Adaptin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUT8_LEIMU

TriTrypDb:

LmxM.20.1490

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AUT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT8

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003700	DNA-binding transcription factor activity	2	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.311
CLV_C14_Caspase3-7	828	832	PF00656	0.710
CLV_NRD_NRD_1	139	141	PF00675	0.630
CLV_NRD_NRD_1	163	165	PF00675	0.648
CLV_NRD_NRD_1	313	315	PF00675	0.609
CLV_NRD_NRD_1	468	470	PF00675	0.680
CLV_NRD_NRD_1	56	58	PF00675	0.533
CLV_NRD_NRD_1	954	956	PF00675	0.602
CLV_PCSK_KEX2_1	139	141	PF00082	0.630
CLV_PCSK_KEX2_1	228	230	PF00082	0.313
CLV_PCSK_KEX2_1	313	315	PF00082	0.609
CLV_PCSK_KEX2_1	468	470	PF00082	0.680
CLV_PCSK_KEX2_1	683	685	PF00082	0.373
CLV_PCSK_KEX2_1	73	75	PF00082	0.470
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.313
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.455
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.509
CLV_PCSK_PC7_1	224	230	PF00082	0.292
CLV_PCSK_SKI1_1	495	499	PF00082	0.556
CLV_PCSK_SKI1_1	540	544	PF00082	0.550
CLV_PCSK_SKI1_1	61	65	PF00082	0.651
CLV_PCSK_SKI1_1	643	647	PF00082	0.661
DEG_APCC_DBOX_1	650	658	PF00400	0.361
DEG_MDM2_SWIB_1	551	559	PF02201	0.361
DEG_SPOP_SBC_1	270	274	PF00917	0.499
DEG_SPOP_SBC_1	528	532	PF00917	0.503
DEG_SPOP_SBC_1	791	795	PF00917	0.720
DOC_CDC14_PxL_1	296	304	PF14671	0.434
DOC_CDC14_PxL_1	881	889	PF14671	0.783
DOC_MAPK_DCC_7	561	571	PF00069	0.429
DOC_MAPK_gen_1	16	24	PF00069	0.367
DOC_MAPK_gen_1	313	320	PF00069	0.395
DOC_MAPK_gen_1	54	64	PF00069	0.358
DOC_MAPK_gen_1	70	79	PF00069	0.283
DOC_MAPK_gen_1	913	921	PF00069	0.662
DOC_MAPK_gen_1	955	963	PF00069	0.798
DOC_MAPK_HePTP_8	55	67	PF00069	0.369
DOC_MAPK_JIP1_4	314	320	PF00069	0.351
DOC_MAPK_MEF2A_6	332	340	PF00069	0.417
DOC_MAPK_MEF2A_6	58	67	PF00069	0.353
DOC_MAPK_MEF2A_6	70	79	PF00069	0.302
DOC_MAPK_MEF2A_6	913	921	PF00069	0.732
DOC_MAPK_RevD_3	453	469	PF00069	0.433
DOC_PP1_RVXF_1	89	96	PF00149	0.375
DOC_PP1_SILK_1	832	837	PF00149	0.727
DOC_PP4_FxxP_1	941	944	PF00568	0.659
DOC_USP7_MATH_1	3	7	PF00917	0.544
DOC_USP7_MATH_1	437	441	PF00917	0.468
DOC_USP7_MATH_1	518	522	PF00917	0.483
DOC_USP7_MATH_1	629	633	PF00917	0.575
DOC_USP7_MATH_1	790	794	PF00917	0.770
DOC_USP7_MATH_1	830	834	PF00917	0.612
DOC_USP7_UBL2_3	14	18	PF12436	0.496
DOC_USP7_UBL2_3	557	561	PF12436	0.415
DOC_WW_Pin1_4	238	243	PF00397	0.735
DOC_WW_Pin1_4	440	445	PF00397	0.493
DOC_WW_Pin1_4	529	534	PF00397	0.579
DOC_WW_Pin1_4	564	569	PF00397	0.368
DOC_WW_Pin1_4	614	619	PF00397	0.441
DOC_WW_Pin1_4	644	649	PF00397	0.429
DOC_WW_Pin1_4	913	918	PF00397	0.715
LIG_14-3-3_CanoR_1	128	133	PF00244	0.394
LIG_14-3-3_CanoR_1	164	174	PF00244	0.258
LIG_14-3-3_CanoR_1	332	336	PF00244	0.432
