WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUW1_LEIMU

TriTrypDb:

LmxM.20.1600

Length:

1005

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	418	420	PF00675	0.561
CLV_NRD_NRD_1	455	457	PF00675	0.510
CLV_NRD_NRD_1	614	616	PF00675	0.560
CLV_NRD_NRD_1	757	759	PF00675	0.273
CLV_NRD_NRD_1	9	11	PF00675	0.661
CLV_PCSK_KEX2_1	201	203	PF00082	0.455
CLV_PCSK_KEX2_1	455	457	PF00082	0.456
CLV_PCSK_KEX2_1	503	505	PF00082	0.615
CLV_PCSK_KEX2_1	614	616	PF00082	0.583
CLV_PCSK_KEX2_1	8	10	PF00082	0.698
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.455
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.615
CLV_PCSK_SKI1_1	367	371	PF00082	0.481
CLV_PCSK_SKI1_1	410	414	PF00082	0.621
CLV_PCSK_SKI1_1	514	518	PF00082	0.410
CLV_PCSK_SKI1_1	622	626	PF00082	0.602
CLV_PCSK_SKI1_1	711	715	PF00082	0.602
CLV_PCSK_SKI1_1	758	762	PF00082	0.523
CLV_PCSK_SKI1_1	88	92	PF00082	0.565
CLV_PCSK_SKI1_1	9	13	PF00082	0.622
CLV_PCSK_SKI1_1	956	960	PF00082	0.414
DEG_APCC_DBOX_1	513	521	PF00400	0.418
DEG_APCC_DBOX_1	621	629	PF00400	0.588
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DOC_MAPK_gen_1	419	426	PF00069	0.526
DOC_MAPK_MEF2A_6	479	488	PF00069	0.444
DOC_MAPK_MEF2A_6	803	810	PF00069	0.528
DOC_MAPK_MEF2A_6	969	977	PF00069	0.600
DOC_PP2B_LxvP_1	369	372	PF13499	0.579
DOC_PP2B_PxIxI_1	803	809	PF00149	0.490
DOC_PP4_FxxP_1	3	6	PF00568	0.670
DOC_PP4_FxxP_1	992	995	PF00568	0.511
DOC_USP7_MATH_1	267	271	PF00917	0.601
DOC_USP7_MATH_1	272	276	PF00917	0.568
DOC_USP7_MATH_1	399	403	PF00917	0.518
DOC_USP7_MATH_1	650	654	PF00917	0.628
DOC_USP7_MATH_1	866	870	PF00917	0.390
DOC_USP7_MATH_1	937	941	PF00917	0.608
DOC_USP7_MATH_1	962	966	PF00917	0.618
DOC_USP7_MATH_2	260	266	PF00917	0.499
DOC_WW_Pin1_4	2	7	PF00397	0.676
DOC_WW_Pin1_4	404	409	PF00397	0.485
DOC_WW_Pin1_4	446	451	PF00397	0.506
DOC_WW_Pin1_4	588	593	PF00397	0.513
DOC_WW_Pin1_4	614	619	PF00397	0.586
DOC_WW_Pin1_4	693	698	PF00397	0.670
DOC_WW_Pin1_4	933	938	PF00397	0.579
DOC_WW_Pin1_4	983	988	PF00397	0.435
DOC_WW_Pin1_4	991	996	PF00397	0.418
LIG_14-3-3_CanoR_1	237	243	PF00244	0.606
LIG_14-3-3_CanoR_1	410	417	PF00244	0.620
LIG_14-3-3_CanoR_1	444	450	PF00244	0.625
LIG_14-3-3_CanoR_1	504	508	PF00244	0.613
LIG_14-3-3_CanoR_1	609	614	PF00244	0.605
LIG_14-3-3_CanoR_1	703	708	PF00244	0.542
LIG_14-3-3_CanoR_1	859	868	PF00244	0.491
LIG_14-3-3_CanoR_1	88	93	PF00244	0.558
LIG_Actin_WH2_2	600	616	PF00022	0.534
LIG_APCC_ABBA_1	796	801	PF00400	0.290
LIG_BRCT_BRCA1_1	199	203	PF00533	0.520
LIG_BRCT_BRCA1_1	229	233	PF00533	0.431
