Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUS8_LEIMU

TriTrypDb:

LmxM.20.1390

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.642
CLV_C14_Caspase3-7	334	338	PF00656	0.735
CLV_NRD_NRD_1	170	172	PF00675	0.636
CLV_NRD_NRD_1	254	256	PF00675	0.560
CLV_NRD_NRD_1	265	267	PF00675	0.441
CLV_NRD_NRD_1	375	377	PF00675	0.625
CLV_PCSK_FUR_1	168	172	PF00082	0.558
CLV_PCSK_KEX2_1	170	172	PF00082	0.636
CLV_PCSK_KEX2_1	254	256	PF00082	0.621
CLV_PCSK_KEX2_1	265	267	PF00082	0.468
CLV_PCSK_KEX2_1	375	377	PF00082	0.625
CLV_PCSK_PC7_1	371	377	PF00082	0.620
CLV_PCSK_SKI1_1	361	365	PF00082	0.430
CLV_PCSK_SKI1_1	89	93	PF00082	0.640
DEG_Nend_UBRbox_1	1	4	PF02207	0.644
DEG_SIAH_1	326	334	PF03145	0.663
DOC_CKS1_1	289	294	PF01111	0.536
DOC_CYCLIN_RxL_1	371	381	PF00134	0.620
DOC_MAPK_gen_1	275	283	PF00069	0.562
DOC_MAPK_gen_1	383	392	PF00069	0.574
DOC_MAPK_MEF2A_6	383	392	PF00069	0.574
DOC_USP7_MATH_1	209	213	PF00917	0.752
DOC_USP7_MATH_1	226	230	PF00917	0.642
DOC_USP7_MATH_1	235	239	PF00917	0.583
DOC_USP7_MATH_1	24	28	PF00917	0.576
DOC_USP7_MATH_1	243	247	PF00917	0.500
DOC_USP7_MATH_1	311	315	PF00917	0.697
DOC_USP7_MATH_1	318	322	PF00917	0.684
DOC_USP7_MATH_1	59	63	PF00917	0.641
DOC_WW_Pin1_4	1	6	PF00397	0.537
DOC_WW_Pin1_4	144	149	PF00397	0.578
DOC_WW_Pin1_4	285	290	PF00397	0.736
DOC_WW_Pin1_4	294	299	PF00397	0.650
DOC_WW_Pin1_4	399	404	PF00397	0.735
DOC_WW_Pin1_4	99	104	PF00397	0.718
LIG_14-3-3_CanoR_1	113	118	PF00244	0.602
LIG_14-3-3_CanoR_1	54	59	PF00244	0.575
LIG_14-3-3_CanoR_1	81	85	PF00244	0.667
LIG_14-3-3_CanoR_1	97	103	PF00244	0.624
LIG_APCC_ABBA_1	395	400	PF00400	0.600
LIG_BIR_III_4	356	360	PF00653	0.636
LIG_Clathr_ClatBox_1	408	412	PF01394	0.415
LIG_DLG_GKlike_1	113	120	PF00625	0.685
LIG_FHA_1	1	7	PF00498	0.574
LIG_FHA_1	160	166	PF00498	0.627
LIG_FHA_1	262	268	PF00498	0.603
LIG_FHA_1	53	59	PF00498	0.515
LIG_FHA_1	70	76	PF00498	0.567
LIG_FHA_2	135	141	PF00498	0.628
LIG_FHA_2	271	277	PF00498	0.461
LIG_FHA_2	303	309	PF00498	0.775
LIG_FHA_2	338	344	PF00498	0.740
LIG_LIR_Gen_1	180	191	PF02991	0.552
LIG_LIR_Gen_1	44	53	PF02991	0.581
LIG_LIR_Nem_3	180	186	PF02991	0.544
LIG_LIR_Nem_3	44	49	PF02991	0.571
LIG_PCNA_yPIPBox_3	383	396	PF02747	0.406
LIG_Pex14_1	179	183	PF04695	0.604
LIG_SH2_NCK_1	138	142	PF00017	0.606
LIG_SH2_STAP1	35	39	PF00017	0.599
LIG_SH2_STAT3	443	446	PF00017	0.597
LIG_SH2_STAT5	138	141	PF00017	0.618
LIG_SH2_STAT5	35	38	PF00017	0.606
