Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUX1_LEIMU

TriTrypDb:

LmxM.21.0055

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006720	isoprenoid metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008299	isoprenoid biosynthetic process	4	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.440
CLV_C14_Caspase3-7	412	416	PF00656	0.425
CLV_NRD_NRD_1	12	14	PF00675	0.442
CLV_NRD_NRD_1	246	248	PF00675	0.442
CLV_NRD_NRD_1	376	378	PF00675	0.450
CLV_PCSK_KEX2_1	12	14	PF00082	0.441
CLV_PCSK_KEX2_1	376	378	PF00082	0.470
CLV_PCSK_SKI1_1	158	162	PF00082	0.414
CLV_PCSK_SKI1_1	21	25	PF00082	0.419
CLV_PCSK_SKI1_1	351	355	PF00082	0.358
CLV_PCSK_SKI1_1	64	68	PF00082	0.400
DEG_APCC_DBOX_1	262	270	PF00400	0.426
DOC_ANK_TNKS_1	410	417	PF00023	0.467
DOC_CKS1_1	438	443	PF01111	0.502
DOC_CYCLIN_RxL_1	61	70	PF00134	0.422
DOC_MAPK_gen_1	247	253	PF00069	0.464
DOC_MAPK_gen_1	376	384	PF00069	0.393
DOC_PP1_RVXF_1	156	163	PF00149	0.437
DOC_PP1_RVXF_1	84	90	PF00149	0.508
DOC_WW_Pin1_4	302	307	PF00397	0.584
DOC_WW_Pin1_4	38	43	PF00397	0.585
DOC_WW_Pin1_4	437	442	PF00397	0.509
LIG_14-3-3_CanoR_1	189	199	PF00244	0.368
LIG_14-3-3_CanoR_1	230	235	PF00244	0.379
LIG_14-3-3_CanoR_1	263	267	PF00244	0.485
LIG_14-3-3_CanoR_1	404	410	PF00244	0.648
LIG_14-3-3_CanoR_1	437	441	PF00244	0.620
LIG_14-3-3_CanoR_1	91	95	PF00244	0.580
LIG_Actin_WH2_2	62	79	PF00022	0.392
LIG_Actin_WH2_2	99	117	PF00022	0.497
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BRCT_BRCA1_1	255	259	PF00533	0.351
LIG_eIF4E_1	19	25	PF01652	0.551
LIG_eIF4E_1	365	371	PF01652	0.374
LIG_FHA_1	109	115	PF00498	0.531
LIG_FHA_1	118	124	PF00498	0.676
LIG_FHA_1	164	170	PF00498	0.517
LIG_FHA_1	185	191	PF00498	0.494
LIG_FHA_1	2	8	PF00498	0.573
LIG_FHA_1	358	364	PF00498	0.468
LIG_FHA_1	366	372	PF00498	0.332
LIG_FHA_1	82	88	PF00498	0.399
LIG_FHA_2	29	35	PF00498	0.547
LIG_FHA_2	333	339	PF00498	0.386
LIG_FHA_2	373	379	PF00498	0.493
LIG_LIR_Apic_2	436	441	PF02991	0.457
LIG_LIR_Gen_1	256	266	PF02991	0.388
LIG_LIR_Gen_1	366	373	PF02991	0.423
LIG_LIR_Nem_3	137	142	PF02991	0.427
LIG_LIR_Nem_3	256	262	PF02991	0.341
LIG_LIR_Nem_3	311	316	PF02991	0.485
LIG_LIR_Nem_3	347	353	PF02991	0.361
LIG_LIR_Nem_3	366	370	PF02991	0.280
LIG_LIR_Nem_3	387	393	PF02991	0.440
LIG_LYPXL_SIV_4	18	26	PF13949	0.475
LIG_Pex14_1	85	89	PF04695	0.370
LIG_Pex14_2	349	353	PF04695	0.441
LIG_SH2_CRK	288	292	PF00017	0.267
LIG_SH2_CRK	313	317	PF00017	0.417
LIG_SH2_CRK	367	371	PF00017	0.419
LIG_SH2_SRC	313	316	PF00017	0.558
LIG_SH2_STAP1	19	23	PF00017	0.546
LIG_SH2_STAP1	288	292	PF00017	0.267
LIG_SH2_STAP1	365	369	PF00017	0.395
LIG_SH2_STAT5	168	171	PF00017	0.501
LIG_SH2_STAT5	315	318	PF00017	0.433
LIG_SH2_STAT5	367	370	PF00017	0.389
LIG_SH2_STAT5	393	396	PF00017	0.473
LIG_SH2_STAT5	419	422	PF00017	0.520
LIG_SH3_3	281	287	PF00018	0.407
LIG_SH3_CIN85_PxpxPR_1	59	64	PF14604	0.504
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.542
