Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUU7_LEIMU

TriTrypDb:

LmxM.20.1660

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AUU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.363
CLV_NRD_NRD_1	388	390	PF00675	0.555
CLV_PCSK_FUR_1	239	243	PF00082	0.444
CLV_PCSK_KEX2_1	241	243	PF00082	0.379
CLV_PCSK_KEX2_1	387	389	PF00082	0.525
CLV_PCSK_SKI1_1	50	54	PF00082	0.570
DEG_Nend_UBRbox_3	1	3	PF02207	0.727
DEG_SPOP_SBC_1	370	374	PF00917	0.683
DOC_CKS1_1	225	230	PF01111	0.655
DOC_CKS1_1	332	337	PF01111	0.731
DOC_MAPK_gen_1	10	18	PF00069	0.634
DOC_PP2B_LxvP_1	278	281	PF13499	0.727
DOC_PP2B_LxvP_1	321	324	PF13499	0.725
DOC_PP4_MxPP_1	362	365	PF00568	0.631
DOC_USP7_MATH_1	369	373	PF00917	0.716
DOC_USP7_MATH_1	392	396	PF00917	0.750
DOC_WW_Pin1_4	224	229	PF00397	0.683
DOC_WW_Pin1_4	296	301	PF00397	0.566
DOC_WW_Pin1_4	331	336	PF00397	0.694
DOC_WW_Pin1_4	354	359	PF00397	0.688
DOC_WW_Pin1_4	371	376	PF00397	0.800
DOC_WW_Pin1_4	390	395	PF00397	0.702
DOC_WW_Pin1_4	62	67	PF00397	0.419
LIG_APCC_ABBA_1	22	27	PF00400	0.348
LIG_BRCT_BRCA1_1	131	135	PF00533	0.481
LIG_CaM_NSCaTE_8	145	152	PF13499	0.491
LIG_EH1_1	39	47	PF00400	0.440
LIG_FHA_1	117	123	PF00498	0.372
LIG_FHA_1	150	156	PF00498	0.340
LIG_FHA_1	192	198	PF00498	0.328
LIG_FHA_1	205	211	PF00498	0.396
LIG_FHA_1	275	281	PF00498	0.651
LIG_FHA_1	34	40	PF00498	0.396
LIG_FHA_1	366	372	PF00498	0.763
LIG_FHA_1	41	47	PF00498	0.411
LIG_FHA_1	51	57	PF00498	0.294
LIG_FHA_1	63	69	PF00498	0.413
LIG_FHA_2	225	231	PF00498	0.652
LIG_LIR_Gen_1	31	42	PF02991	0.419
LIG_LIR_Gen_1	357	367	PF02991	0.710
LIG_LIR_Gen_1	76	85	PF02991	0.349
LIG_LIR_Nem_3	187	191	PF02991	0.326
LIG_LIR_Nem_3	299	305	PF02991	0.578
LIG_LIR_Nem_3	31	37	PF02991	0.419
LIG_LIR_Nem_3	76	80	PF02991	0.411
LIG_Pex14_2	135	139	PF04695	0.574
LIG_PTAP_UEV_1	306	311	PF05743	0.559
LIG_SH2_CRK	292	296	PF00017	0.709
LIG_SH2_GRB2like	215	218	PF00017	0.526
LIG_SH2_NCK_1	298	302	PF00017	0.610
LIG_SH2_SRC	292	295	PF00017	0.573
LIG_SH2_STAP1	84	88	PF00017	0.421
LIG_SH2_STAT3	159	162	PF00017	0.408
LIG_SH2_STAT5	143	146	PF00017	0.621
LIG_SH2_STAT5	159	162	PF00017	0.342
LIG_SH2_STAT5	177	180	PF00017	0.205
LIG_SH2_STAT5	188	191	PF00017	0.268
LIG_SH2_STAT5	205	208	PF00017	0.241
LIG_SH2_STAT5	215	218	PF00017	0.385
LIG_SH3_1	294	300	PF00018	0.631
LIG_SH3_3	164	170	PF00018	0.448
LIG_SH3_3	222	228	PF00018	0.627
LIG_SH3_3	284	290	PF00018	0.686
LIG_SH3_3	294	300	PF00018	0.697
LIG_SH3_3	304	310	PF00018	0.667
LIG_SH3_3	316	322	PF00018	0.689
LIG_SH3_3	332	338	PF00018	0.694
LIG_SH3_3	350	356	PF00018	0.680
LIG_SH3_3	376	382	PF00018	0.750
LIG_SH3_3	388	394	PF00018	0.742
