Mediator complex subunit 6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUW2_LEIMU

TriTrypDb:

LmxM.20.1610

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AUW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.436
CLV_NRD_NRD_1	127	129	PF00675	0.462
CLV_NRD_NRD_1	242	244	PF00675	0.486
CLV_NRD_NRD_1	56	58	PF00675	0.394
CLV_PCSK_KEX2_1	236	238	PF00082	0.416
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.416
CLV_PCSK_SKI1_1	145	149	PF00082	0.286
CLV_PCSK_SKI1_1	236	240	PF00082	0.449
CLV_PCSK_SKI1_1	243	247	PF00082	0.373
CLV_PCSK_SKI1_1	71	75	PF00082	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.419
DOC_CKS1_1	166	171	PF01111	0.294
DOC_CYCLIN_RxL_1	237	249	PF00134	0.309
DOC_CYCLIN_yClb5_NLxxxL_5	172	181	PF00134	0.517
DOC_MAPK_gen_1	171	180	PF00069	0.383
DOC_MAPK_gen_1	80	88	PF00069	0.351
DOC_PP1_RVXF_1	211	217	PF00149	0.448
DOC_PP2B_LxvP_1	14	17	PF13499	0.417
DOC_PP4_FxxP_1	216	219	PF00568	0.499
DOC_USP7_MATH_1	7	11	PF00917	0.466
DOC_USP7_UBL2_3	125	129	PF12436	0.440
DOC_USP7_UBL2_3	58	62	PF12436	0.341
DOC_WW_Pin1_4	110	115	PF00397	0.476
DOC_WW_Pin1_4	165	170	PF00397	0.443
DOC_WW_Pin1_4	23	28	PF00397	0.435
DOC_WW_Pin1_4	88	93	PF00397	0.354
LIG_14-3-3_CanoR_1	154	160	PF00244	0.407
LIG_14-3-3_CanoR_1	193	198	PF00244	0.473
LIG_14-3-3_CanoR_1	243	253	PF00244	0.342
LIG_BRCT_BRCA1_1	187	191	PF00533	0.443
LIG_DLG_GKlike_1	193	201	PF00625	0.475
LIG_FHA_1	121	127	PF00498	0.418
LIG_FHA_1	134	140	PF00498	0.409
LIG_FHA_1	150	156	PF00498	0.425
LIG_FHA_1	196	202	PF00498	0.491
LIG_FHA_1	233	239	PF00498	0.386
LIG_FHA_1	3	9	PF00498	0.604
LIG_LIR_Gen_1	182	192	PF02991	0.324
LIG_LIR_Nem_3	182	187	PF02991	0.308
LIG_LIR_Nem_3	24	28	PF02991	0.532
LIG_PTB_Apo_2	101	108	PF02174	0.411
LIG_PTB_Phospho_1	101	107	PF10480	0.417
LIG_SH2_CRK	64	68	PF00017	0.470
LIG_SH2_STAT5	107	110	PF00017	0.373
LIG_SH2_STAT5	120	123	PF00017	0.319
LIG_SH2_STAT5	142	145	PF00017	0.242
LIG_SH2_STAT5	37	40	PF00017	0.455
LIG_SH2_STAT5	59	62	PF00017	0.425
LIG_SH3_2	166	171	PF14604	0.453
LIG_SH3_3	163	169	PF00018	0.510
LIG_UBA3_1	140	148	PF00899	0.403
LIG_UBA3_1	238	244	PF00899	0.374
MOD_CDK_SPxK_1	165	171	PF00069	0.299
MOD_CDK_SPxxK_3	110	117	PF00069	0.418
MOD_CK1_1	149	155	PF00069	0.471
MOD_CK1_1	39	45	PF00069	0.367
MOD_CK1_1	96	102	PF00069	0.540
MOD_CK2_1	155	161	PF00069	0.553
MOD_Cter_Amidation	55	58	PF01082	0.393
MOD_GlcNHglycan	252	256	PF01048	0.409
MOD_GlcNHglycan	38	41	PF01048	0.364
MOD_GlcNHglycan	95	98	PF01048	0.633
MOD_GSK3_1	106	113	PF00069	0.446
MOD_GSK3_1	116	123	PF00069	0.368
MOD_GSK3_1	244	251	PF00069	0.389
MOD_N-GLC_1	193	198	PF02516	0.461
MOD_NEK2_1	29	34	PF00069	0.428
MOD_NEK2_1	93	98	PF00069	0.471
MOD_PIKK_1	120	126	PF00454	0.479
MOD_PIKK_1	133	139	PF00454	0.400
MOD_PIKK_1	16	22	PF00454	0.406
MOD_PIKK_1	41	47	PF00454	0.385
MOD_Plk_1	193	199	PF00069	0.466
MOD_Plk_1	2	8	PF00069	0.422
MOD_Plk_4	155	161	PF00069	0.370
MOD_ProDKin_1	110	116	PF00069	0.474
MOD_ProDKin_1	165	171	PF00069	0.445
MOD_ProDKin_1	23	29	PF00069	0.434
MOD_ProDKin_1	88	94	PF00069	0.365
TRG_ENDOCYTIC_2	107	110	PF00928	0.431
TRG_ENDOCYTIC_2	64	67	PF00928	0.421
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT0	Leptomonas seymouri	40%	100%
A0A1X0NWH7	Trypanosomatidae	26%	100%
A0A3Q8IEZ9	Leishmania donovani	81%	100%
A4HZ15	Leishmania infantum	80%	100%
C9ZIL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4QCM0	Leishmania major	78%	100%
V5D8U8	Trypanosoma cruzi	25%	91%