Putative pumilio protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 9, putative

Species:

Leishmania mexicana

UniProt:

E9AUS6_LEIMU

TriTrypDb:

LmxM.20.1370

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9AUS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUS6

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	3
GO:0010608	post-transcriptional regulation of gene expression	6	3
GO:0019222	regulation of metabolic process	3	3
GO:0050789	regulation of biological process	2	3
GO:0060255	regulation of macromolecule metabolic process	4	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	25
GO:0003723	RNA binding	4	25
GO:0005488	binding	1	25
GO:0097159	organic cyclic compound binding	2	25
GO:1901363	heterocyclic compound binding	2	25
GO:0003729	mRNA binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.338
CLV_NRD_NRD_1	125	127	PF00675	0.360
CLV_NRD_NRD_1	134	136	PF00675	0.402
CLV_NRD_NRD_1	19	21	PF00675	0.602
CLV_NRD_NRD_1	250	252	PF00675	0.285
CLV_NRD_NRD_1	419	421	PF00675	0.701
CLV_PCSK_KEX2_1	125	127	PF00082	0.360
CLV_PCSK_KEX2_1	134	136	PF00082	0.402
CLV_PCSK_KEX2_1	19	21	PF00082	0.434
CLV_PCSK_KEX2_1	250	252	PF00082	0.300
CLV_PCSK_KEX2_1	291	293	PF00082	0.470
CLV_PCSK_KEX2_1	317	319	PF00082	0.569
CLV_PCSK_KEX2_1	419	421	PF00082	0.547
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.470
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.472
CLV_PCSK_SKI1_1	180	184	PF00082	0.300
CLV_PCSK_SKI1_1	250	254	PF00082	0.388
CLV_PCSK_SKI1_1	298	302	PF00082	0.360
CLV_PCSK_SKI1_1	394	398	PF00082	0.481
CLV_PCSK_SKI1_1	51	55	PF00082	0.388
CLV_Separin_Metazoa	177	181	PF03568	0.439
CLV_Separin_Metazoa	391	395	PF03568	0.475
DEG_APCC_DBOX_1	124	132	PF00400	0.403
DEG_APCC_DBOX_1	179	187	PF00400	0.300
DEG_APCC_DBOX_1	250	258	PF00400	0.457
DEG_Kelch_Keap1_1	370	375	PF01344	0.471
DOC_CYCLIN_RxL_1	247	256	PF00134	0.406
DOC_MAPK_gen_1	76	84	PF00069	0.278
DOC_MAPK_MEF2A_6	76	84	PF00069	0.406
DOC_USP7_MATH_1	316	320	PF00917	0.428
DOC_USP7_MATH_1	362	366	PF00917	0.539
DOC_USP7_MATH_1	376	380	PF00917	0.569
DOC_USP7_MATH_1	399	403	PF00917	0.484
DOC_USP7_UBL2_3	309	313	PF12436	0.474
DOC_WW_Pin1_4	44	49	PF00397	0.370
LIG_14-3-3_CanoR_1	125	129	PF00244	0.370
LIG_14-3-3_CanoR_1	208	216	PF00244	0.487
LIG_14-3-3_CanoR_1	34	41	PF00244	0.440
LIG_14-3-3_CanoR_1	394	399	PF00244	0.482
LIG_14-3-3_CanoR_1	59	69	PF00244	0.486
LIG_14-3-3_CterR_2	428	433	PF00244	0.504
LIG_Actin_WH2_1	250	267	PF00022	0.346
LIG_Actin_WH2_1	62	80	PF00022	0.364
LIG_Actin_WH2_2	63	80	PF00022	0.362
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_BIR_III_2	353	357	PF00653	0.434
LIG_BIR_III_3	1	5	PF00653	0.440
LIG_EH1_1	274	282	PF00400	0.408
LIG_FHA_1	100	106	PF00498	0.331
LIG_FHA_1	16	22	PF00498	0.519
LIG_FHA_1	218	224	PF00498	0.486
LIG_FHA_2	90	96	PF00498	0.421
LIG_LIR_Gen_1	397	407	PF02991	0.738
LIG_LIR_Nem_3	192	197	PF02991	0.394
LIG_LIR_Nem_3	270	275	PF02991	0.360
LIG_LIR_Nem_3	289	293	PF02991	0.404
LIG_SH2_SRC	351	354	PF00017	0.450
LIG_SH2_STAT3	197	200	PF00017	0.324
LIG_SH2_STAT3	421	424	PF00017	0.454
LIG_SH2_STAT5	123	126	PF00017	0.442
LIG_SH2_STAT5	152	155	PF00017	0.421
LIG_SH2_STAT5	214	217	PF00017	0.422
LIG_SH2_STAT5	351	354	PF00017	0.407
LIG_SH2_STAT5	384	387	PF00017	0.516
