Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUT4_LEIMU

TriTrypDb:

LmxM.20.1450

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.461
CLV_NRD_NRD_1	141	143	PF00675	0.579
CLV_NRD_NRD_1	151	153	PF00675	0.596
CLV_NRD_NRD_1	192	194	PF00675	0.563
CLV_PCSK_KEX2_1	141	143	PF00082	0.579
CLV_PCSK_KEX2_1	151	153	PF00082	0.596
CLV_PCSK_KEX2_1	191	193	PF00082	0.487
CLV_PCSK_KEX2_1	375	377	PF00082	0.555
CLV_PCSK_KEX2_1	99	101	PF00082	0.515
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.522
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.515
CLV_PCSK_SKI1_1	129	133	PF00082	0.444
CLV_PCSK_SKI1_1	151	155	PF00082	0.509
CLV_PCSK_SKI1_1	214	218	PF00082	0.607
DOC_CKS1_1	18	23	PF01111	0.489
DOC_CYCLIN_RxL_1	363	373	PF00134	0.506
DOC_CYCLIN_RxL_1	43	54	PF00134	0.421
DOC_MAPK_gen_1	57	66	PF00069	0.367
DOC_MAPK_gen_1	76	86	PF00069	0.382
DOC_MAPK_gen_1	99	106	PF00069	0.484
DOC_MAPK_MEF2A_6	273	280	PF00069	0.514
DOC_MAPK_MEF2A_6	57	66	PF00069	0.367
DOC_MAPK_MEF2A_6	87	94	PF00069	0.400
DOC_MAPK_MEF2A_6	99	106	PF00069	0.391
DOC_PP1_RVXF_1	159	165	PF00149	0.356
DOC_PP2B_LxvP_1	306	309	PF13499	0.472
DOC_USP7_MATH_1	200	204	PF00917	0.593
DOC_USP7_MATH_1	235	239	PF00917	0.637
DOC_USP7_MATH_1	279	283	PF00917	0.655
DOC_USP7_MATH_1	327	331	PF00917	0.411
DOC_USP7_MATH_1	44	48	PF00917	0.421
DOC_USP7_MATH_1	74	78	PF00917	0.464
DOC_WW_Pin1_4	17	22	PF00397	0.495
DOC_WW_Pin1_4	193	198	PF00397	0.634
DOC_WW_Pin1_4	201	206	PF00397	0.668
DOC_WW_Pin1_4	233	238	PF00397	0.615
DOC_WW_Pin1_4	256	261	PF00397	0.626
LIG_14-3-3_CanoR_1	151	160	PF00244	0.491
LIG_14-3-3_CanoR_1	179	186	PF00244	0.417
LIG_14-3-3_CanoR_1	191	197	PF00244	0.648
LIG_14-3-3_CanoR_1	214	221	PF00244	0.754
LIG_APCC_ABBAyCdc20_2	69	75	PF00400	0.499
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BIR_III_4	266	270	PF00653	0.593
LIG_BIR_III_4	29	33	PF00653	0.461
LIG_CaM_IQ_9	335	351	PF13499	0.462
LIG_FHA_1	10	16	PF00498	0.534
LIG_FHA_1	112	118	PF00498	0.412
LIG_FHA_1	18	24	PF00498	0.394
LIG_FHA_1	180	186	PF00498	0.462
LIG_FHA_1	321	327	PF00498	0.519
LIG_FHA_2	122	128	PF00498	0.387
LIG_FHA_2	315	321	PF00498	0.567
LIG_FHA_2	35	41	PF00498	0.460
LIG_FHA_2	4	10	PF00498	0.621
LIG_LIR_Apic_2	224	230	PF02991	0.637
LIG_LIR_Apic_2	282	287	PF02991	0.627
LIG_LIR_Gen_1	89	98	PF02991	0.351
LIG_LIR_Nem_3	174	180	PF02991	0.368
LIG_LIR_Nem_3	53	58	PF02991	0.467
LIG_LIR_Nem_3	89	94	PF02991	0.346
LIG_NRBOX	93	99	PF00104	0.426
LIG_PCNA_PIPBox_1	49	58	PF02747	0.455
LIG_PCNA_yPIPBox_3	46	56	PF02747	0.450
LIG_SH2_CRK	284	288	PF00017	0.624
LIG_SH2_NCK_1	264	268	PF00017	0.646
LIG_SH2_NCK_1	284	288	PF00017	0.624
LIG_SH2_PTP2	91	94	PF00017	0.331
LIG_SH2_STAT5	115	118	PF00017	0.451
LIG_SH2_STAT5	284	287	PF00017	0.712
LIG_SH2_STAT5	34	37	PF00017	0.457
