Cell division cycle protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell division cycle protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AUU2_LEIMU

TriTrypDb:

LmxM.20.1530

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AUU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUU2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0051301	cell division	2	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.588
CLV_C14_Caspase3-7	622	626	PF00656	0.333
CLV_C14_Caspase3-7	651	655	PF00656	0.335
CLV_C14_Caspase3-7	795	799	PF00656	0.648
CLV_C14_Caspase3-7	99	103	PF00656	0.536
CLV_MEL_PAP_1	387	393	PF00089	0.586
CLV_NRD_NRD_1	12	14	PF00675	0.597
CLV_NRD_NRD_1	205	207	PF00675	0.300
CLV_NRD_NRD_1	237	239	PF00675	0.651
CLV_NRD_NRD_1	287	289	PF00675	0.408
CLV_NRD_NRD_1	412	414	PF00675	0.555
CLV_NRD_NRD_1	466	468	PF00675	0.582
CLV_NRD_NRD_1	572	574	PF00675	0.355
CLV_NRD_NRD_1	580	582	PF00675	0.355
CLV_NRD_NRD_1	719	721	PF00675	0.613
CLV_PCSK_KEX2_1	12	14	PF00082	0.597
CLV_PCSK_KEX2_1	205	207	PF00082	0.516
CLV_PCSK_KEX2_1	287	289	PF00082	0.417
CLV_PCSK_KEX2_1	412	414	PF00082	0.555
CLV_PCSK_KEX2_1	572	574	PF00082	0.354
CLV_PCSK_KEX2_1	580	582	PF00082	0.353
CLV_PCSK_KEX2_1	718	720	PF00082	0.602
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.648
CLV_PCSK_PC7_1	715	721	PF00082	0.599
CLV_PCSK_SKI1_1	174	178	PF00082	0.712
CLV_PCSK_SKI1_1	184	188	PF00082	0.652
CLV_PCSK_SKI1_1	206	210	PF00082	0.506
CLV_PCSK_SKI1_1	260	264	PF00082	0.558
CLV_PCSK_SKI1_1	551	555	PF00082	0.390
CLV_PCSK_SKI1_1	563	567	PF00082	0.315
DEG_APCC_DBOX_1	259	267	PF00400	0.553
DEG_SPOP_SBC_1	3	7	PF00917	0.529
DEG_SPOP_SBC_1	320	324	PF00917	0.672
DEG_SPOP_SBC_1	399	403	PF00917	0.403
DEG_SPOP_SBC_1	636	640	PF00917	0.188
DOC_CYCLIN_RxL_1	569	578	PF00134	0.447
DOC_CYCLIN_RxL_1	78	86	PF00134	0.608
DOC_MAPK_gen_1	482	490	PF00069	0.683
DOC_MAPK_gen_1	580	587	PF00069	0.424
DOC_MAPK_gen_1	683	693	PF00069	0.335
DOC_MAPK_JIP1_4	683	689	PF00069	0.335
DOC_MAPK_MEF2A_6	612	620	PF00069	0.289
DOC_MAPK_MEF2A_6	683	691	PF00069	0.335
DOC_PP1_RVXF_1	285	292	PF00149	0.382
DOC_PP2B_LxvP_1	310	313	PF13499	0.575
DOC_PP2B_LxvP_1	33	36	PF13499	0.630
DOC_PP2B_LxvP_1	545	548	PF13499	0.576
DOC_PP2B_LxvP_1	574	577	PF13499	0.447
DOC_PP2B_LxvP_1	627	630	PF13499	0.335
DOC_PP2B_PxIxI_1	497	503	PF00149	0.481
DOC_PP4_MxPP_1	107	110	PF00568	0.425
