Histone H4

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania mexicana

UniProt:

E9AUW4_LEIMU

TriTrypDb:

LmxM.21.0015

Length:

107

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	32
GO:0005634	nucleus	5	32
GO:0032991	protein-containing complex	1	32
GO:0032993	protein-DNA complex	2	32
GO:0043226	organelle	2	32
GO:0043227	membrane-bounded organelle	3	32
GO:0043229	intracellular organelle	3	32
GO:0043231	intracellular membrane-bounded organelle	4	32
GO:0044815	DNA packaging complex	2	32
GO:0110165	cellular anatomical entity	1	32

Expansion

Sequence features

E9AUW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUW4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3
GO:0071824	protein-DNA complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	32
GO:0003677	DNA binding	4	32
GO:0005198	structural molecule activity	1	32
GO:0005488	binding	1	32
GO:0005515	protein binding	2	32
GO:0030527	structural constituent of chromatin	2	32
GO:0046982	protein heterodimerization activity	4	32
GO:0046983	protein dimerization activity	3	32
GO:0097159	organic cyclic compound binding	2	32
GO:1901363	heterocyclic compound binding	2	32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.303
CLV_NRD_NRD_1	19	21	PF00675	0.306
CLV_NRD_NRD_1	35	37	PF00675	0.201
CLV_NRD_NRD_1	56	58	PF00675	0.302
CLV_NRD_NRD_1	70	72	PF00675	0.434
CLV_PCSK_FUR_1	13	17	PF00082	0.193
CLV_PCSK_KEX2_1	15	17	PF00082	0.305
CLV_PCSK_KEX2_1	19	21	PF00082	0.308
CLV_PCSK_KEX2_1	24	26	PF00082	0.314
CLV_PCSK_KEX2_1	35	37	PF00082	0.201
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.308
CLV_PCSK_PC7_1	11	17	PF00082	0.344
CLV_PCSK_PC7_1	20	26	PF00082	0.302
CLV_PCSK_SKI1_1	35	39	PF00082	0.350
CLV_PCSK_SKI1_1	59	63	PF00082	0.354
DEG_Nend_Nbox_1	1	3	PF02207	0.382
LIG_14-3-3_CanoR_1	25	31	PF00244	0.524
LIG_14-3-3_CanoR_1	57	62	PF00244	0.462
LIG_14-3-3_CanoR_1	85	89	PF00244	0.438
LIG_FHA_1	89	95	PF00498	0.453
LIG_FHA_2	60	66	PF00498	0.508
LIG_LIR_Nem_3	29	34	PF02991	0.592
LIG_SH2_STAP1	52	56	PF00017	0.566
LIG_SH2_STAT5	104	107	PF00017	0.455
LIG_SH2_STAT5	41	44	PF00017	0.592
LIG_SH3_3	95	101	PF00018	0.418
MOD_CK1_1	96	102	PF00069	0.417
MOD_GlcNHglycan	26	29	PF01048	0.245
MOD_GlcNHglycan	81	84	PF01048	0.409
MOD_GSK3_1	84	91	PF00069	0.443
MOD_N-GLC_2	5	7	PF02516	0.305
MOD_PKA_1	24	30	PF00069	0.501
MOD_PKA_1	57	63	PF00069	0.501
MOD_PKA_2	24	30	PF00069	0.569
MOD_PKA_2	46	52	PF00069	0.592
MOD_PKA_2	84	90	PF00069	0.441
TRG_ENDOCYTIC_2	31	34	PF00928	0.505
TRG_ER_diArg_1	11	14	PF00400	0.351
TRG_ER_diArg_1	15	17	PF00400	0.502
TRG_ER_diArg_1	34	36	PF00400	0.402
TRG_NLS_Bipartite_1	57	75	PF00514	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJN5	Trypanosomatidae	70%	100%
A0A1X0P2G0	Trypanosomatidae	69%	100%
A0A3Q8IFP7	Leishmania donovani	88%	100%
A0A3R7MKW7	Trypanosoma rangeli	69%	92%
A0A3S7WPA9	Leishmania donovani	85%	100%
A0A3S7WTF1	Leishmania donovani	85%	100%
A0A3S7X8Y8	Leishmania donovani	89%	100%
A0A451EJE0	Leishmania donovani	86%	100%
A4H399	Leishmania braziliensis	85%	100%
A4H3A0	Leishmania braziliensis	85%	100%
A4H7X1	Leishmania braziliensis	86%	100%
A4HD43	Leishmania braziliensis	84%	100%
A4HMF3	Leishmania braziliensis	85%	100%
A4HNK8	Leishmania braziliensis	86%	74%
A4HSP4	Leishmania infantum	85%	100%
A4HW98	Leishmania infantum	86%	100%
A4IB25	Leishmania infantum	89%	100%
C9ZJ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
C9ZPV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	70%
C9ZPV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	70%
C9ZPV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	94%
E9AKM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9APZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9ASB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P02309	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	100%
P02310	Tetrahymena pyriformis	57%	100%
P04914	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	57%	100%
P04915	Physarum polycephalum	58%	100%
P08436	Volvox carteri	59%	100%
P09322	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	100%
P0CG89	Glycine max	58%	100%