LIG_14-3-3_CanoR_1	413	417	PF00244	0.405
LIG_14-3-3_CanoR_1	643	648	PF00244	0.453
LIG_14-3-3_CanoR_1	714	724	PF00244	0.654
LIG_14-3-3_CanoR_1	74	80	PF00244	0.320
LIG_14-3-3_CanoR_1	792	797	PF00244	0.737
LIG_14-3-3_CanoR_1	955	963	PF00244	0.754
LIG_14-3-3_CanoR_1	970	975	PF00244	0.755
LIG_Actin_RPEL_3	67	86	PF02755	0.348
LIG_Actin_WH2_2	400	415	PF00022	0.444
LIG_Actin_WH2_2	445	463	PF00022	0.444
LIG_APCC_ABBA_1	22	27	PF00400	0.393
LIG_APCC_ABBA_1	887	892	PF00400	0.764
LIG_BRCT_BRCA1_1	300	304	PF00533	0.363
LIG_BRCT_BRCA1_1	805	809	PF00533	0.772
LIG_BRCT_BRCA1_1	902	906	PF00533	0.678
LIG_BRCT_BRCA1_1	937	941	PF00533	0.663
LIG_deltaCOP1_diTrp_1	748	758	PF00928	0.676
LIG_EH1_1	654	662	PF00400	0.485
LIG_EVH1_1	881	885	PF00568	0.780
LIG_FHA_1	272	278	PF00498	0.407
LIG_FHA_1	283	289	PF00498	0.411
LIG_FHA_1	406	412	PF00498	0.424
LIG_FHA_1	445	451	PF00498	0.397
LIG_FHA_1	472	478	PF00498	0.424
LIG_FHA_1	496	502	PF00498	0.353
LIG_FHA_1	537	543	PF00498	0.558
LIG_FHA_1	561	567	PF00498	0.419
LIG_FHA_1	615	621	PF00498	0.577
LIG_FHA_1	626	632	PF00498	0.520
LIG_FHA_1	644	650	PF00498	0.464
LIG_FHA_1	868	874	PF00498	0.688
LIG_FHA_1	876	882	PF00498	0.703
LIG_FHA_2	542	548	PF00498	0.486
LIG_FHA_2	6	12	PF00498	0.491
LIG_GBD_Chelix_1	183	191	PF00786	0.544
LIG_GBD_Chelix_1	574	582	PF00786	0.583
LIG_LIR_Apic_2	292	297	PF02991	0.373
LIG_LIR_Apic_2	938	944	PF02991	0.714
LIG_LIR_Gen_1	172	180	PF02991	0.379
LIG_LIR_Gen_1	301	311	PF02991	0.305
LIG_LIR_Gen_1	430	438	PF02991	0.409
LIG_LIR_Gen_1	554	562	PF02991	0.245
LIG_LIR_Gen_1	650	661	PF02991	0.337
LIG_LIR_Gen_1	738	747	PF02991	0.577
LIG_LIR_Gen_1	748	758	PF02991	0.615
LIG_LIR_Gen_1	969	975	PF02991	0.603
LIG_LIR_Nem_3	172	177	PF02991	0.380
LIG_LIR_Nem_3	301	307	PF02991	0.367
LIG_LIR_Nem_3	430	435	PF02991	0.400
LIG_LIR_Nem_3	554	558	PF02991	0.306
LIG_LIR_Nem_3	738	742	PF02991	0.586
LIG_LIR_Nem_3	748	754	PF02991	0.629
LIG_NRBOX	430	436	PF00104	0.358
LIG_PCNA_PIPBox_1	425	434	PF02747	0.398
LIG_PDZ_Class_1	970	975	PF00595	0.755
LIG_Pex14_2	551	555	PF04695	0.444
LIG_Pex14_2	592	596	PF04695	0.388
LIG_SH2_CRK	174	178	PF00017	0.325
LIG_SH2_CRK	323	327	PF00017	0.424
LIG_SH2_CRK	668	672	PF00017	0.571
LIG_SH2_GRB2like	480	483	PF00017	0.441
LIG_SH2_NCK_1	509	513	PF00017	0.383
LIG_SH2_SRC	480	483	PF00017	0.441
LIG_SH2_SRC	668	671	PF00017	0.566
LIG_SH2_STAP1	166	170	PF00017	0.269
LIG_SH2_STAP1	174	178	PF00017	0.325
LIG_SH2_STAT5	44	47	PF00017	0.338
LIG_SH2_STAT5	459	462	PF00017	0.345
LIG_SH2_STAT5	480	483	PF00017	0.411
LIG_SH2_STAT5	708	711	PF00017	0.644
LIG_SH2_STAT5	741	744	PF00017	0.600
LIG_SH2_STAT5	920	923	PF00017	0.740
LIG_SH2_STAT5	971	974	PF00017	0.700
LIG_SH3_3	236	242	PF00018	0.676
LIG_SH3_3	294	300	PF00018	0.389
LIG_SH3_3	452	458	PF00018	0.386
LIG_SH3_3	530	536	PF00018	0.566
LIG_SH3_3	615	621	PF00018	0.376
