Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUV5_LEIMU

TriTrypDb:

LmxM.20.1740

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.403
CLV_C14_Caspase3-7	274	278	PF00656	0.465
CLV_NRD_NRD_1	24	26	PF00675	0.407
CLV_NRD_NRD_1	245	247	PF00675	0.496
CLV_NRD_NRD_1	91	93	PF00675	0.537
CLV_PCSK_FUR_1	243	247	PF00082	0.448
CLV_PCSK_KEX2_1	122	124	PF00082	0.530
CLV_PCSK_KEX2_1	171	173	PF00082	0.482
CLV_PCSK_KEX2_1	24	26	PF00082	0.443
CLV_PCSK_KEX2_1	245	247	PF00082	0.459
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.595
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.444
CLV_PCSK_PC7_1	167	173	PF00082	0.494
CLV_PCSK_SKI1_1	199	203	PF00082	0.342
CLV_PCSK_SKI1_1	268	272	PF00082	0.407
CLV_PCSK_SKI1_1	7	11	PF00082	0.661
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.259
DOC_MAPK_gen_1	171	180	PF00069	0.506
DOC_MAPK_gen_1	199	209	PF00069	0.380
DOC_MAPK_gen_1	292	299	PF00069	0.541
DOC_MAPK_RevD_3	158	172	PF00069	0.597
DOC_MAPK_RevD_3	280	295	PF00069	0.473
DOC_WW_Pin1_4	170	175	PF00397	0.504
DOC_WW_Pin1_4	49	54	PF00397	0.544
DOC_WW_Pin1_4	99	104	PF00397	0.631
LIG_14-3-3_CanoR_1	24	31	PF00244	0.297
LIG_Actin_WH2_2	187	204	PF00022	0.476
LIG_Clathr_ClatBox_1	71	75	PF01394	0.437
LIG_FHA_1	106	112	PF00498	0.531
LIG_FHA_2	58	64	PF00498	0.503
LIG_LIR_Apic_2	106	112	PF02991	0.421
LIG_LIR_Gen_1	231	239	PF02991	0.316
LIG_LIR_Nem_3	130	134	PF02991	0.498
LIG_LIR_Nem_3	231	235	PF02991	0.305
LIG_LIR_Nem_3	260	265	PF02991	0.455
LIG_LIR_Nem_3	45	51	PF02991	0.544
LIG_NRBOX	39	45	PF00104	0.524
LIG_SH2_CRK	109	113	PF00017	0.364
LIG_SH2_STAP1	238	242	PF00017	0.228
LIG_SH2_STAT5	109	112	PF00017	0.516
LIG_SH2_STAT5	136	139	PF00017	0.417
LIG_SH2_STAT5	232	235	PF00017	0.442
LIG_SH2_STAT5	248	251	PF00017	0.509
LIG_SH2_STAT5	281	284	PF00017	0.328
LIG_SH3_3	207	213	PF00018	0.448
LIG_SH3_3	279	285	PF00018	0.346
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.482
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.488
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.484
LIG_SUMO_SIM_par_1	70	76	PF11976	0.440
LIG_TRAF2_1	94	97	PF00917	0.453
LIG_UBA3_1	287	295	PF00899	0.419
LIG_WRC_WIRS_1	48	53	PF05994	0.410
MOD_CDK_SPK_2	170	175	PF00069	0.504
MOD_CDK_SPK_2	99	104	PF00069	0.503
MOD_CK1_1	205	211	PF00069	0.396
MOD_CK1_1	33	39	PF00069	0.528
MOD_CK2_1	49	55	PF00069	0.511
MOD_CK2_1	57	63	PF00069	0.436
MOD_GlcNHglycan	218	221	PF01048	0.540
MOD_GlcNHglycan	26	29	PF01048	0.435
MOD_GlcNHglycan	32	35	PF01048	0.433
MOD_GSK3_1	201	208	PF00069	0.438
MOD_GSK3_1	212	219	PF00069	0.414
MOD_GSK3_1	47	54	PF00069	0.611
MOD_GSK3_1	99	106	PF00069	0.719
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	201	206	PF00069	0.405
MOD_NEK2_1	35	40	PF00069	0.448
MOD_NEK2_2	57	62	PF00069	0.382
MOD_PIKK_1	257	263	PF00454	0.479
MOD_PIKK_1	35	41	PF00454	0.430
MOD_PIKK_1	75	81	PF00454	0.503
MOD_PK_1	202	208	PF00069	0.564
MOD_PKA_1	24	30	PF00069	0.295
MOD_PKA_2	24	30	PF00069	0.295
MOD_PKA_2	86	92	PF00069	0.494
MOD_Plk_1	202	208	PF00069	0.421
MOD_Plk_2-3	70	76	PF00069	0.397
MOD_Plk_4	127	133	PF00069	0.632
MOD_Plk_4	202	208	PF00069	0.441
MOD_Plk_4	228	234	PF00069	0.445
MOD_Plk_4	283	289	PF00069	0.408
MOD_ProDKin_1	170	176	PF00069	0.491
MOD_ProDKin_1	49	55	PF00069	0.545
MOD_ProDKin_1	99	105	PF00069	0.624
MOD_SUMO_rev_2	192	201	PF00179	0.252
TRG_ENDOCYTIC_2	131	134	PF00928	0.448
TRG_ENDOCYTIC_2	232	235	PF00928	0.309
TRG_ER_diArg_1	123	126	PF00400	0.483
TRG_ER_diArg_1	23	25	PF00400	0.408
TRG_ER_diArg_1	242	245	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB90	Leptomonas seymouri	61%	100%
A0A1X0NW23	Trypanosomatidae	39%	100%
A0A3Q8IBV6	Leishmania donovani	91%	100%
A0A422NTN5	Trypanosoma rangeli	41%	88%
A4HZ03	Leishmania infantum	91%	100%
C9ZIL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	81%
E9AIM2	Leishmania braziliensis	82%	100%
Q4QCM8	Leishmania major	92%	100%
V5BHE7	Trypanosoma cruzi	39%	80%