Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AUS2_LEIMU

TriTrypDb:

LmxM.20.1320

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AUS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.573
CLV_C14_Caspase3-7	354	358	PF00656	0.424
CLV_NRD_NRD_1	11	13	PF00675	0.488
CLV_NRD_NRD_1	410	412	PF00675	0.412
CLV_NRD_NRD_1	62	64	PF00675	0.629
CLV_PCSK_KEX2_1	151	153	PF00082	0.683
CLV_PCSK_KEX2_1	323	325	PF00082	0.437
CLV_PCSK_KEX2_1	410	412	PF00082	0.412
CLV_PCSK_KEX2_1	62	64	PF00082	0.578
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.683
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.437
CLV_PCSK_SKI1_1	292	296	PF00082	0.411
CLV_PCSK_SKI1_1	310	314	PF00082	0.348
DEG_APCC_DBOX_1	252	260	PF00400	0.471
DEG_APCC_DBOX_1	418	426	PF00400	0.439
DEG_Nend_UBRbox_1	1	4	PF02207	0.557
DOC_CDC14_PxL_1	373	381	PF14671	0.362
DOC_MAPK_DCC_7	371	381	PF00069	0.381
DOC_MAPK_gen_1	296	305	PF00069	0.395
DOC_MAPK_MEF2A_6	296	304	PF00069	0.397
DOC_MIT_MIM_1	293	302	PF04212	0.411
DOC_PP1_RVXF_1	308	315	PF00149	0.354
DOC_USP7_MATH_1	111	115	PF00917	0.645
DOC_USP7_MATH_1	120	124	PF00917	0.559
DOC_USP7_MATH_1	45	49	PF00917	0.546
DOC_USP7_MATH_1	53	57	PF00917	0.695
DOC_WW_Pin1_4	281	286	PF00397	0.441
DOC_WW_Pin1_4	323	328	PF00397	0.439
DOC_WW_Pin1_4	68	73	PF00397	0.618
LIG_14-3-3_CanoR_1	197	201	PF00244	0.593
LIG_14-3-3_CanoR_1	2	6	PF00244	0.517
LIG_14-3-3_CanoR_1	214	220	PF00244	0.351
LIG_14-3-3_CanoR_1	310	315	PF00244	0.409
LIG_14-3-3_CanoR_1	392	402	PF00244	0.373
LIG_BRCT_BRCA1_1	310	314	PF00533	0.348
LIG_BRCT_BRCA1_1	325	329	PF00533	0.363
LIG_BRCT_BRCA1_1	57	61	PF00533	0.643
LIG_BRCT_BRCA1_1	80	84	PF00533	0.642
LIG_FHA_1	178	184	PF00498	0.600
LIG_FHA_1	383	389	PF00498	0.398
LIG_FHA_2	304	310	PF00498	0.361
LIG_FHA_2	352	358	PF00498	0.411
LIG_Integrin_RGD_1	139	141	PF01839	0.514
LIG_LIR_Apic_2	17	21	PF02991	0.522
LIG_LIR_Gen_1	208	217	PF02991	0.497
LIG_LIR_Gen_1	326	337	PF02991	0.350
LIG_LIR_Nem_3	208	212	PF02991	0.515
LIG_LIR_Nem_3	311	317	PF02991	0.492
LIG_LIR_Nem_3	326	332	PF02991	0.270
LIG_LIR_Nem_3	345	351	PF02991	0.307
LIG_LIR_Nem_3	4	8	PF02991	0.530
LIG_NRBOX	298	304	PF00104	0.381
LIG_PCNA_yPIPBox_3	214	223	PF02747	0.467
LIG_SH2_CRK	130	134	PF00017	0.642
LIG_SH2_STAP1	116	120	PF00017	0.662
LIG_SH2_STAT5	275	278	PF00017	0.383
LIG_SH2_STAT5	317	320	PF00017	0.441
LIG_SH3_3	180	186	PF00018	0.482
LIG_SH3_3	230	236	PF00018	0.579
LIG_SH3_3	366	372	PF00018	0.421
LIG_SH3_3	93	99	PF00018	0.661