LIG_SH3_3	869	875	PF00018	0.760
LIG_SH3_3	879	885	PF00018	0.775
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.424
LIG_SUMO_SIM_anti_2	753	758	PF11976	0.673
LIG_SUMO_SIM_par_1	206	212	PF11976	0.369
LIG_SUMO_SIM_par_1	402	408	PF11976	0.386
LIG_SUMO_SIM_par_1	567	573	PF11976	0.399
LIG_SUMO_SIM_par_1	78	84	PF11976	0.391
LIG_TRAF2_1	544	547	PF00917	0.499
LIG_TRAF2_1	761	764	PF00917	0.681
LIG_TYR_ITSM	170	177	PF00017	0.387
LIG_UBA3_1	500	508	PF00899	0.363
LIG_UBA3_1	62	70	PF00899	0.357
LIG_WRC_WIRS_1	736	741	PF05994	0.587
LIG_WW_1	917	920	PF00397	0.782
LIG_WW_2	882	885	PF00397	0.781
MOD_CDK_SPxxK_3	644	651	PF00069	0.451
MOD_CK1_1	158	164	PF00069	0.414
MOD_CK1_1	219	225	PF00069	0.646
MOD_CK1_1	238	244	PF00069	0.721
MOD_CK1_1	334	340	PF00069	0.429
MOD_CK1_1	440	446	PF00069	0.431
MOD_CK1_1	534	540	PF00069	0.583
MOD_CK1_1	560	566	PF00069	0.471
MOD_CK1_1	647	653	PF00069	0.377
MOD_CK1_1	718	724	PF00069	0.638
MOD_CK1_1	740	746	PF00069	0.649
MOD_CK1_1	779	785	PF00069	0.663
MOD_CK1_1	803	809	PF00069	0.698
MOD_CK1_1	867	873	PF00069	0.770
MOD_CK1_1	901	907	PF00069	0.751
MOD_CK2_1	44	50	PF00069	0.373
MOD_CK2_1	5	11	PF00069	0.513
MOD_CK2_1	507	513	PF00069	0.479
MOD_CK2_1	518	524	PF00069	0.460
MOD_CK2_1	541	547	PF00069	0.526
MOD_CK2_1	66	72	PF00069	0.450
MOD_CK2_1	689	695	PF00069	0.613
MOD_CK2_1	758	764	PF00069	0.603
MOD_CK2_1	81	87	PF00069	0.345
MOD_GlcNHglycan	136	139	PF01048	0.644
MOD_GlcNHglycan	308	311	PF01048	0.599
MOD_GlcNHglycan	392	395	PF01048	0.691
MOD_GlcNHglycan	440	443	PF01048	0.664
MOD_GlcNHglycan	483	486	PF01048	0.683
MOD_GlcNHglycan	509	512	PF01048	0.697
MOD_GlcNHglycan	587	590	PF01048	0.608
MOD_GlcNHglycan	610	613	PF01048	0.769
MOD_GlcNHglycan	639	642	PF01048	0.685
MOD_GlcNHglycan	700	703	PF01048	0.491
MOD_GlcNHglycan	710	713	PF01048	0.364
MOD_GlcNHglycan	786	789	PF01048	0.441
MOD_GlcNHglycan	846	849	PF01048	0.516
MOD_GlcNHglycan	866	869	PF01048	0.330
MOD_GlcNHglycan	893	899	PF01048	0.572
MOD_GlcNHglycan	931	934	PF01048	0.603
MOD_GlcNHglycan	937	940	PF01048	0.525
MOD_GSK3_1	105	112	PF00069	0.356
MOD_GSK3_1	128	135	PF00069	0.433
MOD_GSK3_1	154	161	PF00069	0.377
MOD_GSK3_1	165	172	PF00069	0.290
MOD_GSK3_1	234	241	PF00069	0.751
MOD_GSK3_1	265	272	PF00069	0.375
MOD_GSK3_1	298	305	PF00069	0.276
MOD_GSK3_1	3	10	PF00069	0.532
MOD_GSK3_1	330	337	PF00069	0.415
MOD_GSK3_1	40	47	PF00069	0.378
MOD_GSK3_1	419	426	PF00069	0.399
MOD_GSK3_1	440	447	PF00069	0.473
MOD_GSK3_1	491	498	PF00069	0.422
MOD_GSK3_1	523	530	PF00069	0.546
MOD_GSK3_1	534	541	PF00069	0.578
MOD_GSK3_1	560	567	PF00069	0.400
MOD_GSK3_1	608	615	PF00069	0.405
MOD_GSK3_1	625	632	PF00069	0.566
MOD_GSK3_1	635	642	PF00069	0.532
MOD_GSK3_1	643	650	PF00069	0.354
MOD_GSK3_1	731	738	PF00069	0.584
MOD_GSK3_1	799	806	PF00069	0.748
MOD_GSK3_1	821	828	PF00069	0.622
MOD_GSK3_1	830	837	PF00069	0.581
