Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUW7_LEIMU

TriTrypDb:

LmxM.21.0027

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.482
CLV_PCSK_KEX2_1	163	165	PF00082	0.482
CLV_Separin_Metazoa	212	216	PF03568	0.376
DEG_APCC_DBOX_1	113	121	PF00400	0.398
DOC_MAPK_gen_1	236	245	PF00069	0.405
DOC_MAPK_MEF2A_6	101	109	PF00069	0.462
DOC_USP7_MATH_1	22	26	PF00917	0.542
DOC_USP7_MATH_1	65	69	PF00917	0.516
DOC_WW_Pin1_4	164	169	PF00397	0.494
DOC_WW_Pin1_4	194	199	PF00397	0.448
DOC_WW_Pin1_4	61	66	PF00397	0.537
LIG_14-3-3_CanoR_1	43	48	PF00244	0.451
LIG_14-3-3_CanoR_1	5	11	PF00244	0.558
LIG_APCC_ABBA_1	45	50	PF00400	0.447
LIG_BIR_II_1	1	5	PF00653	0.485
LIG_BRCT_BRCA1_1	190	194	PF00533	0.404
LIG_FHA_1	104	110	PF00498	0.437
LIG_FHA_1	35	41	PF00498	0.485
LIG_FHA_2	129	135	PF00498	0.438
LIG_LIR_Gen_1	240	250	PF02991	0.513
LIG_LIR_Gen_1	42	52	PF02991	0.428
LIG_LIR_Nem_3	240	245	PF02991	0.510
LIG_LIR_Nem_3	42	48	PF02991	0.340
LIG_NRP_CendR_1	253	256	PF00754	0.554
LIG_SH2_CRK	145	149	PF00017	0.376
LIG_SH2_STAT5	226	229	PF00017	0.376
LIG_SH3_3	162	168	PF00018	0.494
LIG_SUMO_SIM_par_1	103	108	PF11976	0.406
MOD_CDC14_SPxK_1	64	67	PF00782	0.338
MOD_CDK_SPxK_1	61	67	PF00069	0.302
MOD_CK1_1	14	20	PF00069	0.637
MOD_CK1_1	188	194	PF00069	0.481
MOD_CK1_1	248	254	PF00069	0.354
MOD_CK2_1	128	134	PF00069	0.519
MOD_CK2_1	248	254	PF00069	0.354
MOD_DYRK1A_RPxSP_1	164	168	PF00069	0.418
MOD_GlcNHglycan	180	183	PF01048	0.411
MOD_GlcNHglycan	84	87	PF01048	0.499
MOD_GSK3_1	105	112	PF00069	0.369
MOD_GSK3_1	185	192	PF00069	0.471
MOD_GSK3_1	194	201	PF00069	0.396
MOD_GSK3_1	39	46	PF00069	0.363
MOD_GSK3_1	61	68	PF00069	0.447
MOD_N-GLC_1	150	155	PF02516	0.422
MOD_N-GLC_1	52	57	PF02516	0.482
MOD_N-GLC_2	98	100	PF02516	0.413
MOD_NEK2_1	105	110	PF00069	0.396
MOD_NEK2_1	11	16	PF00069	0.526
MOD_NEK2_1	150	155	PF00069	0.447
MOD_NEK2_1	186	191	PF00069	0.347
MOD_NEK2_1	23	28	PF00069	0.564
MOD_NEK2_1	34	39	PF00069	0.459
MOD_NEK2_1	4	9	PF00069	0.548
MOD_NEK2_2	198	203	PF00069	0.495
MOD_OFUCOSY	12	18	PF10250	0.647
MOD_PKA_2	4	10	PF00069	0.708
MOD_Plk_1	150	156	PF00069	0.429
MOD_Plk_4	128	134	PF00069	0.490
MOD_Plk_4	189	195	PF00069	0.545
MOD_Plk_4	245	251	PF00069	0.442
MOD_ProDKin_1	164	170	PF00069	0.496
MOD_ProDKin_1	194	200	PF00069	0.449
MOD_ProDKin_1	61	67	PF00069	0.548
MOD_SUMO_for_1	202	205	PF00179	0.436
MOD_SUMO_rev_2	225	231	PF00179	0.395
TRG_ER_diArg_1	163	165	PF00400	0.482
TRG_NES_CRM1_1	208	221	PF08389	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IYT2	Bodo saltans	27%	80%
A0A1X0NXA5	Trypanosomatidae	32%	94%
A0A3Q8IB00	Leishmania donovani	88%	100%
A0A3R7N8W3	Trypanosoma rangeli	33%	97%
A4HBJ8	Leishmania braziliensis	64%	100%
D0A1J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
E9AGU4	Leishmania infantum	89%	100%
Q4QCL5	Leishmania major	87%	100%