C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUT5_LEIMU

TriTrypDb:

LmxM.20.1460

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.411
CLV_PCSK_KEX2_1	113	115	PF00082	0.593
CLV_PCSK_KEX2_1	229	231	PF00082	0.512
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.512
CLV_PCSK_SKI1_1	113	117	PF00082	0.431
CLV_PCSK_SKI1_1	76	80	PF00082	0.502
DEG_MDM2_SWIB_1	70	78	PF02201	0.460
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.631
DOC_MAPK_gen_1	113	121	PF00069	0.458
DOC_MAPK_gen_1	63	73	PF00069	0.482
DOC_MAPK_gen_1	95	104	PF00069	0.424
DOC_MAPK_HePTP_8	17	29	PF00069	0.477
DOC_MAPK_MEF2A_6	113	121	PF00069	0.436
DOC_MAPK_MEF2A_6	20	29	PF00069	0.448
DOC_MAPK_MEF2A_6	66	73	PF00069	0.460
DOC_MAPK_MEF2A_6	98	106	PF00069	0.569
DOC_PP2B_LxvP_1	195	198	PF13499	0.675
DOC_USP7_MATH_1	155	159	PF00917	0.663
DOC_USP7_MATH_1	163	167	PF00917	0.658
DOC_USP7_MATH_1	169	173	PF00917	0.671
DOC_USP7_MATH_1	62	66	PF00917	0.356
DOC_WW_Pin1_4	119	124	PF00397	0.444
DOC_WW_Pin1_4	149	154	PF00397	0.607
LIG_14-3-3_CanoR_1	113	118	PF00244	0.446
LIG_14-3-3_CanoR_1	20	24	PF00244	0.557
LIG_14-3-3_CanoR_1	35	44	PF00244	0.355
LIG_APCC_ABBAyCdc20_2	66	72	PF00400	0.465
LIG_deltaCOP1_diTrp_1	72	79	PF00928	0.472
LIG_FHA_1	114	120	PF00498	0.534
LIG_FHA_1	73	79	PF00498	0.390
LIG_FHA_2	120	126	PF00498	0.463
LIG_FHA_2	171	177	PF00498	0.749
LIG_IBAR_NPY_1	154	156	PF08397	0.690
LIG_LIR_Gen_1	85	96	PF02991	0.476
LIG_LIR_Nem_3	22	26	PF02991	0.434
LIG_LYPXL_S_1	199	203	PF13949	0.702
LIG_LYPXL_yS_3	200	203	PF13949	0.705
LIG_MYND_1	197	201	PF01753	0.718
LIG_Pex14_2	49	53	PF04695	0.470
LIG_Pex14_2	70	74	PF04695	0.446
LIG_SH2_CRK	141	145	PF00017	0.754
LIG_SH2_NCK_1	156	160	PF00017	0.641
LIG_SH2_PTP2	26	29	PF00017	0.446
LIG_SH2_STAP1	156	160	PF00017	0.729
LIG_SH2_STAT5	156	159	PF00017	0.754
LIG_SH2_STAT5	161	164	PF00017	0.704
LIG_SH2_STAT5	217	220	PF00017	0.615
LIG_SH2_STAT5	26	29	PF00017	0.446
LIG_SH2_STAT5	48	51	PF00017	0.286
LIG_SH3_3	130	136	PF00018	0.642
LIG_SH3_3	178	184	PF00018	0.621
LIG_SH3_3	195	201	PF00018	0.587
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.438
LIG_UBA3_1	69	76	PF00899	0.447
LIG_WW_1	197	200	PF00397	0.640
MOD_CK1_1	222	228	PF00069	0.684
MOD_CK1_1	82	88	PF00069	0.458
MOD_Cter_Amidation	111	114	PF01082	0.548
MOD_GlcNHglycan	157	160	PF01048	0.725
MOD_GlcNHglycan	165	168	PF01048	0.569
MOD_GlcNHglycan	211	214	PF01048	0.791
MOD_GlcNHglycan	39	42	PF01048	0.500
MOD_GSK3_1	115	122	PF00069	0.408
MOD_GSK3_1	15	22	PF00069	0.574
MOD_GSK3_1	199	206	PF00069	0.569
MOD_GSK3_1	33	40	PF00069	0.296
MOD_GSK3_1	58	65	PF00069	0.444
MOD_N-GLC_1	163	168	PF02516	0.470
MOD_NEK2_1	126	131	PF00069	0.524
MOD_NEK2_1	170	175	PF00069	0.608
MOD_NEK2_1	19	24	PF00069	0.522
MOD_NEK2_1	203	208	PF00069	0.507
MOD_NEK2_1	79	84	PF00069	0.572
MOD_NEK2_2	74	79	PF00069	0.455
MOD_PIKK_1	179	185	PF00454	0.717
MOD_PIKK_1	201	207	PF00454	0.719
MOD_PIKK_1	222	228	PF00454	0.780
MOD_PIKK_1	77	83	PF00454	0.476
MOD_PK_1	230	236	PF00069	0.702
MOD_PKA_1	113	119	PF00069	0.490
MOD_PKA_2	106	112	PF00069	0.465
MOD_PKA_2	113	119	PF00069	0.475
MOD_PKA_2	19	25	PF00069	0.528
MOD_PKA_2	62	68	PF00069	0.524
MOD_Plk_1	230	236	PF00069	0.702
MOD_Plk_1	4	10	PF00069	0.394
MOD_Plk_4	4	10	PF00069	0.428
MOD_Plk_4	74	80	PF00069	0.457
MOD_ProDKin_1	119	125	PF00069	0.452
MOD_ProDKin_1	149	155	PF00069	0.604
TRG_ENDOCYTIC_2	200	203	PF00928	0.622
TRG_ENDOCYTIC_2	26	29	PF00928	0.387
TRG_ER_diArg_1	66	69	PF00400	0.465
TRG_ER_diLys_1	238	242	PF00400	0.697
TRG_NES_CRM1_1	135	146	PF08389	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P409	Leptomonas seymouri	50%	86%
A0A3Q8IDQ9	Leishmania donovani	91%	100%
A4HYY9	Leishmania infantum	91%	100%
E9AIK3	Leishmania braziliensis	67%	100%
Q4QCP8	Leishmania major	86%	100%