tRNA N(3)-methylcytidine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AUW5_LEIMU

TriTrypDb:

LmxM.21.0020

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUW5

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	13
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006396	RNA processing	6	5
GO:0006399	tRNA metabolic process	7	5
GO:0006400	tRNA modification	6	5
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008033	tRNA processing	8	5
GO:0008152	metabolic process	1	13
GO:0009451	RNA modification	5	13
GO:0009987	cellular process	1	13
GO:0016070	RNA metabolic process	5	13
GO:0030488	tRNA methylation	5	5
GO:0032259	methylation	2	13
GO:0034470	ncRNA processing	7	5
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034660	ncRNA metabolic process	6	5
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043414	macromolecule methylation	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.529
CLV_NRD_NRD_1	324	326	PF00675	0.432
CLV_PCSK_KEX2_1	190	192	PF00082	0.296
CLV_PCSK_KEX2_1	243	245	PF00082	0.302
CLV_PCSK_KEX2_1	329	331	PF00082	0.359
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.319
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.194
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.359
CLV_PCSK_PC7_1	325	331	PF00082	0.388
CLV_PCSK_SKI1_1	240	244	PF00082	0.282
DEG_APCC_DBOX_1	164	172	PF00400	0.488
DEG_Nend_UBRbox_2	1	3	PF02207	0.633
DOC_CKS1_1	184	189	PF01111	0.347
DOC_MAPK_DCC_7	163	173	PF00069	0.530
DOC_MAPK_gen_1	243	254	PF00069	0.425
DOC_MAPK_gen_1	325	336	PF00069	0.391
DOC_MAPK_MEF2A_6	216	225	PF00069	0.538
DOC_USP7_MATH_1	208	212	PF00917	0.522
DOC_USP7_MATH_1	62	66	PF00917	0.349
DOC_USP7_UBL2_3	243	247	PF12436	0.536
DOC_USP7_UBL2_3	270	274	PF12436	0.532
DOC_USP7_UBL2_3	329	333	PF12436	0.375
DOC_WW_Pin1_4	106	111	PF00397	0.510
DOC_WW_Pin1_4	141	146	PF00397	0.550
DOC_WW_Pin1_4	183	188	PF00397	0.347
LIG_14-3-3_CanoR_1	163	169	PF00244	0.472
LIG_Actin_WH2_2	228	245	PF00022	0.517
LIG_Actin_WH2_2	86	103	PF00022	0.453
LIG_APCC_ABBA_1	251	256	PF00400	0.487
LIG_Clathr_ClatBox_1	305	309	PF01394	0.493
LIG_deltaCOP1_diTrp_1	73	80	PF00928	0.514
LIG_FHA_1	183	189	PF00498	0.532
LIG_FHA_1	197	203	PF00498	0.474
LIG_FHA_1	284	290	PF00498	0.459
LIG_FHA_1	300	306	PF00498	0.318
LIG_FHA_1	337	343	PF00498	0.398
LIG_FHA_2	130	136	PF00498	0.503
LIG_FHA_2	178	184	PF00498	0.529
LIG_FHA_2	204	210	PF00498	0.547
LIG_FHA_2	39	45	PF00498	0.537
LIG_IBAR_NPY_1	4	6	PF08397	0.426
LIG_LIR_Apic_2	256	260	PF02991	0.334
LIG_LIR_Gen_1	214	225	PF02991	0.440
LIG_LIR_LC3C_4	199	202	PF02991	0.503
LIG_LIR_Nem_3	135	141	PF02991	0.523
LIG_LIR_Nem_3	214	220	PF02991	0.466
LIG_LIR_Nem_3	261	267	PF02991	0.410
LIG_Pex14_1	76	80	PF04695	0.410
LIG_Pex14_2	291	295	PF04695	0.360
LIG_PTB_Apo_2	274	281	PF02174	0.471
LIG_PTB_Apo_2	334	341	PF02174	0.343
LIG_REV1ctd_RIR_1	262	270	PF16727	0.435
LIG_REV1ctd_RIR_1	288	297	PF16727	0.423
LIG_SH2_NCK_1	257	261	PF00017	0.340
LIG_SH2_PTP2	6	9	PF00017	0.412
LIG_SH2_SRC	6	9	PF00017	0.412
LIG_SH2_SRC	92	95	PF00017	0.395
LIG_SH2_STAT5	160	163	PF00017	0.536
