Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AUR6_LEIMU

TriTrypDb:

LmxM.20.1260

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.535
CLV_C14_Caspase3-7	358	362	PF00656	0.754
CLV_C14_Caspase3-7	71	75	PF00656	0.523
CLV_C14_Caspase3-7	766	770	PF00656	0.690
CLV_NRD_NRD_1	334	336	PF00675	0.756
CLV_NRD_NRD_1	369	371	PF00675	0.618
CLV_NRD_NRD_1	48	50	PF00675	0.570
CLV_NRD_NRD_1	699	701	PF00675	0.690
CLV_NRD_NRD_1	88	90	PF00675	0.544
CLV_PCSK_FUR_1	367	371	PF00082	0.622
CLV_PCSK_KEX2_1	369	371	PF00082	0.637
CLV_PCSK_KEX2_1	48	50	PF00082	0.570
CLV_PCSK_KEX2_1	699	701	PF00082	0.690
CLV_PCSK_KEX2_1	72	74	PF00082	0.454
CLV_PCSK_KEX2_1	83	85	PF00082	0.585
CLV_PCSK_KEX2_1	87	89	PF00082	0.663
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.454
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.585
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.663
CLV_PCSK_PC7_1	84	90	PF00082	0.448
CLV_PCSK_SKI1_1	370	374	PF00082	0.600
CLV_PCSK_SKI1_1	385	389	PF00082	0.473
CLV_PCSK_SKI1_1	479	483	PF00082	0.517
CLV_PCSK_SKI1_1	557	561	PF00082	0.522
CLV_PCSK_SKI1_1	618	622	PF00082	0.686
CLV_PCSK_SKI1_1	73	77	PF00082	0.462
DEG_APCC_DBOX_1	130	138	PF00400	0.463
DEG_APCC_DBOX_1	368	376	PF00400	0.703
DEG_APCC_DBOX_1	478	486	PF00400	0.427
DEG_COP1_1	684	691	PF00400	0.542
DEG_SCF_FBW7_1	452	459	PF00400	0.436
DEG_SCF_FBW7_2	493	499	PF00400	0.611
DEG_SPOP_SBC_1	619	623	PF00917	0.517
DOC_CKS1_1	188	193	PF01111	0.751
DOC_CKS1_1	319	324	PF01111	0.713
DOC_CKS1_1	493	498	PF01111	0.611
DOC_CKS1_1	558	563	PF01111	0.659
DOC_CYCLIN_RxL_1	379	393	PF00134	0.488
DOC_CYCLIN_RxL_1	458	469	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	228	231	PF00134	0.576
DOC_MAPK_DCC_7	473	483	PF00069	0.458
DOC_MAPK_DCC_7	779	789	PF00069	0.579
DOC_MAPK_gen_1	367	377	PF00069	0.595
DOC_MAPK_gen_1	575	585	PF00069	0.779
DOC_MAPK_MEF2A_6	538	546	PF00069	0.641
DOC_MIT_MIM_1	533	542	PF04212	0.495
DOC_PP1_RVXF_1	383	390	PF00149	0.477
DOC_PP2B_LxvP_1	228	231	PF13499	0.576
DOC_PP2B_LxvP_1	542	545	PF13499	0.539
DOC_PP2B_LxvP_1	686	689	PF13499	0.705
DOC_PP4_FxxP_1	652	655	PF00568	0.690
DOC_PP4_FxxP_1	730	733	PF00568	0.599
DOC_USP7_MATH_1	159	163	PF00917	0.705
DOC_USP7_MATH_1	170	174	PF00917	0.557
DOC_USP7_MATH_1	194	198	PF00917	0.521
DOC_USP7_MATH_1	296	300	PF00917	0.752
DOC_USP7_MATH_1	302	306	PF00917	0.737
DOC_USP7_MATH_1	320	324	PF00917	0.667
DOC_USP7_MATH_1	344	348	PF00917	0.663
DOC_USP7_MATH_1	397	401	PF00917	0.607
DOC_USP7_MATH_1	43	47	PF00917	0.586
DOC_USP7_MATH_1	60	64	PF00917	0.588
DOC_USP7_MATH_1	620	624	PF00917	0.619
DOC_USP7_MATH_1	633	637	PF00917	0.669
DOC_USP7_MATH_1	65	69	PF00917	0.583
DOC_USP7_MATH_1	671	675	PF00917	0.675
DOC_USP7_MATH_1	710	714	PF00917	0.546
DOC_USP7_MATH_1	724	728	PF00917	0.527
