Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUT0_LEIMU

TriTrypDb:

LmxM.20.1410

Length:

933

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.732
CLV_NRD_NRD_1	343	345	PF00675	0.554
CLV_NRD_NRD_1	811	813	PF00675	0.776
CLV_PCSK_FUR_1	114	118	PF00082	0.732
CLV_PCSK_KEX2_1	116	118	PF00082	0.741
CLV_PCSK_KEX2_1	343	345	PF00082	0.554
CLV_PCSK_KEX2_1	811	813	PF00082	0.776
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.733
CLV_PCSK_PC7_1	114	120	PF00082	0.826
CLV_PCSK_SKI1_1	130	134	PF00082	0.439
CLV_PCSK_SKI1_1	318	322	PF00082	0.539
CLV_PCSK_SKI1_1	349	353	PF00082	0.539
CLV_PCSK_SKI1_1	699	703	PF00082	0.510
CLV_Separin_Metazoa	236	240	PF03568	0.476
CLV_Separin_Metazoa	461	465	PF03568	0.721
DEG_APCC_DBOX_1	348	356	PF00400	0.536
DEG_SCF_FBW7_1	701	706	PF00400	0.804
DEG_SPOP_SBC_1	682	686	PF00917	0.736
DEG_SPOP_SBC_1	688	692	PF00917	0.701
DEG_SPOP_SBC_1	837	841	PF00917	0.749
DOC_CKS1_1	832	837	PF01111	0.521
DOC_CYCLIN_RxL_1	315	326	PF00134	0.554
DOC_CYCLIN_RxL_1	846	855	PF00134	0.728
DOC_CYCLIN_RxL_1	894	904	PF00134	0.737
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.459
DOC_MAPK_DCC_7	17	27	PF00069	0.516
DOC_MAPK_gen_1	116	125	PF00069	0.579
DOC_MAPK_gen_1	811	818	PF00069	0.758
DOC_MAPK_MEF2A_6	239	248	PF00069	0.467
DOC_PP2B_LxvP_1	19	22	PF13499	0.743
DOC_PP2B_LxvP_1	669	672	PF13499	0.525
DOC_USP7_MATH_1	485	489	PF00917	0.745
DOC_USP7_MATH_1	682	686	PF00917	0.626
DOC_USP7_MATH_1	703	707	PF00917	0.817
DOC_USP7_MATH_1	712	716	PF00917	0.642
DOC_USP7_MATH_1	735	739	PF00917	0.674
DOC_USP7_MATH_1	773	777	PF00917	0.786
DOC_USP7_MATH_1	810	814	PF00917	0.494
DOC_USP7_MATH_1	837	841	PF00917	0.709
DOC_USP7_MATH_1	879	883	PF00917	0.628
DOC_WW_Pin1_4	103	108	PF00397	0.544
DOC_WW_Pin1_4	179	184	PF00397	0.704
DOC_WW_Pin1_4	200	205	PF00397	0.488
DOC_WW_Pin1_4	227	232	PF00397	0.585
DOC_WW_Pin1_4	239	244	PF00397	0.429
DOC_WW_Pin1_4	39	44	PF00397	0.725
DOC_WW_Pin1_4	445	450	PF00397	0.682
DOC_WW_Pin1_4	495	500	PF00397	0.744
DOC_WW_Pin1_4	646	651	PF00397	0.744
DOC_WW_Pin1_4	699	704	PF00397	0.789
DOC_WW_Pin1_4	718	723	PF00397	0.748
DOC_WW_Pin1_4	728	733	PF00397	0.801
DOC_WW_Pin1_4	740	745	PF00397	0.542
DOC_WW_Pin1_4	831	836	PF00397	0.598
LIG_14-3-3_CanoR_1	101	107	PF00244	0.749
LIG_14-3-3_CanoR_1	117	125	PF00244	0.489
