Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AUX2_LEIMU

TriTrypDb:

LmxM.21.0060

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	14
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0015935	small ribosomal subunit	4	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

E9AUX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	2
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0043021	ribonucleoprotein complex binding	3	2
GO:0043022	ribosome binding	4	2
GO:0044877	protein-containing complex binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.742
CLV_PCSK_KEX2_1	311	313	PF00082	0.434
CLV_PCSK_KEX2_1	59	61	PF00082	0.354
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.454
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.354
CLV_PCSK_SKI1_1	110	114	PF00082	0.497
CLV_PCSK_SKI1_1	162	166	PF00082	0.277
CLV_PCSK_SKI1_1	312	316	PF00082	0.360
CLV_PCSK_SKI1_1	53	57	PF00082	0.641
CLV_PCSK_SKI1_1	85	89	PF00082	0.510
CLV_PCSK_SKI1_1	95	99	PF00082	0.408
DEG_SCF_FBW7_1	146	152	PF00400	0.541
DOC_CKS1_1	146	151	PF01111	0.520
DOC_MAPK_DCC_7	405	415	PF00069	0.538
DOC_MAPK_gen_1	414	423	PF00069	0.495
DOC_MAPK_gen_1	93	100	PF00069	0.511
DOC_MAPK_MEF2A_6	69	76	PF00069	0.536
DOC_PP4_FxxP_1	370	373	PF00568	0.527
DOC_USP7_MATH_1	149	153	PF00917	0.470
DOC_USP7_MATH_1	156	160	PF00917	0.447
DOC_USP7_MATH_1	321	325	PF00917	0.526
DOC_USP7_MATH_1	70	74	PF00917	0.602
DOC_USP7_MATH_1	99	103	PF00917	0.444
DOC_USP7_UBL2_3	31	35	PF12436	0.721
DOC_WW_Pin1_4	145	150	PF00397	0.520
LIG_14-3-3_CanoR_1	179	184	PF00244	0.497
LIG_14-3-3_CanoR_1	231	237	PF00244	0.511
LIG_14-3-3_CanoR_1	376	381	PF00244	0.450
LIG_14-3-3_CanoR_1	48	55	PF00244	0.593
LIG_14-3-3_CanoR_1	85	91	PF00244	0.504
LIG_Actin_WH2_2	385	403	PF00022	0.418
LIG_Actin_WH2_2	54	71	PF00022	0.624
LIG_BRCT_BRCA1_1	151	155	PF00533	0.475
LIG_BRCT_BRCA1_1	21	25	PF00533	0.691
LIG_CtBP_PxDLS_1	243	249	PF00389	0.380
LIG_FHA_1	126	132	PF00498	0.471
LIG_FHA_1	161	167	PF00498	0.533
LIG_FHA_1	180	186	PF00498	0.459
LIG_FHA_1	203	209	PF00498	0.475
LIG_FHA_1	345	351	PF00498	0.519
LIG_FHA_1	6	12	PF00498	0.736
LIG_FHA_2	172	178	PF00498	0.330
LIG_FHA_2	184	190	PF00498	0.523
LIG_FHA_2	278	284	PF00498	0.448
LIG_FHA_2	339	345	PF00498	0.527
LIG_FHA_2	376	382	PF00498	0.392
LIG_IBAR_NPY_1	284	286	PF08397	0.543
LIG_LIR_Apic_2	30	36	PF02991	0.665
LIG_LIR_Apic_2	367	373	PF02991	0.517
LIG_LIR_Nem_3	22	28	PF02991	0.677
LIG_LIR_Nem_3	272	276	PF02991	0.385
LIG_LIR_Nem_3	283	289	PF02991	0.411
LIG_LIR_Nem_3	357	362	PF02991	0.421
LIG_LIR_Nem_3	82	87	PF02991	0.419
LIG_NRBOX	75	81	PF00104	0.495
LIG_PCNA_PIPBox_1	363	372	PF02747	0.394
LIG_Pex14_2	87	91	PF04695	0.397
LIG_PTB_Apo_2	333	340	PF02174	0.534
LIG_SH2_CRK	286	290	PF00017	0.456
LIG_SH2_NCK_1	33	37	PF00017	0.760
LIG_SH2_PTP2	417	420	PF00017	0.513
LIG_SH2_STAT3	301	304	PF00017	0.460