LIG_SH3_3	286	292	PF00018	0.520
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.647
MOD_CK1_1	116	122	PF00069	0.703
MOD_CK1_1	288	294	PF00069	0.763
MOD_CK1_1	321	327	PF00069	0.642
MOD_CK1_1	349	355	PF00069	0.778
MOD_CK1_1	401	407	PF00069	0.709
MOD_CK1_1	61	67	PF00069	0.694
MOD_CK1_1	7	13	PF00069	0.581
MOD_CK2_1	136	142	PF00069	0.619
MOD_CK2_1	199	205	PF00069	0.718
MOD_CK2_1	270	276	PF00069	0.460
MOD_CK2_1	302	308	PF00069	0.761
MOD_CK2_1	311	317	PF00069	0.657
MOD_CK2_1	337	343	PF00069	0.741
MOD_GlcNHglycan	125	128	PF01048	0.526
MOD_GlcNHglycan	200	204	PF01048	0.671
MOD_GlcNHglycan	209	212	PF01048	0.759
MOD_GlcNHglycan	237	240	PF01048	0.502
MOD_GlcNHglycan	26	29	PF01048	0.596
MOD_GlcNHglycan	320	323	PF01048	0.746
MOD_GlcNHglycan	403	406	PF01048	0.660
MOD_GlcNHglycan	6	9	PF01048	0.579
MOD_GSK3_1	112	119	PF00069	0.597
MOD_GSK3_1	216	223	PF00069	0.710
MOD_GSK3_1	290	297	PF00069	0.789
MOD_GSK3_1	54	61	PF00069	0.670
MOD_GSK3_1	75	82	PF00069	0.676
MOD_LATS_1	95	101	PF00433	0.721
MOD_N-GLC_1	302	307	PF02516	0.681
MOD_NEK2_1	366	371	PF00069	0.617
MOD_NEK2_1	53	58	PF00069	0.701
MOD_NEK2_1	79	84	PF00069	0.553
MOD_NEK2_1	98	103	PF00069	0.717
MOD_NEK2_2	270	275	PF00069	0.460
MOD_PIKK_1	159	165	PF00454	0.629
MOD_PIKK_1	331	337	PF00454	0.576
MOD_PKA_2	112	118	PF00069	0.586
MOD_PKA_2	193	199	PF00069	0.517
MOD_PKA_2	346	352	PF00069	0.704
MOD_PKA_2	366	372	PF00069	0.618
MOD_PKA_2	398	404	PF00069	0.685
MOD_PKA_2	53	59	PF00069	0.709
MOD_PKA_2	80	86	PF00069	0.666
MOD_PKA_2	96	102	PF00069	0.606
MOD_Plk_1	270	276	PF00069	0.661
MOD_Plk_1	31	37	PF00069	0.684
MOD_Plk_1	359	365	PF00069	0.666
MOD_Plk_4	220	226	PF00069	0.726
MOD_Plk_4	41	47	PF00069	0.565
MOD_ProDKin_1	1	7	PF00069	0.536
MOD_ProDKin_1	144	150	PF00069	0.577
MOD_ProDKin_1	285	291	PF00069	0.740
MOD_ProDKin_1	294	300	PF00069	0.652
MOD_ProDKin_1	399	405	PF00069	0.731
MOD_ProDKin_1	99	105	PF00069	0.718
MOD_SUMO_rev_2	185	191	PF00179	0.587
MOD_SUMO_rev_2	334	342	PF00179	0.561
TRG_ENDOCYTIC_2	183	186	PF00928	0.609
TRG_ER_diArg_1	168	171	PF00400	0.562
TRG_ER_diArg_1	253	255	PF00400	0.560
TRG_ER_diArg_1	265	267	PF00400	0.431
TRG_ER_diArg_1	375	377	PF00400	0.625
TRG_ER_diArg_1	435	438	PF00400	0.593
TRG_NES_CRM1_1	386	400	PF08389	0.585
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WW39	Leishmania donovani	85%	100%
A4HYY2	Leishmania infantum	85%	100%
E9AIJ6	Leishmania braziliensis	66%	100%
Q4QCQ5	Leishmania major	83%	100%