DOC_USP7_MATH_1	18	22	PF00917	0.505
DOC_USP7_MATH_1	240	244	PF00917	0.487
DOC_USP7_MATH_1	319	323	PF00917	0.636
DOC_USP7_MATH_1	419	423	PF00917	0.613
DOC_USP7_MATH_1	558	562	PF00917	0.355
DOC_USP7_MATH_1	636	640	PF00917	0.320
DOC_USP7_MATH_1	69	73	PF00917	0.659
DOC_USP7_MATH_1	770	774	PF00917	0.695
DOC_USP7_MATH_1	814	818	PF00917	0.615
DOC_USP7_UBL2_3	757	761	PF12436	0.536
DOC_WW_Pin1_4	253	258	PF00397	0.538
DOC_WW_Pin1_4	267	272	PF00397	0.524
DOC_WW_Pin1_4	326	331	PF00397	0.571
DOC_WW_Pin1_4	380	385	PF00397	0.542
DOC_WW_Pin1_4	459	464	PF00397	0.537
DOC_WW_Pin1_4	494	499	PF00397	0.694
DOC_WW_Pin1_4	772	777	PF00397	0.633
DOC_WW_Pin1_4	798	803	PF00397	0.747
LIG_14-3-3_CanoR_1	147	153	PF00244	0.722
LIG_14-3-3_CanoR_1	165	173	PF00244	0.622
LIG_14-3-3_CanoR_1	644	650	PF00244	0.335
LIG_14-3-3_CanoR_1	719	726	PF00244	0.715
LIG_14-3-3_CanoR_1	816	824	PF00244	0.498
LIG_BRCT_BRCA1_1	248	252	PF00533	0.445
LIG_Clathr_ClatBox_1	333	337	PF01394	0.362
LIG_CSL_BTD_1	38	41	PF09270	0.560
LIG_FHA_1	147	153	PF00498	0.743
LIG_FHA_1	183	189	PF00498	0.601
LIG_FHA_1	26	32	PF00498	0.584
LIG_FHA_1	268	274	PF00498	0.549
LIG_FHA_1	375	381	PF00498	0.425
LIG_FHA_1	405	411	PF00498	0.526
LIG_FHA_1	428	434	PF00498	0.592
LIG_FHA_1	464	470	PF00498	0.740
LIG_FHA_1	475	481	PF00498	0.585
LIG_FHA_1	562	568	PF00498	0.297
LIG_FHA_1	592	598	PF00498	0.480
LIG_FHA_1	734	740	PF00498	0.636
LIG_FHA_1	753	759	PF00498	0.626
LIG_FHA_1	778	784	PF00498	0.625
LIG_FHA_1	80	86	PF00498	0.684
LIG_FHA_2	294	300	PF00498	0.533
LIG_FHA_2	400	406	PF00498	0.557
LIG_FHA_2	632	638	PF00498	0.447
LIG_FHA_2	649	655	PF00498	0.339
LIG_Integrin_RGD_1	796	798	PF01839	0.651
LIG_LIR_Gen_1	199	208	PF02991	0.560
LIG_LIR_Gen_1	513	521	PF02991	0.548
LIG_LIR_Gen_1	95	104	PF02991	0.655
LIG_LIR_Nem_3	199	204	PF02991	0.567
LIG_LIR_Nem_3	513	518	PF02991	0.450
LIG_LIR_Nem_3	95	101	PF02991	0.634
LIG_MYND_1	772	776	PF01753	0.665
LIG_NRBOX	246	252	PF00104	0.555
LIG_NRBOX	261	267	PF00104	0.320
LIG_NRBOX	645	651	PF00104	0.335
LIG_Rb_pABgroove_1	602	610	PF01858	0.402
LIG_SH2_CRK	201	205	PF00017	0.593
LIG_SH2_CRK	515	519	PF00017	0.455
LIG_SH2_SRC	100	103	PF00017	0.445
LIG_SH2_STAP1	515	519	PF00017	0.580
LIG_SH2_STAT5	100	103	PF00017	0.445
LIG_SH2_STAT5	124	127	PF00017	0.459
LIG_SH2_STAT5	409	412	PF00017	0.493
LIG_SH2_STAT5	750	753	PF00017	0.599
LIG_SH3_3	111	117	PF00018	0.534
LIG_SH3_3	239	245	PF00018	0.602
