Adaptin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUT8_LEIMU

TriTrypDb:

LmxM.20.1490

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AUT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT8

Function

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Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003700	DNA-binding transcription factor activity	2	1
GO:0140110	transcription regulator activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.311
CLV_C14_Caspase3-7	828	832	PF00656	0.710
CLV_NRD_NRD_1	139	141	PF00675	0.630
CLV_NRD_NRD_1	163	165	PF00675	0.648
CLV_NRD_NRD_1	313	315	PF00675	0.609
CLV_NRD_NRD_1	468	470	PF00675	0.680
CLV_NRD_NRD_1	56	58	PF00675	0.533
CLV_NRD_NRD_1	954	956	PF00675	0.602
CLV_PCSK_KEX2_1	139	141	PF00082	0.630
CLV_PCSK_KEX2_1	228	230	PF00082	0.313

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU24	Leptomonas seymouri	62%	99%
A0A1X0NW53	Trypanosomatidae	30%	97%
A0A3R7NMU6	Trypanosoma rangeli	31%	100%
A0A3S7WW45	Leishmania donovani	90%	100%
A4HYZ2	Leishmania infantum	90%	100%
C9ZIP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9AIK6	Leishmania braziliensis	81%	100%
Q4QCP5	Leishmania major	89%	99%

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