LIG_SH2_STAT5	301	304	PF00017	0.377
LIG_SH2_STAT5	417	420	PF00017	0.415
LIG_SH3_3	103	109	PF00018	0.526
LIG_SH3_3	279	285	PF00018	0.524
LIG_SH3_3	37	43	PF00018	0.723
LIG_SH3_3	396	402	PF00018	0.406
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.446
LIG_SUMO_SIM_par_1	387	393	PF11976	0.418
LIG_TYR_ITIM	415	420	PF00017	0.504
LIG_WRC_WIRS_1	377	382	PF05994	0.427
MOD_CK1_1	16	22	PF00069	0.683
MOD_CK1_1	171	177	PF00069	0.369
MOD_CK1_1	187	193	PF00069	0.527
MOD_CK1_1	338	344	PF00069	0.561
MOD_CK2_1	171	177	PF00069	0.404
MOD_CK2_1	277	283	PF00069	0.440
MOD_CK2_1	375	381	PF00069	0.507
MOD_Cter_Amidation	309	312	PF01082	0.482
MOD_GlcNHglycan	151	154	PF01048	0.272
MOD_GlcNHglycan	198	201	PF01048	0.239
MOD_GSK3_1	1	8	PF00069	0.729
MOD_GSK3_1	144	151	PF00069	0.480
MOD_GSK3_1	156	163	PF00069	0.392
MOD_GSK3_1	167	174	PF00069	0.518
MOD_GSK3_1	179	186	PF00069	0.457
MOD_GSK3_1	198	205	PF00069	0.437
MOD_GSK3_1	335	342	PF00069	0.524
MOD_GSK3_1	405	412	PF00069	0.448
MOD_GSK3_1	70	77	PF00069	0.517
MOD_N-GLC_1	13	18	PF02516	0.687
MOD_N-GLC_1	167	172	PF02516	0.403
MOD_N-GLC_1	183	188	PF02516	0.225
MOD_N-GLC_1	335	340	PF02516	0.353
MOD_N-GLC_2	296	298	PF02516	0.574
MOD_N-GLC_2	3	5	PF02516	0.723
MOD_N-GLC_2	394	396	PF02516	0.415
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	183	188	PF00069	0.514
MOD_NEK2_1	196	201	PF00069	0.347
MOD_NEK2_1	232	237	PF00069	0.503
MOD_NEK2_1	262	267	PF00069	0.403
MOD_NEK2_1	287	292	PF00069	0.443
MOD_NEK2_2	335	340	PF00069	0.554
MOD_NMyristoyl	1	7	PF02799	0.729
MOD_PK_1	405	411	PF00069	0.471
MOD_PKA_1	53	59	PF00069	0.667
MOD_PKA_2	375	381	PF00069	0.387
MOD_PKA_2	47	53	PF00069	0.614
MOD_Plk_1	117	123	PF00069	0.434
MOD_Plk_1	160	166	PF00069	0.482
MOD_Plk_1	171	177	PF00069	0.320
MOD_Plk_1	183	189	PF00069	0.462
MOD_Plk_1	202	208	PF00069	0.447
MOD_Plk_4	297	303	PF00069	0.467
MOD_Plk_4	335	341	PF00069	0.544
MOD_Plk_4	405	411	PF00069	0.485
MOD_Plk_4	53	59	PF00069	0.614
MOD_Plk_4	70	76	PF00069	0.536
MOD_Plk_4	86	92	PF00069	0.455
MOD_ProDKin_1	145	151	PF00069	0.520
MOD_SUMO_for_1	34	37	PF00179	0.662
MOD_SUMO_rev_2	215	224	PF00179	0.446
MOD_SUMO_rev_2	46	55	PF00179	0.687
TRG_DiLeu_BaEn_1	393	398	PF01217	0.416
TRG_DiLeu_BaEn_3	383	389	PF01217	0.212
TRG_ENDOCYTIC_2	259	262	PF00928	0.468
TRG_ENDOCYTIC_2	273	276	PF00928	0.364
TRG_ENDOCYTIC_2	286	289	PF00928	0.337
TRG_ENDOCYTIC_2	359	362	PF00928	0.455
TRG_ENDOCYTIC_2	417	420	PF00928	0.448
TRG_ER_diArg_1	413	416	PF00400	0.482
TRG_NES_CRM1_1	65	78	PF08389	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I307	Leptomonas seymouri	65%	98%
A0A0S4IWU9	Bodo saltans	23%	100%
A0A0S4J1I0	Bodo saltans	39%	94%
A0A1X0NQ96	Trypanosomatidae	23%	100%
A0A1X0NQI7	Trypanosomatidae	27%	100%
A0A1X0NYQ0	Trypanosomatidae	47%	94%
A0A3Q8IBR2	Leishmania donovani	94%	100%
A0A3S7XBP3	Leishmania donovani	21%	83%
