Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUX3_LEIMU

TriTrypDb:

LmxM.21.0070

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AUX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.562
CLV_NRD_NRD_1	109	111	PF00675	0.513
CLV_NRD_NRD_1	223	225	PF00675	0.571
CLV_PCSK_KEX2_1	108	110	PF00082	0.520
CLV_PCSK_KEX2_1	223	225	PF00082	0.571
CLV_PCSK_KEX2_1	267	269	PF00082	0.670
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.601
CLV_PCSK_SKI1_1	112	116	PF00082	0.419
CLV_PCSK_SKI1_1	145	149	PF00082	0.530
CLV_PCSK_SKI1_1	22	26	PF00082	0.483
CLV_PCSK_SKI1_1	264	268	PF00082	0.667
CLV_PCSK_SKI1_1	28	32	PF00082	0.476
CLV_PCSK_SKI1_1	281	285	PF00082	0.689
CLV_PCSK_SKI1_1	46	50	PF00082	0.449
CLV_PCSK_SKI1_1	55	59	PF00082	0.414
DEG_MDM2_SWIB_1	89	96	PF02201	0.660
DEG_Nend_UBRbox_2	1	3	PF02207	0.693
DEG_SPOP_SBC_1	229	233	PF00917	0.735
DOC_CKS1_1	159	164	PF01111	0.707
DOC_CYCLIN_RxL_1	10	21	PF00134	0.633
DOC_CYCLIN_RxL_1	261	273	PF00134	0.333
DOC_MAPK_gen_1	264	272	PF00069	0.466
DOC_MAPK_MEF2A_6	129	136	PF00069	0.574
DOC_MAPK_MEF2A_6	239	247	PF00069	0.531
DOC_PP1_RVXF_1	242	249	PF00149	0.423
DOC_PP1_RVXF_1	44	51	PF00149	0.587
DOC_USP7_MATH_1	139	143	PF00917	0.599
DOC_USP7_MATH_1	192	196	PF00917	0.772
DOC_USP7_MATH_1	197	201	PF00917	0.722
DOC_USP7_MATH_1	230	234	PF00917	0.710
DOC_WW_Pin1_4	158	163	PF00397	0.706
LIG_14-3-3_CanoR_1	22	30	PF00244	0.683
LIG_14-3-3_CanoR_1	279	284	PF00244	0.532
LIG_14-3-3_CanoR_1	46	51	PF00244	0.626
LIG_14-3-3_CterR_2	281	285	PF00244	0.504
LIG_Actin_WH2_2	240	258	PF00022	0.600
LIG_Clathr_ClatBox_1	133	137	PF01394	0.575
LIG_FHA_1	121	127	PF00498	0.621
LIG_FHA_1	19	25	PF00498	0.657
LIG_FHA_1	89	95	PF00498	0.597
LIG_FHA_2	162	168	PF00498	0.702
LIG_FHA_2	216	222	PF00498	0.753
LIG_GBD_Chelix_1	246	254	PF00786	0.500
LIG_GBD_Chelix_1	262	270	PF00786	0.599
LIG_LIR_Gen_1	91	100	PF02991	0.683
LIG_LIR_Nem_3	56	61	PF02991	0.696
LIG_LIR_Nem_3	91	96	PF02991	0.630
LIG_NRBOX	245	251	PF00104	0.502
LIG_NRBOX	265	271	PF00104	0.336
LIG_PCNA_PIPBox_1	30	39	PF02747	0.654
LIG_PDZ_Class_2	280	285	PF00595	0.529
LIG_Pex14_2	107	111	PF04695	0.707
LIG_Pex14_2	124	128	PF04695	0.465
LIG_Pex14_2	89	93	PF04695	0.656
LIG_Pex3_1	246	257	PF04882	0.423
LIG_SH2_STAT3	151	154	PF00017	0.707
LIG_SH2_STAT3	209	212	PF00017	0.766
LIG_SH2_STAT5	85	88	PF00017	0.544
LIG_SH3_3	186	192	PF00018	0.695
LIG_WRC_WIRS_1	47	52	PF05994	0.668
MOD_CDK_SPxxK_3	158	165	PF00069	0.707
MOD_CK1_1	200	206	PF00069	0.751
MOD_CK2_1	161	167	PF00069	0.645
MOD_CK2_1	215	221	PF00069	0.755
MOD_GlcNHglycan	141	144	PF01048	0.441
MOD_GlcNHglycan	203	206	PF01048	0.515
MOD_GlcNHglycan	232	235	PF01048	0.523
MOD_GlcNHglycan	68	71	PF01048	0.380
MOD_GlcNHglycan	78	82	PF01048	0.382
MOD_GSK3_1	18	25	PF00069	0.627
MOD_GSK3_1	193	200	PF00069	0.714
MOD_GSK3_1	211	218	PF00069	0.687
MOD_LATS_1	44	50	PF00433	0.675
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	193	198	PF00069	0.592
MOD_NEK2_1	270	275	PF00069	0.466
MOD_NEK2_1	36	41	PF00069	0.718
MOD_NEK2_2	120	125	PF00069	0.623
MOD_PIKK_1	150	156	PF00454	0.698
MOD_PIKK_1	211	217	PF00454	0.812
MOD_PIKK_1	22	28	PF00454	0.747
MOD_Plk_1	171	177	PF00069	0.654
MOD_Plk_4	184	190	PF00069	0.668
MOD_Plk_4	46	52	PF00069	0.512
MOD_ProDKin_1	158	164	PF00069	0.708
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.380
TRG_ER_diArg_1	107	110	PF00400	0.712
TRG_ER_diArg_1	222	224	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4B3	Leptomonas seymouri	46%	80%
A0A3Q8IA76	Leishmania donovani	91%	100%
A4HBK4	Leishmania braziliensis	74%	100%
A4HZL1	Leishmania infantum	91%	100%
Q4QCK9	Leishmania major	89%	100%