BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUW9_LEIMU

TriTrypDb:

LmxM.21.0040

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.596
CLV_NRD_NRD_1	168	170	PF00675	0.413
CLV_NRD_NRD_1	24	26	PF00675	0.525
CLV_NRD_NRD_1	51	53	PF00675	0.560
CLV_PCSK_FUR_1	24	28	PF00082	0.530
CLV_PCSK_KEX2_1	127	129	PF00082	0.552
CLV_PCSK_KEX2_1	168	170	PF00082	0.451
CLV_PCSK_KEX2_1	24	26	PF00082	0.435
CLV_PCSK_KEX2_1	51	53	PF00082	0.525
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.519
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.456
CLV_PCSK_PC7_1	123	129	PF00082	0.329
CLV_PCSK_SKI1_1	154	158	PF00082	0.450
CLV_PCSK_SKI1_1	27	31	PF00082	0.478
CLV_PCSK_SKI1_1	8	12	PF00082	0.561
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DOC_CYCLIN_RxL_1	151	159	PF00134	0.377
DOC_MAPK_gen_1	6	13	PF00069	0.647
DOC_USP7_MATH_1	102	106	PF00917	0.472
DOC_USP7_MATH_1	175	179	PF00917	0.470
DOC_USP7_MATH_1	204	208	PF00917	0.382
DOC_USP7_MATH_1	46	50	PF00917	0.444
DOC_USP7_UBL2_3	154	158	PF12436	0.526
DOC_USP7_UBL2_3	26	30	PF12436	0.319
DOC_USP7_UBL2_3	8	12	PF12436	0.569
LIG_14-3-3_CanoR_1	151	157	PF00244	0.637
LIG_14-3-3_CanoR_1	194	202	PF00244	0.367
LIG_Actin_WH2_2	209	226	PF00022	0.500
LIG_BRCT_BRCA1_1	216	220	PF00533	0.411
LIG_BRCT_BRCA1_1	60	64	PF00533	0.432
LIG_FHA_1	109	115	PF00498	0.527
LIG_FHA_1	197	203	PF00498	0.577
LIG_FHA_2	135	141	PF00498	0.568
LIG_FHA_2	15	21	PF00498	0.521
LIG_FHA_2	39	45	PF00498	0.467
LIG_FHA_2	93	99	PF00498	0.433
LIG_LIR_Apic_2	226	232	PF02991	0.385
LIG_LIR_Gen_1	61	71	PF02991	0.494
LIG_LIR_Nem_3	134	138	PF02991	0.469
LIG_LIR_Nem_3	217	223	PF02991	0.491
LIG_LIR_Nem_3	61	67	PF02991	0.388
LIG_LIR_Nem_3	94	99	PF02991	0.552
LIG_LYPXL_yS_3	70	73	PF13949	0.367
LIG_Rb_pABgroove_1	112	120	PF01858	0.354
LIG_SH2_GRB2like	161	164	PF00017	0.293
LIG_SH2_PTP2	229	232	PF00017	0.388
LIG_SH2_STAT5	229	232	PF00017	0.388
LIG_UBA3_1	4	12	PF00899	0.668
MOD_CK1_1	195	201	PF00069	0.349
MOD_CK1_1	207	213	PF00069	0.333
MOD_CK1_1	74	80	PF00069	0.487
MOD_CK2_1	134	140	PF00069	0.522
MOD_CK2_1	14	20	PF00069	0.569
MOD_CK2_1	38	44	PF00069	0.480
MOD_CK2_1	92	98	PF00069	0.566
MOD_Cter_Amidation	125	128	PF01082	0.293
MOD_GlcNHglycan	177	180	PF01048	0.453
MOD_GSK3_1	102	109	PF00069	0.439
MOD_GSK3_1	140	147	PF00069	0.508
MOD_GSK3_1	152	159	PF00069	0.498
MOD_GSK3_1	192	199	PF00069	0.445
MOD_N-GLC_1	71	76	PF02516	0.456
MOD_NEK2_1	103	108	PF00069	0.329
MOD_NEK2_1	156	161	PF00069	0.461
MOD_NEK2_1	190	195	PF00069	0.549
MOD_NEK2_1	84	89	PF00069	0.503
MOD_PKA_1	144	150	PF00069	0.450
MOD_PKA_2	150	156	PF00069	0.521
MOD_Plk_1	103	109	PF00069	0.431
MOD_Plk_1	58	64	PF00069	0.433
MOD_Plk_2-3	134	140	PF00069	0.512
MOD_Plk_2-3	92	98	PF00069	0.323
MOD_Plk_4	103	109	PF00069	0.418
MOD_Plk_4	152	158	PF00069	0.645
MOD_SUMO_rev_2	177	183	PF00179	0.534
TRG_DiLeu_BaEn_4	218	224	PF01217	0.271
TRG_ENDOCYTIC_2	70	73	PF00928	0.490
TRG_ER_diArg_1	24	27	PF00400	0.532
TRG_ER_diArg_1	51	53	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S1	Leptomonas seymouri	53%	100%
A0A0N1PD85	Leptomonas seymouri	34%	100%
A0A1X0NEE3	Trypanosomatidae	26%	89%
A0A1X0NFG5	Trypanosomatidae	26%	89%
A0A1X0NXA6	Trypanosomatidae	25%	81%
A0A1X0NXA8	Trypanosomatidae	36%	100%
A0A3Q8IKU7	Leishmania donovani	31%	100%
A0A3S5H792	Leishmania donovani	90%	100%
A0A3S5H7I1	Leishmania donovani	25%	72%
A0A422MZP2	Trypanosoma rangeli	27%	81%
A4HBJ9	Leishmania braziliensis	32%	100%
A4HBK0	Leishmania braziliensis	60%	100%
A4HFU7	Leishmania braziliensis	26%	72%
A4HZL5	Leishmania infantum	90%	100%
A4HZL6	Leishmania infantum	31%	100%
A4I2W4	Leishmania infantum	25%	72%
E9ADF0	Leishmania major	23%	72%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	72%
Q4Q6I6	Leishmania major	24%	100%
Q4QCL3	Leishmania major	82%	100%
Q4QCL4	Leishmania major	31%	100%
V5BG41	Trypanosoma cruzi	38%	100%
V5BKK3	Trypanosoma cruzi	28%	81%