LIG_SUMO_SIM_par_1	484	489	PF11976	0.399
LIG_SxIP_EBH_1	387	400	PF03271	0.496
LIG_UBA3_1	66	74	PF00899	0.543
MOD_CK1_1	2	8	PF00069	0.511
MOD_CK1_1	233	239	PF00069	0.364
MOD_CK1_1	33	39	PF00069	0.674
MOD_CK1_1	386	392	PF00069	0.518
MOD_CK1_1	41	47	PF00069	0.441
MOD_CK1_1	422	428	PF00069	0.455
MOD_CK1_1	90	96	PF00069	0.470
MOD_CK2_1	255	261	PF00069	0.461
MOD_CK2_1	28	34	PF00069	0.561
MOD_CK2_1	332	338	PF00069	0.551
MOD_CK2_1	372	378	PF00069	0.512
MOD_CK2_1	464	470	PF00069	0.466
MOD_GlcNHglycan	1	4	PF01048	0.402
MOD_GlcNHglycan	154	157	PF01048	0.411
MOD_GlcNHglycan	235	238	PF01048	0.402
MOD_GlcNHglycan	254	258	PF01048	0.356
MOD_GlcNHglycan	308	311	PF01048	0.550
MOD_GlcNHglycan	316	319	PF01048	0.419
MOD_GlcNHglycan	412	415	PF01048	0.547
MOD_GlcNHglycan	77	80	PF01048	0.512
MOD_GSK3_1	109	116	PF00069	0.570
MOD_GSK3_1	163	170	PF00069	0.308
MOD_GSK3_1	249	256	PF00069	0.336
MOD_GSK3_1	287	294	PF00069	0.415
MOD_GSK3_1	29	36	PF00069	0.535
MOD_GSK3_1	296	303	PF00069	0.551
MOD_GSK3_1	37	44	PF00069	0.528
MOD_GSK3_1	394	401	PF00069	0.574
MOD_GSK3_1	405	412	PF00069	0.500
MOD_GSK3_1	415	422	PF00069	0.501
MOD_NEK2_1	253	258	PF00069	0.406
MOD_NEK2_1	291	296	PF00069	0.410
MOD_NEK2_1	383	388	PF00069	0.402
MOD_NEK2_1	396	401	PF00069	0.489
MOD_NEK2_1	405	410	PF00069	0.573
MOD_NEK2_1	67	72	PF00069	0.447
MOD_NEK2_1	87	92	PF00069	0.392
MOD_PIKK_1	221	227	PF00454	0.412
MOD_PIKK_1	33	39	PF00454	0.621
MOD_PIKK_1	332	338	PF00454	0.383
MOD_PIKK_1	394	400	PF00454	0.678
MOD_PKA_2	262	268	PF00069	0.564
MOD_PKA_2	410	416	PF00069	0.624
MOD_PKA_2	422	428	PF00069	0.493
MOD_PKA_2	436	442	PF00069	0.566
MOD_PKA_2	90	96	PF00069	0.541
MOD_Plk_1	108	114	PF00069	0.613
MOD_Plk_1	127	133	PF00069	0.482
MOD_Plk_1	365	371	PF00069	0.396
MOD_Plk_4	109	115	PF00069	0.566
MOD_Plk_4	128	134	PF00069	0.547
MOD_Plk_4	255	261	PF00069	0.371
MOD_Plk_4	308	314	PF00069	0.602
MOD_Plk_4	386	392	PF00069	0.520
MOD_Plk_4	415	421	PF00069	0.495
MOD_Plk_4	422	428	PF00069	0.407
MOD_Plk_4	474	480	PF00069	0.665
MOD_ProDKin_1	302	308	PF00069	0.582
MOD_ProDKin_1	38	44	PF00069	0.582
MOD_ProDKin_1	437	443	PF00069	0.511
TRG_DiLeu_BaEn_1	20	25	PF01217	0.563
TRG_DiLeu_BaEn_1	6	11	PF01217	0.584
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.533
TRG_ENDOCYTIC_2	139	142	PF00928	0.422
TRG_ENDOCYTIC_2	19	22	PF00928	0.545
TRG_ENDOCYTIC_2	288	291	PF00928	0.272
TRG_ENDOCYTIC_2	313	316	PF00928	0.425
TRG_ENDOCYTIC_2	350	353	PF00928	0.315
TRG_ENDOCYTIC_2	367	370	PF00928	0.369
TRG_ENDOCYTIC_2	393	396	PF00928	0.568
TRG_ER_diArg_1	11	13	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWC8	Leptomonas seymouri	47%	97%
A0A1X0NXR3	Trypanosomatidae	28%	92%
A0A3Q8IBT1	Leishmania donovani	92%	100%
A0A3R7K7L8	Trypanosoma rangeli	28%	94%
A4HBK2	Leishmania braziliensis	81%	100%
A4HZL3	Leishmania infantum	93%	100%
D0A1J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	96%
Q4QCL1	Leishmania major	91%	100%
V5BQ24	Trypanosoma cruzi	26%	100%