LIG_14-3-3_CanoR_1	177	186	PF00244	0.718
LIG_14-3-3_CanoR_1	360	367	PF00244	0.566
LIG_14-3-3_CanoR_1	517	523	PF00244	0.705
LIG_14-3-3_CanoR_1	52	58	PF00244	0.730
LIG_14-3-3_CanoR_1	646	650	PF00244	0.695
LIG_14-3-3_CanoR_1	737	744	PF00244	0.701
LIG_14-3-3_CanoR_1	811	816	PF00244	0.682
LIG_APCC_ABBA_1	132	137	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_BIR_III_4	434	438	PF00653	0.571
LIG_BIR_III_4	855	859	PF00653	0.514
LIG_BRCT_BRCA1_1	922	926	PF00533	0.598
LIG_Clathr_ClatBox_1	24	28	PF01394	0.522
LIG_deltaCOP1_diTrp_1	663	667	PF00928	0.587
LIG_FHA_1	103	109	PF00498	0.813
LIG_FHA_1	118	124	PF00498	0.578
LIG_FHA_1	14	20	PF00498	0.702
LIG_FHA_1	215	221	PF00498	0.528
LIG_FHA_1	382	388	PF00498	0.551
LIG_FHA_1	43	49	PF00498	0.711
LIG_FHA_1	554	560	PF00498	0.515
LIG_FHA_1	592	598	PF00498	0.646
LIG_FHA_1	628	634	PF00498	0.554
LIG_FHA_1	772	778	PF00498	0.731
LIG_FHA_1	837	843	PF00498	0.650
LIG_FHA_2	819	825	PF00498	0.663
LIG_FHA_2	876	882	PF00498	0.633
LIG_GBD_Chelix_1	617	625	PF00786	0.528
LIG_LIR_Gen_1	124	133	PF02991	0.499
LIG_LIR_Gen_1	260	270	PF02991	0.503
LIG_LIR_Gen_1	358	368	PF02991	0.584
LIG_LIR_Gen_1	510	519	PF02991	0.516
LIG_LIR_Gen_1	820	826	PF02991	0.666
LIG_LIR_Nem_3	124	128	PF02991	0.517
LIG_LIR_Nem_3	131	136	PF02991	0.491
LIG_LIR_Nem_3	233	238	PF02991	0.527
LIG_LIR_Nem_3	260	266	PF02991	0.500
LIG_LIR_Nem_3	326	330	PF02991	0.555
LIG_LIR_Nem_3	358	364	PF02991	0.569
LIG_LIR_Nem_3	510	516	PF02991	0.633
LIG_LIR_Nem_3	798	804	PF02991	0.727
LIG_LIR_Nem_3	820	825	PF02991	0.667
LIG_LIR_Nem_3	889	895	PF02991	0.639
LIG_NRBOX	351	357	PF00104	0.542
LIG_NRBOX	664	670	PF00104	0.485
LIG_NRBOX	872	878	PF00104	0.731
LIG_SH2_CRK	280	284	PF00017	0.359
LIG_SH2_CRK	361	365	PF00017	0.563
LIG_SH2_CRK	447	451	PF00017	0.488
LIG_SH2_CRK	622	626	PF00017	0.531
LIG_SH2_GRB2like	787	790	PF00017	0.750
LIG_SH2_NCK_1	172	176	PF00017	0.732
LIG_SH2_NCK_1	178	182	PF00017	0.641
LIG_SH2_NCK_1	447	451	PF00017	0.488
LIG_SH2_PTP2	263	266	PF00017	0.382
LIG_SH2_SRC	414	417	PF00017	0.636
LIG_SH2_STAP1	280	284	PF00017	0.541
LIG_SH2_STAP1	822	826	PF00017	0.637
LIG_SH2_STAT5	135	138	PF00017	0.509
LIG_SH2_STAT5	172	175	PF00017	0.731
LIG_SH2_STAT5	178	181	PF00017	0.643
LIG_SH2_STAT5	263	266	PF00017	0.382