LIG_Clathr_ClatBox_1	311	315	PF01394	0.560
LIG_EH1_1	287	295	PF00400	0.260
LIG_eIF4E_1	288	294	PF01652	0.503
LIG_FAT_LD_1	488	496	PF03623	0.532
LIG_FHA_1	103	109	PF00498	0.526
LIG_FHA_1	156	162	PF00498	0.530
LIG_FHA_1	244	250	PF00498	0.569
LIG_FHA_1	307	313	PF00498	0.501
LIG_FHA_1	320	326	PF00498	0.365
LIG_FHA_1	40	46	PF00498	0.601
LIG_FHA_1	411	417	PF00498	0.536
LIG_FHA_1	429	435	PF00498	0.366
LIG_FHA_1	437	443	PF00498	0.444
LIG_FHA_1	712	718	PF00498	0.490
LIG_FHA_1	737	743	PF00498	0.375
LIG_FHA_1	788	794	PF00498	0.547
LIG_FHA_1	860	866	PF00498	0.490
LIG_FHA_1	914	920	PF00498	0.485
LIG_FHA_2	146	152	PF00498	0.534
LIG_FHA_2	73	79	PF00498	0.502
LIG_FHA_2	825	831	PF00498	0.451
LIG_FHA_2	921	927	PF00498	0.519
LIG_HCF-1_HBM_1	316	319	PF13415	0.593
LIG_LIR_Apic_2	302	307	PF02991	0.616
LIG_LIR_Apic_2	991	995	PF02991	0.530
LIG_LIR_Gen_1	378	388	PF02991	0.463
LIG_LIR_Gen_1	422	427	PF02991	0.540
LIG_LIR_Gen_1	552	561	PF02991	0.504
LIG_LIR_Gen_1	672	681	PF02991	0.548
LIG_LIR_Gen_1	696	707	PF02991	0.614
LIG_LIR_Gen_1	747	757	PF02991	0.492
LIG_LIR_Gen_1	820	829	PF02991	0.384
LIG_LIR_LC3C_4	540	545	PF02991	0.649
LIG_LIR_Nem_3	200	206	PF02991	0.456
LIG_LIR_Nem_3	255	261	PF02991	0.601
LIG_LIR_Nem_3	286	291	PF02991	0.514
LIG_LIR_Nem_3	378	384	PF02991	0.297
LIG_LIR_Nem_3	422	426	PF02991	0.536
LIG_LIR_Nem_3	452	457	PF02991	0.525
LIG_LIR_Nem_3	552	558	PF02991	0.496
LIG_LIR_Nem_3	608	613	PF02991	0.594
LIG_LIR_Nem_3	672	677	PF02991	0.552
LIG_LIR_Nem_3	696	702	PF02991	0.567
LIG_LIR_Nem_3	747	752	PF02991	0.508
LIG_LIR_Nem_3	794	799	PF02991	0.418
LIG_LIR_Nem_3	801	805	PF02991	0.369
LIG_LIR_Nem_3	820	825	PF02991	0.440
LIG_LIR_Nem_3	954	958	PF02991	0.532
LIG_NRBOX	456	462	PF00104	0.676
LIG_NRBOX	560	566	PF00104	0.550
LIG_NRBOX	676	682	PF00104	0.503
LIG_PCNA_yPIPBox_3	746	757	PF02747	0.518
LIG_Pex14_1	26	30	PF04695	0.596
LIG_Pex14_2	169	173	PF04695	0.509
LIG_Pex14_2	606	610	PF04695	0.537
LIG_Pex14_2	809	813	PF04695	0.429
LIG_Pex14_2	980	984	PF04695	0.507
LIG_Pex14_2	992	996	PF04695	0.522
LIG_PTB_Apo_2	813	820	PF02174	0.505
LIG_PTB_Phospho_1	813	819	PF10480	0.506
LIG_SH2_CRK	195	199	PF00017	0.488
LIG_SH2_CRK	245	249	PF00017	0.650
LIG_SH2_CRK	288	292	PF00017	0.507
LIG_SH2_CRK	304	308	PF00017	0.600
LIG_SH2_CRK	334	338	PF00017	0.522
LIG_SH2_CRK	423	427	PF00017	0.532
LIG_SH2_CRK	474	478	PF00017	0.604
LIG_SH2_NCK_1	304	308	PF00017	0.642
LIG_SH2_NCK_1	578	582	PF00017	0.474
LIG_SH2_PTP2	805	808	PF00017	0.494
LIG_SH2_SRC	127	130	PF00017	0.518
LIG_SH2_SRC	805	808	PF00017	0.536
LIG_SH2_STAP1	195	199	PF00017	0.488