LIG_SH2_STAT5	55	58	PF00017	0.466
LIG_SH2_STAT5	91	94	PF00017	0.331
LIG_SH3_2	21	26	PF14604	0.418
LIG_SH3_3	18	24	PF00018	0.498
LIG_SH3_3	199	205	PF00018	0.602
LIG_SH3_3	38	44	PF00018	0.254
LIG_SH3_4	59	66	PF00018	0.457
LIG_Sin3_3	377	384	PF02671	0.455
LIG_SUMO_SIM_par_1	317	325	PF11976	0.502
LIG_SUMO_SIM_par_1	366	373	PF11976	0.500
LIG_TYR_ITIM	175	180	PF00017	0.371
LIG_UBA3_1	367	375	PF00899	0.467
MOD_CK1_1	2	8	PF00069	0.703
MOD_CK1_1	236	242	PF00069	0.626
MOD_CK1_1	282	288	PF00069	0.624
MOD_CK2_1	121	127	PF00069	0.393
MOD_CK2_1	247	253	PF00069	0.710
MOD_CK2_1	256	262	PF00069	0.639
MOD_CK2_1	3	9	PF00069	0.627
MOD_CK2_1	314	320	PF00069	0.569
MOD_DYRK1A_RPxSP_1	193	197	PF00069	0.446
MOD_GlcNHglycan	1	4	PF01048	0.753
MOD_GlcNHglycan	233	236	PF01048	0.639
MOD_GlcNHglycan	238	241	PF01048	0.658
MOD_GlcNHglycan	249	252	PF01048	0.455
MOD_GlcNHglycan	281	284	PF01048	0.660
MOD_GSK3_1	147	154	PF00069	0.516
MOD_GSK3_1	215	222	PF00069	0.656
MOD_GSK3_1	231	238	PF00069	0.577
MOD_GSK3_1	316	323	PF00069	0.586
MOD_GSK3_1	9	16	PF00069	0.647
MOD_LATS_1	190	196	PF00433	0.567
MOD_N-GLC_1	212	217	PF02516	0.787
MOD_N-GLC_2	81	83	PF02516	0.365
MOD_NEK2_1	212	217	PF00069	0.672
MOD_NEK2_1	370	375	PF00069	0.481
MOD_NEK2_2	74	79	PF00069	0.410
MOD_PIKK_1	215	221	PF00454	0.538
MOD_PIKK_1	282	288	PF00454	0.584
MOD_PKA_1	151	157	PF00069	0.518
MOD_PKA_1	192	198	PF00069	0.703
MOD_PKA_2	151	157	PF00069	0.518
MOD_PKA_2	178	184	PF00069	0.416
MOD_PKA_2	192	198	PF00069	0.652
MOD_PKA_2	254	260	PF00069	0.546
MOD_PKB_1	229	237	PF00069	0.479
MOD_Plk_1	212	218	PF00069	0.662
MOD_Plk_1	370	376	PF00069	0.561
MOD_Plk_1	74	80	PF00069	0.381
MOD_Plk_2-3	121	127	PF00069	0.441
MOD_Plk_4	111	117	PF00069	0.402
MOD_Plk_4	121	127	PF00069	0.381
MOD_Plk_4	287	293	PF00069	0.587
MOD_ProDKin_1	17	23	PF00069	0.479
MOD_ProDKin_1	193	199	PF00069	0.637
MOD_ProDKin_1	201	207	PF00069	0.671
MOD_ProDKin_1	233	239	PF00069	0.616
MOD_ProDKin_1	256	262	PF00069	0.629
MOD_SUMO_for_1	58	61	PF00179	0.466
MOD_SUMO_rev_2	121	131	PF00179	0.440
TRG_DiLeu_BaEn_1	158	163	PF01217	0.449
TRG_DiLeu_BaEn_1	61	66	PF01217	0.456
TRG_DiLeu_LyEn_5	158	163	PF01217	0.449
TRG_ENDOCYTIC_2	166	169	PF00928	0.376
TRG_ENDOCYTIC_2	177	180	PF00928	0.379
TRG_ENDOCYTIC_2	55	58	PF00928	0.466
TRG_ENDOCYTIC_2	91	94	PF00928	0.331
TRG_ER_diArg_1	151	153	PF00400	0.554
TRG_ER_diArg_1	159	162	PF00400	0.307
TRG_ER_diArg_1	191	193	PF00400	0.524
TRG_NES_CRM1_1	158	171	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV9	Leptomonas seymouri	56%	96%
A0A1X0NWT1	Trypanosomatidae	36%	100%
A0A3S7WW52	Leishmania donovani	92%	100%
A0A422N975	Trypanosoma rangeli	36%	100%
A4HYY8	Leishmania infantum	92%	100%
E9AIK2	Leishmania braziliensis	80%	96%
Q4QCP9	Leishmania major	93%	100%