LIG_SH2_STAT5	286	289	PF00017	0.441
LIG_SH2_STAT5	361	364	PF00017	0.674
LIG_SH2_STAT5	447	450	PF00017	0.586
LIG_SH2_STAT5	62	65	PF00017	0.724
LIG_SH2_STAT5	693	696	PF00017	0.553
LIG_SH2_STAT5	787	790	PF00017	0.828
LIG_SH3_2	732	737	PF14604	0.633
LIG_SH3_3	180	186	PF00018	0.751
LIG_SH3_3	201	207	PF00018	0.581
LIG_SH3_3	459	465	PF00018	0.726
LIG_SH3_3	552	558	PF00018	0.501
LIG_SH3_3	594	600	PF00018	0.692
LIG_SH3_3	719	725	PF00018	0.697
LIG_SH3_3	726	732	PF00018	0.697
LIG_SH3_3	829	835	PF00018	0.716
LIG_SH3_3	892	898	PF00018	0.632
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.284
LIG_SUMO_SIM_anti_2	317	323	PF11976	0.552
LIG_SUMO_SIM_anti_2	383	391	PF11976	0.654
LIG_SUMO_SIM_par_1	206	211	PF11976	0.346
LIG_SUMO_SIM_par_1	350	358	PF11976	0.543
LIG_SUMO_SIM_par_1	383	391	PF11976	0.654
LIG_TRAF2_1	878	881	PF00917	0.723
LIG_WW_3	461	465	PF00397	0.721
MOD_CK1_1	103	109	PF00069	0.584
MOD_CK1_1	124	130	PF00069	0.479
MOD_CK1_1	171	177	PF00069	0.802
MOD_CK1_1	32	38	PF00069	0.737
MOD_CK1_1	380	386	PF00069	0.591
MOD_CK1_1	42	48	PF00069	0.588
MOD_CK1_1	515	521	PF00069	0.495
MOD_CK1_1	579	585	PF00069	0.393
MOD_CK1_1	588	594	PF00069	0.554
MOD_CK1_1	683	689	PF00069	0.762
MOD_CK1_1	706	712	PF00069	0.772
MOD_CK1_1	715	721	PF00069	0.747
MOD_CK1_1	736	742	PF00069	0.760
MOD_CK1_1	756	762	PF00069	0.606
MOD_CK1_1	776	782	PF00069	0.730
MOD_CK1_1	791	797	PF00069	0.519
MOD_CK1_1	841	847	PF00069	0.813
MOD_CK1_1	919	925	PF00069	0.597
MOD_CK2_1	150	156	PF00069	0.508
MOD_CK2_1	875	881	PF00069	0.636
MOD_CMANNOS	50	53	PF00535	0.774
MOD_CMANNOS	664	667	PF00535	0.582
MOD_Cter_Amidation	114	117	PF01082	0.756
MOD_GlcNHglycan	102	105	PF01048	0.743
MOD_GlcNHglycan	110	113	PF01048	0.790
MOD_GlcNHglycan	179	182	PF01048	0.651
MOD_GlcNHglycan	194	199	PF01048	0.761
MOD_GlcNHglycan	307	310	PF01048	0.444
MOD_GlcNHglycan	31	34	PF01048	0.750
MOD_GlcNHglycan	334	337	PF01048	0.556
MOD_GlcNHglycan	37	40	PF01048	0.678
MOD_GlcNHglycan	450	453	PF01048	0.670
MOD_GlcNHglycan	517	520	PF01048	0.746
MOD_GlcNHglycan	523	526	PF01048	0.658
MOD_GlcNHglycan	573	576	PF01048	0.524
MOD_GlcNHglycan	578	581	PF01048	0.356
MOD_GlcNHglycan	587	590	PF01048	0.615
MOD_GlcNHglycan	614	617	PF01048	0.556
MOD_GlcNHglycan	686	689	PF01048	0.783
MOD_GlcNHglycan	708	711	PF01048	0.714
