Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUT6_LEIMU

TriTrypDb:

LmxM.20.1470

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.631
CLV_NRD_NRD_1	261	263	PF00675	0.471
CLV_NRD_NRD_1	357	359	PF00675	0.692
CLV_NRD_NRD_1	452	454	PF00675	0.543
CLV_PCSK_KEX2_1	261	263	PF00082	0.471
CLV_PCSK_KEX2_1	357	359	PF00082	0.692
CLV_PCSK_KEX2_1	381	383	PF00082	0.597
CLV_PCSK_KEX2_1	452	454	PF00082	0.543
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.597
CLV_PCSK_PC7_1	377	383	PF00082	0.595
CLV_PCSK_SKI1_1	107	111	PF00082	0.462
CLV_PCSK_SKI1_1	157	161	PF00082	0.433
CLV_PCSK_SKI1_1	346	350	PF00082	0.654
CLV_PCSK_SKI1_1	423	427	PF00082	0.310
CLV_Separin_Metazoa	258	262	PF03568	0.644
DEG_APCC_DBOX_1	156	164	PF00400	0.634
DEG_Nend_Nbox_1	1	3	PF02207	0.677
DEG_SPOP_SBC_1	220	224	PF00917	0.670
DOC_CKS1_1	426	431	PF01111	0.310
DOC_CKS1_1	444	449	PF01111	0.652
DOC_CYCLIN_RxL_1	343	352	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.654
DOC_MAPK_gen_1	357	363	PF00069	0.470
DOC_MAPK_gen_1	87	95	PF00069	0.693
DOC_PP2B_LxvP_1	518	521	PF13499	0.383
DOC_PP2B_LxvP_1	72	75	PF13499	0.740
DOC_PP2B_LxvP_1	93	96	PF13499	0.663
DOC_USP7_MATH_1	164	168	PF00917	0.754
DOC_USP7_MATH_1	221	225	PF00917	0.675
DOC_USP7_MATH_1	243	247	PF00917	0.618
DOC_USP7_MATH_1	33	37	PF00917	0.687
DOC_USP7_MATH_1	400	404	PF00917	0.502
DOC_WW_Pin1_4	213	218	PF00397	0.712
DOC_WW_Pin1_4	396	401	PF00397	0.451
DOC_WW_Pin1_4	425	430	PF00397	0.310
DOC_WW_Pin1_4	443	448	PF00397	0.642
DOC_WW_Pin1_4	556	561	PF00397	0.391
DOC_WW_Pin1_4	60	65	PF00397	0.714
LIG_14-3-3_CanoR_1	262	270	PF00244	0.721
LIG_14-3-3_CanoR_1	92	96	PF00244	0.697
LIG_BIR_III_4	190	194	PF00653	0.754
LIG_BRCT_BRCA1_1	271	275	PF00533	0.602
LIG_BRCT_BRCA1_1	295	299	PF00533	0.616
LIG_BRCT_BRCA1_1	505	509	PF00533	0.536
LIG_FAT_LD_1	563	571	PF03623	0.424
LIG_FHA_1	139	145	PF00498	0.653
LIG_FHA_1	208	214	PF00498	0.577
LIG_FHA_1	275	281	PF00498	0.624
LIG_FHA_1	416	422	PF00498	0.488
LIG_FHA_1	426	432	PF00498	0.271
LIG_FHA_1	546	552	PF00498	0.416
LIG_FHA_2	202	208	PF00498	0.644
LIG_FHA_2	295	301	PF00498	0.670
LIG_FHA_2	47	53	PF00498	0.631
LIG_LIR_Gen_1	143	154	PF02991	0.701
LIG_LIR_Gen_1	204	213	PF02991	0.642
LIG_LIR_Gen_1	26	35	PF02991	0.659
LIG_LIR_Gen_1	296	306	PF02991	0.643
LIG_LIR_Gen_1	572	581	PF02991	0.456
LIG_LIR_Nem_3	143	149	PF02991	0.646
LIG_LIR_Nem_3	204	208	PF02991	0.636
LIG_LIR_Nem_3	26	31	PF02991	0.662
LIG_LIR_Nem_3	272	278	PF02991	0.597
LIG_LIR_Nem_3	296	302	PF02991	0.645
LIG_LIR_Nem_3	572	577	PF02991	0.400
LIG_LIR_Nem_3	582	587	PF02991	0.431
LIG_MLH1_MIPbox_1	295	299	PF16413	0.616
LIG_Pex14_1	295	299	PF04695	0.591
LIG_Pex14_1	434	438	PF04695	0.310
LIG_Pex14_2	208	212	PF04695	0.645
LIG_Pex14_2	299	303	PF04695	0.586
LIG_Pex14_2	493	497	PF04695	0.581
LIG_SH2_CRK	318	322	PF00017	0.383
LIG_SH2_CRK	574	578	PF00017	0.448
LIG_SH2_CRK	62	66	PF00017	0.715
LIG_SH2_NCK_1	62	66	PF00017	0.715
LIG_SH2_PTP2	196	199	PF00017	0.685
LIG_SH2_STAP1	318	322	PF00017	0.383
LIG_SH2_STAT5	196	199	PF00017	0.685
LIG_SH2_STAT5	379	382	PF00017	0.446
LIG_SH2_STAT5	492	495	PF00017	0.583
LIG_SH2_STAT5	580	583	PF00017	0.414