LIG_SH2_STAP1	245	249	PF00017	0.650
LIG_SH2_STAP1	334	338	PF00017	0.465
LIG_SH2_STAP1	482	486	PF00017	0.555
LIG_SH2_STAP1	509	513	PF00017	0.540
LIG_SH2_STAP1	623	627	PF00017	0.391
LIG_SH2_STAP1	690	694	PF00017	0.652
LIG_SH2_STAP1	889	893	PF00017	0.269
LIG_SH2_STAT3	690	693	PF00017	0.571
LIG_SH2_STAT5	245	248	PF00017	0.623
LIG_SH2_STAT5	611	614	PF00017	0.601
LIG_SH2_STAT5	791	794	PF00017	0.487
LIG_SH2_STAT5	805	808	PF00017	0.387
LIG_SH2_STAT5	822	825	PF00017	0.328
LIG_SH2_STAT5	979	982	PF00017	0.480
LIG_SH3_1	447	453	PF00018	0.431
LIG_SH3_2	450	455	PF14604	0.440
LIG_SH3_3	136	142	PF00018	0.483
LIG_SH3_3	212	218	PF00018	0.575
LIG_SH3_3	405	411	PF00018	0.469
LIG_SH3_3	44	50	PF00018	0.591
LIG_SH3_3	447	453	PF00018	0.431
LIG_SH3_3	523	529	PF00018	0.541
LIG_SH3_3	659	665	PF00018	0.657
LIG_SH3_3	958	964	PF00018	0.420
LIG_SH3_3	999	1005	PF00018	0.574
LIG_SUMO_SIM_anti_2	104	112	PF11976	0.630
LIG_SUMO_SIM_anti_2	273	280	PF11976	0.547
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.529
LIG_SUMO_SIM_anti_2	971	977	PF11976	0.546
LIG_SUMO_SIM_par_1	104	112	PF11976	0.650
LIG_SUMO_SIM_par_1	259	265	PF11976	0.607
LIG_SUMO_SIM_par_1	273	280	PF11976	0.453
LIG_SUMO_SIM_par_1	309	316	PF11976	0.579
LIG_SUMO_SIM_par_1	557	563	PF11976	0.279
LIG_SUMO_SIM_par_1	916	923	PF11976	0.522
LIG_TRAF2_1	313	316	PF00917	0.489
LIG_TYR_ITIM	193	198	PF00017	0.486
LIG_TYR_ITIM	421	426	PF00017	0.544
LIG_TYR_ITIM	472	477	PF00017	0.586
LIG_TYR_ITIM	977	982	PF00017	0.489
LIG_UBA3_1	368	373	PF00899	0.579
LIG_UBA3_1	806	815	PF00899	0.407
LIG_WRC_WIRS_1	943	948	PF05994	0.641
LIG_WRPW_2	802	805	PF00400	0.334
MOD_CDC14_SPxK_1	407	410	PF00782	0.573
MOD_CDC14_SPxK_1	452	455	PF00782	0.442
MOD_CDC14_SPxK_1	5	8	PF00782	0.685
MOD_CDK_SPxK_1	2	8	PF00069	0.680
MOD_CDK_SPxK_1	404	410	PF00069	0.562
MOD_CDK_SPxK_1	449	455	PF00069	0.438
MOD_CDK_SPxxK_3	2	9	PF00069	0.479
MOD_CDK_SPxxK_3	449	456	PF00069	0.437
MOD_CK1_1	238	244	PF00069	0.711
MOD_CK1_1	270	276	PF00069	0.531
MOD_CK1_1	383	389	PF00069	0.442
MOD_CK1_1	39	45	PF00069	0.548
MOD_CK1_1	428	434	PF00069	0.510
MOD_CK1_1	449	455	PF00069	0.455
MOD_CK1_1	467	473	PF00069	0.617
MOD_CK1_1	490	496	PF00069	0.595
MOD_CK1_1	633	639	PF00069	0.580
MOD_CK1_1	66	72	PF00069	0.522
MOD_CK1_1	724	730	PF00069	0.545
MOD_CK1_1	736	742	PF00069	0.487
MOD_CK1_1	834	840	PF00069	0.493
MOD_CK1_1	864	870	PF00069	0.559
MOD_CK1_1	895	901	PF00069	0.441
MOD_CK1_1	913	919	PF00069	0.357
MOD_CK1_1	942	948	PF00069	0.570
MOD_CK2_1	145	151	PF00069	0.529
MOD_CK2_1	248	254	PF00069	0.580