MOD_GlcNHglycan	738	741	PF01048	0.683
MOD_GlcNHglycan	791	794	PF01048	0.705
MOD_GlcNHglycan	859	862	PF01048	0.523
MOD_GSK3_1	117	124	PF00069	0.648
MOD_GSK3_1	135	142	PF00069	0.423
MOD_GSK3_1	164	171	PF00069	0.669
MOD_GSK3_1	173	180	PF00069	0.745
MOD_GSK3_1	278	285	PF00069	0.436
MOD_GSK3_1	35	42	PF00069	0.620
MOD_GSK3_1	373	380	PF00069	0.656
MOD_GSK3_1	511	518	PF00069	0.693
MOD_GSK3_1	576	583	PF00069	0.375
MOD_GSK3_1	588	595	PF00069	0.636
MOD_GSK3_1	600	607	PF00069	0.662
MOD_GSK3_1	608	615	PF00069	0.452
MOD_GSK3_1	627	634	PF00069	0.383
MOD_GSK3_1	680	687	PF00069	0.628
MOD_GSK3_1	688	695	PF00069	0.710
MOD_GSK3_1	699	706	PF00069	0.492
MOD_GSK3_1	717	724	PF00069	0.754
MOD_GSK3_1	736	743	PF00069	0.551
MOD_GSK3_1	749	756	PF00069	0.711
MOD_GSK3_1	771	778	PF00069	0.715
MOD_GSK3_1	791	798	PF00069	0.671
MOD_GSK3_1	827	834	PF00069	0.636
MOD_GSK3_1	837	844	PF00069	0.811
MOD_GSK3_1	847	854	PF00069	0.701
MOD_GSK3_1	857	864	PF00069	0.471
MOD_GSK3_1	875	882	PF00069	0.550
MOD_GSK3_1	915	922	PF00069	0.612
MOD_N-GLC_1	330	335	PF02516	0.585
MOD_N-GLC_1	380	385	PF02516	0.595
MOD_N-GLC_1	67	72	PF02516	0.544
MOD_N-GLC_1	703	708	PF02516	0.519
MOD_N-GLC_1	756	761	PF02516	0.725
MOD_N-GLC_1	788	793	PF02516	0.551
MOD_N-GLC_1	915	920	PF02516	0.615
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	248	253	PF00069	0.457
MOD_NEK2_1	27	32	PF00069	0.738
MOD_NEK2_1	330	335	PF00069	0.585
MOD_NEK2_1	372	377	PF00069	0.642
MOD_NEK2_1	388	393	PF00069	0.599
MOD_NEK2_1	433	438	PF00069	0.764
MOD_NEK2_1	512	517	PF00069	0.691
MOD_NEK2_1	523	528	PF00069	0.663
MOD_NEK2_1	571	576	PF00069	0.580
MOD_NEK2_1	749	754	PF00069	0.614
MOD_NEK2_1	760	765	PF00069	0.714
MOD_NEK2_1	788	793	PF00069	0.706
MOD_NEK2_1	818	823	PF00069	0.702
MOD_NEK2_1	915	920	PF00069	0.717
MOD_NEK2_2	879	884	PF00069	0.633
MOD_PIKK_1	139	145	PF00454	0.551
MOD_PIKK_1	604	610	PF00454	0.702
MOD_PIKK_1	62	68	PF00454	0.748
MOD_PIKK_1	712	718	PF00454	0.811
MOD_PKA_1	117	123	PF00069	0.786
MOD_PKA_1	811	817	PF00069	0.760
MOD_PKA_2	100	106	PF00069	0.736
MOD_PKA_2	117	123	PF00069	0.558
MOD_PKA_2	176	182	PF00069	0.722
MOD_PKA_2	359	365	PF00069	0.557
MOD_PKA_2	406	412	PF00069	0.630
MOD_PKA_2	463	469	PF00069	0.549
MOD_PKA_2	645	651	PF00069	0.695
MOD_PKA_2	706	712	PF00069	0.653
MOD_PKA_2	736	742	PF00069	0.639