DOC_USP7_MATH_1	743	747	PF00917	0.649
DOC_USP7_MATH_1	793	797	PF00917	0.683
DOC_USP7_UBL2_3	281	285	PF12436	0.662
DOC_USP7_UBL2_3	72	76	PF12436	0.469
DOC_USP7_UBL2_3	83	87	PF12436	0.569
DOC_WW_Pin1_4	166	171	PF00397	0.742
DOC_WW_Pin1_4	183	188	PF00397	0.499
DOC_WW_Pin1_4	250	255	PF00397	0.837
DOC_WW_Pin1_4	279	284	PF00397	0.527
DOC_WW_Pin1_4	318	323	PF00397	0.752
DOC_WW_Pin1_4	361	366	PF00397	0.694
DOC_WW_Pin1_4	411	416	PF00397	0.700
DOC_WW_Pin1_4	434	439	PF00397	0.674
DOC_WW_Pin1_4	447	452	PF00397	0.501
DOC_WW_Pin1_4	492	497	PF00397	0.612
DOC_WW_Pin1_4	557	562	PF00397	0.563
DOC_WW_Pin1_4	629	634	PF00397	0.555
DOC_WW_Pin1_4	741	746	PF00397	0.595
LIG_14-3-3_CanoR_1	374	378	PF00244	0.666
LIG_14-3-3_CanoR_1	379	387	PF00244	0.576
LIG_14-3-3_CanoR_1	411	415	PF00244	0.531
LIG_14-3-3_CanoR_1	431	440	PF00244	0.573
LIG_14-3-3_CanoR_1	579	584	PF00244	0.654
LIG_14-3-3_CanoR_1	647	655	PF00244	0.577
LIG_14-3-3_CanoR_1	699	704	PF00244	0.693
LIG_Actin_WH2_2	365	381	PF00022	0.634
LIG_Actin_WH2_2	552	570	PF00022	0.433
LIG_APCC_ABBAyCdc20_2	385	391	PF00400	0.476
LIG_BIR_III_2	753	757	PF00653	0.587
LIG_BIR_III_4	661	665	PF00653	0.526
LIG_BRCT_BRCA1_1	118	122	PF00533	0.551
LIG_BRCT_BRCA1_1	648	652	PF00533	0.686
LIG_BRCT_BRCA1_1	726	730	PF00533	0.508
LIG_Clathr_ClatBox_1	543	547	PF01394	0.594
LIG_DLG_GKlike_1	200	208	PF00625	0.526
LIG_eIF4E_1	537	543	PF01652	0.506
LIG_FHA_1	231	237	PF00498	0.705
LIG_FHA_1	287	293	PF00498	0.747
LIG_FHA_1	319	325	PF00498	0.725
LIG_FHA_1	382	388	PF00498	0.689
LIG_FHA_1	414	420	PF00498	0.602
LIG_FHA_1	485	491	PF00498	0.569
LIG_FHA_1	524	530	PF00498	0.439
LIG_FHA_1	539	545	PF00498	0.473
LIG_FHA_1	626	632	PF00498	0.722
LIG_FHA_1	654	660	PF00498	0.605
LIG_FHA_2	307	313	PF00498	0.720
LIG_FHA_2	493	499	PF00498	0.611
LIG_FHA_2	648	654	PF00498	0.688
LIG_Integrin_RGD_1	200	202	PF01839	0.693
LIG_LIR_Apic_2	649	655	PF02991	0.688
LIG_LIR_Apic_2	727	733	PF02991	0.644
LIG_LIR_Gen_1	384	391	PF02991	0.551
LIG_LIR_Gen_1	472	483	PF02991	0.486
LIG_LIR_Gen_1	516	525	PF02991	0.426
LIG_LIR_Nem_3	162	167	PF02991	0.702
LIG_LIR_Nem_3	384	389	PF02991	0.507
LIG_LIR_Nem_3	472	478	PF02991	0.500
LIG_LIR_Nem_3	516	521	PF02991	0.421
LIG_MYND_1	112	116	PF01753	0.560
LIG_NRBOX	538	544	PF00104	0.514
LIG_PDZ_Class_2	821	826	PF00595	0.721
LIG_PTB_Apo_2	137	144	PF02174	0.582
LIG_PTB_Phospho_1	137	143	PF10480	0.584
LIG_SH2_PTP2	475	478	PF00017	0.588
LIG_SH2_SRC	475	478	PF00017	0.588
LIG_SH2_STAT5	475	478	PF00017	0.588
LIG_SH2_STAT5	528	531	PF00017	0.594
LIG_SH3_3	13	19	PF00018	0.716
LIG_SH3_3	185	191	PF00018	0.738
LIG_SH3_3	218	224	PF00018	0.583
LIG_SH3_3	245	251	PF00018	0.776
LIG_SH3_3	412	418	PF00018	0.682
LIG_SH3_3	422	428	PF00018	0.598
LIG_SH3_3	44	50	PF00018	0.541
LIG_SH3_3	490	496	PF00018	0.598
LIG_SH3_3	517	523	PF00018	0.420