MOD_GSK3_1	894	901	PF00069	0.759
MOD_GSK3_1	925	932	PF00069	0.720
MOD_N-GLC_1	419	424	PF02516	0.665
MOD_N-GLC_1	481	486	PF02516	0.641
MOD_N-GLC_1	864	869	PF02516	0.518
MOD_N-GLC_2	5	7	PF02516	0.694
MOD_NEK2_1	105	110	PF00069	0.354
MOD_NEK2_1	20	25	PF00069	0.412
MOD_NEK2_1	259	264	PF00069	0.444
MOD_NEK2_1	411	416	PF00069	0.341
MOD_NEK2_1	596	601	PF00069	0.297
MOD_NEK2_1	639	644	PF00069	0.525
MOD_NEK2_1	698	703	PF00069	0.683
MOD_NEK2_1	809	814	PF00069	0.768
MOD_NEK2_1	81	86	PF00069	0.420
MOD_NEK2_1	825	830	PF00069	0.681
MOD_NEK2_2	538	543	PF00069	0.455
MOD_NMyristoyl	1	7	PF02799	0.547
MOD_PIKK_1	128	134	PF00454	0.467
MOD_PIKK_1	287	293	PF00454	0.313
MOD_PIKK_1	419	425	PF00454	0.462
MOD_PIKK_1	531	537	PF00454	0.387
MOD_PIKK_1	800	806	PF00454	0.774
MOD_PIKK_1	834	840	PF00454	0.699
MOD_PIKK_1	867	873	PF00454	0.697
MOD_PKA_2	127	133	PF00069	0.416
MOD_PKA_2	282	288	PF00069	0.441
MOD_PKA_2	331	337	PF00069	0.428
MOD_PKA_2	412	418	PF00069	0.394
MOD_PKA_2	698	704	PF00069	0.668
MOD_PKA_2	791	797	PF00069	0.722
MOD_Plk_1	219	225	PF00069	0.675
MOD_Plk_1	234	240	PF00069	0.766
MOD_Plk_1	419	425	PF00069	0.433
MOD_Plk_1	779	785	PF00069	0.709
MOD_Plk_1	830	836	PF00069	0.758
MOD_Plk_4	20	26	PF00069	0.382
MOD_Plk_4	298	304	PF00069	0.384
MOD_Plk_4	366	372	PF00069	0.428
MOD_Plk_4	40	46	PF00069	0.351
MOD_Plk_4	412	418	PF00069	0.408
MOD_Plk_4	423	429	PF00069	0.391
MOD_Plk_4	538	544	PF00069	0.545
MOD_Plk_4	567	573	PF00069	0.424
MOD_Plk_4	75	81	PF00069	0.388
MOD_Plk_4	830	836	PF00069	0.721
MOD_ProDKin_1	238	244	PF00069	0.725
MOD_ProDKin_1	440	446	PF00069	0.486
MOD_ProDKin_1	529	535	PF00069	0.580
MOD_ProDKin_1	564	570	PF00069	0.364
MOD_ProDKin_1	614	620	PF00069	0.442
MOD_ProDKin_1	644	650	PF00069	0.425
MOD_ProDKin_1	913	919	PF00069	0.715
MOD_SUMO_rev_2	761	766	PF00179	0.631
MOD_SUMO_rev_2	810	819	PF00179	0.739
TRG_DiLeu_BaEn_1	554	559	PF01217	0.240
TRG_DiLeu_BaEn_2	936	942	PF01217	0.662
TRG_DiLeu_BaEn_3	763	769	PF01217	0.633
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.348
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.543
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.375
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.435
TRG_ENDOCYTIC_2	174	177	PF00928	0.323
TRG_ENDOCYTIC_2	323	326	PF00928	0.396
TRG_ENDOCYTIC_2	971	974	PF00928	0.700
TRG_ER_diArg_1	139	141	PF00400	0.430
TRG_ER_diArg_1	313	315	PF00400	0.386
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	964	969	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU24	Leptomonas seymouri	62%	99%
A0A1X0NW53	Trypanosomatidae	30%	97%
A0A3R7NMU6	Trypanosoma rangeli	31%	100%
A0A3S7WW45	Leishmania donovani	90%	100%
A4HYZ2	Leishmania infantum	90%	100%
C9ZIP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9AIK6	Leishmania braziliensis	81%	100%
Q4QCP5	Leishmania major	89%	99%