LIG_SH3_3	306	312	PF00018	0.522
LIG_SH3_3	44	50	PF00018	0.668
LIG_SH3_3	457	463	PF00018	0.664
LIG_SH3_3	492	498	PF00018	0.530
LIG_SH3_3	504	510	PF00018	0.587
LIG_SH3_3	678	684	PF00018	0.447
LIG_SH3_3	766	772	PF00018	0.764
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.494
LIG_SUMO_SIM_anti_2	588	594	PF11976	0.335
LIG_SUMO_SIM_anti_2	662	668	PF11976	0.438
LIG_SUMO_SIM_anti_2	736	742	PF11976	0.623
LIG_SUMO_SIM_par_1	293	299	PF11976	0.500
LIG_SUMO_SIM_par_1	331	338	PF11976	0.458
LIG_SUMO_SIM_par_1	664	670	PF11976	0.446
LIG_SUMO_SIM_par_1	735	742	PF11976	0.649
LIG_WRC_WIRS_1	373	378	PF05994	0.493
LIG_WW_3	628	632	PF00397	0.335
LIG_WW_3	768	772	PF00397	0.662
MOD_CDK_SPxxK_3	253	260	PF00069	0.529
MOD_CK1_1	135	141	PF00069	0.685
MOD_CK1_1	243	249	PF00069	0.614
MOD_CK1_1	474	480	PF00069	0.726
MOD_CK1_1	561	567	PF00069	0.335
MOD_CK1_1	591	597	PF00069	0.402
MOD_CK1_1	670	676	PF00069	0.424
MOD_CK2_1	148	154	PF00069	0.660
MOD_CK2_1	169	175	PF00069	0.679
MOD_CK2_1	293	299	PF00069	0.462
MOD_CK2_1	372	378	PF00069	0.472
MOD_CK2_1	390	396	PF00069	0.361
MOD_CK2_1	398	404	PF00069	0.498
MOD_CK2_1	631	637	PF00069	0.447
MOD_CK2_1	70	76	PF00069	0.682
MOD_CK2_1	772	778	PF00069	0.550
MOD_Cter_Amidation	570	573	PF01082	0.402
MOD_GlcNHglycan	242	245	PF01048	0.618
MOD_GlcNHglycan	317	320	PF01048	0.705
MOD_GlcNHglycan	323	326	PF01048	0.628
MOD_GlcNHglycan	366	369	PF01048	0.295
MOD_GlcNHglycan	558	561	PF01048	0.339
MOD_GlcNHglycan	669	672	PF01048	0.366
MOD_GlcNHglycan	698	701	PF01048	0.573
MOD_GSK3_1	182	189	PF00069	0.628
MOD_GSK3_1	2	9	PF00069	0.635
MOD_GSK3_1	230	237	PF00069	0.673
MOD_GSK3_1	315	322	PF00069	0.612
MOD_GSK3_1	345	352	PF00069	0.555
MOD_GSK3_1	386	393	PF00069	0.397
MOD_GSK3_1	400	407	PF00069	0.566
MOD_GSK3_1	419	426	PF00069	0.537
MOD_GSK3_1	436	443	PF00069	0.509
MOD_GSK3_1	454	461	PF00069	0.636
MOD_GSK3_1	463	470	PF00069	0.682
MOD_GSK3_1	494	501	PF00069	0.686
MOD_GSK3_1	561	568	PF00069	0.364
MOD_GSK3_1	610	617	PF00069	0.445
MOD_GSK3_1	631	638	PF00069	0.382
MOD_GSK3_1	644	651	PF00069	0.346
MOD_GSK3_1	691	698	PF00069	0.624
MOD_GSK3_1	71	78	PF00069	0.711
MOD_GSK3_1	79	86	PF00069	0.599
MOD_GSK3_1	88	95	PF00069	0.418
MOD_N-GLC_1	752	757	PF02516	0.373
MOD_NEK2_1	230	235	PF00069	0.536
MOD_NEK2_1	266	271	PF00069	0.576
MOD_NEK2_1	314	319	PF00069	0.697
MOD_NEK2_1	349	354	PF00069	0.504
MOD_NEK2_1	364	369	PF00069	0.549
