DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania mexicana

UniProt:

E9AUR7_LEIMU

TriTrypDb:

LmxM.20.1270

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.349
CLV_C14_Caspase3-7	139	143	PF00656	0.439
CLV_PCSK_SKI1_1	48	52	PF00082	0.581
CLV_PCSK_SKI1_1	97	101	PF00082	0.328
DEG_APCC_KENBOX_2	41	45	PF00400	0.386
DOC_CYCLIN_yClb1_LxF_4	135	140	PF00134	0.360
DOC_MAPK_MEF2A_6	18	26	PF00069	0.513
DOC_PP1_RVXF_1	135	141	PF00149	0.360
DOC_PP1_RVXF_1	46	52	PF00149	0.586
DOC_PP1_RVXF_1	95	102	PF00149	0.262
DOC_PP4_FxxP_1	67	70	PF00568	0.753
DOC_USP7_MATH_1	10	14	PF00917	0.676
DOC_USP7_MATH_1	148	152	PF00917	0.439
DOC_USP7_MATH_1	177	181	PF00917	0.489
DOC_USP7_UBL2_3	42	46	PF12436	0.564
DOC_WW_Pin1_4	131	136	PF00397	0.567
LIG_14-3-3_CanoR_1	20	25	PF00244	0.673
LIG_14-3-3_CanoR_1	88	96	PF00244	0.614
LIG_APCC_ABBA_1	38	43	PF00400	0.619
LIG_APCC_ABBAyCdc20_2	97	103	PF00400	0.404
LIG_deltaCOP1_diTrp_1	94	101	PF00928	0.390
LIG_FHA_1	54	60	PF00498	0.548
LIG_LIR_Apic_2	64	70	PF02991	0.714
LIG_LIR_Gen_1	28	38	PF02991	0.524
LIG_LIR_Gen_1	95	103	PF02991	0.385
LIG_LIR_Nem_3	28	33	PF02991	0.534
LIG_LIR_Nem_3	95	101	PF02991	0.403
LIG_REV1ctd_RIR_1	112	120	PF16727	0.439
LIG_SH3_3	147	153	PF00018	0.564
LIG_SH3_3	158	164	PF00018	0.427
LIG_SH3_3	171	177	PF00018	0.385
LIG_SH3_3	34	40	PF00018	0.627
LIG_SH3_3	68	74	PF00018	0.561
LIG_SH3_4	69	76	PF00018	0.729
LIG_SUMO_SIM_anti_2	34	39	PF11976	0.385
LIG_TRAF2_1	82	85	PF00917	0.716
LIG_TRAF2_1	92	95	PF00917	0.640
MOD_CDC14_SPxK_1	134	137	PF00782	0.360
MOD_CDK_SPxK_1	131	137	PF00069	0.360
MOD_CK1_1	106	112	PF00069	0.503
MOD_CK1_1	6	12	PF00069	0.530
MOD_CK2_1	177	183	PF00069	0.453
MOD_CK2_1	88	94	PF00069	0.664
MOD_GlcNHglycan	11	15	PF01048	0.647
MOD_GlcNHglycan	5	8	PF01048	0.750
MOD_GlcNHglycan	90	93	PF01048	0.648
MOD_GSK3_1	106	113	PF00069	0.503
MOD_GSK3_1	2	9	PF00069	0.568
MOD_N-GLC_1	101	106	PF02516	0.375
MOD_NEK2_1	101	106	PF00069	0.375
MOD_NEK2_1	60	65	PF00069	0.348
MOD_NMyristoyl	1	7	PF02799	0.605
MOD_PIKK_1	61	67	PF00454	0.367
MOD_PK_1	20	26	PF00069	0.661
MOD_Plk_1	10	16	PF00069	0.551
MOD_Plk_1	106	112	PF00069	0.401
MOD_Plk_4	110	116	PF00069	0.385
MOD_ProDKin_1	131	137	PF00069	0.567
MOD_SPalmitoyl_4	1	7	PF01529	0.605
MOD_SUMO_for_1	136	139	PF00179	0.360
MOD_SUMO_for_1	74	77	PF00179	0.657
MOD_SUMO_rev_2	23	28	PF00179	0.618
TRG_DiLeu_BaEn_3	94	100	PF01217	0.264
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE64	Leptomonas seymouri	45%	100%
A0A3S7WW30	Leishmania donovani	88%	100%
A4HYX0	Leishmania infantum	88%	100%
E9AII2	Leishmania braziliensis	72%	100%
Q4QCR9	Leishmania major	86%	100%