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.354
LIG_TRAF2_1	227	230	PF00917	0.610
LIG_TRAF2_1	243	246	PF00917	0.542
LIG_TRFH_1	62	66	PF08558	0.351
LIG_WRC_WIRS_1	34	39	PF05994	0.348
MOD_CK1_1	76	82	PF00069	0.430
MOD_CK2_1	147	153	PF00069	0.294
MOD_CK2_1	224	230	PF00069	0.596
MOD_CK2_1	354	360	PF00069	0.711
MOD_CK2_1	370	376	PF00069	0.589
MOD_CK2_1	397	403	PF00069	0.578
MOD_GlcNHglycan	149	152	PF01048	0.332
MOD_GlcNHglycan	302	305	PF01048	0.498
MOD_GlcNHglycan	86	89	PF01048	0.598
MOD_GSK3_1	14	21	PF00069	0.475
MOD_GSK3_1	296	303	PF00069	0.581
MOD_GSK3_1	310	317	PF00069	0.758
MOD_GSK3_1	365	372	PF00069	0.741
MOD_GSK3_1	48	55	PF00069	0.286
MOD_GSK3_1	69	76	PF00069	0.353
MOD_N-GLC_1	265	270	PF02516	0.444
MOD_N-GLC_1	274	279	PF02516	0.421
MOD_N-GLC_1	48	53	PF02516	0.465
MOD_N-GLC_1	73	78	PF02516	0.489
MOD_N-GLC_1	89	94	PF02516	0.451
MOD_NEK2_1	129	134	PF00069	0.606
MOD_NEK2_1	184	189	PF00069	0.417
MOD_NEK2_1	191	196	PF00069	0.319
MOD_NEK2_1	28	33	PF00069	0.350
MOD_NEK2_1	38	43	PF00069	0.293
MOD_NEK2_1	52	57	PF00069	0.250
MOD_NEK2_1	91	96	PF00069	0.404
MOD_PIKK_1	392	398	PF00454	0.688
MOD_PIKK_1	91	97	PF00454	0.354
MOD_PKA_2	14	20	PF00069	0.656
MOD_Plk_1	18	24	PF00069	0.450
MOD_Plk_1	274	280	PF00069	0.787
MOD_Plk_1	48	54	PF00069	0.290
MOD_Plk_1	73	79	PF00069	0.446
MOD_Plk_1	89	95	PF00069	0.262
MOD_Plk_4	18	24	PF00069	0.515
MOD_Plk_4	184	190	PF00069	0.399
MOD_Plk_4	204	210	PF00069	0.363
MOD_Plk_4	280	286	PF00069	0.677
MOD_Plk_4	33	39	PF00069	0.314
MOD_Plk_4	341	347	PF00069	0.684
MOD_Plk_4	397	403	PF00069	0.624
MOD_Plk_4	41	47	PF00069	0.374
MOD_Plk_4	64	70	PF00069	0.363
MOD_ProDKin_1	224	230	PF00069	0.678
MOD_ProDKin_1	296	302	PF00069	0.569
MOD_ProDKin_1	331	337	PF00069	0.695
MOD_ProDKin_1	354	360	PF00069	0.689
MOD_ProDKin_1	371	377	PF00069	0.800
MOD_ProDKin_1	390	396	PF00069	0.703
MOD_ProDKin_1	62	68	PF00069	0.415
MOD_SUMO_rev_2	230	236	PF00179	0.603
MOD_SUMO_rev_2	253	258	PF00179	0.634
TRG_DiLeu_BaEn_2	130	136	PF01217	0.590
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.298
TRG_ENDOCYTIC_2	188	191	PF00928	0.298
TRG_ENDOCYTIC_2	223	226	PF00928	0.614
TRG_ENDOCYTIC_2	359	362	PF00928	0.763
TRG_ER_diArg_1	238	241	PF00400	0.610
TRG_ER_diArg_1	386	389	PF00400	0.757
TRG_NLS_MonoExtN_4	10	16	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH38	Leptomonas seymouri	56%	99%
A0A0N1PA63	Leptomonas seymouri	23%	69%
A0A1X0NHW5	Trypanosomatidae	23%	96%
A0A3S7WW58	Leishmania donovani	93%	100%
C9ZIN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AGU2	Leishmania infantum	93%	100%
E9AIL4	Leishmania braziliensis	77%	99%
Q4QCN6	Leishmania major	91%	100%
V5ASX9	Trypanosoma cruzi	44%	100%