LIG_SH2_STAT5	62	65	PF00017	0.719
LIG_SH3_1	196	202	PF00018	0.697
LIG_SH3_1	237	243	PF00018	0.638
LIG_SH3_3	147	153	PF00018	0.642
LIG_SH3_3	194	200	PF00018	0.713
LIG_SH3_3	211	217	PF00018	0.658
LIG_SH3_3	237	243	PF00018	0.638
LIG_SH3_3	445	451	PF00018	0.684
LIG_SH3_3	457	463	PF00018	0.644
LIG_SH3_CIN85_PxpxPR_1	447	452	PF14604	0.641
LIG_SUMO_SIM_anti_2	51	59	PF11976	0.635
LIG_TRAF2_1	16	19	PF00917	0.704
LIG_TRFH_1	196	200	PF08558	0.734
MOD_CDK_SPK_2	396	401	PF00069	0.427
MOD_CDK_SPxK_1	556	562	PF00069	0.390
MOD_CK1_1	375	381	PF00069	0.455
MOD_CK1_1	403	409	PF00069	0.507
MOD_CK1_1	411	417	PF00069	0.492
MOD_CK1_1	51	57	PF00069	0.720
MOD_CK1_1	539	545	PF00069	0.399
MOD_CK1_1	73	79	PF00069	0.663
MOD_CK2_1	265	271	PF00069	0.732
MOD_CK2_1	294	300	PF00069	0.674
MOD_CK2_1	484	490	PF00069	0.587
MOD_Cter_Amidation	355	358	PF01082	0.642
MOD_GlcNHglycan	127	130	PF01048	0.363
MOD_GlcNHglycan	234	237	PF01048	0.610
MOD_GlcNHglycan	265	268	PF01048	0.476
MOD_GlcNHglycan	271	274	PF01048	0.482
MOD_GlcNHglycan	354	357	PF01048	0.653
MOD_GlcNHglycan	4	7	PF01048	0.437
MOD_GlcNHglycan	411	414	PF01048	0.715
MOD_GlcNHglycan	46	49	PF01048	0.499
MOD_GlcNHglycan	487	490	PF01048	0.420
MOD_GlcNHglycan	541	544	PF01048	0.501
MOD_GSK3_1	2	9	PF00069	0.658
MOD_GSK3_1	203	210	PF00069	0.639
MOD_GSK3_1	215	222	PF00069	0.669
MOD_GSK3_1	265	272	PF00069	0.686
MOD_GSK3_1	294	301	PF00069	0.642
MOD_GSK3_1	348	355	PF00069	0.447
MOD_GSK3_1	390	397	PF00069	0.487
MOD_GSK3_1	402	409	PF00069	0.550
MOD_GSK3_1	411	418	PF00069	0.431
MOD_GSK3_1	44	51	PF00069	0.759
MOD_N-GLC_1	263	268	PF02516	0.398
MOD_NEK2_1	1	6	PF00069	0.665
MOD_NEK2_1	265	270	PF00069	0.726
MOD_NEK2_1	298	303	PF00069	0.587
MOD_NEK2_1	372	377	PF00069	0.443
MOD_NEK2_1	44	49	PF00069	0.772
MOD_NEK2_2	243	248	PF00069	0.614
MOD_NEK2_2	33	38	PF00069	0.676
MOD_NEK2_2	463	468	PF00069	0.614
MOD_PIKK_1	144	150	PF00454	0.699
MOD_PIKK_1	164	170	PF00454	0.572
MOD_PIKK_1	533	539	PF00454	0.400
MOD_PIKK_1	6	12	PF00454	0.658
MOD_PIKK_1	63	69	PF00454	0.673
MOD_PKA_1	173	179	PF00069	0.670
MOD_PKA_2	400	406	PF00069	0.500
MOD_PKA_2	415	421	PF00069	0.437
MOD_PKA_2	44	50	PF00069	0.706
MOD_PKA_2	545	551	PF00069	0.419
MOD_PKA_2	91	97	PF00069	0.720
MOD_Plk_1	105	111	PF00069	0.779
MOD_Plk_1	51	57	PF00069	0.676
MOD_Plk_4	118	124	PF00069	0.679
MOD_Plk_4	294	300	PF00069	0.608
MOD_Plk_4	33	39	PF00069	0.690
MOD_Plk_4	463	469	PF00069	0.693
MOD_Plk_4	579	585	PF00069	0.417
MOD_ProDKin_1	213	219	PF00069	0.715
MOD_ProDKin_1	396	402	PF00069	0.452
MOD_ProDKin_1	425	431	PF00069	0.310
MOD_ProDKin_1	443	449	PF00069	0.645
MOD_ProDKin_1	556	562	PF00069	0.390
MOD_ProDKin_1	60	66	PF00069	0.715
TRG_DiLeu_BaEn_3	342	348	PF01217	0.419
TRG_ENDOCYTIC_2	318	321	PF00928	0.310
TRG_ENDOCYTIC_2	574	577	PF00928	0.415
TRG_ER_diArg_1	260	262	PF00400	0.663
TRG_ER_diArg_1	357	359	PF00400	0.499
TRG_ER_diArg_1	451	453	PF00400	0.706
TRG_ER_diArg_1	87	90	PF00400	0.759

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ42	Leptomonas seymouri	50%	100%
A0A3Q8IAX6	Leishmania donovani	88%	100%
A4HYZ0	Leishmania infantum	89%	99%
E9AIK4	Leishmania braziliensis	74%	97%
Q4QCP7	Leishmania major	87%	99%