LIG_SH3_3	255	261	PF00018	0.474
LIG_SH3_3	281	287	PF00018	0.524
LIG_SH3_3	393	399	PF00018	0.469
LIG_SH3_3	4	10	PF00018	0.674
LIG_SUMO_SIM_par_1	279	285	PF11976	0.210
LIG_UBA3_1	223	230	PF00899	0.378
MOD_CDK_SPxxK_3	44	51	PF00069	0.365
MOD_CK1_1	121	127	PF00069	0.347
MOD_CK1_1	206	212	PF00069	0.334
MOD_CK1_1	282	288	PF00069	0.395
MOD_CK1_1	365	371	PF00069	0.483
MOD_CK1_1	377	383	PF00069	0.478
MOD_CK1_1	402	408	PF00069	0.446
MOD_CK1_1	68	74	PF00069	0.347
MOD_CK2_1	127	133	PF00069	0.341
MOD_CK2_1	369	375	PF00069	0.579
MOD_CK2_1	89	95	PF00069	0.400
MOD_GlcNHglycan	138	142	PF01048	0.529
MOD_GlcNHglycan	21	24	PF01048	0.485
MOD_GlcNHglycan	318	321	PF01048	0.545
MOD_GlcNHglycan	364	367	PF01048	0.548
MOD_GlcNHglycan	375	379	PF01048	0.503
MOD_GlcNHglycan	405	408	PF01048	0.603
MOD_GlcNHglycan	415	418	PF01048	0.499
MOD_GSK3_1	117	124	PF00069	0.402
MOD_GSK3_1	15	22	PF00069	0.491
MOD_GSK3_1	199	206	PF00069	0.425
MOD_GSK3_1	362	369	PF00069	0.689
MOD_GSK3_1	370	377	PF00069	0.719
MOD_GSK3_1	399	406	PF00069	0.491
MOD_GSK3_1	95	102	PF00069	0.416
MOD_N-GLC_1	369	374	PF02516	0.463
MOD_N-GLC_2	116	118	PF02516	0.418
MOD_NEK2_1	109	114	PF00069	0.371
MOD_NEK2_1	117	122	PF00069	0.373
MOD_NEK2_1	153	158	PF00069	0.385
MOD_NEK2_1	224	229	PF00069	0.339
MOD_NEK2_1	403	408	PF00069	0.442
MOD_PIKK_1	118	124	PF00454	0.401
MOD_PIKK_1	153	159	PF00454	0.355
MOD_PIKK_1	57	63	PF00454	0.420
MOD_PKA_1	19	25	PF00069	0.398
MOD_PKA_2	124	130	PF00069	0.328
MOD_PKA_2	19	25	PF00069	0.408
MOD_PKA_2	207	213	PF00069	0.498
MOD_PKA_2	33	39	PF00069	0.469
MOD_PKA_2	366	372	PF00069	0.714
MOD_Plk_1	137	143	PF00069	0.372
MOD_Plk_4	109	115	PF00069	0.392
MOD_Plk_4	127	133	PF00069	0.341
MOD_Plk_4	49	55	PF00069	0.260
MOD_Plk_4	65	71	PF00069	0.445
MOD_ProDKin_1	44	50	PF00069	0.365
MOD_SUMO_for_1	308	311	PF00179	0.498
MOD_SUMO_rev_2	375	385	PF00179	0.457
TRG_DiLeu_BaEn_2	390	396	PF01217	0.482
TRG_ENDOCYTIC_2	272	275	PF00928	0.345
TRG_ER_diArg_1	19	21	PF00400	0.431
TRG_ER_diArg_1	249	251	PF00400	0.400
TRG_ER_diArg_1	296	299	PF00400	0.395
TRG_ER_diArg_1	419	421	PF00400	0.486
TRG_ER_diArg_1	75	78	PF00400	0.374
TRG_NES_CRM1_1	181	192	PF08389	0.304
TRG_NES_CRM1_1	72	83	PF08389	0.374
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J9I9	Bodo saltans	33%	88%
A0A1X0NJM4	Trypanosomatidae	39%	99%
A0A1X0NW83	Trypanosomatidae	55%	75%
A0A1X0P8D8	Trypanosomatidae	21%	75%
A0A3Q8IA47	Leishmania donovani	85%	74%
A0A3Q8IK20	Leishmania donovani	25%	78%
A0A3R7NFN9	Trypanosoma rangeli	52%	80%
A0A3R7NHA6	Trypanosoma rangeli	25%	76%
A0A3S5IQY1	Trypanosoma rangeli	35%	100%
A0A3S7WW64	Leishmania donovani	93%	79%
A4H4H3	Leishmania braziliensis	34%	90%
A4HNL0	Leishmania braziliensis	25%	79%
A4HYX9	Leishmania infantum	85%	74%
A4HYY0	Leishmania infantum	93%	79%
A4ICY3	Leishmania infantum	25%	78%
C9ZT94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AIJ1	Leishmania braziliensis	71%	100%
E9AKN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	92%
E9ASC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	78%
Q10238	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	75%
Q4Q274	Leishmania major	24%	78%
Q4QCQ8	Leishmania major	91%	99%
Q4QCQ9	Leishmania major	73%	98%
Q9LDW3	Arabidopsis thaliana	24%	78%
V5B968	Trypanosoma cruzi	35%	93%