P23750	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	57%	100%
P23751	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	57%	100%
P27996	Solaster stimpsoni	56%	100%
P35057	Solanum lycopersicum	59%	100%
P35059	Acropora formosa	57%	100%
P40287	Entamoeba histolytica	51%	91%
P50566	Chlamydomonas reinhardtii	59%	100%
P59259	Arabidopsis thaliana	58%	100%
P62776	Holothuria tubulosa	57%	100%
P62777	Pisaster brevispinus	57%	100%
P62778	Pisaster ochraceus	57%	100%
P62779	Pycnopodia helianthoides	57%	100%
P62780	Paracentrotus lividus	57%	100%
P62781	Psammechinus miliaris	57%	100%
P62782	Lytechinus pictus	57%	100%
P62783	Strongylocentrotus purpuratus	57%	100%
P62784	Caenorhabditis elegans	57%	100%
P62785	Triticum aestivum	58%	100%
P62786	Triticum aestivum	58%	100%
P62787	Zea mays	58%	100%
P62788	Pisum sativum	58%	100%
P62790	Sterkiella nova	54%	100%
P62791	Stylonychia lemnae	54%	100%
P62792	Phanerodontia chrysosporium	57%	100%
P62793	Agaricus bisporus	57%	100%
P62794	Urechis caupo	57%	100%
P62795	Platynereis dumerilii	57%	100%
P62796	Oreochromis niloticus	57%	100%
P62797	Oncorhynchus mykiss	57%	100%
P62798	Xenopus borealis	57%	100%
P62799	Xenopus laevis	57%	100%
P62800	Cairina moschata	57%	100%
P62801	Gallus gallus	57%	100%
P62802	Sus scrofa	57%	100%
P62803	Bos taurus	57%	100%
P62804	Rattus norvegicus	57%	100%
P62805	Homo sapiens	57%	100%
P62806	Mus musculus	57%	100%
P62887	Lolium temulentum	58%	100%
P69151	Tetrahymena pyriformis	57%	100%
P69152	Tetrahymena thermophila (strain SB210)	57%	100%
P70081	Gallus gallus	56%	100%
P80737	Blepharisma japonicum	53%	100%
P80739	Euplotes crassus	54%	100%
P82888	Olisthodiscus luteus	58%	100%
P83865	Penaeus vannamei	56%	100%
P84040	Drosophila melanogaster	57%	100%
P84041	Drosophila erecta	57%	100%
P84042	Drosophila hydei	57%	100%
P84043	Drosophila simulans	57%	100%
P84044	Drosophila yakuba	57%	100%
P84045	Tigriopus californicus	57%	100%
P84046	Chironomus thummi thummi	57%	100%
P84047	Asellus aquaticus	57%	100%
P84048	Acrolepiopsis assectella	57%	100%
P84049	Myrmica ruginodis	57%	100%
P84050	Rhynchosciara americana	57%	100%
P90516	Blepharisma japonicum	49%	100%
P91849	Apis mellifera	54%	100%
P91882	Diadromus pulchellus	56%	100%
P91890	Trichogramma cacaeciae	56%	100%
Q27443	Ascaris suum	57%	100%
Q27765	Styela plicata	57%	100%
Q28DR4	Xenopus tropicalis	57%	100%
Q41811	Zea mays	57%	100%
Q43083	Pyrenomonas salina	58%	100%
Q4JHM5	Leishmania donovani	86%	100%
Q4Q277	Leishmania major	85%	100%
Q4QFI3	Leishmania major	86%	100%
Q4QJ78	Leishmania major	84%	100%
Q4R362	Macaca fascicularis	57%	100%
Q5RCS7	Pongo abelii	57%	100%
Q6LAF1	Dendronephthya klunzingeri	57%	100%
Q6LAF3	Flaveria trinervia	58%	100%
Q6PMI5	Chelidonium majus	58%	100%
Q6V9I2	Solanum chacoense	59%	100%
Q6WV72	Mytilus trossulus	57%	100%
Q6WV73	Mytilus californianus	57%	100%
Q6WV74	Mytilus chilensis	57%	100%
Q6WV90	Mytilus galloprovincialis	57%	100%
Q6WZ83	Eucalyptus globulus	58%	100%
Q6ZXX3	Ustilago maydis (strain 521 / FGSC 9021)	55%	100%
Q711M0	Talaromyces funiculosus	57%	100%
Q71V09	Capsicum annuum	59%	100%
Q757K0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	57%	100%
Q75AX1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	57%	100%
Q76FD9	Drosophila sechellia	57%	100%
Q76FE7	Drosophila mauritiana	57%	100%
Q76FF1	Drosophila orena	57%	100%
Q76FF5	Drosophila teissieri	57%	100%
Q76H85	Silene latifolia	58%	100%
Q76MU7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	57%	100%
Q76NW2	Dictyostelium discoideum	52%	99%
Q7K8C0	Mytilus edulis	57%	100%
Q7KQD1	Chaetopterus variopedatus	57%	100%
Q7LKT3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	57%	100%
Q8I0Y4	Oikopleura dioica	57%	100%
Q8J1L3	Blastobotrys adeninivorans	57%	100%
Q8MTV8	Aplysia californica	57%	100%
Q8NIG3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	57%	100%
Q8NIQ8	Talaromyces funiculosus	57%	100%
Q8SQP4	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q8T7J8	Eimeria tenella	57%	100%
Q99525	Homo sapiens	48%	100%
Q9HDF5	Mortierella alpina	56%	100%
Q9U7D0	Mastigamoeba balamuthi	59%	99%
R9TL77	Trypanosoma rangeli	70%	100%
V5BAE8	Trypanosoma cruzi	69%	100%