A0A422N793	Trypanosoma rangeli	45%	96%
A1CUD6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	91%
A4H666	Leishmania braziliensis	24%	100%
A4HBK3	Leishmania braziliensis	78%	100%
A4HGX7	Leishmania braziliensis	24%	100%
A4HZL2	Leishmania infantum	94%	100%
A4IDR0	Leishmania infantum	24%	83%
A4R3M4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	92%
A7MB12	Bos taurus	24%	82%
A8IZG4	Chlamydomonas reinhardtii	23%	100%
B0XM00	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	91%
B3S4I5	Trichoplax adhaerens	25%	100%
B8M0Q1	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	26%	93%
B8P4B0	Postia placenta (strain ATCC 44394 / Madison 698-R)	24%	97%
B8PD53	Postia placenta (strain ATCC 44394 / Madison 698-R)	24%	100%
C4YFX2	Candida albicans (strain WO-1)	25%	83%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A1J9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
D0A8Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D1ZEB4	Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)	23%	92%
E8NHN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	83%
O13615	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	90%
O74319	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	66%
P0CY34	Candida albicans (strain SC5314 / ATCC MYA-2876)	25%	83%
P36130	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	66%
P39014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	66%
P49027	Oryza sativa subsp. japonica	24%	100%
P61964	Homo sapiens	24%	100%
P61965	Mus musculus	24%	100%
P62884	Leishmania infantum	24%	100%
P69103	Trypanosoma brucei brucei	28%	100%
P69104	Trypanosoma brucei rhodesiense	28%	100%
Q0D0X6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	95%
Q0U1B1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	92%
Q229Z6	Tetrahymena thermophila (strain SB210)	20%	67%
Q2KIG2	Bos taurus	24%	100%
Q3KQ62	Xenopus laevis	25%	100%
Q498M4	Rattus norvegicus	24%	100%
Q4P9P9	Ustilago maydis (strain 521 / FGSC 9021)	21%	94%
Q4Q0T1	Leishmania major	21%	83%
Q4Q7Y7	Leishmania major	24%	100%
Q4QCL0	Leishmania major	94%	100%
Q4QHD6	Leishmania major	24%	100%
Q4WLM7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	91%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	21%	94%
Q5BK30	Rattus norvegicus	22%	100%
Q5FWQ6	Xenopus laevis	22%	100%
Q5M786	Xenopus tropicalis	24%	100%
Q5XGI5	Xenopus tropicalis	23%	100%
Q6DH44	Danio rerio	25%	100%
Q6FLI3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	20%	73%
Q6L4F8	Oryza sativa subsp. japonica	25%	100%
Q6P2Y2	Xenopus tropicalis	22%	100%
Q76LS6	Leishmania donovani	24%	100%
Q7RY30	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	94%
Q8I0F4	Dictyostelium discoideum	24%	100%
Q9LV28	Arabidopsis thaliana	21%	100%
V5BDQ2	Trypanosoma cruzi	25%	100%
V5BFZ8	Trypanosoma cruzi	44%	100%