MOD_CK2_1	292	298	PF00069	0.482
MOD_CK2_1	502	508	PF00069	0.658
MOD_CK2_1	576	582	PF00069	0.492
MOD_CK2_1	702	708	PF00069	0.551
MOD_CK2_1	920	926	PF00069	0.495
MOD_GlcNHglycan	131	134	PF01048	0.529
MOD_GlcNHglycan	229	232	PF01048	0.585
MOD_GlcNHglycan	237	240	PF01048	0.609
MOD_GlcNHglycan	264	267	PF01048	0.684
MOD_GlcNHglycan	427	430	PF01048	0.332
MOD_GlcNHglycan	466	469	PF01048	0.544
MOD_GlcNHglycan	492	495	PF01048	0.642
MOD_GlcNHglycan	510	513	PF01048	0.319
MOD_GlcNHglycan	669	672	PF01048	0.581
MOD_GlcNHglycan	726	729	PF01048	0.484
MOD_GlcNHglycan	833	836	PF01048	0.501
MOD_GlcNHglycan	840	843	PF01048	0.589
MOD_GlcNHglycan	903	906	PF01048	0.510
MOD_GlcNHglycan	912	915	PF01048	0.435
MOD_GlcNHglycan	947	950	PF01048	0.598
MOD_GSK3_1	267	274	PF00069	0.589
MOD_GSK3_1	37	44	PF00069	0.516
MOD_GSK3_1	383	390	PF00069	0.391
MOD_GSK3_1	406	413	PF00069	0.489
MOD_GSK3_1	442	449	PF00069	0.510
MOD_GSK3_1	503	510	PF00069	0.559
MOD_GSK3_1	520	527	PF00069	0.468
MOD_GSK3_1	543	550	PF00069	0.630
MOD_GSK3_1	576	583	PF00069	0.450
MOD_GSK3_1	605	612	PF00069	0.571
MOD_GSK3_1	66	73	PF00069	0.533
MOD_GSK3_1	693	700	PF00069	0.564
MOD_GSK3_1	787	794	PF00069	0.494
MOD_GSK3_1	820	827	PF00069	0.480
MOD_GSK3_1	834	841	PF00069	0.482
MOD_GSK3_1	84	91	PF00069	0.509
MOD_GSK3_1	845	852	PF00069	0.471
MOD_GSK3_1	910	917	PF00069	0.453
MOD_GSK3_1	920	927	PF00069	0.405
MOD_GSK3_1	933	940	PF00069	0.486
MOD_GSK3_1	947	954	PF00069	0.617
MOD_N-GLC_1	88	93	PF02516	0.485
MOD_N-GLC_1	914	919	PF02516	0.456
MOD_N-GLC_1	937	942	PF02516	0.568
MOD_NEK2_1	12	17	PF00069	0.617
MOD_NEK2_1	154	159	PF00069	0.512
MOD_NEK2_1	165	170	PF00069	0.523
MOD_NEK2_1	248	253	PF00069	0.560
MOD_NEK2_1	271	276	PF00069	0.542
MOD_NEK2_1	442	447	PF00069	0.449
MOD_NEK2_1	507	512	PF00069	0.495
MOD_NEK2_1	520	525	PF00069	0.355
MOD_NEK2_1	543	548	PF00069	0.564
MOD_NEK2_1	613	618	PF00069	0.587
MOD_NEK2_1	627	632	PF00069	0.441
MOD_NEK2_1	643	648	PF00069	0.384
MOD_NEK2_1	667	672	PF00069	0.478
MOD_NEK2_1	702	707	PF00069	0.608
MOD_NEK2_1	733	738	PF00069	0.531
MOD_NEK2_1	787	792	PF00069	0.459
MOD_NEK2_1	858	863	PF00069	0.501
MOD_NEK2_1	947	952	PF00069	0.660
MOD_NEK2_2	299	304	PF00069	0.484
MOD_NEK2_2	951	956	PF00069	0.609
MOD_NEK2_2	97	102	PF00069	0.345
MOD_OFUCOSY	519	524	PF10250	0.549
MOD_PIKK_1	682	688	PF00454	0.585
MOD_PIKK_1	70	76	PF00454	0.563
MOD_PIKK_1	852	858	PF00454	0.496
MOD_PK_1	892	898	PF00069	0.575
MOD_PK_1	969	975	PF00069	0.452
MOD_PKA_1	503	509	PF00069	0.560
MOD_PKA_2	114	120	PF00069	0.633
MOD_PKA_2	243	249	PF00069	0.644
MOD_PKA_2	267	273	PF00069	0.641