LIG_SH3_3	593	599	PF00018	0.491
LIG_SH3_3	627	633	PF00018	0.573
LIG_SH3_3	675	681	PF00018	0.636
LIG_SH3_3	685	691	PF00018	0.636
LIG_SH3_3	753	759	PF00018	0.494
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.669
LIG_SUMO_SIM_par_1	479	484	PF11976	0.448
LIG_SUMO_SIM_par_1	785	791	PF11976	0.591
LIG_SUMO_SIM_par_1	820	825	PF11976	0.493
LIG_TRAF2_1	420	423	PF00917	0.685
LIG_TRAF2_1	496	499	PF00917	0.617
LIG_TRAF2_1	93	96	PF00917	0.517
LIG_WRC_WIRS_1	287	292	PF05994	0.670
MOD_CDC14_SPxK_1	186	189	PF00782	0.675
MOD_CDC14_SPxK_1	364	367	PF00782	0.688
MOD_CDC14_SPxK_1	414	417	PF00782	0.685
MOD_CDK_SPK_2	166	171	PF00069	0.750
MOD_CDK_SPxK_1	183	189	PF00069	0.674
MOD_CDK_SPxK_1	279	285	PF00069	0.500
MOD_CDK_SPxK_1	361	367	PF00069	0.694
MOD_CDK_SPxK_1	411	417	PF00069	0.675
MOD_CK1_1	117	123	PF00069	0.662
MOD_CK1_1	288	294	PF00069	0.627
MOD_CK1_1	3	9	PF00069	0.640
MOD_CK1_1	318	324	PF00069	0.618
MOD_CK1_1	381	387	PF00069	0.542
MOD_CK1_1	429	435	PF00069	0.663
MOD_CK1_1	467	473	PF00069	0.487
MOD_CK1_1	632	638	PF00069	0.783
MOD_CK1_1	68	74	PF00069	0.604
MOD_CK2_1	239	245	PF00069	0.541
MOD_CK2_1	262	268	PF00069	0.510
MOD_CK2_1	390	396	PF00069	0.367
MOD_CK2_1	471	477	PF00069	0.663
MOD_CK2_1	492	498	PF00069	0.510
MOD_CK2_1	647	653	PF00069	0.688
MOD_CK2_1	89	95	PF00069	0.612
MOD_DYRK1A_RPxSP_1	411	415	PF00069	0.575
MOD_GlcNHglycan	13	16	PF01048	0.622
MOD_GlcNHglycan	2	5	PF01048	0.627
MOD_GlcNHglycan	241	244	PF01048	0.732
MOD_GlcNHglycan	293	296	PF01048	0.625
MOD_GlcNHglycan	357	360	PF01048	0.583
MOD_GlcNHglycan	428	431	PF01048	0.697
MOD_GlcNHglycan	547	551	PF01048	0.394
MOD_GlcNHglycan	569	572	PF01048	0.477
MOD_GlcNHglycan	600	603	PF01048	0.654
MOD_GlcNHglycan	610	613	PF01048	0.720
MOD_GlcNHglycan	622	625	PF01048	0.575
MOD_GlcNHglycan	67	70	PF01048	0.384
MOD_GlcNHglycan	673	676	PF01048	0.697
MOD_GlcNHglycan	711	715	PF01048	0.637
MOD_GlcNHglycan	765	768	PF01048	0.697
MOD_GlcNHglycan	779	782	PF01048	0.539
MOD_GlcNHglycan	799	803	PF01048	0.609
MOD_GlcNHglycan	8	11	PF01048	0.645
MOD_GlcNHglycan	90	94	PF01048	0.449
MOD_GlcNHglycan	98	102	PF01048	0.348
MOD_GSK3_1	110	117	PF00069	0.563
MOD_GSK3_1	166	173	PF00069	0.635
MOD_GSK3_1	179	186	PF00069	0.685
MOD_GSK3_1	291	298	PF00069	0.696
MOD_GSK3_1	302	309	PF00069	0.590
MOD_GSK3_1	355	362	PF00069	0.641
MOD_GSK3_1	409	416	PF00069	0.517
MOD_GSK3_1	429	436	PF00069	0.731
MOD_GSK3_1	452	459	PF00069	0.643
MOD_GSK3_1	464	471	PF00069	0.465
MOD_GSK3_1	567	574	PF00069	0.667
MOD_GSK3_1	6	13	PF00069	0.646
MOD_GSK3_1	608	615	PF00069	0.692
MOD_GSK3_1	625	632	PF00069	0.517
MOD_GSK3_1	653	660	PF00069	0.642
MOD_GSK3_1	732	739	PF00069	0.601
MOD_GSK3_1	798	805	PF00069	0.668
MOD_N-GLC_1	11	16	PF02516	0.538
MOD_N-GLC_1	151	156	PF02516	0.693
MOD_N-GLC_1	389	394	PF02516	0.673
