DUF1935 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania mexicana

UniProt:

E9AUR5_LEIMU

TriTrypDb:

LmxM.20.1250

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AUR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AUR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	182	184	PF00082	0.405
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.405
CLV_PCSK_SKI1_1	128	132	PF00082	0.545
DOC_CKS1_1	40	45	PF01111	0.526
DOC_SPAK_OSR1_1	141	145	PF12202	0.609
DOC_USP7_MATH_1	205	209	PF00917	0.405
DOC_USP7_MATH_1	211	215	PF00917	0.343
DOC_USP7_MATH_1	91	95	PF00917	0.655
DOC_USP7_MATH_2	235	241	PF00917	0.296
DOC_WW_Pin1_4	104	109	PF00397	0.622
DOC_WW_Pin1_4	145	150	PF00397	0.585
DOC_WW_Pin1_4	253	258	PF00397	0.503
DOC_WW_Pin1_4	39	44	PF00397	0.758
DOC_WW_Pin1_4	94	99	PF00397	0.706
LIG_14-3-3_CanoR_1	198	205	PF00244	0.405
LIG_14-3-3_CanoR_1	216	221	PF00244	0.220
LIG_APCC_ABBA_1	54	59	PF00400	0.488
LIG_BIR_III_2	254	258	PF00653	0.437
LIG_BRCT_BRCA1_1	199	203	PF00533	0.405
LIG_FHA_1	129	135	PF00498	0.611
LIG_FHA_1	16	22	PF00498	0.541
LIG_FHA_1	213	219	PF00498	0.275
LIG_FHA_1	24	30	PF00498	0.516
LIG_FHA_1	47	53	PF00498	0.500
LIG_FHA_1	98	104	PF00498	0.654
LIG_FHA_2	107	113	PF00498	0.576
LIG_FHA_2	249	255	PF00498	0.356
LIG_HCF-1_HBM_1	162	165	PF13415	0.296
LIG_LIR_Apic_2	147	153	PF02991	0.656
LIG_LIR_Nem_3	162	168	PF02991	0.344
LIG_LIR_Nem_3	245	249	PF02991	0.405
LIG_LIR_Nem_3	55	60	PF02991	0.486
LIG_LYPXL_S_1	56	60	PF13949	0.487
LIG_PCNA_yPIPBox_3	166	179	PF02747	0.405
LIG_PDZ_Class_2	261	266	PF00595	0.573
LIG_SH2_PTP2	150	153	PF00017	0.474
LIG_SH2_STAT3	64	67	PF00017	0.566
LIG_SH2_STAT5	150	153	PF00017	0.528
LIG_SH2_STAT5	250	253	PF00017	0.356
LIG_SH3_3	102	108	PF00018	0.690
LIG_SH3_3	154	160	PF00018	0.528
LIG_SH3_3	40	46	PF00018	0.710
LIG_SUMO_SIM_anti_2	99	107	PF11976	0.591
LIG_UBA3_1	174	182	PF00899	0.405
MOD_CDK_SPK_2	106	111	PF00069	0.530
MOD_CDK_SPxxK_3	104	111	PF00069	0.531
MOD_CK1_1	104	110	PF00069	0.660
MOD_CK1_1	39	45	PF00069	0.686
MOD_CK1_1	48	54	PF00069	0.747
MOD_CK1_1	94	100	PF00069	0.754
MOD_CK2_1	216	222	PF00069	0.296
MOD_CK2_1	5	11	PF00069	0.577
MOD_GlcNHglycan	199	202	PF01048	0.278
MOD_GlcNHglycan	32	35	PF01048	0.519
MOD_GlcNHglycan	73	76	PF01048	0.644
MOD_GlcNHglycan	77	80	PF01048	0.612
MOD_GlcNHglycan	92	96	PF01048	0.700
MOD_GSK3_1	212	219	PF00069	0.296
MOD_GSK3_1	32	39	PF00069	0.783
MOD_GSK3_1	48	55	PF00069	0.535
MOD_GSK3_1	71	78	PF00069	0.740
MOD_GSK3_1	97	104	PF00069	0.725
MOD_N-GLC_1	101	106	PF02516	0.675
MOD_N-GLC_1	16	21	PF02516	0.543
MOD_N-GLC_1	189	194	PF02516	0.405
MOD_NEK2_1	197	202	PF00069	0.441
MOD_NEK2_1	212	217	PF00069	0.365
MOD_NEK2_1	32	37	PF00069	0.574
MOD_NEK2_2	205	210	PF00069	0.477
MOD_NEK2_2	248	253	PF00069	0.405
MOD_NEK2_2	5	10	PF00069	0.489
MOD_NMyristoyl	1	7	PF02799	0.555
MOD_PIKK_1	135	141	PF00454	0.621
MOD_PIKK_1	235	241	PF00454	0.405
MOD_PKA_2	197	203	PF00069	0.405
MOD_Plk_1	101	107	PF00069	0.692
MOD_Plk_1	205	211	PF00069	0.322
MOD_Plk_4	101	107	PF00069	0.598
MOD_Plk_4	237	243	PF00069	0.308
MOD_Plk_4	52	58	PF00069	0.487
MOD_ProDKin_1	104	110	PF00069	0.617
MOD_ProDKin_1	145	151	PF00069	0.581
MOD_ProDKin_1	253	259	PF00069	0.513
MOD_ProDKin_1	39	45	PF00069	0.760
MOD_ProDKin_1	94	100	PF00069	0.706
MOD_SPalmitoyl_4	1	7	PF01529	0.555
TRG_DiLeu_BaEn_2	236	242	PF01217	0.405
TRG_ENDOCYTIC_2	165	168	PF00928	0.405
TRG_ENDOCYTIC_2	246	249	PF00928	0.405
TRG_ENDOCYTIC_2	57	60	PF00928	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEW9	Leishmania donovani	79%	100%
A4HYW8	Leishmania infantum	79%	100%
E9AII0	Leishmania braziliensis	45%	100%
Q4QCS1	Leishmania major	75%	100%