MOD_PKA_2	810	816	PF00069	0.761
MOD_Plk_1	380	386	PF00069	0.591
MOD_Plk_1	592	598	PF00069	0.646
MOD_Plk_1	627	633	PF00069	0.601
MOD_Plk_1	756	762	PF00069	0.726
MOD_Plk_1	886	892	PF00069	0.644
MOD_Plk_1	915	921	PF00069	0.612
MOD_Plk_4	1	7	PF00069	0.602
MOD_Plk_4	124	130	PF00069	0.502
MOD_Plk_4	278	284	PF00069	0.452
MOD_Plk_4	373	379	PF00069	0.682
MOD_Plk_4	381	387	PF00069	0.522
MOD_Plk_4	388	394	PF00069	0.488
MOD_Plk_4	463	469	PF00069	0.512
MOD_Plk_4	497	503	PF00069	0.786
MOD_Plk_4	518	524	PF00069	0.763
MOD_Plk_4	811	817	PF00069	0.760
MOD_Plk_4	886	892	PF00069	0.645
MOD_ProDKin_1	103	109	PF00069	0.543
MOD_ProDKin_1	179	185	PF00069	0.705
MOD_ProDKin_1	200	206	PF00069	0.480
MOD_ProDKin_1	227	233	PF00069	0.585
MOD_ProDKin_1	239	245	PF00069	0.421
MOD_ProDKin_1	39	45	PF00069	0.725
MOD_ProDKin_1	445	451	PF00069	0.682
MOD_ProDKin_1	495	501	PF00069	0.745
MOD_ProDKin_1	646	652	PF00069	0.737
MOD_ProDKin_1	699	705	PF00069	0.791
MOD_ProDKin_1	718	724	PF00069	0.748
MOD_ProDKin_1	728	734	PF00069	0.804
MOD_ProDKin_1	740	746	PF00069	0.542
MOD_ProDKin_1	831	837	PF00069	0.599
MOD_SUMO_rev_2	854	859	PF00179	0.513
TRG_DiLeu_BaEn_1	236	241	PF01217	0.490
TRG_DiLeu_BaEn_1	910	915	PF01217	0.714
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.513
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.655
TRG_DiLeu_LyEn_5	236	241	PF01217	0.490
TRG_DiLeu_LyEn_5	910	915	PF01217	0.598
TRG_ENDOCYTIC_2	263	266	PF00928	0.470
TRG_ENDOCYTIC_2	280	283	PF00928	0.428
TRG_ENDOCYTIC_2	361	364	PF00928	0.567
TRG_ENDOCYTIC_2	447	450	PF00928	0.489
TRG_ENDOCYTIC_2	622	625	PF00928	0.543
TRG_ENDOCYTIC_2	822	825	PF00928	0.668
TRG_ER_diArg_1	117	119	PF00400	0.744
TRG_ER_diArg_1	288	291	PF00400	0.607
TRG_ER_diArg_1	343	345	PF00400	0.554
TRG_ER_diArg_1	810	812	PF00400	0.792
TRG_ER_diArg_1	926	929	PF00400	0.627
TRG_NLS_MonoCore_2	115	120	PF00514	0.823
TRG_NLS_MonoExtC_3	115	121	PF00514	0.721
TRG_NLS_MonoExtN_4	114	120	PF00514	0.725
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.727
TRG_PTS1	930	933	PF00515	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y6	Leptomonas seymouri	43%	88%
A0A3S7WW50	Leishmania donovani	88%	100%
A4HYY4	Leishmania infantum	88%	100%
E9AIJ8	Leishmania braziliensis	73%	99%
Q4QCQ3	Leishmania major	87%	100%