MOD_Plk_4	290	296	PF00069	0.365
MOD_Plk_4	305	311	PF00069	0.205
MOD_Plk_4	345	351	PF00069	0.302
MOD_Plk_4	352	358	PF00069	0.290
MOD_ProDKin_1	123	129	PF00069	0.296
MOD_ProDKin_1	338	344	PF00069	0.369
MOD_SUMO_rev_2	224	228	PF00179	0.350
TRG_DiLeu_BaEn_1	238	243	PF01217	0.361
TRG_DiLeu_BaEn_3	286	292	PF01217	0.341
TRG_ENDOCYTIC_2	165	168	PF00928	0.284
TRG_ENDOCYTIC_2	183	186	PF00928	0.276
TRG_ENDOCYTIC_2	262	265	PF00928	0.354
TRG_ENDOCYTIC_2	280	283	PF00928	0.164
TRG_ENDOCYTIC_2	321	324	PF00928	0.289
TRG_ENDOCYTIC_2	376	379	PF00928	0.284
TRG_ENDOCYTIC_2	407	410	PF00928	0.284
TRG_ENDOCYTIC_2	78	81	PF00928	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJH4	Leptomonas seymouri	80%	99%
A0A0N1ILZ7	Leptomonas seymouri	23%	85%
A0A0S4J692	Bodo saltans	23%	76%
A0A0S4J989	Bodo saltans	49%	92%
A0A1X0NWR8	Trypanosomatidae	25%	95%
A0A1X0NXK8	Trypanosomatidae	65%	100%
A0A3R7NE20	Trypanosoma rangeli	60%	100%
A0A3S7WUW1	Leishmania donovani	23%	89%
A0A3S7WW86	Leishmania donovani	98%	100%
A4HBK5	Leishmania braziliensis	90%	100%
A4HXM1	Leishmania infantum	23%	89%
B2RXV4	Mus musculus	24%	82%
D0A244	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	84%
E9AGU5	Leishmania infantum	98%	100%
O01735	Caenorhabditis elegans	24%	78%
P60815	Rattus norvegicus	22%	84%
Q4QCK8	Leishmania major	96%	100%
Q4QE46	Leishmania major	24%	100%
Q6GNV7	Xenopus laevis	21%	100%
Q8BFQ6	Mus musculus	23%	96%
Q8CE47	Mus musculus	22%	89%
Q91X85	Mus musculus	23%	83%
Q9ES43	Mus terricolor	24%	82%
Q9N1F2	Felis catus	22%	82%
Q9UPI3	Homo sapiens	21%	87%
Q9Y5Y0	Homo sapiens	22%	82%
V5BQV3	Trypanosoma cruzi	25%	83%
V5DGX2	Trypanosoma cruzi	60%	100%