SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUT2_LEIMU

TriTrypDb:

LmxM.20.1430

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	331	337	PF00089	0.455
CLV_NRD_NRD_1	189	191	PF00675	0.417
CLV_NRD_NRD_1	249	251	PF00675	0.584
CLV_PCSK_FUR_1	246	250	PF00082	0.553
CLV_PCSK_KEX2_1	189	191	PF00082	0.415
CLV_PCSK_KEX2_1	248	250	PF00082	0.510
CLV_PCSK_SKI1_1	162	166	PF00082	0.369
CLV_PCSK_SKI1_1	178	182	PF00082	0.340
CLV_PCSK_SKI1_1	207	211	PF00082	0.308
CLV_PCSK_SKI1_1	249	253	PF00082	0.521
DEG_APCC_DBOX_1	206	214	PF00400	0.334
DEG_COP1_1	264	274	PF00400	0.452
DEG_Nend_Nbox_1	1	3	PF02207	0.527
DOC_CDC14_PxL_1	268	276	PF14671	0.348
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.343
DOC_MAPK_DCC_7	160	170	PF00069	0.462
DOC_MAPK_MEF2A_6	162	171	PF00069	0.511
DOC_PP2B_LxvP_1	195	198	PF13499	0.346
DOC_PP4_MxPP_1	97	100	PF00568	0.427
DOC_USP7_MATH_1	13	17	PF00917	0.497
DOC_USP7_MATH_1	76	80	PF00917	0.482
DOC_WW_Pin1_4	135	140	PF00397	0.447
DOC_WW_Pin1_4	190	195	PF00397	0.467
DOC_WW_Pin1_4	278	283	PF00397	0.482
LIG_14-3-3_CanoR_1	321	331	PF00244	0.474
LIG_14-3-3_CanoR_1	8	14	PF00244	0.486
LIG_Clathr_ClatBox_1	168	172	PF01394	0.506
LIG_FHA_1	109	115	PF00498	0.452
LIG_FHA_1	26	32	PF00498	0.442
LIG_FHA_1	279	285	PF00498	0.414
LIG_FHA_1	315	321	PF00498	0.491
LIG_LIR_Gen_1	121	131	PF02991	0.354
LIG_LIR_Gen_1	141	152	PF02991	0.376
LIG_LIR_Gen_1	229	238	PF02991	0.529
LIG_LIR_Gen_1	266	276	PF02991	0.517
LIG_LIR_Gen_1	44	52	PF02991	0.300
LIG_LIR_Nem_3	121	127	PF02991	0.354
LIG_LIR_Nem_3	141	147	PF02991	0.369
LIG_LIR_Nem_3	172	176	PF02991	0.392
LIG_LIR_Nem_3	229	235	PF02991	0.518
LIG_LIR_Nem_3	266	271	PF02991	0.439
LIG_LIR_Nem_3	44	48	PF02991	0.459
LIG_LIR_Nem_3	5	9	PF02991	0.602
LIG_MYND_1	272	276	PF01753	0.313
LIG_NRBOX	183	189	PF00104	0.470
LIG_PCNA_PIPBox_1	180	189	PF02747	0.401
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.459
LIG_Pex14_1	247	251	PF04695	0.620
LIG_Pex14_2	333	337	PF04695	0.458
LIG_SH2_CRK	144	148	PF00017	0.469
LIG_SH2_CRK	232	236	PF00017	0.520
LIG_SH2_CRK	268	272	PF00017	0.392
LIG_SH2_GRB2like	143	146	PF00017	0.474
LIG_SH2_STAT5	124	127	PF00017	0.351
LIG_SH2_STAT5	232	235	PF00017	0.519
LIG_SH3_3	133	139	PF00018	0.454
LIG_SH3_3	161	167	PF00018	0.358
LIG_SH3_3	191	197	PF00018	0.424
LIG_SH3_3	279	285	PF00018	0.395
LIG_SH3_5	139	143	PF00018	0.515
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.491
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.363
LIG_SUMO_SIM_par_1	166	172	PF11976	0.511
LIG_TRAF2_1	52	55	PF00917	0.404
LIG_TRFH_1	144	148	PF08558	0.469
LIG_TRFH_1	268	272	PF08558	0.377
LIG_TYR_ITIM	201	206	PF00017	0.436
LIG_TYR_ITIM	230	235	PF00017	0.472
MOD_CDK_SPK_2	135	140	PF00069	0.447
MOD_CK1_1	138	144	PF00069	0.418
MOD_CK1_1	17	23	PF00069	0.518
MOD_CK1_1	228	234	PF00069	0.563
MOD_CK1_1	253	259	PF00069	0.663
MOD_GlcNHglycan	16	19	PF01048	0.495
MOD_GSK3_1	13	20	PF00069	0.482
MOD_GSK3_1	226	233	PF00069	0.519
MOD_GSK3_1	250	257	PF00069	0.636
MOD_GSK3_1	67	74	PF00069	0.357
MOD_GSK3_1	76	83	PF00069	0.318
MOD_N-GLC_1	322	327	PF02516	0.386
MOD_N-GLC_2	110	112	PF02516	0.277
MOD_NEK2_1	2	7	PF00069	0.559
MOD_NEK2_1	230	235	PF00069	0.491
MOD_NEK2_1	322	327	PF00069	0.415
MOD_PIKK_1	322	328	PF00454	0.412
MOD_PK_1	250	256	PF00069	0.573
MOD_PKA_2	295	301	PF00069	0.386
MOD_PKA_2	7	13	PF00069	0.559
MOD_PKB_1	248	256	PF00069	0.558
MOD_Plk_4	179	185	PF00069	0.373
MOD_Plk_4	250	256	PF00069	0.607
MOD_Plk_4	270	276	PF00069	0.339
MOD_Plk_4	68	74	PF00069	0.320
MOD_ProDKin_1	135	141	PF00069	0.444
MOD_ProDKin_1	190	196	PF00069	0.460
MOD_ProDKin_1	278	284	PF00069	0.485
TRG_DiLeu_BaEn_1	266	271	PF01217	0.459
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.509
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.329
TRG_ENDOCYTIC_2	124	127	PF00928	0.364
TRG_ENDOCYTIC_2	143	146	PF00928	0.340
TRG_ENDOCYTIC_2	161	164	PF00928	0.441
TRG_ENDOCYTIC_2	203	206	PF00928	0.388
TRG_ENDOCYTIC_2	232	235	PF00928	0.486
TRG_ENDOCYTIC_2	268	271	PF00928	0.406
TRG_ER_diArg_1	188	190	PF00400	0.422
TRG_ER_diArg_1	247	250	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5T0	Leptomonas seymouri	73%	100%
A0A0S4INP7	Bodo saltans	39%	88%
A0A1X0NW56	Trypanosomatidae	54%	98%
A0A3R7RG23	Trypanosoma rangeli	52%	99%
A0A3S7WW32	Leishmania donovani	95%	100%
A4HYY6	Leishmania infantum	95%	100%
C9ZIJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
E9AIK0	Leishmania braziliensis	88%	100%
Q4QCQ1	Leishmania major	94%	100%
V5BDU9	Trypanosoma cruzi	51%	100%