MOD_PKA_2	503	509	PF00069	0.600
MOD_PKA_2	613	619	PF00069	0.617
MOD_PKA_2	702	708	PF00069	0.581
MOD_PKA_2	858	864	PF00069	0.553
MOD_Plk_1	377	383	PF00069	0.565
MOD_Plk_1	442	448	PF00069	0.471
MOD_Plk_1	688	694	PF00069	0.639
MOD_Plk_1	719	725	PF00069	0.559
MOD_Plk_1	88	94	PF00069	0.508
MOD_Plk_1	914	920	PF00069	0.547
MOD_Plk_2-3	920	926	PF00069	0.495
MOD_Plk_4	122	128	PF00069	0.460
MOD_Plk_4	272	278	PF00069	0.541
MOD_Plk_4	299	305	PF00069	0.445
MOD_Plk_4	306	312	PF00069	0.442
MOD_Plk_4	377	383	PF00069	0.525
MOD_Plk_4	41	47	PF00069	0.519
MOD_Plk_4	467	473	PF00069	0.606
MOD_Plk_4	487	493	PF00069	0.258
MOD_Plk_4	748	754	PF00069	0.463
MOD_Plk_4	787	793	PF00069	0.514
MOD_Plk_4	820	826	PF00069	0.445
MOD_Plk_4	845	851	PF00069	0.516
MOD_Plk_4	88	94	PF00069	0.508
MOD_Plk_4	892	898	PF00069	0.498
MOD_Plk_4	942	948	PF00069	0.609
MOD_Plk_4	971	977	PF00069	0.502
MOD_ProDKin_1	2	8	PF00069	0.680
MOD_ProDKin_1	404	410	PF00069	0.491
MOD_ProDKin_1	446	452	PF00069	0.510
MOD_ProDKin_1	588	594	PF00069	0.512
MOD_ProDKin_1	614	620	PF00069	0.580
MOD_ProDKin_1	693	699	PF00069	0.662
MOD_ProDKin_1	933	939	PF00069	0.589
MOD_ProDKin_1	983	989	PF00069	0.431
MOD_ProDKin_1	991	997	PF00069	0.420
MOD_SUMO_for_1	161	164	PF00179	0.517
MOD_SUMO_rev_2	251	258	PF00179	0.570
MOD_SUMO_rev_2	882	887	PF00179	0.464
MOD_SUMO_rev_2	926	933	PF00179	0.532
TRG_DiLeu_BaEn_1	151	156	PF01217	0.600
TRG_DiLeu_BaEn_1	971	976	PF01217	0.554
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.578
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.650
TRG_ENDOCYTIC_2	195	198	PF00928	0.488
TRG_ENDOCYTIC_2	245	248	PF00928	0.659
TRG_ENDOCYTIC_2	288	291	PF00928	0.509
TRG_ENDOCYTIC_2	334	337	PF00928	0.491
TRG_ENDOCYTIC_2	423	426	PF00928	0.525
TRG_ENDOCYTIC_2	454	457	PF00928	0.523
TRG_ENDOCYTIC_2	474	477	PF00928	0.637
TRG_ENDOCYTIC_2	578	581	PF00928	0.467
TRG_ENDOCYTIC_2	805	808	PF00928	0.473
TRG_ENDOCYTIC_2	822	825	PF00928	0.259
TRG_ENDOCYTIC_2	979	982	PF00928	0.480
TRG_ER_diArg_1	454	456	PF00400	0.435
TRG_ER_diArg_1	613	615	PF00400	0.601
TRG_ER_diArg_1	644	647	PF00400	0.573
TRG_ER_diArg_1	8	10	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	647	652	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY6	Leptomonas seymouri	54%	100%
A0A1X0NXF3	Trypanosomatidae	26%	88%
A0A3R7M4E0	Trypanosoma rangeli	27%	88%
A0A3S7WWC6	Leishmania donovani	90%	100%
A4HZ14	Leishmania infantum	90%	100%
C9ZIL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
E9AIM8	Leishmania braziliensis	75%	100%
Q4QCM1	Leishmania major	89%	100%