LIG_SUMO_SIM_par_1	19	26	PF11976	0.534
LIG_SUMO_SIM_par_1	330	335	PF11976	0.322
LIG_TRAF2_1	159	162	PF00917	0.641
LIG_WW_1	127	130	PF00397	0.625
MOD_CK1_1	114	120	PF00069	0.706
MOD_CK1_1	167	173	PF00069	0.710
MOD_CK1_1	308	314	PF00069	0.357
MOD_CK1_1	360	366	PF00069	0.436
MOD_CK1_1	43	49	PF00069	0.658
MOD_CK1_1	56	62	PF00069	0.634
MOD_CK2_1	14	20	PF00069	0.524
MOD_CK2_1	303	309	PF00069	0.353
MOD_CK2_1	383	389	PF00069	0.374
MOD_GlcNHglycan	102	105	PF01048	0.680
MOD_GlcNHglycan	135	138	PF01048	0.683
MOD_GlcNHglycan	143	146	PF01048	0.682
MOD_GlcNHglycan	167	170	PF01048	0.646
MOD_GlcNHglycan	285	288	PF01048	0.417
MOD_GlcNHglycan	385	388	PF01048	0.478
MOD_GlcNHglycan	42	45	PF01048	0.619
MOD_GlcNHglycan	47	50	PF01048	0.619
MOD_GlcNHglycan	51	54	PF01048	0.641
MOD_GlcNHglycan	55	58	PF01048	0.676
MOD_GlcNHglycan	63	66	PF01048	0.734
MOD_GSK3_1	170	177	PF00069	0.738
MOD_GSK3_1	39	46	PF00069	0.514
MOD_GSK3_1	49	56	PF00069	0.513
MOD_N-GLC_1	382	387	PF02516	0.416
MOD_N-GLC_1	89	94	PF02516	0.655
MOD_NEK2_1	1	6	PF00069	0.507
MOD_NEK2_1	217	222	PF00069	0.453
MOD_NEK2_1	227	232	PF00069	0.531
MOD_NEK2_1	23	28	PF00069	0.556
MOD_NEK2_1	342	347	PF00069	0.389
MOD_NEK2_1	351	356	PF00069	0.326
MOD_NEK2_1	39	44	PF00069	0.646
MOD_NEK2_1	61	66	PF00069	0.646
MOD_NEK2_1	8	13	PF00069	0.486
MOD_NEK2_2	421	426	PF00069	0.482
MOD_NEK2_2	79	84	PF00069	0.640
MOD_PIKK_1	23	29	PF00454	0.641
MOD_PIKK_1	89	95	PF00454	0.610
MOD_PKA_2	1	7	PF00069	0.518
MOD_PKA_2	165	171	PF00069	0.679
MOD_PKA_2	196	202	PF00069	0.603
MOD_PKA_2	61	67	PF00069	0.650
MOD_PKA_2	8	14	PF00069	0.468
MOD_Plk_1	207	213	PF00069	0.525
MOD_Plk_1	227	233	PF00069	0.518
MOD_Plk_1	308	314	PF00069	0.357
MOD_Plk_4	1	7	PF00069	0.561
MOD_Plk_4	111	117	PF00069	0.651
MOD_Plk_4	310	316	PF00069	0.418
MOD_Plk_4	357	363	PF00069	0.357
MOD_Plk_4	421	427	PF00069	0.430
MOD_Plk_4	79	85	PF00069	0.637
MOD_ProDKin_1	281	287	PF00069	0.442
MOD_ProDKin_1	323	329	PF00069	0.430
MOD_ProDKin_1	68	74	PF00069	0.618
MOD_SUMO_rev_2	251	259	PF00179	0.486
TRG_DiLeu_BaEn_1	254	259	PF01217	0.489
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.404
TRG_ER_diArg_1	124	127	PF00400	0.656
TRG_ER_diArg_1	409	411	PF00400	0.385
TRG_ER_diArg_1	61	63	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7C6	Leptomonas seymouri	65%	100%
A0A1X0NWG2	Trypanosomatidae	54%	100%
A0A3S7WW26	Leishmania donovani	92%	100%
A4HYX5	Leishmania infantum	92%	100%
E9AII7	Leishmania braziliensis	85%	98%
Q4QCR4	Leishmania major	95%	100%