Putative syntaxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative syntaxin

Gene product:

syntaxin, putative

Species:

Leishmania mexicana

UniProt:

E9AUX0_LEIMU

TriTrypDb:

LmxM.21.0050

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005886	plasma membrane	3	1
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9AUX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUX0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0006886	intracellular protein transport	4	1
GO:0006887	exocytosis	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0016192	vesicle-mediated transport	4	4
GO:0022406	membrane docking	2	1
GO:0032940	secretion by cell	3	1
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046903	secretion	4	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.591
CLV_PCSK_SKI1_1	22	26	PF00082	0.324
CLV_PCSK_SKI1_1	43	47	PF00082	0.399
CLV_PCSK_SKI1_1	57	61	PF00082	0.315
CLV_Separin_Metazoa	58	62	PF03568	0.618
DEG_Nend_Nbox_1	1	3	PF02207	0.717
DOC_MAPK_gen_1	160	169	PF00069	0.607
DOC_MAPK_gen_1	211	220	PF00069	0.410
DOC_MAPK_MEF2A_6	185	194	PF00069	0.516
DOC_MAPK_MEF2A_6	213	222	PF00069	0.252
DOC_PP1_RVXF_1	152	158	PF00149	0.605
DOC_USP7_MATH_1	122	126	PF00917	0.711
DOC_USP7_MATH_1	206	210	PF00917	0.465
DOC_USP7_UBL2_3	69	73	PF12436	0.644
DOC_WW_Pin1_4	118	123	PF00397	0.727
DOC_WW_Pin1_4	32	37	PF00397	0.613
LIG_14-3-3_CanoR_1	111	119	PF00244	0.601
LIG_14-3-3_CanoR_1	154	158	PF00244	0.591
LIG_Actin_WH2_2	148	165	PF00022	0.606
LIG_Actin_WH2_2	180	197	PF00022	0.516
LIG_AP2alpha_2	5	7	PF02296	0.518
LIG_APCC_ABBA_1	167	172	PF00400	0.698
LIG_BRCT_BRCA1_1	3	7	PF00533	0.597
LIG_CaM_IQ_9	187	202	PF13499	0.498
LIG_FHA_1	154	160	PF00498	0.631
LIG_FHA_2	46	52	PF00498	0.593
LIG_LIR_Gen_1	99	109	PF02991	0.579
LIG_LIR_Nem_3	99	104	PF02991	0.569
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.464
LIG_Pex14_2	222	226	PF04695	0.361
LIG_SH2_NCK_1	101	105	PF00017	0.576
LIG_SH2_STAP1	101	105	PF00017	0.632
LIG_SH3_3	116	122	PF00018	0.714
LIG_SH3_3	30	36	PF00018	0.615
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.336
LIG_TRAF2_1	48	51	PF00917	0.561
LIG_UBA3_1	204	213	PF00899	0.471
LIG_UBA3_1	52	57	PF00899	0.608
MOD_CK1_1	35	41	PF00069	0.617
MOD_CK2_1	118	124	PF00069	0.732
MOD_CK2_1	35	41	PF00069	0.605
MOD_CK2_1	45	51	PF00069	0.530
MOD_CK2_1	7	13	PF00069	0.579
MOD_CK2_1	73	79	PF00069	0.542
MOD_CK2_1	96	102	PF00069	0.565
MOD_GlcNHglycan	106	109	PF01048	0.410
MOD_GlcNHglycan	134	137	PF01048	0.483
MOD_GlcNHglycan	186	190	PF01048	0.278
MOD_GlcNHglycan	75	78	PF01048	0.409
MOD_GSK3_1	118	125	PF00069	0.700
MOD_N-GLC_1	7	12	PF02516	0.420
MOD_NEK2_1	162	167	PF00069	0.615
MOD_NEK2_1	204	209	PF00069	0.471
MOD_NEK2_1	7	12	PF00069	0.544
MOD_PIKK_1	172	178	PF00454	0.666
MOD_PIKK_1	26	32	PF00454	0.636
MOD_PKA_2	112	118	PF00069	0.584
MOD_PKA_2	153	159	PF00069	0.585
MOD_PKA_2	162	168	PF00069	0.604
MOD_Plk_1	7	13	PF00069	0.557
MOD_Plk_2-3	96	102	PF00069	0.589
MOD_Plk_4	213	219	PF00069	0.270
MOD_ProDKin_1	118	124	PF00069	0.728
MOD_ProDKin_1	32	38	PF00069	0.610
MOD_SUMO_rev_2	143	147	PF00179	0.668
MOD_SUMO_rev_2	38	48	PF00179	0.615
TRG_DiLeu_BaEn_3	50	56	PF01217	0.592
TRG_ENDOCYTIC_2	101	104	PF00928	0.619
TRG_ER_diArg_1	111	114	PF00400	0.648
TRG_ER_diArg_1	192	195	PF00400	0.502
TRG_NES_CRM1_1	50	65	PF08389	0.559
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.357
TRG_PTS2	1	28	PF00400	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	73%	98%
A0A0S4J237	Bodo saltans	28%	81%
A0A0S4JJL1	Bodo saltans	31%	95%
A0A1X0NSP4	Trypanosomatidae	30%	97%
A0A1X0NXA4	Trypanosomatidae	45%	100%
A0A3Q8IBW4	Leishmania donovani	94%	100%
A0A3R7M3G3	Trypanosoma rangeli	43%	100%
A4HBK1	Leishmania braziliensis	82%	100%
A4HZL4	Leishmania infantum	94%	100%
D0A1J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QCL2	Leishmania major	95%	100%
Q54IX6	Dictyostelium discoideum	24%	93%
V5BUP0	Trypanosoma cruzi	28%	98%