Translation initiation factor if-2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUV1_LEIMU

TriTrypDb:

LmxM.20.1700

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUV1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	37	39	PF00082	0.697
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.697
DEG_SCF_FBW7_2	62	68	PF00400	0.603
DEG_SPOP_SBC_1	151	155	PF00917	0.674
DOC_CKS1_1	218	223	PF01111	0.577
DOC_CKS1_1	248	253	PF01111	0.476
DOC_CKS1_1	62	67	PF01111	0.655
DOC_CKS1_1	70	75	PF01111	0.606
DOC_CYCLIN_yClb5_NLxxxL_5	7	13	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.575
DOC_MAPK_gen_1	37	43	PF00069	0.695
DOC_PP2B_LxvP_1	50	53	PF13499	0.567
DOC_PP2B_LxvP_1	98	101	PF13499	0.555
DOC_USP7_MATH_1	266	270	PF00917	0.484
DOC_USP7_MATH_1	39	43	PF00917	0.693
DOC_USP7_MATH_1	60	64	PF00917	0.655
DOC_WW_Pin1_4	16	21	PF00397	0.662
DOC_WW_Pin1_4	217	222	PF00397	0.580
DOC_WW_Pin1_4	247	252	PF00397	0.480
DOC_WW_Pin1_4	61	66	PF00397	0.693
DOC_WW_Pin1_4	69	74	PF00397	0.631
LIG_14-3-3_CanoR_1	201	209	PF00244	0.622
LIG_14-3-3_CanoR_1	224	234	PF00244	0.580
LIG_14-3-3_CanoR_1	38	44	PF00244	0.695
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_FHA_2	29	35	PF00498	0.647
LIG_LIR_Apic_2	217	221	PF02991	0.579
LIG_LIR_Gen_1	80	91	PF02991	0.647
LIG_LIR_Nem_3	80	86	PF02991	0.664
LIG_PCNA_yPIPBox_3	176	185	PF02747	0.650
LIG_PCNA_yPIPBox_3	6	17	PF02747	0.570
LIG_RPA_C_Insects	2	17	PF08784	0.638
LIG_SH2_CRK	175	179	PF00017	0.609
LIG_SH2_CRK	218	222	PF00017	0.578
LIG_SH2_CRK	83	87	PF00017	0.651
LIG_SH2_NCK_1	83	87	PF00017	0.651
LIG_SH2_STAP1	227	231	PF00017	0.642
LIG_SH2_STAT3	209	212	PF00017	0.657
LIG_SH2_STAT3	245	248	PF00017	0.653
LIG_SH2_STAT5	182	185	PF00017	0.661
LIG_SH2_STAT5	83	86	PF00017	0.659
LIG_SH3_1	256	262	PF00018	0.582
LIG_SH3_2	262	267	PF14604	0.651
LIG_SH3_3	107	113	PF00018	0.605
LIG_SH3_3	136	142	PF00018	0.610
LIG_SH3_3	167	173	PF00018	0.669
LIG_SH3_3	210	216	PF00018	0.647
LIG_SH3_3	256	262	PF00018	0.615
LIG_SH3_3	33	39	PF00018	0.646
LIG_SH3_3	42	48	PF00018	0.607
LIG_SH3_3	59	65	PF00018	0.532
LIG_SH3_3	70	76	PF00018	0.590
LIG_SH3_3	86	92	PF00018	0.547
LIG_SH3_5	178	182	PF00018	0.607
LIG_SUMO_SIM_par_1	39	44	PF11976	0.628
LIG_TYR_ITIM	81	86	PF00017	0.660
LIG_WW_1	261	264	PF00397	0.646
LIG_WW_3	264	268	PF00397	0.653
MOD_CDK_SPxxK_3	217	224	PF00069	0.582
MOD_CK1_1	19	25	PF00069	0.647
MOD_CK1_1	2	8	PF00069	0.642
MOD_CK1_1	63	69	PF00069	0.698
MOD_CK2_1	72	78	PF00069	0.633
MOD_GlcNHglycan	1	4	PF01048	0.651
MOD_GlcNHglycan	229	232	PF01048	0.588
MOD_GlcNHglycan	275	278	PF01048	0.581
MOD_GSK3_1	147	154	PF00069	0.665
MOD_NEK2_1	240	245	PF00069	0.600
MOD_PIKK_1	159	165	PF00454	0.580
MOD_PKA_2	266	272	PF00069	0.485
MOD_Plk_1	267	273	PF00069	0.486
MOD_ProDKin_1	16	22	PF00069	0.667
MOD_ProDKin_1	217	223	PF00069	0.579
MOD_ProDKin_1	247	253	PF00069	0.477
MOD_ProDKin_1	61	67	PF00069	0.695
MOD_ProDKin_1	69	75	PF00069	0.632
MOD_SUMO_rev_2	42	48	PF00179	0.597
TRG_ENDOCYTIC_2	237	240	PF00928	0.682
TRG_ENDOCYTIC_2	83	86	PF00928	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW51	Leishmania donovani	89%	100%
A4HYZ9	Leishmania infantum	89%	100%
E9AIL8	Leishmania braziliensis	71%	97%
Q4QCN2	Leishmania major	89%	100%