MOD_NEK2_1	398	403	PF00069	0.593
MOD_NEK2_1	423	428	PF00069	0.604
MOD_NEK2_1	435	440	PF00069	0.387
MOD_NEK2_1	607	612	PF00069	0.408
MOD_NEK2_1	83	88	PF00069	0.540
MOD_PIKK_1	255	261	PF00454	0.585
MOD_PIKK_1	390	396	PF00454	0.432
MOD_PIKK_1	648	654	PF00454	0.447
MOD_PKA_1	467	473	PF00069	0.586
MOD_PKA_1	719	725	PF00069	0.722
MOD_PKA_2	146	152	PF00069	0.685
MOD_PKA_2	166	172	PF00069	0.661
MOD_PKA_2	632	638	PF00069	0.378
MOD_PKA_2	719	725	PF00069	0.727
MOD_PKA_2	770	776	PF00069	0.644
MOD_PKA_2	815	821	PF00069	0.608
MOD_Plk_1	404	410	PF00069	0.385
MOD_Plk_1	642	648	PF00069	0.335
MOD_Plk_1	96	102	PF00069	0.622
MOD_Plk_2-3	293	299	PF00069	0.540
MOD_Plk_4	246	252	PF00069	0.411
MOD_Plk_4	269	275	PF00069	0.530
MOD_Plk_4	345	351	PF00069	0.472
MOD_Plk_4	454	460	PF00069	0.584
MOD_Plk_4	588	594	PF00069	0.355
MOD_Plk_4	614	620	PF00069	0.298
MOD_Plk_4	645	651	PF00069	0.335
MOD_Plk_4	75	81	PF00069	0.662
MOD_ProDKin_1	253	259	PF00069	0.534
MOD_ProDKin_1	267	273	PF00069	0.525
MOD_ProDKin_1	326	332	PF00069	0.560
MOD_ProDKin_1	380	386	PF00069	0.546
MOD_ProDKin_1	459	465	PF00069	0.538
MOD_ProDKin_1	494	500	PF00069	0.695
MOD_ProDKin_1	772	778	PF00069	0.633
MOD_ProDKin_1	798	804	PF00069	0.752
MOD_SUMO_for_1	756	759	PF00179	0.412
TRG_DiLeu_BaEn_1	337	342	PF01217	0.460
TRG_DiLeu_BaEn_1	742	747	PF01217	0.605
TRG_DiLeu_BaEn_2	52	58	PF01217	0.528
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.342
TRG_ENDOCYTIC_2	124	127	PF00928	0.566
TRG_ENDOCYTIC_2	201	204	PF00928	0.514
TRG_ENDOCYTIC_2	515	518	PF00928	0.442
TRG_ER_diArg_1	165	168	PF00400	0.585
TRG_ER_diArg_1	204	206	PF00400	0.595
TRG_ER_diArg_1	287	289	PF00400	0.529
TRG_ER_diArg_1	412	414	PF00400	0.557
TRG_ER_diArg_1	572	574	PF00400	0.354
TRG_ER_diArg_1	580	582	PF00400	0.353
TRG_ER_diArg_1	630	633	PF00400	0.355
TRG_NES_CRM1_1	530	544	PF08389	0.548
TRG_NLS_MonoExtC_3	717	723	PF00514	0.652
TRG_NLS_MonoExtN_4	715	722	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.726
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E7	Leptomonas seymouri	51%	100%
A0A1X0NXH5	Trypanosomatidae	36%	100%
A0A3Q8IBN9	Leishmania donovani	90%	100%
A0A3R7NWG6	Trypanosoma rangeli	37%	100%
A4HZ08	Leishmania infantum	90%	100%
C9ZIP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AIL0	Leishmania braziliensis	75%	100%
Q4QCP1	Leishmania major	88%	100%
V5BCV9	Trypanosoma cruzi	34%	100%