LIG_SH2_STAT5	6	9	PF00017	0.412
LIG_SH2_STAT5	92	95	PF00017	0.343
LIG_SH3_3	181	187	PF00018	0.526
LIG_SH3_3	69	75	PF00018	0.651
LIG_SUMO_SIM_anti_2	218	224	PF11976	0.483
LIG_SUMO_SIM_par_1	198	203	PF11976	0.562
LIG_SUMO_SIM_par_1	304	310	PF11976	0.489
LIG_TRAF2_1	67	70	PF00917	0.624
LIG_TRFH_1	340	344	PF08558	0.439
LIG_UBA3_1	235	243	PF00899	0.466
MOD_CDK_SPxxK_3	183	190	PF00069	0.347
MOD_CK1_1	146	152	PF00069	0.491
MOD_CK1_1	313	319	PF00069	0.427
MOD_CK1_1	64	70	PF00069	0.596
MOD_CK2_1	38	44	PF00069	0.443
MOD_CK2_1	64	70	PF00069	0.621
MOD_Cter_Amidation	327	330	PF01082	0.450
MOD_GlcNHglycan	145	148	PF01048	0.285
MOD_GlcNHglycan	226	229	PF01048	0.309
MOD_GlcNHglycan	236	239	PF01048	0.298
MOD_GlcNHglycan	80	83	PF01048	0.566
MOD_GSK3_1	14	21	PF00069	0.541
MOD_GSK3_1	146	153	PF00069	0.493
MOD_GSK3_1	224	231	PF00069	0.462
MOD_N-GLC_1	196	201	PF02516	0.302
MOD_N-GLC_1	336	341	PF02516	0.376
MOD_NEK2_1	224	229	PF00069	0.455
MOD_NEK2_1	299	304	PF00069	0.406
MOD_NEK2_1	78	83	PF00069	0.553
MOD_PIKK_1	130	136	PF00454	0.347
MOD_PIKK_1	284	290	PF00454	0.464
MOD_PKA_2	164	170	PF00069	0.372
MOD_PKA_2	18	24	PF00069	0.595
MOD_Plk_1	196	202	PF00069	0.536
MOD_Plk_1	208	214	PF00069	0.508
MOD_Plk_4	120	126	PF00069	0.466
MOD_Plk_4	164	170	PF00069	0.482
MOD_Plk_4	196	202	PF00069	0.470
MOD_ProDKin_1	106	112	PF00069	0.504
MOD_ProDKin_1	141	147	PF00069	0.550
MOD_ProDKin_1	183	189	PF00069	0.347
MOD_SUMO_rev_2	209	217	PF00179	0.521
MOD_SUMO_rev_2	269	275	PF00179	0.509
MOD_SUMO_rev_2	30	38	PF00179	0.436
TRG_DiLeu_BaEn_1	196	201	PF01217	0.439
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.369
TRG_ENDOCYTIC_2	292	295	PF00928	0.331
TRG_ENDOCYTIC_2	6	9	PF00928	0.412
TRG_ER_diArg_1	10	13	PF00400	0.639
TRG_ER_diArg_1	163	166	PF00400	0.347
TRG_ER_diArg_1	191	194	PF00400	0.482
TRG_NLS_MonoExtC_3	189	195	PF00514	0.519
TRG_NLS_MonoExtN_4	187	194	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J3	Leptomonas seymouri	25%	97%
A0A0N1I1R8	Leptomonas seymouri	66%	99%
A0A0S4ISJ6	Bodo saltans	32%	78%
A0A1X0NXB7	Trypanosomatidae	46%	99%
A0A3Q8IDT0	Leishmania donovani	88%	100%
A0A3R7M2M3	Trypanosoma rangeli	26%	100%
A0A3S7X9Q3	Leishmania donovani	26%	89%
A0A422MZQ7	Trypanosoma rangeli	44%	100%
A4HBJ6	Leishmania braziliensis	71%	100%
A4HN30	Leishmania braziliensis	23%	100%
A4HZL8	Leishmania infantum	88%	100%
A4IBP9	Leishmania infantum	26%	89%
A8KBL7	Danio rerio	27%	98%
C9ZYX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A1J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AFI4	Leishmania major	25%	100%
E9B6N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O74386	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q0P5B2	Bos taurus	27%	92%
Q4QCL7	Leishmania major	88%	100%
Q5RDV8	Pongo abelii	26%	100%
Q6AXU8	Rattus norvegicus	29%	100%
Q6P1Q9	Homo sapiens	28%	92%
Q86BS6	Drosophila melanogaster	25%	100%
Q8BMK1	Mus musculus	27%	89%
Q8BVH9	Mus musculus	28%	100%
Q8T199	Dictyostelium discoideum	27%	79%
Q8TCB7	Homo sapiens	26%	100%
V5BCV4	Trypanosoma cruzi	29%	100%
V5DGW7	Trypanosoma cruzi	42%	100%