MOD_N-GLC_2	718	720	PF02516	0.705
MOD_NEK2_1	151	156	PF00069	0.668
MOD_NEK2_1	179	184	PF00069	0.731
MOD_NEK2_1	286	291	PF00069	0.702
MOD_NEK2_1	389	394	PF00069	0.519
MOD_NEK2_1	468	473	PF00069	0.462
MOD_NEK2_1	5	10	PF00069	0.523
MOD_NEK2_1	505	510	PF00069	0.529
MOD_NEK2_1	546	551	PF00069	0.552
MOD_NEK2_1	567	572	PF00069	0.532
MOD_NEK2_1	608	613	PF00069	0.774
MOD_NEK2_1	646	651	PF00069	0.722
MOD_NEK2_2	43	48	PF00069	0.663
MOD_NEK2_2	523	528	PF00069	0.507
MOD_NMyristoyl	1	7	PF02799	0.639
MOD_PIKK_1	456	462	PF00454	0.494
MOD_PKA_1	699	705	PF00069	0.670
MOD_PKA_2	170	176	PF00069	0.675
MOD_PKA_2	209	215	PF00069	0.634
MOD_PKA_2	334	340	PF00069	0.712
MOD_PKA_2	373	379	PF00069	0.669
MOD_PKA_2	410	416	PF00069	0.525
MOD_PKA_2	578	584	PF00069	0.656
MOD_PKA_2	646	652	PF00069	0.575
MOD_PKA_2	692	698	PF00069	0.544
MOD_PKA_2	699	705	PF00069	0.674
MOD_PKA_2	814	820	PF00069	0.515
MOD_Plk_1	315	321	PF00069	0.608
MOD_Plk_1	381	387	PF00069	0.560
MOD_Plk_1	97	103	PF00069	0.379
MOD_Plk_2-3	308	314	PF00069	0.591
MOD_Plk_4	104	110	PF00069	0.491
MOD_Plk_4	170	176	PF00069	0.675
MOD_Plk_4	200	206	PF00069	0.524
MOD_Plk_4	224	230	PF00069	0.629
MOD_Plk_4	323	329	PF00069	0.616
MOD_Plk_4	397	403	PF00069	0.394
MOD_Plk_4	523	529	PF00069	0.499
MOD_Plk_4	538	544	PF00069	0.465
MOD_Plk_4	579	585	PF00069	0.642
MOD_Plk_4	647	653	PF00069	0.616
MOD_ProDKin_1	166	172	PF00069	0.740
MOD_ProDKin_1	183	189	PF00069	0.502
MOD_ProDKin_1	250	256	PF00069	0.838
MOD_ProDKin_1	279	285	PF00069	0.525
MOD_ProDKin_1	318	324	PF00069	0.750
MOD_ProDKin_1	361	367	PF00069	0.694
MOD_ProDKin_1	411	417	PF00069	0.705
MOD_ProDKin_1	434	440	PF00069	0.670
MOD_ProDKin_1	447	453	PF00069	0.501
MOD_ProDKin_1	492	498	PF00069	0.611
MOD_ProDKin_1	557	563	PF00069	0.561
MOD_ProDKin_1	629	635	PF00069	0.555
MOD_ProDKin_1	741	747	PF00069	0.597
MOD_SUMO_rev_2	498	508	PF00179	0.530
MOD_SUMO_rev_2	68	78	PF00179	0.538
MOD_SUMO_rev_2	766	773	PF00179	0.690
TRG_DiLeu_BaEn_1	130	135	PF01217	0.679
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.637
TRG_ENDOCYTIC_2	24	27	PF00928	0.720
TRG_ENDOCYTIC_2	475	478	PF00928	0.588
TRG_ER_diArg_1	131	134	PF00400	0.439
TRG_ER_diArg_1	367	370	PF00400	0.627
TRG_ER_diArg_1	383	386	PF00400	0.503
TRG_ER_diArg_1	47	49	PF00400	0.581
TRG_ER_diArg_1	699	701	PF00400	0.727
TRG_NES_CRM1_1	371	382	PF08389	0.532
TRG_NES_CRM1_1	533	547	PF08389	0.508
TRG_NLS_Bipartite_1	72	87	PF00514	0.614
TRG_NLS_MonoExtC_3	82	87	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	557	562	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	699	704	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G6	Leptomonas seymouri	36%	100%
A0A3Q8IAM5	Leishmania donovani	81%	99%
A4HYW9	Leishmania infantum	80%	98%
E9AII1	Leishmania braziliensis	55%	95%
Q4QCS0	Leishmania major	76%	99%