Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUV3_LEIMU

TriTrypDb:

LmxM.20.1720

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.474
CLV_PCSK_KEX2_1	110	112	PF00082	0.465
CLV_PCSK_KEX2_1	243	245	PF00082	0.586
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.500
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.586
CLV_PCSK_SKI1_1	150	154	PF00082	0.620
CLV_Separin_Metazoa	55	59	PF03568	0.606
DOC_MAPK_gen_1	95	104	PF00069	0.479
DOC_MAPK_MEF2A_6	205	214	PF00069	0.396
DOC_USP7_MATH_1	139	143	PF00917	0.765
DOC_USP7_MATH_1	229	233	PF00917	0.530
DOC_USP7_UBL2_3	93	97	PF12436	0.482
DOC_WW_Pin1_4	64	69	PF00397	0.557
DOC_WW_Pin1_4	9	14	PF00397	0.647
LIG_14-3-3_CanoR_1	111	117	PF00244	0.452
LIG_14-3-3_CanoR_1	16	24	PF00244	0.615
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_FHA_1	52	58	PF00498	0.541
LIG_FHA_1	70	76	PF00498	0.670
LIG_FHA_2	158	164	PF00498	0.739
LIG_FHA_2	25	31	PF00498	0.516
LIG_Integrin_isoDGR_2	203	205	PF01839	0.540
LIG_LIR_Nem_3	40	45	PF02991	0.442
LIG_Pex14_2	108	112	PF04695	0.397
LIG_RPA_C_Fungi	232	244	PF08784	0.578
LIG_SH2_CRK	45	49	PF00017	0.429
LIG_SH2_GRB2like	219	222	PF00017	0.477
LIG_SH2_NCK_1	45	49	PF00017	0.429
LIG_SH2_PTP2	208	211	PF00017	0.361
LIG_SH2_SRC	208	211	PF00017	0.493
LIG_SH2_SRC	219	222	PF00017	0.533
LIG_SH2_STAP1	219	223	PF00017	0.530
LIG_SH2_STAT3	41	44	PF00017	0.508
LIG_SH2_STAT5	208	211	PF00017	0.361
LIG_SH2_STAT5	42	45	PF00017	0.427
LIG_SH3_3	125	131	PF00018	0.593
LIG_SH3_3	132	138	PF00018	0.741
LIG_SH3_3	184	190	PF00018	0.581
LIG_SH3_3	209	215	PF00018	0.404
LIG_SH3_3	65	71	PF00018	0.596
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.419
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.475
LIG_SUMO_SIM_par_1	210	218	PF11976	0.398
LIG_TRAF2_1	215	218	PF00917	0.476
MOD_CDK_SPxxK_3	9	16	PF00069	0.684
MOD_CK1_1	12	18	PF00069	0.562
MOD_CK1_1	142	148	PF00069	0.622
MOD_CK1_1	154	160	PF00069	0.691
MOD_CK1_1	2	8	PF00069	0.594
MOD_CK2_1	229	235	PF00069	0.478
MOD_GlcNHglycan	144	147	PF01048	0.769
MOD_GlcNHglycan	153	156	PF01048	0.723
MOD_GlcNHglycan	175	178	PF01048	0.474
MOD_GlcNHglycan	184	187	PF01048	0.615
MOD_GlcNHglycan	4	7	PF01048	0.631
MOD_GlcNHglycan	76	80	PF01048	0.613
MOD_GSK3_1	11	18	PF00069	0.599
MOD_GSK3_1	112	119	PF00069	0.426
MOD_GSK3_1	150	157	PF00069	0.663
MOD_GSK3_1	20	27	PF00069	0.591
MOD_GSK3_1	229	236	PF00069	0.560
MOD_GSK3_1	47	54	PF00069	0.521
MOD_N-GLC_1	112	117	PF02516	0.440
MOD_N-GLC_1	139	144	PF02516	0.785
MOD_N-GLC_1	20	25	PF02516	0.602
MOD_NEK2_1	112	117	PF00069	0.421
MOD_NEK2_1	166	171	PF00069	0.279
MOD_NEK2_1	199	204	PF00069	0.380
MOD_PK_1	58	64	PF00069	0.603
MOD_PKA_2	15	21	PF00069	0.475
MOD_PKA_2	157	163	PF00069	0.533
MOD_Plk_1	112	118	PF00069	0.426
MOD_Plk_1	179	185	PF00069	0.410
MOD_Plk_1	20	26	PF00069	0.637
MOD_Plk_1	58	64	PF00069	0.472
MOD_Plk_4	229	235	PF00069	0.554
MOD_ProDKin_1	64	70	PF00069	0.563
MOD_ProDKin_1	9	15	PF00069	0.645
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.495
TRG_ENDOCYTIC_2	208	211	PF00928	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J0	Leptomonas seymouri	74%	82%
A0A1X0NWJ0	Trypanosomatidae	53%	90%
A0A3Q8IKS5	Leishmania donovani	95%	100%
A0A422NTQ6	Trypanosoma rangeli	55%	91%
A4HZ01	Leishmania infantum	94%	100%
C9ZIM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	91%
E9AIM0	Leishmania braziliensis	84%	100%
Q4QCN0	Leishmania major	95%	100%
V5B8D6	Trypanosoma cruzi	53%	90%